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6BV7	NMR structure of Sodium/Calcium Exchanger 1 (NCX1) Two-helix Bundle (THB) domain Descriptor: Sodium/calcium exchanger 1 Authors: Yuan, J, Yuan, C, Bruschweiler, R. Deposit date: 2017-12-12 Release date: 2018-06-20 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: The Intracellular Loop of the Na+/Ca2+Exchanger Contains an "Awareness Ribbon"-Shaped Two-Helix Bundle Domain. Biochemistry, 57, 2018
8THH	Cryo-EM structure of Nav1.7 with LTG Descriptor: (6M)-6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... Authors: Fan, X, Huang, J, Yan, N. Deposit date: 2023-07-16 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Dual-pocket inhibition of Na v channels by the antiepileptic drug lamotrigine. Proc.Natl.Acad.Sci.USA, 120, 2023
8THG	Cryo-EM structure of Nav1.7 with RLZ Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Fan, X, Huang, J, Yan, N. Deposit date: 2023-07-16 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Dual-pocket inhibition of Na v channels by the antiepileptic drug lamotrigine. Proc.Natl.Acad.Sci.USA, 120, 2023
3K0G	Crystal Structure of CNG mimicking NaK mutant, NaK-ETPP, Na+ complex Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Potassium channel protein NaK, SODIUM ION Authors: Jiang, Y, Derebe, M.G. Deposit date: 2009-09-24 Release date: 2011-01-12 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Structural studies of ion permeation and Ca2+ blockage of a bacterial channel mimicking the cyclic nucleotide-gated channel pore. Proc.Natl.Acad.Sci.USA, 108, 2011
3LDE	High resolution open MthK pore structure crystallized in 100 mM K+ and further soaked in 100 mM Na+. Descriptor: Calcium-gated potassium channel mthK, SODIUM ION Authors: Ye, S. Deposit date: 2010-01-12 Release date: 2010-08-11 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.208 Å) Cite: Novel insights into K(+) selectivity from high-resolution structures of an open K(+) channel pore. Nat.Struct.Mol.Biol., 17, 2010
5U70	Chicken Slo2.2 in an open conformation vitrified in the presence of 300 mM NaCl Descriptor: Potassium channel subfamily T member 1 Authors: Hite, R.K, MacKinnon, R. Deposit date: 2016-12-09 Release date: 2017-02-08 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.76 Å) Cite: Structural Titration of Slo2.2, a Na(+)-Dependent K(+) Channel. Cell, 168, 2017
7W9K	Cryo-EM structure of human Nav1.7-beta1-beta2 complex at 2.2 angstrom resolution Descriptor: (2S,3R,4E)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... Authors: Yan, N, Huang, G, Liu, D, Wei, P, Shen, H. Deposit date: 2021-12-09 Release date: 2022-06-01 Method: ELECTRON MICROSCOPY (2.2 Å) Cite: High-resolution structures of human Na v 1.7 reveal gating modulation through alpha-pi helical transition of S6 IV. Cell Rep, 39, 2022
8HYA	Cryo-EM structure of Arabidopsis thaliana SOS1 in an occluded state, with expanded TMD Descriptor: HEXADECANE, Sodium/hydrogen exchanger 7 Authors: Wang, Y, Zhao, Y, Gao, Y. Deposit date: 2023-01-06 Release date: 2023-08-09 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Architecture and autoinhibitory mechanism of the plasma membrane Na + /H + antiporter SOS1 in Arabidopsis. Nat Commun, 14, 2023
7XVE	Human Nav1.7 mutant class-I Descriptor: (2S,3R,4E)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... Authors: Huang, G, Wu, Q, Li, Z, Pan, X, Yan, N. Deposit date: 2022-05-21 Release date: 2022-08-10 Last modified: 2023-03-01 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Unwinding and spiral sliding of S4 and domain rotation of VSD during the electromechanical coupling in Na v 1.7. Proc.Natl.Acad.Sci.USA, 119, 2022
7XVF	Nav1.7 mutant class2 Descriptor: (2S,3R,4E)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... Authors: Huang, G, Wu, Q, Li, Z, Pan, X, Yan, N. Deposit date: 2022-05-22 Release date: 2022-08-10 Last modified: 2023-03-01 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Unwinding and spiral sliding of S4 and domain rotation of VSD during the electromechanical coupling in Na v 1.7. Proc.Natl.Acad.Sci.USA, 119, 2022
7T9F	Structure of VcINDY-apo Descriptor: DASS family sodium-coupled anion symporter Authors: Sauer, D.B, Marden, J.J, Song, J.M, Wang, D.N. Deposit date: 2021-12-19 Release date: 2022-05-25 Last modified: 2024-02-28 Method: ELECTRON MICROSCOPY (3.23 Å) Cite: Structural basis of ion - substrate coupling in the Na + -dependent dicarboxylate transporter VcINDY. Nat Commun, 13, 2022
8FT4	Multicrystal structure of Na+, leucine-bound LeuT determined at 5 keV Descriptor: CHLORIDE ION, LEUCINE, Na(+):neurotransmitter symporter (Snf family), ... Authors: Karasawa, A, Liu, H, Quick, M, Hendrickson, A.H, Liu, Q. Deposit date: 2023-01-11 Release date: 2023-11-22 Method: X-RAY DIFFRACTION (4 Å) Cite: Crystallographic characterization of sodium ions in a bacterial leucine/sodium symporter To be Published
