PDB: 5605 resultsInfo pagesStatus searchChemie searchBIRD

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3R4H	Crystal structure of the 4-helix coiled coil CC-Tet-phi22 Descriptor: coiled coil helix CC-Tet-phi22 Authors: Zaccai, N.R, Chi, B.H.C, Woolfson, D.N, Brady, R.L. Deposit date: 2011-03-17 Release date: 2011-11-16 Last modified: 2019-07-17 Method: X-RAY DIFFRACTION (2.7003 Å) Cite: A de novo peptide hexamer with a mutable channel. Nat.Chem.Biol., 7, 2011
1C3C	T. MARITIMA ADENYLOSUCCINATE LYASE Descriptor: PROTEIN (ADENYLOSUCCINATE LYASE) Authors: Toth, E.A, Yeates, T.O. Deposit date: 1999-07-27 Release date: 2000-02-09 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: The structure of adenylosuccinate lyase, an enzyme with dual activity in the de novo purine biosynthetic pathway. Structure Fold.Des., 8, 2000
1NB7	HC-J4 RNA polymerase complexed with short RNA template strand Descriptor: 5'-R(*UP*UP*UP*U)-3', MANGANESE (II) ION, polyprotein Authors: O'Farrell, D.J, Trowbridge, R, Rowlands, D.J, Jaeger, J. Deposit date: 2002-12-02 Release date: 2003-03-25 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Substrate complexes of hepatitis C virus RNA polymerase (HC-J4): structural evidence for nucleotide import and de-novo initiation. J.Mol.Biol., 326, 2003
7TYD	Crystal structure of FGFR4 domain 3 in complex with a de novo-designed mini-binder in P21 space group Descriptor: Binder, Fibroblast growth factor receptor 4 Authors: Park, J.S, Lee, S. Deposit date: 2022-02-12 Release date: 2022-11-09 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.86 Å) Cite: Isoform-specific inhibition of FGFR signaling achieved by a de-novo-designed mini-protein. Cell Rep, 41, 2022
1NB6	HC-J4 RNA polymerase complexed with UTP Descriptor: MANGANESE (II) ION, URIDINE 5'-TRIPHOSPHATE, polyprotein Authors: O'Farrell, D.J, Trowbridge, R, Rowlands, D.J, Jaeger, J. Deposit date: 2002-12-02 Release date: 2003-03-25 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Substrate complexes of hepatitis C virus RNA polymerase (HC-J4): structural evidence for nucleotide import and de-novo initiation. J.Mol.Biol., 326, 2003
1NB4	HC-J4 RNA polymerase apo-form Descriptor: polyprotein Authors: Jaeger, J, O'Farrell, D.J, Trowbridge, R, Rowlands, D.J. Deposit date: 2002-12-02 Release date: 2003-03-25 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2 Å) Cite: Substrate complexes of hepatitis C virus RNA polymerase (HC-J4): structural evidence for nucleotide import and de-novo initiation. J.Mol.Biol., 326, 2003
5K1S	crystal structure of AibC Descriptor: Oxidoreductase, zinc-binding dehydrogenase family, ZINC ION Authors: Bock, T, Mueller, R, Blankenfeldt, W. Deposit date: 2016-05-18 Release date: 2016-08-10 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Crystal structure of AibC, a reductase involved in alternative de novo isovaleryl coenzyme A biosynthesis in Myxococcus xanthus. Acta Crystallogr.,Sect.F, 72, 2016
5CIY	Structural basis of the recognition of H3K36me3 by DNMT3B PWWP domain Descriptor: DNA (5'-D(P*CP*CP*AP*TP*GP*CP*GP*CP*TP*GP*AP*C)-3'), DNA (5'-D(P*GP*TP*CP*AP*GP*(3DR)P*GP*CP*AP*TP*GP*G)-3'), Modification methylase HhaI, ... Authors: Rondelet, G, DAL MASO, T, Willems, L, Wouters, J. Deposit date: 2015-07-13 Release date: 2016-03-30 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.594 Å) Cite: Structural basis for recognition of histone H3K36me3 nucleosome by human de novo DNA methyltransferases 3A and 3B. J.Struct.Biol., 194, 2016
