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6MSG
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BU of 6msg by Molmil
Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome
Descriptor: 26S proteasome complex subunit SEM1, 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, ...
Authors:Mao, Y.D.
Deposit date:2018-10-16
Release date:2018-11-21
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome.
Nature, 565, 2019
7PX9
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BU of 7px9 by Molmil
Substrate-engaged mycobacterial Proteasome-associated ATPase - focused 3D refinement (state A)
Descriptor: AAA ATPase forming ring-shaped complexes, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Jomaa, A, Kavalchuk, M, Weber-Ban, E.
Deposit date:2021-10-08
Release date:2022-01-19
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural basis of prokaryotic ubiquitin-like protein engagement and translocation by the mycobacterial Mpa-proteasome complex.
Nat Commun, 13, 2022
7PXA
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BU of 7pxa by Molmil
Open-gate mycobacterium 20S CP proteasome in complex MPA - global 3D refinement
Descriptor: AAA ATPase forming ring-shaped complexes, Proteasome subunit alpha, Proteasome subunit beta
Authors:Jomaa, A, Kavalchuk, M, Weber-Ban, E.
Deposit date:2021-10-08
Release date:2022-01-19
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural basis of prokaryotic ubiquitin-like protein engagement and translocation by the mycobacterial Mpa-proteasome complex.
Nat Commun, 13, 2022
7PXC
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BU of 7pxc by Molmil
Substrate-engaged mycobacterial Proteasome-associated ATPase in complex with open-gate 20S CP - composite map (state A)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Jomaa, A, Kavalchuk, M, Weber-Ban, E.
Deposit date:2021-10-08
Release date:2022-01-19
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (3.84 Å)
Cite:Structural basis of prokaryotic ubiquitin-like protein engagement and translocation by the mycobacterial Mpa-proteasome complex.
Nat Commun, 13, 2022
7PXB
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BU of 7pxb by Molmil
Substrate-engaged mycobacterial Proteasome-associated ATPase - focused 3D refinement (state B)
Descriptor: AAA ATPase forming ring-shaped complexes, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Jomaa, A, Kavalchuk, M, Weber-Ban, E.
Deposit date:2021-10-08
Release date:2022-01-19
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structural basis of prokaryotic ubiquitin-like protein engagement and translocation by the mycobacterial Mpa-proteasome complex.
Nat Commun, 13, 2022
7PXD
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BU of 7pxd by Molmil
Substrate-engaged mycobacterial Proteasome-associated ATPase in complex with open-gate 20S CP - composite map (state B)
Descriptor: AAA ATPase forming ring-shaped complexes, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Jomaa, A, Kavalchuk, M, Weber-Ban, E.
Deposit date:2021-10-08
Release date:2022-01-19
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structural basis of prokaryotic ubiquitin-like protein engagement and translocation by the mycobacterial Mpa-proteasome complex.
Nat Commun, 13, 2022
7PUX
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BU of 7pux by Molmil
Structure of p97 N-D1(L198W) in complex with Fragment TROLL2
Descriptor: (1S)-2-amino-1-(4-bromophenyl)ethan-1-ol, ADENOSINE-5'-DIPHOSPHATE, DI(HYDROXYETHYL)ETHER, ...
Authors:Bothe, S, Schindelin, H.
Deposit date:2021-10-01
Release date:2022-12-14
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Fragment screening using biolayer interferometry reveals ligands targeting the SHP-motif binding site of the AAA+ ATPase p97
Commun Chem, 5, 2022
7QO4
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BU of 7qo4 by Molmil
26S proteasome WT-Ubp6-UbVS complex in the si state (ATPases, Rpn1, Ubp6, and UbVS)
Descriptor: 26S proteasome regulatory subunit RPN1, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Hung, K.Y.S, Klumpe, S, Eisele, M.R, Elsasser, S, Geng, T.T, Cheng, C, Joshi, T, Rudack, T, Sakata, E, Finley, D.
Deposit date:2021-12-23
Release date:2022-06-01
Method:ELECTRON MICROSCOPY (7 Å)
Cite:Allosteric control of Ubp6 and the proteasome via a bidirectional switch.
Nat Commun, 13, 2022
7QXX
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BU of 7qxx by Molmil
Proteasome-ZFAND5 Complex Z+E state
Descriptor: 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, 26S protease regulatory subunit 7, ...
Authors:Zhu, Y, Lu, Y.
Deposit date:2022-01-27
Release date:2023-02-08
Last modified:2024-09-04
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Molecular mechanism for activation of the 26S proteasome by ZFAND5.
Mol.Cell, 83, 2023
7QY7
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BU of 7qy7 by Molmil
Proteasome-ZFAND5 Complex Z-A state
Descriptor: 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ...
Authors:Zhu, Y, Lu, Y.
Deposit date:2022-01-27
Release date:2023-02-08
Last modified:2024-09-04
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Molecular mechanism for activation of the 26S proteasome by ZFAND5.
Mol.Cell, 83, 2023
7QXN
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BU of 7qxn by Molmil
Proteasome-ZFAND5 Complex Z+A state
Descriptor: 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ...
Authors:Zhu, Y, Lu, Y.
Deposit date:2022-01-26
Release date:2023-02-08
Last modified:2024-09-04
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Molecular mechanism for activation of the 26S proteasome by ZFAND5.
Mol.Cell, 83, 2023
7QXP
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BU of 7qxp by Molmil
Proteasome-ZFAND5 Complex Z+B state
Descriptor: 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ...
Authors:Zhu, Y, Lu, Y.
Deposit date:2022-01-26
Release date:2023-02-08
Last modified:2024-09-04
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Molecular mechanism for activation of the 26S proteasome by ZFAND5.
