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1UYU
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BU of 1uyu by Molmil
Xenon COMPLEX OF wildtype P450CAM FROM PSEUDOMONAS PUTIDA
Descriptor: CAMPHOR, CYTOCHROME P450-CAM, POTASSIUM ION, ...
Authors:Wade, R.C, Winn, P.J, Schlichting, I, Sudarko, X.
Deposit date:2004-03-02
Release date:2005-03-07
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Survey of Active Site Access Channels in Cytochromes P450
J.Inorg.Biochem., 98, 2004
2P85
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BU of 2p85 by Molmil
Structure of Human Lung Cytochrome P450 2A13 with indole bound in two alternate conformations
Descriptor: Cytochrome P450 2A13, INDOLE, PROTOPORPHYRIN IX CONTAINING FE
Authors:Scott, E.E, Stout, C.D.
Deposit date:2007-03-21
Release date:2007-04-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure of the human lung cytochrome P450 2A13.
J.Biol.Chem., 282, 2007
2H7R
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BU of 2h7r by Molmil
L244A mutant of Cytochrome P450cam complexed with imidazole
Descriptor: 1-METHYLIMIDAZOLE, Cytochrome P450-cam, PROTOPORPHYRIN IX CONTAINING FE
Authors:Verras, A, Alian, A, Montellano, P.R.
Deposit date:2006-06-02
Release date:2006-10-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Cytochrome P450 active site plasticity: attenuation of imidazole binding in cytochrome P450cam by an L244A mutation.
Protein Eng.Des.Sel., 19, 2006
2PG5
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BU of 2pg5 by Molmil
Crystal Structure of Human Microsomal P450 2A6 N297Q
Descriptor: 1,2-ETHANEDIOL, Cytochrome P450 2A6, PROTOPORPHYRIN IX CONTAINING FE
Authors:Sansen, S, Hsu, M.H, Stout, C.D, Johnson, E.F.
Deposit date:2007-04-06
Release date:2007-07-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural insight into the altered substrate specificity of human cytochrome P450 2A6 mutants.
Arch.Biochem.Biophys., 464, 2007
2PG7
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BU of 2pg7 by Molmil
Crystal Structure of Human Microsomal P450 2A6 N297Q/I300V
Descriptor: Cytochrome P450 2A6, PROTOPORPHYRIN IX CONTAINING FE
Authors:Sansen, S, Hsu, M.H, Stout, C.D, Johnson, E.F.
Deposit date:2007-04-06
Release date:2007-07-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural insight into the altered substrate specificity of human cytochrome P450 2A6 mutants.
Arch.Biochem.Biophys., 464, 2007
2H7S
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BU of 2h7s by Molmil
L244A mutant of Cytochrome P450cam
Descriptor: Cytochrome P450-cam, HEME C
Authors:Verras, A, Alian, A, Montellano, P.R.
Deposit date:2006-06-02
Release date:2006-10-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Cytochrome P450 active site plasticity: attenuation of imidazole binding in cytochrome P450cam by an L244A mutation.
Protein Eng.Des.Sel., 19, 2006
1T85
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BU of 1t85 by Molmil
Crystal Structure of the Ferrous CO-bound Cytochrome P450cam Mutant (L358P/C334A)
Descriptor: CAMPHOR, CARBON MONOXIDE, Cytochrome P450-cam, ...
Authors:Nagano, S, Tosha, T, Ishimori, K, Morishima, I, Poulos, T.L.
Deposit date:2004-05-11
Release date:2004-06-01
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the cytochrome p450cam mutant that exhibits the same spectral perturbations induced by putidaredoxin binding.
J.Biol.Chem., 279, 2004
1T86
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BU of 1t86 by Molmil
Crystal Structure of the Ferrous Cytochrome P450cam Mutant (L358P/C334A)
Descriptor: CAMPHOR, Cytochrome P450-cam, POTASSIUM ION, ...
Authors:Nagano, S, Tosha, T, Ishimori, K, Morishima, I, Poulos, T.L.
Deposit date:2004-05-11
Release date:2004-05-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the cytochrome p450cam mutant that exhibits the same spectral perturbations induced by putidaredoxin binding.
J.Biol.Chem., 279, 2004
2Q9F
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BU of 2q9f by Molmil
Crystal structure of human cytochrome P450 46A1 in complex with cholesterol-3-sulphate
Descriptor: CHOLEST-5-EN-3-YL HYDROGEN SULFATE, Cytochrome P450 46A1, GLYCEROL, ...
