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6EPD
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Substrate processing state 26S proteasome (SPS1)
Descriptor: 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, 26S proteasome non-ATPase regulatory subunit 13, ...
Authors:Guo, Q, Lehmer, C, Martinez-Sanchez, A, Rudack, T, Beck, F, Hartmann, H, Hipp, M.S, Hartl, F.U, Edbauer, D, Baumeister, W, Fernandez-Busnadiego, R.
Deposit date:2017-10-11
Release date:2018-02-07
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (15.4 Å)
Cite:In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment.
Cell, 172, 2018
6EF3
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Yeast 26S proteasome bound to ubiquitinated substrate (4D motor state)
Descriptor: 26S proteasome regulatory subunit 4 homolog, 26S proteasome regulatory subunit 6A, 26S proteasome regulatory subunit 6B homolog, ...
Authors:de la Pena, A.H, Goodall, E.A, Gates, S.N, Lander, G.C, Martin, A.
Deposit date:2018-08-15
Release date:2018-10-17
Last modified:2020-01-08
Method:ELECTRON MICROSCOPY (4.17 Å)
Cite:Substrate-engaged 26Sproteasome structures reveal mechanisms for ATP-hydrolysis-driven translocation.
Science, 362, 2018
6EMW
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BU of 6emw by Molmil
Structure of S.aureus ClpC in complex with MecA
Descriptor: ATP-dependent Clp protease ATP-binding subunit, ATP-dependent Clp protease ATP-binding subunit ClpC, Adapter protein MecA, ...
Authors:Carroni, M, Mogk, A, Bukau, B, Franke, K.
Deposit date:2017-10-03
Release date:2017-12-27
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (11 Å)
Cite:Regulatory coiled-coil domains promote head-to-head assemblies of AAA+ chaperones essential for tunable activity control.
Elife, 6, 2017
6EPF
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BU of 6epf by Molmil
Ground state 26S proteasome (GS1)
Descriptor: 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, 26S proteasome non-ATPase regulatory subunit 13, ...
Authors:Guo, Q, Lehmer, C, Martinez-Sanchez, A, Rudack, T, Beck, F, Hartmann, H, Hipp, M.S, Hartl, F.U, Edbauer, D, Baumeister, W, Fernandez-Busnadiego, R.
Deposit date:2017-10-11
Release date:2018-02-07
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (11.8 Å)
Cite:In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment.
Cell, 172, 2018
6EPE
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BU of 6epe by Molmil
Substrate processing state 26S proteasome (SPS2)
Descriptor: 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, 26S proteasome non-ATPase regulatory subunit 13, ...
Authors:Guo, Q, Lehmer, C, Martinez-Sanchez, A, Rudack, T, Beck, F, Hartmann, H, Hipp, M.S, Hartl, F.U, Edbauer, D, Baumeister, W, Fernandez-Busnadiego, R.
Deposit date:2017-10-11
Release date:2018-02-07
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (12.8 Å)
Cite:In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment.
Cell, 172, 2018
6EM8
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BU of 6em8 by Molmil
S.aureus ClpC resting state, C2 symmetrised
Descriptor: ATP-dependent Clp protease ATP-binding subunit ClpC
Authors:Carroni, M, Mogk, A.
Deposit date:2017-10-01
Release date:2017-12-27
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (8.4 Å)
Cite:Regulatory coiled-coil domains promote head-to-head assemblies of AAA+ chaperones essential for tunable activity control.
Elife, 6, 2017
6F0X
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BU of 6f0x by Molmil
Cryo-EM structure of TRIP13 in complex with ATP gamma S, p31comet, C-Mad2 and Cdc20
Descriptor: Cell division cycle protein 20 homolog, MAD2L1-binding protein, Mitotic spindle assembly checkpoint protein MAD2A, ...
Authors:Alfieri, C, Chang, L, Barford, D.
Deposit date:2017-11-20
Release date:2018-05-02
Last modified:2020-12-02
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13.
Nature, 559, 2018
7RLC
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BU of 7rlc by Molmil
Cryo-EM structure of human p97-A232E mutant bound to ATPgS.
Descriptor: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase
Authors:Caffrey, B, Zhu, X, Berezuk, A, Tuttle, K, Chittori, S, Subramaniam, S.
