6VCT
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![BU of 6vct by Molmil](/molmil-images/mine/6vct) | Mucor circinelloides FKBP12 protein bound with APX879 in C2221 space group | Descriptor: | N'-[(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-1,20,21-trioxo-8-(prop-2-en-1-yl)-1,3,4,5,6,8,11,12,13,14,15,16,17,18,19,20,21,23,24,25,26,26a-docosahydro-7H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosin-7-ylidene]acetohydrazide, Peptidylprolyl isomerase | Authors: | Gobeil, S, Spicer, L. | Deposit date: | 2019-12-23 | Release date: | 2020-12-16 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs. Mbio, 12, 2021
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6VCV
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![BU of 6vcv by Molmil](/molmil-images/mine/6vcv) | Aspergillus fumigatus FKBP12 protein bound with APX879 in P1 space group | Descriptor: | FK506-binding protein 1A, N'-[(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-1,20,21-trioxo-8-(prop-2-en-1-yl)-1,3,4,5,6,8,11,12,13,14,15,16,17,18,19,20,21,23,24,25,26,26a-docosahydro-7H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosin-7-ylidene]acetohydrazide | Authors: | Gobeil, S, Spicer, L. | Deposit date: | 2019-12-23 | Release date: | 2020-12-16 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs. Mbio, 12, 2021
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6W1N
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![BU of 6w1n by Molmil](/molmil-images/mine/6w1n) | |
6VSI
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![BU of 6vsi by Molmil](/molmil-images/mine/6vsi) | Crystal structure of FKBP12 of Candida auris | Descriptor: | Peptidylprolyl isomerase, SULFATE ION | Authors: | Li, Z, Li, H, Hernandez, G, LeMaster, D. | Deposit date: | 2020-02-11 | Release date: | 2020-04-01 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Crystal structure and transient dimerization for the FKBP12 protein from the pathogenic fungus Candida auris. Biochem.Biophys.Res.Commun., 525, 2020
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6VRX
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![BU of 6vrx by Molmil](/molmil-images/mine/6vrx) | |
3LUO
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![BU of 3luo by Molmil](/molmil-images/mine/3luo) | Crystal Structure and functional characterization of the thermophilic prolyl isomerase and chaperone SlyD | Descriptor: | Peptidyl-prolyl cis-trans isomerase, Suc-Ala-Leu-Pro-Phe-pNA, ZINC ION | Authors: | Loew, C, Neumann, P, Weininger, U, Stubbs, M.T, Balbach, J. | Deposit date: | 2010-02-18 | Release date: | 2010-03-31 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Crystal Structure Determination and Functional Characterization of the Metallochaperone SlyD from Thermus thermophilus J.Mol.Biol., 398, 2010
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3O5E
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![BU of 3o5e by Molmil](/molmil-images/mine/3o5e) | Fk1 domain of FKBP51, crystal form VI | Descriptor: | Peptidyl-prolyl cis-trans isomerase FKBP5 | Authors: | Bracher, A, Kozany, C, Thost, A.-K, Hausch, F. | Deposit date: | 2010-07-28 | Release date: | 2011-06-01 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90. Acta Crystallogr.,Sect.D, 67, 2011
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3O5L
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![BU of 3o5l by Molmil](/molmil-images/mine/3o5l) | Fk1 domain mutant A19T of FKBP51, crystal form I | Descriptor: | PENTAETHYLENE GLYCOL, Peptidyl-prolyl cis-trans isomerase FKBP5 | Authors: | Bracher, A, Kozany, C, Thost, A.-K, Hausch, F. | Deposit date: | 2010-07-28 | Release date: | 2011-06-01 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90. Acta Crystallogr.,Sect.D, 67, 2011
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3O5Q
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![BU of 3o5q by Molmil](/molmil-images/mine/3o5q) | Fk1 domain mutant A19T of FKBP51, crystal form IV, in presence of DMSO | Descriptor: | DIMETHYL SULFOXIDE, Peptidyl-prolyl cis-trans isomerase FKBP5 | Authors: | Bracher, A, Kozany, C, Thost, A.-K, Hausch, F. | Deposit date: | 2010-07-28 | Release date: | 2011-06-01 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (0.96 Å) | Cite: | Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90. Acta Crystallogr.,Sect.D, 67, 2011
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3O5F
