PDB: 30672 resultsInfo pagesStatus searchChemie searchBIRD

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8U7V	Human retinal variant phosphomimetic IMPDH1(546)-S477D filament bound by GTP, ATP, IMP, and NAD+, interface-centered Descriptor: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ... Authors: Calise, S.J, Kollman, J.M. Deposit date: 2023-09-15 Release date: 2024-01-31 Last modified: 2024-02-14 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Light-sensitive phosphorylation regulates retinal IMPDH1 activity and filament assembly. J.Cell Biol., 223, 2024
8U7M	Human retinal variant phosphomimetic IMPDH1(595)-S477D free octamer bound by GTP, ATP, IMP, and NAD+ Descriptor: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ... Authors: Calise, S.J, Kollman, J.M. Deposit date: 2023-09-15 Release date: 2024-01-31 Last modified: 2024-02-14 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Light-sensitive phosphorylation regulates retinal IMPDH1 activity and filament assembly. J.Cell Biol., 223, 2024
8WD5	Crystal structure of farnesyl diphosphate synthase FPPS1 from silkworm, Bombyx mori Descriptor: Farnesyl pyrophosphate synthase, GLYCEROL Authors: Guo, P.C, Fang, H. Deposit date: 2023-09-14 Release date: 2024-05-22 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural Insights into the Substrate Binding of Farnesyl Diphosphate Synthase FPPS1 from Silkworm, Bombyx mori. J.Agric.Food Chem., 72, 2024
8U72	Cryo-EM structure of the SPARTA oligomer with guide RNA and target DNA Descriptor: DNA (5'-D(P*TP*AP*TP*AP*CP*AP*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*C)-3'), MAGNESIUM ION, Piwi domain-containing protein, ... Authors: Malik, R, Kottur, J, Aggarwal, A.K. Deposit date: 2023-09-14 Release date: 2024-06-12 Method: ELECTRON MICROSCOPY (3.15 Å) Cite: Nucleic acid mediated activation of prokaryotic Argonaute immune system Nat Commun, 2024
8QKB	Crystal structure of human cathepsin L in complex with the vinyl sulfone inhibitor K777 Descriptor: 1,2-ETHANEDIOL, Cathepsin L, DI(HYDROXYETHYL)ETHER, ... Authors: Falke, S, Lieske, J, Guenther, S, Reinke, P.Y.A, Ewert, W, Loboda, J, Karnicar, K, Usenik, A, Lindic, N, Sekirnik, A, Chapman, H.N, Hinrichs, W, Turk, D, Meents, A. Deposit date: 2023-09-14 Release date: 2023-09-27 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors. J.Med.Chem., 67, 2024
8U5Y	human RADX trimer bound to ssDNA Descriptor: DNA (25-MER), RPA-related protein RADX Authors: Balakrishnan, S, Chazin, W.J. Deposit date: 2023-09-13 Release date: 2023-10-11 Last modified: 2023-10-18 Method: ELECTRON MICROSCOPY (3.01 Å) Cite: Structure of RADX and mechanism for regulation of RAD51 nucleofilaments. Biorxiv, 2023
8U6K	Crystal Structure of HIV-1 Reverse Transcriptase in Complex with N-(2-(2-((6-cyanonaphthalen-1-yl)oxy)phenoxy)ethyl)-N-methylacrylamide (JLJ747), a non-nucleoside inhibitor Descriptor: MAGNESIUM ION, N-(2-{2-[(6-cyanonaphthalen-1-yl)oxy]phenoxy}ethyl)-N-methylprop-2-enamide, PHOSPHATE ION, ... Authors: Prucha, G, Henry, S, Jorgensen, W.L, Anderson, K.S. Deposit date: 2023-09-13 Release date: 2023-11-08 Method: X-RAY DIFFRACTION (2.72 Å) Cite: Covalent and noncovalent strategies for targeting Lys102 in HIV-1 reverse transcriptase. Eur.J.Med.Chem., 262, 2023