Deposit date:2021-07-23
Release date:2021-09-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation.
J.Biol.Chem., 297, 2021
7RLA
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BU of 7rla by Molmil
Cryo-EM structure of human p97-R191Q mutant bound to ATPgS.
Descriptor: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase
Authors:Caffrey, B, Zhu, X, Berezuk, A, Tuttle, K, Chittori, S, Subramaniam, S.
Deposit date:2021-07-23
Release date:2021-09-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation.
J.Biol.Chem., 297, 2021
7RL9
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BU of 7rl9 by Molmil
Cryo-EM structure of human p97-R191Q mutant bound to ADP.
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase
Authors:Caffrey, B, Zhu, X, Berezuk, A, Tuttle, K, Chittori, S, Subramaniam, S.
Deposit date:2021-07-23
Release date:2021-09-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation.
J.Biol.Chem., 297, 2021
7RL6
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BU of 7rl6 by Molmil
Cryo-EM structure of human p97-R155H mutant bound to ADP.
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase
Authors:Caffrey, B, Zhu, X, Berezuk, A, Tuttle, K, Chittori, S, Subramaniam, S.
Deposit date:2021-07-23
Release date:2021-09-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation.
J.Biol.Chem., 297, 2021
7RLB
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BU of 7rlb by Molmil
Cryo-EM structure of human p97-A232E mutant bound to ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase
Authors:Caffrey, B, Zhu, X, Berezuk, A, Tuttle, K, Chittori, S, Subramaniam, S.
Deposit date:2021-07-23
Release date:2021-09-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation.
J.Biol.Chem., 297, 2021
7RL7
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BU of 7rl7 by Molmil
Cryo-EM structure of human p97-R155H mutant bound to ATPgS.
Descriptor: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase
Authors:Caffrey, B, Zhu, X, Berezuk, A, Tuttle, K, Chittori, S, Subramaniam, S.
Deposit date:2021-07-23
Release date:2021-09-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3 Å)
Cite:AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation.
J.Biol.Chem., 297, 2021
7RLF
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BU of 7rlf by Molmil
Cryo-EM structure of human p97-E470D mutant bound to ATPgS.
Descriptor: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase
Authors:Caffrey, B, Zhu, X, Berezuk, A, Tuttle, K, Chittori, S, Subramaniam, S.
Deposit date:2021-07-23
Release date:2021-09-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation.
J.Biol.Chem., 297, 2021
7RLJ
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BU of 7rlj by Molmil
Cryo-EM structure of human p97 bound to CB-5083 and ATPgS.
Descriptor: 1-[4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-carboxamide, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Caffrey, B, Zhu, X, Berezuk, A, Tuttle, K, Chittori, S, Subramaniam, S.
Deposit date:2021-07-23
Release date:2021-09-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation.
J.Biol.Chem., 297, 2021
7RLD
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BU of 7rld by Molmil
Cryo-EM structure of human p97-E470D mutant bound to ADP.
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase
Authors:Caffrey, B, Zhu, X, Berezuk, A, Tuttle, K, Chittori, S, Subramaniam, S.
Deposit date:2021-07-23
Release date:2021-09-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation.
J.Biol.Chem., 297, 2021
7RLI
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BU of 7rli by Molmil
Cryo-EM structure of human p97 bound to CB-5083 and ADP.
Descriptor: 1-[4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-carboxamide, ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase
Authors:Caffrey, B, Zhu, X, Berezuk, A, Tuttle, K, Chittori, S, Subramaniam, S.
Deposit date:2021-07-23
Release date:2021-09-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation.
J.Biol.Chem., 297, 2021
7PUX
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BU of 7pux by Molmil
Structure of p97 N-D1(L198W) in complex with Fragment TROLL2
Descriptor: (1S)-2-amino-1-(4-bromophenyl)ethan-1-ol, ADENOSINE-5'-DIPHOSPHATE, DI(HYDROXYETHYL)ETHER, ...
Authors:Bothe, S, Schindelin, H.