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![BU of 3o5f by Molmil](/molmil-images/mine/3o5f) | Fk1 domain of FKBP51, crystal form VII | Descriptor: | CARBONATE ION, Peptidyl-prolyl cis-trans isomerase FKBP5 | Authors: | Bracher, A, Kozany, C, Thost, A.-K, Hausch, F. | Deposit date: | 2010-07-28 | Release date: | 2011-06-01 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90. Acta Crystallogr.,Sect.D, 67, 2011
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3O5M
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![BU of 3o5m by Molmil](/molmil-images/mine/3o5m) | Fk1 domain mutant A19T of FKBP51, crystal form II | Descriptor: | GLYCEROL, Peptidyl-prolyl cis-trans isomerase FKBP5 | Authors: | Bracher, A, Kozany, C, Thost, A.-K, Hausch, F. | Deposit date: | 2010-07-28 | Release date: | 2011-06-01 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90. Acta Crystallogr.,Sect.D, 67, 2011
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3O5I
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![BU of 3o5i by Molmil](/molmil-images/mine/3o5i) | Fk1 domain of FKBP51, crystal form II | Descriptor: | ACETATE ION, GLYCEROL, Peptidyl-prolyl cis-trans isomerase FKBP5 | Authors: | Bracher, A, Kozany, C, Thost, A.-K, Hausch, F. | Deposit date: | 2010-07-28 | Release date: | 2011-06-01 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90. Acta Crystallogr.,Sect.D, 67, 2011
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3O5R
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![BU of 3o5r by Molmil](/molmil-images/mine/3o5r) | Complex of Fk506 with the Fk1 domain mutant A19T of FKBP51 | Descriptor: | 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, Peptidyl-prolyl cis-trans isomerase FKBP5 | Authors: | Bracher, A, Kozany, C, Thost, A.-K, Hausch, F. | Deposit date: | 2010-07-28 | Release date: | 2011-06-01 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90. Acta Crystallogr.,Sect.D, 67, 2011
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3NI6
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![BU of 3ni6 by Molmil](/molmil-images/mine/3ni6) | |
3O5D
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![BU of 3o5d by Molmil](/molmil-images/mine/3o5d) | Crystal structure of a fragment of FKBP51 comprising the Fk1 and Fk2 domains | Descriptor: | Peptidyl-prolyl cis-trans isomerase FKBP5 | Authors: | Bracher, A, Kozany, C, Thost, A.-K, Hausch, F. | Deposit date: | 2010-07-28 | Release date: | 2011-06-01 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90. Acta Crystallogr.,Sect.D, 67, 2011
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3O5K
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![BU of 3o5k by Molmil](/molmil-images/mine/3o5k) | Fk1 domain of FKBP51, crystal form VIII | Descriptor: | Peptidyl-prolyl cis-trans isomerase FKBP5 | Authors: | Bracher, A, Kozany, C, Thost, A.-K, Hausch, F. | Deposit date: | 2010-07-28 | Release date: | 2011-06-01 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90. Acta Crystallogr.,Sect.D, 67, 2011
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3O5P
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![BU of 3o5p by Molmil](/molmil-images/mine/3o5p) | Fk1 domain mutant A19T of FKBP51, crystal form IV | Descriptor: | Peptidyl-prolyl cis-trans isomerase FKBP5 | Authors: | Bracher, A, Kozany, C, Thost, A.-K, Hausch, F. | Deposit date: | 2010-07-28 | Release date: | 2011-06-01 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90. Acta Crystallogr.,Sect.D, 67, 2011
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3O5G
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![BU of 3o5g by Molmil](/molmil-images/mine/3o5g) | Fk1 domain of FKBP51, crystal form I | Descriptor: | Peptidyl-prolyl cis-trans isomerase FKBP5 | Authors: | Bracher, A, Kozany, C, Thost, A.-K, Hausch, F. | Deposit date: | 2010-07-28 | Release date: | 2011-06-01 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90. Acta Crystallogr.,Sect.D, 67, 2011
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3O5J
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![BU of 3o5j by Molmil](/molmil-images/mine/3o5j) | Fk1 domain of FKBP51, crystal form III | Descriptor: | Peptidyl-prolyl cis-trans isomerase FKBP5 | Authors: | Bracher, A, Kozany, C, Thost, A.-K, Hausch, F. | Deposit date: | 2010-07-28 | Release date: | 2011-06-01 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90. Acta Crystallogr.,Sect.D, 67, 2011
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3O5O
