3WGN
 
 | | STAPHYLOCOCCUS AUREUS FTSZ bound with GTP-gamma-S | | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Cell division protein FtsZ | | Authors: | Matsui, T, Mogi, N, Tanaka, I, Yao, M. | | Deposit date: | 2013-08-06 | | Release date: | 2013-12-25 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.606 Å) | | Cite: | Structural change in FtsZ Induced by intermolecular interactions between bound GTP and the T7 loop
J.Biol.Chem., 289, 2014
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8JJC
 | | Tubulin-Y62 | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-(6,7-dimethoxy-3,4-dihydro-1~{H}-isoquinolin-2-yl)-6-(3-methoxyphenyl)pyrimidin-2-amine, CALCIUM ION, ... | | Authors: | Yang, J. | | Deposit date: | 2023-05-30 | | Release date: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.76 Å) | | Cite: | Structure-based design and synthesis of BML284 derivatives: A novel class of colchicine-site noncovalent tubulin degradation agents.
Eur.J.Med.Chem., 268, 2024
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8JJB
 | | Crystal structure of T2R-TTL-Y61 complex | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, CHLORIDE ION, ... | | Authors: | Yang, J. | | Deposit date: | 2023-05-30 | | Release date: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.68 Å) | | Cite: | Structure-based design and synthesis of BML284 derivatives: A novel class of colchicine-site noncovalent tubulin degradation agents.
Eur.J.Med.Chem., 268, 2024
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4ATX
 | | Rigor kinesin motor domain with an ordered neck-linker, docked on tubulin dimer, modelled into the 8A cryo-EM map of doublecortin- microtubules decorated with kinesin | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, KINESIN-1 HEAVY CHAIN, ... | | Authors: | Liu, J.S, Schubert, C.R, Fu, X, Fourniol, F.J, Jaiswal, J.K, Houdusse, A, Stultz, C.M, Moores, C.A, Walsh, C.A. | | Deposit date: | 2012-05-10 | | Release date: | 2012-09-26 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (8.2 Å) | | Cite: | Molecular Basis for Specific Regulation of Neuronal Kinesin- 3 Motors by Doublecortin Family Proteins.
Mol.Cell, 47, 2012
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4ABO
 | | Mal3 CH domain homology model and mammalian tubulin (2XRP) docked into the 8.6-Angstrom cryo-EM map of Mal3-GTPgammaS-microtubules | | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MICROTUBULE INTEGRITY PROTEIN MAL3, ... | | Authors: | Maurer, S.P, Fourniol, F.J, Bohner, G, Moores, C.A, Surrey, T. | | Deposit date: | 2011-12-09 | | Release date: | 2012-06-06 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (8.6 Å) | | Cite: | Ebs Recognize a Nucleotide-Dependent Structural CAP at Growing Microtubule Ends.
Cell(Cambridge,Mass.), 149, 2012
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8YER
 | | Tubulin-RB3_SLD-TTL in complex with compound 4 | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-fluoranyl-4-(6-methoxy-3,4-dihydro-2~{H}-quinolin-1-yl)-~{N}-methyl-quinazolin-2-amine, CALCIUM ION, ... | | Authors: | Wu, C.Y, Wang, Y.X. | | Deposit date: | 2024-02-23 | | Release date: | 2025-02-26 | | Method: | X-RAY DIFFRACTION (2.71 Å) | | Cite: | Tubulin-RB3_SLD-TTL in complex with compound 4
To Be Published
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8YEM
 | | Tubulin-RB3_SLD-TTL in complex with compound 9 | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-(2-chloranyl-6-fluoranyl-quinazolin-4-yl)-7-methoxy-1,3-dihydroquinoxalin-2-one, CALCIUM ION, ... | | Authors: | Wu, C.Y, Wang, Y.X. | | Deposit date: | 2024-02-22 | | Release date: | 2025-02-26 | | Method: | X-RAY DIFFRACTION (2.74 Å) | | Cite: | Tubulin-RB3_SLD-TTL in complex with compound 9
To Be Published
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8YEU
 | | Tubulin-RB3_SLD-TTL in complex with compound 2NH2 | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-fluoranyl-4-(6-methoxy-3,4-dihydro-2~{H}-quinolin-1-yl)quinazolin-2-amine, CALCIUM ION, ... | | Authors: | Wu, C.Y, Wang, Y.X. | | Deposit date: | 2024-02-23 | | Release date: | 2025-02-26 | | Method: | X-RAY DIFFRACTION (3.05 Å) | | Cite: | Tubulin-RB3_SLD-TTL in complex with compound 2NH2