8U6N	Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 3-(2-((6-cyanonaphthalen-1-yl)oxy)phenoxy)-N,N-dimethylpropanamide (JLJ752), a non-nucleoside inhibitor Descriptor: 3-{2-[(6-cyanonaphthalen-1-yl)oxy]phenoxy}-N,N-dimethylpropanamide, Gag-Pol polyprotein, p51 RT Authors: Prucha, G, Henry, S, Jorgensen, W.L, Anderson, K.S. Deposit date: 2023-09-13 Release date: 2023-11-08 Method: X-RAY DIFFRACTION (2.74 Å) Cite: Covalent and noncovalent strategies for targeting Lys102 in HIV-1 reverse transcriptase. Eur.J.Med.Chem., 262, 2023
8U69	Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 3-chloro-5-(4-chloro-2-(2-(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)benzonitrile (JLJ334), a non-nucleoside inhibitor Descriptor: 3-chloro-5-{4-chloro-2-[2-(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}benzonitrile, Reverse transcriptase/ribonuclease H, p51 RT Authors: Hollander, K, Carter, Z, Jorgensen, W.L, Anderson, K.S. Deposit date: 2023-09-13 Release date: 2023-11-08 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Covalent and noncovalent strategies for targeting Lys102 in HIV-1 reverse transcriptase. Eur.J.Med.Chem., 262, 2023
8U6F	Crystal Structure of HIV-1 Reverse Transcriptase in Complex with N-(2-(5-chloro-2-(3-chloro-5-cyanophenoxy)phenoxy)ethyl)-N-methylacrylamide (JLJ742), a non-nucleoside inhibitor Descriptor: N-{2-[5-chloro-2-(3-chloro-5-cyanophenoxy)phenoxy]ethyl}-N-methylprop-2-enamide, Reverse transcriptase/ribonuclease H, p51 RT Authors: Prucha, G, Carter, Z, Jorgensen, W.L, Anderson, K.S. Deposit date: 2023-09-13 Release date: 2023-11-08 Method: X-RAY DIFFRACTION (2.69 Å) Cite: Covalent and noncovalent strategies for targeting Lys102 in HIV-1 reverse transcriptase. Eur.J.Med.Chem., 262, 2023
8U6C	Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 2-chloro-N-(4-chloro-3-(3-chloro-5-cyanophenoxy)phenethyl)acetamide (JLJ732), a non-nucleoside inhibitor Descriptor: 2-chloro-N-{2-[4-chloro-3-(3-chloro-5-cyanophenoxy)phenyl]ethyl}acetamide, Reverse transcriptase/ribonuclease H, p51 RT Authors: Hollander, K, Henry, S, Jorgensen, W.L, Anderson, K.S. Deposit date: 2023-09-13 Release date: 2023-11-08 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Covalent and noncovalent strategies for targeting Lys102 in HIV-1 reverse transcriptase. Eur.J.Med.Chem., 262, 2023
8U6I	Crystal Structure of HIV-1 Reverse Transcriptase in Complex with N-(2-(2-((2-cyanoindolizin-8-yl)oxy)phenoxy)ethyl)-N-methylacrylamide (JLJ745), a non-nucleoside inhibitor Descriptor: MAGNESIUM ION, N-[2-(2-{[(4R)-2-cyanoindolizin-8-yl]oxy}phenoxy)ethyl]-N-methylpropanamide, Reverse transcriptase/ribonuclease H, ... Authors: Prucha, G, Henry, S, Jorgensen, W.L, Anderson, K.S. Deposit date: 2023-09-13 Release date: 2023-11-08 Method: X-RAY DIFFRACTION (2.46 Å) Cite: Covalent and noncovalent strategies for targeting Lys102 in HIV-1 reverse transcriptase. Eur.J.Med.Chem., 262, 2023
8U6L	Crystal Structure of HIV-1 Reverse Transcriptase in Complex with N-(2-(5-chloro-2-((6-cyanonaphthalen-1-yl)oxy)phenoxy)ethyl)-N-methylacrylamide (JLJ748), a non-nucleoside inhibitor Descriptor: MAGNESIUM ION, N-(2-{5-chloro-2-[(6-cyanonaphthalen-1-yl)oxy]phenoxy}ethyl)-N-methylprop-2-enamide, Reverse transcriptase/ribonuclease H, ... Authors: Prucha, G, Henry, S, Jorgensen, W.L, Anderson, K.S. Deposit date: 2023-09-13 Release date: 2023-11-08 Method: X-RAY DIFFRACTION (2.486 Å) Cite: Covalent and noncovalent strategies for targeting Lys102 in HIV-1 reverse transcriptase. Eur.J.Med.Chem., 262, 2023
