7RLB
Cryo-EM structure of human p97-A232E mutant bound to ADP
Summary for 7RLB
| Entry DOI | 10.2210/pdb7rlb/pdb |
| EMDB information | 24524 |
| Descriptor | Transitional endoplasmic reticulum ATPase, ADENOSINE-5'-DIPHOSPHATE (2 entities in total) |
| Functional Keywords | p97, vcp, tera, inhibitor, cb-5083, hydrolase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 6 |
| Total formula weight | 552864.49 |
| Authors | Caffrey, B.,Zhu, X.,Berezuk, A.,Tuttle, K.,Chittori, S.,Subramaniam, S. (deposition date: 2021-07-23, release date: 2021-09-22, Last modification date: 2021-11-17) |
| Primary citation | Caffrey, B.,Zhu, X.,Berezuk, A.,Tuttle, K.,Chittori, S.,Subramaniam, S. AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation. J.Biol.Chem., 297:101187-101187, 2021 Cited by PubMed: 34520757DOI: 10.1016/j.jbc.2021.101187 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.3 Å) |
Structure validation
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