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1W14
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BU of 1w14 by Molmil
UROKINASE TYPE PLASMINOGEN ACTIVATOR
Descriptor: N-[(2-PHENYLETHYL)SULFONYL]-D-SERYL-N-[(1S)-4-[(DIAMINOMETHYLENE)AMINO]-1-(HYDROXYMETHYL)BUTYL]-L-ALANINAMIDE, SULFATE ION, UROKINASE-TYPE PLASMINOGEN ACTIVATOR
Authors:Jacob, U.
Deposit date:2004-06-15
Release date:2008-05-20
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystals of Urokinase Type Plasminogen Activator Complexes Reveal the Binding Mode of Peptidomimetic Inhibitors.
J.Mol.Biol., 328, 2003
8T8T
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BU of 8t8t by Molmil
Crystal structure of TET25 in complex with PyDH2 ligand in P212121 space group
Descriptor: 4,4'-{pyridine-2,6-diylbis[carbonyl-(1E)-hydrazin-2-yl-1-ylidene-(E)-methanylylidene]}bis(1-methylquinolin-1-ium), POTASSIUM ION, TET25
Authors:Lam, G, Yatsunyk, L.A.
Deposit date:2023-06-23
Release date:2024-09-04
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Crystal structure of TET25 in complex with PyDH2 ligand in P212121 space group
To be Published
3S9L
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BU of 3s9l by Molmil
Complex between transferrin receptor 1 and transferrin with iron in the N-Lobe, cryocooled 2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CARBONATE ION, ...
Authors:Eckenroth, B.E, Steere, A.N, Mason, A.B, Everse, S.J.
Deposit date:2011-06-01
Release date:2011-08-10
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.22 Å)
Cite:How the binding of human transferrin primes the transferrin receptor potentiating iron release at endosomal pH.
Proc.Natl.Acad.Sci.USA, 108, 2011
2BIV
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BU of 2biv by Molmil
Crystal structure of the wild-type MBT domains of Human SCML2
Descriptor: IODIDE ION, SEX COMB ON MIDLEG-LIKE PROTEIN 2, SODIUM ION
Authors:Santiveri, C.M, Allen, M.D, Sait, F, Bycroft, M.
Deposit date:2005-01-26
Release date:2005-02-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Malignant Brain Tumor Repeats of Human Scml2 Bind to Peptides Containing Monomethylated Lysine.
J.Mol.Biol., 382, 2008
1YKJ
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BU of 1ykj by Molmil
A45G p-hydroxybenzoate hydroxylase with p-hydroxybenzoate bound
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, P-HYDROXYBENZOIC ACID, P-hydroxybenzoate hydroxylase, ...
Authors:Cole, L.J, Gatti, D.L, Entsch, B, Ballou, D.P.
Deposit date:2005-01-18
Release date:2005-07-26
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Removal of a methyl group causes global changes in p-hydroxybenzoate hydroxylase.
Biochemistry, 44, 2005
1YI2
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BU of 1yi2 by Molmil
Crystal Structure Of Erythromycin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui
Descriptor: 23S Ribosomal RNA, 50S RIBOSOMAL PROTEIN L10E, 50S RIBOSOMAL PROTEIN L11P, ...
Authors:Tu, D, Blaha, G, Moore, P.B, Steitz, T.A.
Deposit date:2005-01-11
Release date:2005-04-26
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance.
Cell(Cambridge,Mass.), 121, 2005
1YHQ
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BU of 1yhq by Molmil
Crystal Structure Of Azithromycin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui
Descriptor: 23S Ribosomal RNA, 50S RIBOSOMAL PROTEIN L10E, 50S RIBOSOMAL PROTEIN L11P, ...
Authors:Tu, D, Blaha, G, Moore, P.B, Steitz, T.A.
Deposit date:2005-01-10
Release date:2005-04-26
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance.
Cell(Cambridge,Mass.), 121, 2005
1DUQ
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BU of 1duq by Molmil
CRYSTAL STRUCTURE OF THE REV BINDING ELEMENT OF HIV-1
Descriptor: SODIUM ION, THE REV BINDING ELEMENT
Authors:Hung, L.-W, Holbrook, E.L, Holbrook, S.R.
Deposit date:2000-01-18
Release date:2000-05-16
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The crystal structure of the Rev binding element of HIV-1 reveals novel base pairing and conformational variability.
Proc.Natl.Acad.Sci.USA, 97, 2000
1YIT
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BU of 1yit by Molmil
Crystal Structure Of Virginiamycin M and S Bound To The 50S Ribosomal Subunit Of Haloarcula Marismortui
Descriptor: 23S RIBOSOMAL RNA, 50S RIBOSOMAL PROTEIN L10E, 50S RIBOSOMAL PROTEIN L11P, ...