Mol.Cell, 83, 2023
7QYB
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BU of 7qyb by Molmil
Proteasome-ZFAND5 Complex Z-C state
Descriptor: 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ...
Authors:Zhu, Y, Lu, Y.
Deposit date:2022-01-27
Release date:2023-02-08
Last modified:2024-09-04
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Molecular mechanism for activation of the 26S proteasome by ZFAND5.
Mol.Cell, 83, 2023
7QXU
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BU of 7qxu by Molmil
Proteasome-ZFAND5 Complex Z+C state
Descriptor: 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, 26S protease regulatory subunit 7, ...
Authors:Zhu, Y, Lu, Y.
Deposit date:2022-01-27
Release date:2023-02-08
Last modified:2024-09-04
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Molecular mechanism for activation of the 26S proteasome by ZFAND5.
Mol.Cell, 83, 2023
7QXW
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BU of 7qxw by Molmil
Proteasome-ZFAND5 Complex Z+D state
Descriptor: 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, 26S protease regulatory subunit 7, ...
Authors:Zhu, Y, Lu, Y.
Deposit date:2022-01-27
Release date:2023-02-08
Last modified:2024-09-04
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Molecular mechanism for activation of the 26S proteasome by ZFAND5.
Mol.Cell, 83, 2023
7QYA
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BU of 7qya by Molmil
Proteasome-ZFAND5 Complex Z-B state
Descriptor: 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ...
Authors:Zhu, Y, Lu, Y.
Deposit date:2022-01-27
Release date:2023-02-08
Last modified:2024-09-04
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Molecular mechanism for activation of the 26S proteasome by ZFAND5.
Mol.Cell, 83, 2023
7R7S
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BU of 7r7s by Molmil
p47-bound p97-R155H mutant with ATPgammaS
Descriptor: NSFL1 cofactor p47, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase
Authors:Nandi, P, Li, S, Coulmbres, R.C.A, Wang, F, Williams, D.R, Malyutin, A.G, Poh, Y.-P, Chou, T.-F, Chiu, P.-L.
Deposit date:2021-06-25
Release date:2021-08-04
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (4.23 Å)
Cite:Structural and Functional Analysis of Disease-Linked p97 ATPase Mutant Complexes.
Int J Mol Sci, 22, 2021
7R7T
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BU of 7r7t by Molmil
p47-bound p97-R155H mutant with ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, NSFL1 cofactor p47, Transitional endoplasmic reticulum ATPase
Authors:Nandi, P, Li, S, Coulmbres, R.C.A, Wang, F, Williams, D.R, Malyutin, A.G, Poh, Y.-P, Chou, T.-F, Chiu, P.-L.
Deposit date:2021-06-25
Release date:2021-08-04
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Structural and Functional Analysis of Disease-Linked p97 ATPase Mutant Complexes.
Int J Mol Sci, 22, 2021
7R7U
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BU of 7r7u by Molmil
D1 and D2 domain structure of the p97(R155H)-p47 complex
Descriptor: Transitional endoplasmic reticulum ATPase
Authors:Nandi, P, Li, S, Coulmbres, R.C.A, Wang, F, Williams, D.R, Poh, Y.-P, Chou, T.-F, Chiu, P.-L.
Deposit date:2021-06-25
Release date:2021-08-04
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structural and Functional Analysis of Disease-Linked p97 ATPase Mutant Complexes.
Int J Mol Sci, 22, 2021
7RLH
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BU of 7rlh by Molmil
Cryo-EM structure of human p97-D592N mutant bound to ATPgS.
Descriptor: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase
Authors:Caffrey, B, Zhu, X, Berezuk, A, Tuttle, K, Chittori, S, Subramaniam, S.
Deposit date:2021-07-23
Release date:2021-09-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3 Å)
Cite:AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation.
J.Biol.Chem., 297, 2021
7RLG
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BU of 7rlg by Molmil
Cryo-EM structure of human p97-D592N mutant bound to ADP.
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase
Authors:Caffrey, B, Zhu, X, Berezuk, A, Tuttle, K, Chittori, S, Subramaniam, S.
Deposit date:2021-07-23
Release date:2021-09-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation.
J.Biol.Chem., 297, 2021
7RLC
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BU of 7rlc by Molmil
Cryo-EM structure of human p97-A232E mutant bound to ATPgS.
Descriptor: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase
Authors:Caffrey, B, Zhu, X, Berezuk, A, Tuttle, K, Chittori, S, Subramaniam, S.
Deposit date:2021-07-23
Release date:2021-09-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation.
J.Biol.Chem., 297, 2021
7RL9
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BU of 7rl9 by Molmil
Cryo-EM structure of human p97-R191Q mutant bound to ADP.
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase
Authors:Caffrey, B, Zhu, X, Berezuk, A, Tuttle, K, Chittori, S, Subramaniam, S.
Deposit date:2021-07-23
Release date:2021-09-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation.
J.Biol.Chem., 297, 2021
7RLB
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BU of 7rlb by Molmil
Cryo-EM structure of human p97-A232E mutant bound to ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase
Authors:Caffrey, B, Zhu, X, Berezuk, A, Tuttle, K, Chittori, S, Subramaniam, S.
Deposit date:2021-07-23
Release date:2021-09-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation.
J.Biol.Chem., 297, 2021
7RLA
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BU of 7rla by Molmil
Cryo-EM structure of human p97-R191Q mutant bound to ATPgS.
Descriptor: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase
Authors:Caffrey, B, Zhu, X, Berezuk, A, Tuttle, K, Chittori, S, Subramaniam, S.
Deposit date:2021-07-23
Release date:2021-09-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation.
J.Biol.Chem., 297, 2021

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PDB entries from 2024-09-18

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