PDB: 46984 resultsInfo pagesStatus searchChemie searchBIRD

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6BYL	Structure of 14-3-3 gamma bound to O-GlcNAcylated thr peptide Descriptor: 14-3-3 protein gamma, 2-acetamido-2-deoxy-beta-D-glucopyranose, TSASTTVPVTTATTTTTSTW O-GlcNac peptide Authors: Schumacher, M.A. Deposit date: 2017-12-20 Release date: 2018-05-09 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.35 Å) Cite: Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins. Proc.Natl.Acad.Sci.USA, 115, 2018
6BYJ	Structure of human 14-3-3 gamma bound to O-GlcNAc peptide Descriptor: 14-3-3 protein gamma, 2-acetamido-2-deoxy-beta-D-glucopyranose, TSTTATPPVSQASSTTTSTW O-GlcNac peptide Authors: Schumacher, M.A. Deposit date: 2017-12-20 Release date: 2018-05-09 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins. Proc.Natl.Acad.Sci.USA, 115, 2018
5BY9	The crystal structure of polyglycilated 14-3-3 protein from Giardia intestinalis Descriptor: 14-3-3 protein Authors: Fiorillo, A, Ilari, A, Lalle, M. Deposit date: 2015-06-10 Release date: 2016-04-27 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (4 Å) Cite: Molecular Dynamics Simulations and Structural Analysis of Giardia duodenalis 14-3-3 Protein-Protein Interactions. J.Chem.Inf.Model., 55, 2015
7OBH	Crystal structure of 14-3-3 sigma in complex with NPM1 phosphopeptide and stabilizer Fusicoccin-A Descriptor: 14-3-3 protein sigma, CHLORIDE ION, FUSICOCCIN, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-04-22 Release date: 2022-05-04 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
7OBX	Crystal structure of 14-3-3 sigma in complex with SSBP4 phosphopeptide Descriptor: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-04-23 Release date: 2022-05-04 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
7OBY	Crystal structure of 14-3-3 sigma in complex with SSBP4 phosphopeptide and stabilizer Fusicoccin-A Descriptor: 14-3-3 protein sigma, CHLORIDE ION, FUSICOCCIN, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-04-24 Release date: 2022-05-04 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.1 Å) Cite: IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
7OBG	Crystal structure of 14-3-3 sigma in complex with NPM1 phosphopeptide Descriptor: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-04-22 Release date: 2022-05-04 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
7OBD	Crystal structure of 14-3-3 sigma in complex with Phosphorylated and Farnesylated Rnd3 peptide and stabilizer Fusicoccin-A Descriptor: 14-3-3 protein sigma, CHLORIDE ION, FARNESYL, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-04-21 Release date: 2022-05-04 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
7OBS	Crystal structure of 14-3-3 sigma in complex with RIPK2 phosphopeptide Descriptor: 14-3-3 protein sigma, CALCIUM ION, MAGNESIUM ION, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-04-23 Release date: 2022-05-04 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
7OBK	Crystal structure of 14-3-3 sigma in complex with PKR phosphopeptide Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, PKR phosphopeptide Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-04-22 Release date: 2022-05-04 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
7OB8	Crystal structure of 14-3-3 sigma in complex with LDB1 phosphopeptide and stabilizer Fusicoccin-A Descriptor: 14-3-3 protein sigma, CHLORIDE ION, FUSICOCCIN, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-04-21 Release date: 2022-05-04 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
7OBT	Crystal structure of 14-3-3 sigma in complex with RIPK2 phosphopeptide and stabilizer Fusicoccin-A Descriptor: 14-3-3 protein sigma, CHLORIDE ION, FUSICOCCIN, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-04-23 Release date: 2022-05-04 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.3 Å) Cite: IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
7OB5	Crystal structure of 14-3-3 sigma in complex with LDB1 phosphopeptide Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-04-21 Release date: 2022-05-04 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
7OBL	Crystal structure of 14-3-3 sigma in complex with PKR phosphopeptide and stabilizer Fusicoccin-A Descriptor: 14-3-3 protein sigma, FUSICOCCIN, MAGNESIUM ION, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-04-22 Release date: 2022-05-04 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