Authors:Tu, D, Blaha, G, Moore, P.B, Steitz, T.A.
Deposit date:2005-01-13
Release date:2005-04-26
Last modified:2024-07-10
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of Mlsbk Antibiotics Bound to Mutated Large Ribosomal Subunits Provide a Structural Explanation for Resistance.
Cell(Cambridge,Mass.), 121, 2005
3CR6
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BU of 3cr6 by Molmil
Crystal Structure of the R132K:R111L:A32E Mutant of Cellular Retinoic Acid Binding Protein Type II Complexed with C15-aldehyde (a retinal analog) at 1.22 Angstrom resolution.
Descriptor: 1,3,3-trimethyl-2-[(1E,3E)-3-methylpenta-1,3-dien-1-yl]cyclohexene, Cellular retinoic acid-binding protein 2
Authors:Jia, X, Geiger, J.H.
Deposit date:2008-04-04
Release date:2009-03-17
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.22 Å)
Cite:Two distinctive orientations of binding determined by a single mutation in the CRABPII mutant-C15-aldehyde complexes
To be Published
2CE8
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BU of 2ce8 by Molmil
An EH1 peptide bound to the Groucho-TLE WD40 domain.
Descriptor: EH1 PEPTIDE, TRANSDUCIN-LIKE ENHANCER PROTEIN 1
Authors:Pickles, L.M, Roe, S.M, Pearl, L.H.
Deposit date:2006-02-03
Release date:2006-06-14
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Molecular Recognition of Transcriptional Repressor Motifs by the Wd Domain of the Groucho/Tle Corepressor.
Mol.Cell, 22, 2006
1W7F
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BU of 1w7f by Molmil
Crystal structure of the class A beta-lactamase BS3 inhibited with isocitrate
Descriptor: BETA-LACTAMASE, ISOCITRIC ACID
Authors:Petrella, S, Sauvage, E, Herman, R, Charlier, P.
Deposit date:2004-09-01
Release date:2006-05-24
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of the Class a Beta-Lactamase Bs3 Bs3 Inhibited with Isocitrate
To be Published
3D8C
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BU of 3d8c by Molmil
Factor inhibiting HIF-1 alpha D201G mutant in complex with ZN(II), alpha-ketoglutarate and HIF-1 alpha 19mer
Descriptor: 2-OXOGLUTARIC ACID, GLYCEROL, HYPOXIA-INDUCIBLE FACTOR 1 ALPHA, ...
Authors:McDonough, M.A, Chowdhury, R, Schofield, C.J.
Deposit date:2008-05-23
Release date:2008-08-12
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH).
J.Biol.Chem., 283, 2008
2MV7
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BU of 2mv7 by Molmil
Solution NMR structure of DOT1L in complex with AF9 (DOT1L-AF9)
Descriptor: Histone-lysine N-methyltransferase, H3 lysine-79 specific, Protein AF-9
Authors:Kuntimaddi, A, Bushweller, J.H.
Deposit date:2014-09-24
Release date:2015-04-22
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Degree of Recruitment of DOT1L to MLL-AF9 Defines Level of H3K79 Di- and Tri-methylation on Target Genes and Transformation Potential.
Cell Rep, 11, 2015
2MUK
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BU of 2muk by Molmil
1H, 13C, and 15N Chemical Shift Assignments for AUX/IAA17
Descriptor: Auxin-responsive protein IAA17
Authors:Suh, J, Han, M.
Deposit date:2014-09-11
Release date:2014-12-17
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Structural basis for the auxin-induced transcriptional regulation by Aux/IAA17.
Proc.Natl.Acad.Sci.USA, 111, 2014
3D96
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BU of 3d96 by Molmil
Crystal Structure of the R132K:Y134F Mutant of Apo-Cellular Retinoic Acid Binding Protein Type II at 1.71 Angstroms Resolution
Descriptor: ACETATE ION, Cellular retinoic acid-binding protein 2
Authors:Vaezeslami, S, Geiger, J.H.
Deposit date:2008-05-26
Release date:2008-07-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Structural analysis of site-directed mutants of cellular retinoic acid-binding protein II addresses the relationship between structural integrity and ligand binding.
Acta Crystallogr.,Sect.D, 64, 2008
1CSL
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BU of 1csl by Molmil
CRYSTAL STRUCTURE OF THE RRE HIGH AFFINITY SITE
Descriptor: 5'-R(*AP*AP*CP*GP*GP*GP*CP*GP*CP*AP*GP*AP*A)-3', 5'-R(*UP*CP*UP*GP*AP*CP*GP*GP*UP*AP*CP*GP*UP*UP*U)-3'
Authors:Ippolito, J.A, Steitz, T.A.
Deposit date:1999-08-18
Release date:2000-02-14
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The structure of the HIV-1 RRE high affinity rev binding site at 1.6 A resolution.