5CIU	Structural basis of the recognition of H3K36me3 by DNMT3B PWWP domain Descriptor: DNA (cytosine-5)-methyltransferase 3B, GLYCEROL, Histone H3.2 Authors: Rondelet, G, DAL MASO, T, Willems, L, Wouters, J. Deposit date: 2015-07-13 Release date: 2016-03-30 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.24 Å) Cite: Structural basis for recognition of histone H3K36me3 nucleosome by human de novo DNA methyltransferases 3A and 3B. J.Struct.Biol., 194, 2016
5NNL	Inactive dihydroorotase-like domain of Chaetomium thermophilum CAD-like multifunctional protein Descriptor: Inactive dihydroorotase-like domain Authors: Ramon-Maiques, S, Moreno-Morcillo, M, Grande-Garcia, A. Deposit date: 2017-04-10 Release date: 2017-06-07 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.13 Å) Cite: Structural Insight into the Core of CAD, the Multifunctional Protein Leading De Novo Pyrimidine Biosynthesis. Structure, 25, 2017
3R3K	Crystal structure of a parallel 6-helix coiled coil Descriptor: 1,2-ETHANEDIOL, CChex-Phi22 helix, CHLORIDE ION, ... Authors: Zaccai, N.R, Chi, B.H.C, Woolfson, D.N, Brady, R.L. Deposit date: 2011-03-16 Release date: 2011-11-16 Last modified: 2011-11-30 Method: X-RAY DIFFRACTION (2.2009 Å) Cite: A de novo peptide hexamer with a mutable channel. Nat.Chem.Biol., 7, 2011
5OER	Hen egg-white lysozyme refined against 5000 9 keV diffraction patterns Descriptor: 10-((2R)-2-HYDROXYPROPYL)-1,4,7,10-TETRAAZACYCLODODECANE 1,4,7-TRIACETIC ACID, GADOLINIUM ATOM, Lysozyme C, ... Authors: Gorel, A, Schlichting, I. Deposit date: 2017-07-09 Release date: 2017-10-25 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Multi-wavelength anomalous diffraction de novo phasing using a two-colour X-ray free-electron laser with wide tunability. Nat Commun, 8, 2017
3R47	Crystal structure of a 6-helix coiled coil CC-hex-H24 Descriptor: BROMIDE ION, coiled coil helix L24H Authors: Zaccai, N.R, Chi, B.H.C, Woolfson, D.N, Brady, R.L. Deposit date: 2011-03-17 Release date: 2011-11-16 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.5002 Å) Cite: A de novo peptide hexamer with a mutable channel. Nat.Chem.Biol., 7, 2011
3R46	Crystal structure of a parallel 6-helix coiled coil CC-hex-D24 Descriptor: CHLORIDE ION, GLYCEROL, SODIUM ION, ... Authors: Zaccai, N.R, Chi, B.H.C, Woolfson, D.N, Brady, R.L. Deposit date: 2011-03-17 Release date: 2011-11-16 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.751 Å) Cite: A de novo peptide hexamer with a mutable channel. Nat.Chem.Biol., 7, 2011
3R4A	Crystal structure of the 4-helix coiled coil CC-tet Descriptor: coiled coil helix CC-tet Authors: Zaccai, N.R, Chi, B.H.C, Woolfson, D.N, Brady, R.L. Deposit date: 2011-03-17 Release date: 2011-11-16 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.0701 Å) Cite: A de novo peptide hexamer with a mutable channel. Nat.Chem.Biol., 7, 2011
3R48	Crystal structure of a hetero-hexamer coiled coil Descriptor: GLYCEROL, coiled coil helix W22-L24H, coiled coil helix Y15-L24D Authors: Zaccai, N.R, Chi, B.H.C, Woolfson, D.N, Brady, R.L. Deposit date: 2011-03-17 Release date: 2011-11-16 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.0011 Å) Cite: A de novo peptide hexamer with a mutable channel. Nat.Chem.Biol., 7, 2011
8B16	A hexameric barrel state of a de novo coiled-coil assembly: CC-Pent2-I17Q Descriptor: 1,2-ETHANEDIOL, CC-Pent2-I17Q Authors: Martin, F.J.O, Dawson, W.M, Woolfson, D.N. Deposit date: 2022-09-09 Release date: 2023-09-20 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Exchange, promiscuity, and orthogonality in a set of de novo coiled-coil assemblies To Be Published