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![BU of 3o5o by Molmil](/molmil-images/mine/3o5o) | Fk1 domain mutant A19T of FKBP51, crystal form III | Descriptor: | Peptidyl-prolyl cis-trans isomerase FKBP5, THIOCYANATE ION | Authors: | Bracher, A, Kozany, C, Thost, A.-K, Hausch, F. | Deposit date: | 2010-07-28 | Release date: | 2011-06-01 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90. Acta Crystallogr.,Sect.D, 67, 2011
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3PA7
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![BU of 3pa7 by Molmil](/molmil-images/mine/3pa7) | Crystal structure of FKBP from plasmodium vivax in complex with tetrapeptide ALPF | Descriptor: | 4-mer Peptide ALPF, 70 kDa peptidylprolyl isomerase, putative | Authors: | Balakrishna, A.M, Alag, R, Yoon, H.S. | Deposit date: | 2010-10-18 | Release date: | 2012-02-29 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Structural insights into substrate binding by PvFKBP35, a peptidylprolyl cis-trans isomerase from the human malarial parasite Plasmodium vivax EUKARYOTIC CELL, 12, 2013
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8CCF
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![BU of 8ccf by Molmil](/molmil-images/mine/8ccf) | The Fk1 domain of FKBP51 in complex with 2-(3-((R)-1-(((S)-1-((S)-2-(5-chlorothiophen-2-yl)pent-4-enoyl)piperidine-2-carbonyl)oxy)-3-(3,4-dimethoxyphenyl)propyl)phenoxy)acetic acid | Descriptor: | 2-[3-[(1~{R})-1-[(2~{S})-1-[(2~{S})-2-(5-chloranylthiophen-2-yl)pent-4-enoyl]piperidin-2-yl]carbonyloxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]ethanoic acid, Peptidyl-prolyl cis-trans isomerase FKBP5 | Authors: | Meyners, C, Knaup, F.H, Walz, C.M, Hausch, F. | Deposit date: | 2023-01-27 | Release date: | 2023-04-26 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-Based Discovery of a New Selectivity-Enabling Motif for the FK506-Binding Protein 51. J.Med.Chem., 66, 2023
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8CCH
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![BU of 8cch by Molmil](/molmil-images/mine/8cch) | The Fk1 domain of FKBP51 in complex with 2-(3-((1R)-1-(((2S)-1-(2-cyclohexyl-2-(thiophen-2-yl)acetyl)piperidine-2-carbonyl)oxy)-3-(3,4-dimethoxyphenyl)propyl)phenoxy)acetic acid | Descriptor: | 2-[3-[(1~{R})-1-[(2~{S})-1-[(2~{S})-2-cyclohexyl-2-thiophen-2-yl-ethanoyl]piperidin-2-yl]carbonyloxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]ethanoic acid, Peptidyl-prolyl cis-trans isomerase FKBP5 | Authors: | Meyners, C, Knaup, F.H, Walz, C.M, Hausch, F. | Deposit date: | 2023-01-27 | Release date: | 2023-04-26 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Structure-Based Discovery of a New Selectivity-Enabling Motif for the FK506-Binding Protein 51. J.Med.Chem., 66, 2023
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8CCG
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![BU of 8ccg by Molmil](/molmil-images/mine/8ccg) | The Fk1 domain of FKBP51 in complex with (2R,5S,12S)-12-(thiophen-2-yl)-2-[2-(3,4-dimethoxyphenyl)ethyl]-15,15-dimethyl-3,19-dioxa-10,13,16-triazatricyclo[18.3.1.0^5,^10]tetracosa-1(24),20,22-triene-4,11,14,17-tetrone | Descriptor: | (2~{R},5~{S},12~{S})-2-[2-(3,4-dimethoxyphenyl)ethyl]-15,15-dimethyl-12-thiophen-2-yl-3,19-dioxa-10,13,16-triazatricyclo[18.3.1.0^{5,10}]tetracosa-1(24),20,22-triene-4,11,14,17-tetrone, Peptidyl-prolyl cis-trans isomerase FKBP5 | Authors: | Meyners, C, Knaup, F.H, Walz, C.M, Hausch, F. | Deposit date: | 2023-01-27 | Release date: | 2023-04-26 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Structure-Based Discovery of a New Selectivity-Enabling Motif for the FK506-Binding Protein 51. J.Med.Chem., 66, 2023
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8CCE
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![BU of 8cce by Molmil](/molmil-images/mine/8cce) | The Fk1 domain of FKBP51 in complex with 2-(3-((R)-1-(((S)-1-((S)-2-(5-chlorothiophen-2-yl)butanoyl)piperidine-2-carbonyl)oxy)-3-(3,4-dimethoxyphenyl)propyl)phenoxy)acetic acid | Descriptor: | 2-[3-[(1~{R})-1-[(2~{S})-1-[(2~{S})-2-(5-chloranylthiophen-2-yl)butanoyl]piperidin-2-yl]carbonyloxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]ethanoic acid, GLYCEROL, Peptidyl-prolyl cis-trans isomerase FKBP5 | Authors: | Meyners, C, Knaup, F.H, Walz, C.M, Hausch, F. | Deposit date: | 2023-01-27 | Release date: | 2023-04-26 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structure-Based Discovery of a New Selectivity-Enabling Motif for the FK506-Binding Protein 51. J.Med.Chem., 66, 2023
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