7DTD	Voltage-gated sodium channel Nav1.1 and beta4 Descriptor: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium channel protein type 1 subunit alpha, ... Authors: Yan, N, Pan, X, Li, Z, Huang, G. Deposit date: 2021-01-04 Release date: 2021-04-07 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Comparative structural analysis of human Na v 1.1 and Na v 1.5 reveals mutational hotspots for sodium channelopathies. Proc.Natl.Acad.Sci.USA, 118, 2021
3WGV	Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state with oligomycin Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, ... Authors: Kanai, R, Ogawa, H, Vilsen, B, Cornelius, F, Toyoshima, C. Deposit date: 2013-08-09 Release date: 2013-10-09 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Crystal structure of a Na1-bound Na1,K1-ATPase preceding the E1P state Nature, 502, 2013
4HUN	MATE transporter NorM-NG in complex with R6G and monobody Descriptor: Multidrug efflux protein, RHODAMINE 6G, protein B Authors: Lu, M. Deposit date: 2012-11-02 Release date: 2013-02-06 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.59 Å) Cite: Structures of a Na+-coupled, substrate-bound MATE multidrug transporter. Proc.Natl.Acad.Sci.USA, 110, 2013
4HUL	MATE transporter NorM-NG in complex with Cs+ and monobody Descriptor: CESIUM ION, Multidrug efflux protein, Protein B Authors: Lu, M. Deposit date: 2012-11-02 Release date: 2013-02-06 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.81 Å) Cite: Structures of a Na+-coupled, substrate-bound MATE multidrug transporter. Proc.Natl.Acad.Sci.USA, 110, 2013
4HUK	MATE transporter NorM-NG in complex with TPP and monobody Descriptor: Multidrug efflux protein, Protein B, TETRAPHENYLPHOSPHONIUM Authors: Lu, M. Deposit date: 2012-11-02 Release date: 2013-02-06 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.59 Å) Cite: Structures of a Na+-coupled, substrate-bound MATE multidrug transporter. Proc.Natl.Acad.Sci.USA, 110, 2013
4HUM	MATE transporter NorM-NG in complex with ethidium and monobody Descriptor: ETHIDIUM, Multidrug efflux protein, Protein B Authors: Lu, M. Deposit date: 2012-11-02 Release date: 2013-02-06 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.49 Å) Cite: Structures of a Na+-coupled, substrate-bound MATE multidrug transporter. Proc.Natl.Acad.Sci.USA, 110, 2013
3WGU	Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state without oligomycin Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, ... Authors: Kanai, R, Ogawa, H, Vilsen, B, Cornelius, F, Toyoshima, C. Deposit date: 2013-08-09 Release date: 2013-10-09 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Crystal structure of a Na1-bound Na1,K1-ATPase preceding the E1P state Nature, 502, 2013
3TIC	Crystal structure of 1957 pandemic H2N2 neuraminidase complexed with zanamivir Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... Authors: Vavricka, C.J, Li, Q, Wu, Y, Qi, J, Wang, M, Liu, Y, Gao, F, Liu, J, Feng, E, He, J, Wang, J, Liu, H, Jiang, H, Gao, G.F. Deposit date: 2011-08-20 Release date: 2011-11-16 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition Plos Pathog., 7, 2011
3TIA	Crystal structure of 1957 pandemic H2N2 neuraminidase complexed with laninamivir Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-acetamido-2,6-anhydro-4-carbamimidamido-3,4,5-trideoxy-7-O-methyl-D-glycero-D-galacto-non-2-enonic acid, ... Authors: Vavricka, C.J, Li, Q, Wu, Y, Qi, J, Wang, M, Liu, Y, Gao, F, Liu, J, Feng, E, He, J, Wang, J, Liu, H, Jiang, H, Gao, G.F. Deposit date: 2011-08-20 Release date: 2011-11-16 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition Plos Pathog., 7, 2011
5Y4O	Cryo-EM structure of MscS channel, YnaI Descriptor: Low conductance mechanosensitive channel YnaI Authors: Zhang, Y, Yu, J. Deposit date: 2017-08-04 Release date: 2019-03-20 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: A binding-block ion selective mechanism revealed by a Na/K selective channel. Protein Cell, 9, 2018
4OFT	C- Orthorombic NaGST1 Descriptor: Glutathione S-transferase-1 Authors: Asojo, O.A. Deposit date: 2014-01-15 Release date: 2014-12-03 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structure of glutathione S-transferase 1 from the major human hookworm parasite Necator americanus (Na-GST-1) in complex with glutathione. Acta Crystallogr F Struct Biol Commun, 70, 2014
4OFN	Monoclinic NaGST1 Descriptor: GLUTATHIONE, Glutathione S-transferase-1 Authors: Asojo, O.A. Deposit date: 2014-01-15 Release date: 2014-12-03 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.69 Å) Cite: Structure of glutathione S-transferase 1 from the major human hookworm parasite Necator americanus (Na-GST-1) in complex with glutathione. Acta Crystallogr F Struct Biol Commun, 70, 2014
2MDF	NMR structure of a two-transmembrane segment TM VI-VII of NHE1 Descriptor: Sodium/hydrogen exchanger 1 Authors: Lee, B.L, Sykes, B.D, Alves, C, Fliegel, L. Deposit date: 2013-09-10 Release date: 2014-07-02 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Structural and Functional Analysis of the Transmembrane Segment Pair VI and VII of the NHE1 Isoform of the Na(+)/H(+) Exchanger. Biochemistry, 53, 2014

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