Authors:White, M.A, Mast, N.V, Johnson, E.F, Stout, C.D, Pikuleva, I.A.
Deposit date:2007-06-12
Release date:2008-06-17
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2PG6
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BU of 2pg6 by Molmil
Crystal Structure of Human Microsomal P450 2A6 L240C/N297Q
Descriptor: Cytochrome P450 2A6, PROTOPORPHYRIN IX CONTAINING FE
Authors:Sansen, S, Hsu, M.H, Stout, C.D, Johnson, E.F.
Deposit date:2007-04-06
Release date:2007-07-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Structural insight into the altered substrate specificity of human cytochrome P450 2A6 mutants.
Arch.Biochem.Biophys., 464, 2007
2HI4
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BU of 2hi4 by Molmil
Crystal Structure of Human Microsomal P450 1A2 in complex with alpha-naphthoflavone
Descriptor: 2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE, Cytochrome P450 1A2, PROTOPORPHYRIN IX CONTAINING FE
Authors:Sansen, S, Yano, J.K, Reynald, R.L, Schoch, G.S, Stout, C.D, Johnson, E.F.
Deposit date:2006-06-29
Release date:2007-02-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2.
J.Biol.Chem., 282, 2007
1W0E
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BU of 1w0e by Molmil
Crystal structure of human cytochrome P450 3A4
Descriptor: CYTOCHROME P450 3A4, PROTOPORPHYRIN IX CONTAINING FE
Authors:Williams, P.A, Cosme, J, Vinkovic, D.M, Ward, A, Angove, H.C, Day, P.J, Vonrhein, C, Tickle, I.J, Jhoti, H.
Deposit date:2004-06-03
Release date:2004-07-22
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structures of Human Cytochrome P450 3A4 Bound to Metyrapone and Progesterone
Science, 305, 2004
2H7Q
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BU of 2h7q by Molmil
Cytochrome P450cam complexed with imidazole
Descriptor: Cytochrome P450-cam, IMIDAZOLE, PROTOPORPHYRIN IX CONTAINING FE
Authors:Verras, A, Alian, A, Montellano, P.R.
Deposit date:2006-06-02
Release date:2006-10-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Cytochrome P450 active site plasticity: attenuation of imidazole binding in cytochrome P450cam by an L244A mutation.
Protein Eng.Des.Sel., 19, 2006
2Q6N
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BU of 2q6n by Molmil
Structure of Cytochrome P450 2B4 with Bound 1-(4-cholorophenyl)imidazole
Descriptor: 1-(4-CHLOROPHENYL)-1H-IMIDAZOLE, Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE
Authors:Zhao, Y, Sun, L, Muralidhara, B.K, Kumar, S, White, M.A, Stout, C.D, Halpert, J.R.
Deposit date:2007-06-05
Release date:2007-11-06
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural and thermodynamic consequences of 1-(4-chlorophenyl)imidazole binding to cytochrome P450 2B4.
Biochemistry, 46, 2007
1SE6
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BU of 1se6 by Molmil
Crystal Structure of Streptomyces Coelicolor A3(2) CYP158A2 from antibiotic biosynthetic pathways
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, PROTOPORPHYRIN IX CONTAINING FE, SPERMINE (FULLY PROTONATED FORM), ...
Authors:Zhao, B, Lamb, D.C, Lei, L, Sundaramoorthy, M, Podust, L.M, Waterman, M.R.
Deposit date:2004-02-16
Release date:2005-01-25
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Binding of Two Flaviolin Substrate Molecules, Oxidative Coupling, and Crystal Structure of Streptomyces coelicolor A3(2) Cytochrome P450 158A2.
J.Biol.Chem., 280, 2005
1SMI
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BU of 1smi by Molmil
A single mutation of P450 BM3 induces the conformational rearrangement seen upon substrate-binding in wild-type enzyme
Descriptor: Bifunctional P-450:NADPH-P450 reductase, PROTOPORPHYRIN IX CONTAINING FE
Authors:Joyce, M.G, Girvan, H.M, Munro, A.W, Leys, D.