8B15	A pentameric barrel state of a de novo coiled-coil assembly: CC-Pent2-I10Q Descriptor: CC-Pent2-I10Q Authors: Martin, F.J.O, Dawson, W.M, Woolfson, D.N. Deposit date: 2022-09-09 Release date: 2023-09-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Exchange, promiscuity, and orthogonality in a set of de novo coiled-coil assemblies To Be Published
6FL5	Structure of human SHMT1-H135N-R137A-E168N mutant at 3.6 Ang. resolution Descriptor: CHLORIDE ION, PYRIDOXAL-5'-PHOSPHATE, Serine hydroxymethyltransferase, ... Authors: Giardina, G, Cutruzzola, F, Lucchi, R. Deposit date: 2018-01-25 Release date: 2018-10-10 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (3.6 Å) Cite: The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells. FEBS J., 285, 2018
8IJV	Cryo-EM structure of the gastric proton pump with bound DQ-02 Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[[5-chloranyl-2-(4-chlorophenyl)phenyl]methoxy]-N-methyl-but-2-yn-1-amine, ... Authors: Abe, K, Yokoshima, S, Yoshimori, A. Deposit date: 2023-02-28 Release date: 2023-08-30 Last modified: 2023-10-04 Method: ELECTRON MICROSCOPY (2.1 Å) Cite: Deep learning driven de novo drug design based on gastric proton pump structures. Commun Biol, 6, 2023
8IJW	Cryo-EM structure of the gastric proton pump with bound DQ-06 Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... Authors: Abe, K, Yokoshima, S, Yoshimori, A. Deposit date: 2023-02-28 Release date: 2023-08-30 Last modified: 2023-10-04 Method: ELECTRON MICROSCOPY (2.19 Å) Cite: Deep learning driven de novo drug design based on gastric proton pump structures. Commun Biol, 6, 2023
8IJX	Cryo-EM structure of the gastric proton pump with bound DQ-18 Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[4-[(5-chloranyl-2-phenylmethoxy-phenyl)methoxy]phenyl]-N-methyl-methanamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Abe, K, Yokoshima, S, Yoshimori, A. Deposit date: 2023-02-28 Release date: 2023-08-30 Last modified: 2023-10-04 Method: ELECTRON MICROSCOPY (2.08 Å) Cite: Deep learning driven de novo drug design based on gastric proton pump structures. Commun Biol, 6, 2023
8JMN	Cryo-EM structure of the gastric proton pump with bound DQ-21 Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[4-[[2-[(4-chlorophenyl)methoxy]phenyl]methoxy]phenyl]-N-methyl-methanamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Abe, K, Yokoshima, S, Yoshimori, A. Deposit date: 2023-06-05 Release date: 2023-08-30 Last modified: 2023-10-04 Method: ELECTRON MICROSCOPY (2.26 Å) Cite: Deep learning driven de novo drug design based on gastric proton pump structures. Commun Biol, 6, 2023
8JSL	The structure of EBOV L-VP35-RNA complex Descriptor: Polymerase cofactor VP35, RNA-directed RNA polymerase L, The leader sequence of EBOV, ... Authors: Qi, P, Yi, S. Deposit date: 2023-06-20 Release date: 2023-09-27 Last modified: 2023-11-01 Method: ELECTRON MICROSCOPY (2.95 Å) Cite: Molecular mechanism of de novo replication by the Ebola virus polymerase. Nature, 622, 2023
8JSN	The structure of EBOV L-VP35-RNA complex (conformation 2) Descriptor: Polymerase cofactor VP35, RNA-directed RNA polymerase L, The leader sequence of EBOV genome, ... Authors: Qi, P, Yi, S. Deposit date: 2023-06-20 Release date: 2023-09-27 Last modified: 2023-11-01 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Molecular mechanism of de novo replication by the Ebola virus polymerase. Nature, 622, 2023

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