7OBC	Crystal structure of 14-3-3 sigma in complex with Phosphorylated and Farnesylated Rnd3 peptide Descriptor: 14-3-3 protein sigma, CHLORIDE ION, FARNESYL, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-04-21 Release date: 2022-05-04 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
7QI1	Crystal structure of human 14-3-3 protein beta in complex with CFTR peptide pS753pS768 and PPI stabilizer CY007424 Descriptor: 14-3-3 protein theta, ARGININE, Cystic fibrosis transmembrane conductance regulator, ... Authors: Stevers, L.M, Ottmann, C. Deposit date: 2021-12-14 Release date: 2022-05-25 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.76 Å) Cite: Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR. Nat Commun, 13, 2022
3LW1	Binary complex of 14-3-3 sigma and p53 pT387-peptide Descriptor: 14-3-3 protein sigma, CHLORIDE ION, GLYCEROL, ... Authors: Schumacher, B, Mondry, J, Thiel, P, Weyand, M, Ottmann, C. Deposit date: 2010-02-23 Release date: 2010-03-23 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.28 Å) Cite: Structure of the p53 C-terminus bound to 14-3-3: Implications for stabilization of the p53 tetramer Febs Lett., 584, 2010
5WXN	Structure of the LKB1 and 14-3-3 complex Descriptor: 14-3-3 protein zeta/delta, Serine/threonine-protein kinase STK11 Authors: Ding, S, Shi, Z.B. Deposit date: 2017-01-08 Release date: 2017-04-19 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.93 Å) Cite: Structure of the complex of phosphorylated liver kinase B1 and 14-3-3 zeta Acta Crystallogr F Struct Biol Commun, 73, 2017
3NKX	Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome Descriptor: 14-3-3 protein zeta/delta, PROPANOIC ACID, Peptide of RAF proto-oncogene serine/threonine-protein kinase Authors: Schumacher, B, Weyand, M, Ottmann, C. Deposit date: 2010-06-21 Release date: 2010-09-15 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling Mol.Cell.Biol., 30, 2010
8BZH	FC-NAc stabilizer of 14-3-3 and ERalpha Descriptor: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... Authors: Visser, E.J, Ottmann, C. Deposit date: 2022-12-14 Release date: 2024-06-26 Method: X-RAY DIFFRACTION (1.46 Å) Cite: Stabilization of the Estrogen receptor alpha - 14-3-3 interaction as a potential intervention strategy for endocrine resistance in breast cancer To Be Published
8BZT	FC-NAg stabilizer of 14-3-3 and ERalpha Descriptor: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... Authors: Visser, E.J, Ottmann, C. Deposit date: 2022-12-15 Release date: 2024-06-26 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Stabilization of the Estrogen receptor alpha - 14-3-3 interaction as a potential intervention strategy for endocrine resistance in breast cancer To Be Published
8QT5	Crystal structure of Arabidopsis thaliana 14-3-3 isoform lambda in complex with a phosphopeptide from the transcription factor BZR1. Descriptor: 14-3-3-like protein G-BOX factor 14 lambda,Protein BRASSINAZOLE-RESISTANT 1, ACETATE ION Authors: Hothorn, M, Obergfell, E. Deposit date: 2023-10-12 Release date: 2023-10-25 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.69 Å) Cite: Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis. Plant Cell.Physiol., 2024
6Y4K	Crystal structure of human 14-3-3 gamma in complex with CaMKK2 14-3-3 binding motif Ser100 and Fusicoccin A Descriptor: 14-3-3 protein gamma, Calcium/calmodulin-dependent protein kinase kinase 2, FUSICOCCIN Authors: Lentini Santo, D, Obsilova, V, Obsil, T. Deposit date: 2020-02-21 Release date: 2021-01-27 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (3 Å) Cite: Stabilization of Protein-Protein Interactions between CaMKK2 and 14-3-3 by Fusicoccins. Acs Chem.Biol., 15, 2020
8BZF	FC-J acetonide stabilizer of 14-3-3 and ERalpha Descriptor: 14-3-3 protein sigma, ERalpha peptide, Fusicoccin J-acetonide, ... Authors: Visser, E.J, Ottmann, C. Deposit date: 2022-12-14 Release date: 2023-12-27 Method: X-RAY DIFFRACTION (1.53 Å) Cite: Stabilization of the Estrogen receptor alpha - 14-3-3 interaction as a potential intervention strategy for endocrine resistance in breast cancer To Be Published
8BZD	deAc-FC stabilizer of 14-3-3 and ERalpha Descriptor: 14-3-3 protein sigma, De-acetylated Fusicoccin, ERalpha peptide, ... Authors: Visser, E.J, Ottmann, C. Deposit date: 2022-12-14 Release date: 2024-06-26 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Stabilization of the Estrogen receptor alpha - 14-3-3 interaction as a potential intervention strategy for endocrine resistance in breast cancer To Be Published

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