J.Mol.Biol., 295, 2000
2CMN
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BU of 2cmn by Molmil
A Proximal Arginine Residue in the Switching Mechanism of the FixL Oxygen Sensor
Descriptor: PROTOPORPHYRIN IX CONTAINING FE, SENSOR PROTEIN FIXL
Authors:Gilles-Gonzalez, M.-A, Caceres, A.I, Silva Sousa, E.H, Tomchick, D.R, Brautigam, C.A, Gonzalez, C, Machius, M.
Deposit date:2006-05-11
Release date:2007-05-15
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A Proximal Arginine R206 Participates in Switching of the Bradyrhizobium Japonicum Fixl Oxygen Sensor
J.Mol.Biol., 360, 2006
3DDK
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BU of 3ddk by Molmil
Coxsackievirus B3 3Dpol RNA Dependent RNA Polymerase
Descriptor: RNA polymerase B3 3Dpol, SODIUM ION, SULFATE ION
Authors:Campagnola, G, Weygandt, M.H, Scoggin, K.E, Peersen, O.B.
Deposit date:2008-06-05
Release date:2008-09-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal Structure of Coxsackievirus B3 3Dpol Highlights Functional Importance of Residue 5 in Picornaviral Polymerases
J.Virol., 82, 2008
3DAI
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BU of 3dai by Molmil
Crystal structure of the bromodomain of the human ATAD2
Descriptor: ATPase family AAA domain-containing protein 2, CHLORIDE ION, SULFATE ION
Authors:Filippakopoulos, P, Keates, T, Picaud, S, Fedorov, O, Roos, A.K, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2008-05-29
Release date:2008-09-09
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
1VQ6
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BU of 1vq6 by Molmil
The structure of c-hpmn and CCA-PHE-CAP-BIO bound to the large ribosomal subunit of haloarcula marismortui
Descriptor: 23S ribosomal rna, 5'-R(*CP*(5AA)*(HFA))-3', 5'-R(*CP*CP*AP*(PHE)*(ACA)*(BTN))-3', ...
Authors:Schmeing, T.M, Steitz, T.A.
Deposit date:2004-12-16
Release date:2005-11-29
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:An induced-fit mechanism to promote peptide bond formation and exclude hydrolysis of peptidyl-tRNA.
Nature, 438, 2005
2C1N
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BU of 2c1n by Molmil
Molecular basis for the recognition of phosphorylated and phosphoacetylated histone H3 by 14-3-3
Descriptor: 14-3-3 PROTEIN ZETA/DELTA, HISTONE H3 ACETYLPHOSPHOPEPTIDE
Authors:Welburn, J.P.I, Macdonald, N, Noble, M.E.M, Nguyen, A, Yaffe, M.B, Clynes, D, Moggs, J.G, Orphanides, G, Thomson, S, Edmunds, J.W, Clayton, A.L, Endicott, J.A, Mahadevan, L.C.
Deposit date:2005-09-16
Release date:2005-11-02
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular Basis for the Recognition of Phosphorylated and Phosphoacetylated Histone H3 by 14-3-3.
Mol.Cell, 20, 2005
3T6O
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BU of 3t6o by Molmil
The Structure of an Anti-sigma-factor antagonist (STAS) domain protein from Planctomyces limnophilus.
Descriptor: CHLORIDE ION, Sulfate transporter/antisigma-factor antagonist STAS
Authors:Cuff, M.E, Moser, C, Hatzos-Skintges, C, Bearden, J, Joachimiak, A, Midwest Center for Structural Genomics (MCSG)
Deposit date:2011-07-28
Release date:2011-09-07
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Structure of an Anti-sigma-factor antagonist (STAS) domain protein from Planctomyces limnophilus.
TO BE PUBLISHED
1VQ5
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BU of 1vq5 by Molmil
The structure of the transition state analogue "RAA" bound to the large ribosomal subunit of haloarcula marismortui
Descriptor: 23S ribosomal rna, 5'-D(*(DC)P*(DC)P*(5AA)P*(2OP)P*(PO2)P*AP*C*C)-3'), 50S RIBOSOMAL PROTEIN L10E, ...
Authors:Schmeing, T.M, Steitz, T.A.
Deposit date:2004-12-16
Release date:2005-11-29
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Insights into the Roles of Water and the 2' Hydroxyl of the P Site tRNA in the Peptidyl Transferase Reaction.
Mol.Cell, 20, 2005
5EIZ
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BU of 5eiz by Molmil
Crystal structure of Y99A mutant of human macrophage migration inhibitory factor
Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ...
Authors:Pantouris, G, Lolis, E.
Deposit date:2015-10-30
Release date:2015-11-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Nanosecond Dynamics Regulate the MIF-Induced Activity of CD74.
Angew. Chem. Int. Ed. Engl., 2018

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