Deposit date:2021-10-01
Release date:2022-12-14
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Fragment screening using biolayer interferometry reveals ligands targeting the SHP-motif binding site of the AAA+ ATPase p97
Commun Chem, 5, 2022
7QO4
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BU of 7qo4 by Molmil
26S proteasome WT-Ubp6-UbVS complex in the si state (ATPases, Rpn1, Ubp6, and UbVS)
Descriptor: 26S proteasome regulatory subunit RPN1, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Hung, K.Y.S, Klumpe, S, Eisele, M.R, Elsasser, S, Geng, T.T, Cheng, C, Joshi, T, Rudack, T, Sakata, E, Finley, D.
Deposit date:2021-12-23
Release date:2022-06-01
Method:ELECTRON MICROSCOPY (7 Å)
Cite:Allosteric control of Ubp6 and the proteasome via a bidirectional switch.
Nat Commun, 13, 2022
7SGZ
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BU of 7sgz by Molmil
Structure of the yeast Rad24-RFC loader bound to DNA and the closed 9-1-1 clamp
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Checkpoint protein RAD24, Crick strand, ...
Authors:Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H.
Deposit date:2021-10-07
Release date:2022-03-23
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:DNA is loaded through the 9-1-1 DNA checkpoint clamp in the opposite direction of the PCNA clamp.
Nat.Struct.Mol.Biol., 29, 2022
7SH2
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BU of 7sh2 by Molmil
Structure of the yeast Rad24-RFC loader bound to DNA and the open 9-1-1 clamp
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Checkpoint protein RAD24, Crick strand, ...
Authors:Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H.
Deposit date:2021-10-07
Release date:2022-03-23
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.23 Å)
Cite:DNA is loaded through the 9-1-1 DNA checkpoint clamp in the opposite direction of the PCNA clamp.
Nat.Struct.Mol.Biol., 29, 2022
6FVU
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BU of 6fvu by Molmil
26S proteasome, s2 state
Descriptor: 26S proteasome complex subunit SEM1, 26S proteasome regulatory subunit 4 homolog, 26S proteasome regulatory subunit 6A, ...
Authors:Eisele, M.R, Reed, R.G, Rudack, T, Schweitzer, A, Beck, F, Nagy, I, Pfeifer, G, Plitzko, J.M, Baumeister, W, Tomko, R.J, Sakata, E.
Deposit date:2018-03-05
Release date:2018-08-22
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Expanded Coverage of the 26S Proteasome Conformational Landscape Reveals Mechanisms of Peptidase Gating.
Cell Rep, 24, 2018
6GCO
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BU of 6gco by Molmil
Truncated FtsH from A. aeolicus in P312
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent zinc metalloprotease FtsH, ZINC ION
Authors:Uthoff, M, Baumann, U.
Deposit date:2018-04-18
Release date:2018-08-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.323 Å)
Cite:Conformational flexibility of pore loop-1 gives insights into substrate translocation by the AAA+protease FtsH.
J. Struct. Biol., 204, 2018
6FVX
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BU of 6fvx by Molmil
26S proteasome, s5 state
Descriptor: 26S proteasome complex subunit SEM1, 26S proteasome regulatory subunit 4 homolog, 26S proteasome regulatory subunit 6A, ...
Authors:Eisele, M.R, Reed, R.G, Rudack, T, Schweitzer, A, Beck, F, Nagy, I, Pfeifer, G, Plitzko, J.M, Baumeister, W, Tomko, R.J, Sakata, E.
Deposit date:2018-03-05
Release date:2018-08-22
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Expanded Coverage of the 26S Proteasome Conformational Landscape Reveals Mechanisms of Peptidase Gating.
Cell Rep, 24, 2018
7QO5
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BU of 7qo5 by Molmil
26S proteasome Rpt1-RK -Ubp6-UbVS complex in the si state
Descriptor: 26S proteasome complex subunit SEM1, 26S proteasome regulatory subunit 4 homolog, 26S proteasome regulatory subunit 6A, ...
Authors:Hung, K.Y.S, Klumpe, S, Eisele, M.R, Elsasser, S, Geng, T.T, Cheng, T.C, Joshi, T, Rudack, T, Sakata, E, Finley, D.
Deposit date:2021-12-23
Release date:2022-03-16
Last modified:2023-03-15
Method:ELECTRON MICROSCOPY (6 Å)
Cite:Allosteric control of Ubp6 and the proteasome via a bidirectional switch.
Nat Commun, 13, 2022

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PDB entries from 2024-09-11

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