Deposit date:2004-03-09
Release date:2004-06-08
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Single Mutation in Cytochrome P450 BM3 Induces the Conformational Rearrangement Seen upon Substrate Binding in the Wild-type Enzyme
J.Biol.Chem., 279, 2004
1SMJ
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BU of 1smj by Molmil
Structure of the A264E mutant of cytochrome P450 BM3 complexed with palmitoleate
Descriptor: Bifunctional P-450:NADPH-P450 reductase, PALMITOLEIC ACID, PROTOPORPHYRIN IX CONTAINING FE
Authors:Joyce, M.G, Girvan, H.M, Munro, A.W, Leys, D.
Deposit date:2004-03-09
Release date:2004-06-08
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:A Single Mutation in Cytochrome P450 BM3 Induces the Conformational Rearrangement Seen upon Substrate Binding in the Wild-type Enzyme
J.Biol.Chem., 279, 2004
2NNJ
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BU of 2nnj by Molmil
CYP2C8dH complexed with felodipine
Descriptor: Cytochrome P450 2C8, FELODIPINE, PALMITIC ACID, ...
Authors:Schoch, G.A, Yano, J.K, Stout, C.D, Johnson, E.F.
Deposit date:2006-10-24
Release date:2007-10-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid.
J.Biol.Chem., 283, 2008
1T87
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BU of 1t87 by Molmil
Crystal Structure of the Ferrous CO-bound Cytochrome P450cam (C334A)
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CAMPHOR, CARBON MONOXIDE, ...
Authors:Nagano, S, Tosha, T, Ishimori, K, Morishima, I, Poulos, T.L.
Deposit date:2004-05-11
Release date:2004-05-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the cytochrome p450cam mutant that exhibits the same spectral perturbations induced by putidaredoxin binding.
J.Biol.Chem., 279, 2004
2IAG
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BU of 2iag by Molmil
Crystal structure of human prostacyclin synthase
Descriptor: PROTOPORPHYRIN IX CONTAINING FE, Prostacyclin synthase, SODIUM ION
Authors:Chiang, C.-W, Yeh, H.-C, Wang, L.-H, Chan, N.-L.
Deposit date:2006-09-08
Release date:2006-10-10
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal Structure of the Human Prostacyclin Synthase
J.Mol.Biol., 364, 2006
1T88
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BU of 1t88 by Molmil
Crystal Structure of the Ferrous Cytochrome P450cam (C334A)
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CAMPHOR, Cytochrome P450-cam, ...
Authors:Nagano, S, Tosha, T, Ishimori, K, Morishima, I, Poulos, T.L.
Deposit date:2004-05-11
Release date:2004-05-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the cytochrome p450cam mutant that exhibits the same spectral perturbations induced by putidaredoxin binding.
J.Biol.Chem., 279, 2004
2NNI
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BU of 2nni by Molmil
CYP2C8dH complexed with montelukast
Descriptor: Cytochrome P450 2C8, MONTELUKAST, PALMITIC ACID, ...
Authors:Schoch, G.A, Yano, J.K, Stout, C.D, Johnson, E.F.
Deposit date:2006-10-24
Release date:2007-10-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid.
J.Biol.Chem., 283, 2008
2NNH
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BU of 2nnh by Molmil
CYP2C8dH complexed with 2 molecules of 9-cis retinoic acid
Descriptor: (9cis)-retinoic acid, Cytochrome P450 2C8, PALMITIC ACID, ...
Authors:Schoch, G.A, Yano, J.K, Stout, C.D, Johnson, E.F.
Deposit date:2006-10-24
Release date:2007-10-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid.
J.Biol.Chem., 283, 2008
2Q9G
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BU of 2q9g by Molmil
Crystal structure of human cytochrome P450 46A1
Descriptor: Cytochrome P450 46A1, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE
Authors:White, M.A, Mast, N.V, Johnson, E.F, Stout, C.D, Pikuleva, I.A.
Deposit date:2007-06-12
Release date:2008-06-17
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2QBO
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BU of 2qbo by Molmil
Crystal structure of the P450cam G248V mutant in the cyanide bound state
Descriptor: CAMPHOR, CYANIDE ION, Cytochrome P450-cam, ...
Authors:von Koenig, K, Makris, T.M, Sligar, S.D, Schlichting, I.
Deposit date:2007-06-18
Release date:2007-12-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Alteration of P450 Distal Pocket Solvent Leads to Impaired Proton Delivery and Changes in Heme Geometry.
Biochemistry, 46, 2007

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