8U6E	Crystal Structure of HIV-1 Reverse Transcriptase in Complex with N-(4-chloro-3-(3-chloro-5-cyanophenoxy)phenethyl)-N-methylacrylamide (JLJ738), a non-nucleoside inhibitor Descriptor: MAGNESIUM ION, N-{2-[4-chloro-3-(3-chloro-5-cyanophenoxy)phenyl]ethyl}-N-methylprop-2-enamide, Reverse transcriptase/ribonuclease H, ... Authors: Prucha, G, Henry, S, Jorgensen, W.L, Anderson, K.S. Deposit date: 2023-09-13 Release date: 2023-11-08 Method: X-RAY DIFFRACTION (2.31 Å) Cite: Covalent and noncovalent strategies for targeting Lys102 in HIV-1 reverse transcriptase. Eur.J.Med.Chem., 262, 2023
8U6G	Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 3-(2-(2-(3-acryloyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)ethoxy)-4-chlorophenoxy)-5-chlorobenzonitrile (JLJ744), a non-nucleoside inhibitor Descriptor: 3-chloro-5-{4-chloro-2-[2-(2-oxo-3-propanoyl-2,3-dihydro-1H-benzimidazol-1-yl)ethoxy]phenoxy}benzonitrile, MAGNESIUM ION, Reverse transcriptase/ribonuclease H, ... Authors: Prucha, G, Carter, Z, Jorgensen, W.L, Anderson, K.S. Deposit date: 2023-09-13 Release date: 2023-11-08 Method: X-RAY DIFFRACTION (2.77 Å) Cite: Covalent and noncovalent strategies for targeting Lys102 in HIV-1 reverse transcriptase. Eur.J.Med.Chem., 262, 2023
8U6T	Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 5-(2-(2-(3-acryloyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)ethoxy)phenoxy)-2-naphthonitrile (JLJ758), a non-nucleoside inhibitor Descriptor: 5-(2-{2-[2-oxo-3-(prop-2-enoyl)-2,3-dihydro-1H-benzimidazol-1-yl]ethoxy}phenoxy)naphthalene-2-carbonitrile, MAGNESIUM ION, PHOSPHATE ION, ... Authors: Prucha, G, Henry, S, Jorgensen, W.L, Anderson, K.S. Deposit date: 2023-09-13 Release date: 2023-11-08 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Covalent and noncovalent strategies for targeting Lys102 in HIV-1 reverse transcriptase. Eur.J.Med.Chem., 262, 2023
8U6P	Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 3-(2-((2-cyanoindolizin-8-yl)oxy)phenoxy)-N,N-dimethylpropanamide (JLJ754), a non-nucleoside inhibitor Descriptor: 3-(2-{[(4S)-2-cyanoindolizin-8-yl]oxy}phenoxy)-N,N-dimethylpropanamide, MAGNESIUM ION, PHOSPHATE ION, ... Authors: Prucha, G, Henry, S, Jorgensen, W.L, Anderson, K.S. Deposit date: 2023-09-13 Release date: 2023-11-08 Method: X-RAY DIFFRACTION (2.81 Å) Cite: Covalent and noncovalent strategies for targeting Lys102 in HIV-1 reverse transcriptase. Eur.J.Med.Chem., 262, 2023
8U6R	Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 3-(2-((2-cyanoindolizin-8-yl)oxy)phenoxy)-N-(2,2-difluoroethyl)propanamide (JLJ756), a non-nucleoside inhibitor Descriptor: 3-(2-{[(4R)-2-cyanoindolizin-8-yl]oxy}phenoxy)-N-(2,2-difluoroethyl)propanamide, PHOSPHATE ION, Reverse transcriptase/ribonuclease H, ... Authors: Prucha, G, Henry, S, Jorgensen, W.L, Anderson, K.S. Deposit date: 2023-09-13 Release date: 2023-11-08 Method: X-RAY DIFFRACTION (2.87 Å) Cite: Covalent and noncovalent strategies for targeting Lys102 in HIV-1 reverse transcriptase. Eur.J.Med.Chem., 262, 2023
8U6A	Crystal Structure of HIV-1 Reverse Transcriptase in Complex with (JLJ729), a non-nucleoside inhibitor Descriptor: N-(3-{2-[5-chloro-2-(3-chloro-5-cyanophenoxy)phenoxy]ethyl}phenyl)prop-2-enamide, Reverse transcriptase/ribonuclease H, p51 RT Authors: Hollander, K, Carter, Z, Jorgensen, W.L, Anderson, K.S. Deposit date: 2023-09-13 Release date: 2023-11-08 Method: X-RAY DIFFRACTION (2.37 Å) Cite: Covalent and noncovalent strategies for targeting Lys102 in HIV-1 reverse transcriptase. Eur.J.Med.Chem., 262, 2023
8U6D	Crystal Structure of HIV-1 Reverse Transcriptase in Complex with N-(2-(4-chloro-3-(3-chloro-5-cyanophenoxy)phenoxy)ethyl)-N-methylacrylamide (JLJ736), a non-nucleoside inhibitor Descriptor: N-{2-[4-chloro-3-(3-chloro-5-cyanophenoxy)phenoxy]ethyl}-N-methylprop-2-enamide, Reverse transcriptase/ribonuclease H, p51 RT Authors: Hollander, K, Carter, Z, Jorgensen, W.L, Anderson, K.S. Deposit date: 2023-09-13 Release date: 2023-11-08 Method: X-RAY DIFFRACTION (2.33 Å) Cite: Covalent and noncovalent strategies for targeting Lys102 in HIV-1 reverse transcriptase. Eur.J.Med.Chem., 262, 2023
8U6M	Crystal Structure of HIV-1 Reverse Transcriptase in Complex with N-(2-(2-((6-chloro-2-cyanoindolizin-8-yl)oxy)phenoxy)ethyl)-N-methylacrylamide (JLJ751), a non-nucleoside inhibitor Descriptor: N-[2-(2-{[(4R)-6-chloro-2-cyanoindolizin-8-yl]oxy}phenoxy)ethyl]-N-methylpropanamide, Reverse transcriptase/ribonuclease H, p51 RT Authors: Prucha, G, Henry, S, Jorgensen, W.L, Anderson, K.S. Deposit date: 2023-09-13 Release date: 2023-11-08 Method: X-RAY DIFFRACTION (2.62 Å) Cite: Covalent and noncovalent strategies for targeting Lys102 in HIV-1 reverse transcriptase. Eur.J.Med.Chem., 262, 2023
8U6B	Crystal Structure of HIV-1 Reverse Transcriptase in Complex with N-(4-chloro-3-(3-chloro-5-cyanophenoxy)phenethyl)acrylamide (JLJ731), a non-nucleoside inhibitor Descriptor: N-{2-[4-chloro-3-(3-chloro-5-cyanophenoxy)phenyl]ethyl}prop-2-enamide, Reverse transcriptase/ribonuclease H, p51 RT Authors: Hollander, K, Henry, S, Jorgensen, W.L, Anderson, K.S. Deposit date: 2023-09-13 Release date: 2023-11-08 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Covalent and noncovalent strategies for targeting Lys102 in HIV-1 reverse transcriptase. Eur.J.Med.Chem., 262, 2023
8U6Q	Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 8-(2-(3-oxo-3-(pyrrolidin-1-yl)propoxy)phenoxy)indolizine-2-carbonitrile (JLJ755), a non-nucleoside inhibitor Descriptor: (4S)-8-{2-[3-oxo-3-(pyrrolidin-1-yl)propoxy]phenoxy}indolizine-2-carbonitrile, Reverse transcriptase/ribonuclease H, p51 RT Authors: Prucha, G, Henry, S, Jorgensen, W.L, Anderson, K.S. Deposit date: 2023-09-13 Release date: 2023-11-08 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Covalent and noncovalent strategies for targeting Lys102 in HIV-1 reverse transcriptase. Eur.J.Med.Chem., 262, 2023
8U6J	Crystal Structure of HIV-1 Reverse Transcriptase in Complex with N-(2-(5-chloro-2-((2-cyanoindolizin-8-yl)oxy)phenoxy)ethyl)-N-methylacrylamide (JLJ746), a non-nucleoside inhibitor Descriptor: MAGNESIUM ION, N-[2-(5-chloro-2-{[(4R)-2-cyanoindolizin-8-yl]oxy}phenoxy)ethyl]-N-methylpropanamide, Reverse transcriptase/ribonuclease H, ... Authors: Prucha, G, Henry, S, Jorgensen, W.L, Anderson, K.S. Deposit date: 2023-09-13 Release date: 2023-11-08 Method: X-RAY DIFFRACTION (2.64 Å) Cite: Covalent and noncovalent strategies for targeting Lys102 in HIV-1 reverse transcriptase. Eur.J.Med.Chem., 262, 2023
8U6O	Crystal Structure of HIV-1 Reverse Transcriptase in Complex with5-(2-(3-oxo-3-(pyrrolidin-1-yl)propoxy)phenoxy)-2-naphthonitrile (JLJ753), a non-nucleoside inhibitor Descriptor: 5-{2-[3-oxo-3-(pyrrolidin-1-yl)propoxy]phenoxy}naphthalene-2-carbonitrile, Reverse transcriptase/ribonuclease H, p51 RT Authors: Prucha, G, Henry, S, Jorgensen, W.L, Anderson, K.S. Deposit date: 2023-09-13 Release date: 2023-11-08 Method: X-RAY DIFFRACTION (2.48 Å) Cite: Covalent and noncovalent strategies for targeting Lys102 in HIV-1 reverse transcriptase. Eur.J.Med.Chem., 262, 2023

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