To Be Published
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8YRK
 | | Tubulin-Compound KY216: stathmin-like domain complex | | Descriptor: | (11R,16S)-11-(3,5-dichloro-4-methoxyphenyl)-4,7-dioxa-12,14-diazatetracyclo[8.7.0.03,8.012,16]heptadeca-1,3(8),9-triene-13,15-dione, 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | | Authors: | Xia, Y.Z, He, X.Y. | | Deposit date: | 2024-03-21 | | Release date: | 2025-04-02 | | Method: | X-RAY DIFFRACTION (2.74 Å) | | Cite: | Tubulin-Compound KY216: stathmin-like domain complex
To Be Published
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8ZB8
 | | Crystal structure of T2R-TTL-DPP21 complex | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, Detyrosinated tubulin alpha-1B chain, ... | | Authors: | Wu, C.Y, Chen, J.J. | | Deposit date: | 2024-04-26 | | Release date: | 2024-06-26 | | Method: | X-RAY DIFFRACTION (2.94 Å) | | Cite: | Crystal structure of T2R-TTL-DPP21 complex
To Be Published
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4AQV
 | | Model of human kinesin-5 motor domain (3HQD) and mammalian tubulin heterodimer (1JFF) docked into the 9.7-angstrom cryo-EM map of microtubule-bound kinesin-5 motor domain in the AMPPPNP state. | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, ... | | Authors: | Goulet, A, Behnke-Parks, W.M, Sindelar, C.V, Rosenfeld, S.S, Moores, C.A. | | Deposit date: | 2012-04-19 | | Release date: | 2012-11-21 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (9.7 Å) | | Cite: | The Structural Basis of Force Generation by the Mitotic Motor Kinesin-5.
J.Biol.Chem., 287, 2012
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8YU9
 | | Tubulin-RB3-TTL in complex with compound SI10 | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-(2-chloranylthieno[3,2-d]pyrimidin-4-yl)-7-methoxy-1,3-dihydroquinoxalin-2-one, CALCIUM ION, ... | | Authors: | Wu, C.Y, Wang, Y.X. | | Deposit date: | 2024-03-27 | | Release date: | 2024-06-05 | | Last modified: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (3.25 Å) | | Cite: | Discovery and mechanistic insights into thieno[3,2-d]pyrimidine and heterocyclic fused pyrimidines inhibitors targeting tubulin for cancer therapy.
Eur.J.Med.Chem., 276, 2024
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8YTX
 | | Tubulin-RB3-TTL in complex with compound SI9 | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-chloranyl-~{N}-(4-methoxyphenyl)-~{N}-methyl-thieno[2,3-d]pyrimidin-4-amine, CALCIUM ION, ... | | Authors: | Wu, C.Y, Wang, Y.X. | | Deposit date: | 2024-03-26 | | Release date: | 2024-06-05 | | Last modified: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (2.53 Å) | | Cite: | Discovery and mechanistic insights into thieno[3,2-d]pyrimidine and heterocyclic fused pyrimidines inhibitors targeting tubulin for cancer therapy.
Eur.J.Med.Chem., 276, 2024
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8YUA
 | | Tubulin-RB3-TTL in complex with compound SI10 | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-chloranyl-~{N}-(4-methoxyphenyl)-~{N}-methyl-thieno[3,2-d]pyrimidin-4-amine, CALCIUM ION, ... | | Authors: | Wu, C.Y, Wang, Y.X. | | Deposit date: | 2024-03-27 | | Release date: | 2024-06-05 | | Last modified: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (2.37 Å) | | Cite: | Discovery and mechanistic insights into thieno[3,2-d]pyrimidine and heterocyclic fused pyrimidines inhibitors targeting tubulin for cancer therapy.
Eur.J.Med.Chem., 276, 2024
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8YAR
 | | ATAT-2 bound K40R MEC-12/MEC-7 microtubule | | Descriptor: | ACETYL COENZYME *A, Alpha-tubulin N-acetyltransferase 2, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Lam, W.H, Yu, D, Zhai, Y, Ti, S. | | Deposit date: | 2024-02-09 | | Release date: | 2024-11-06 | | Last modified: | 2025-03-05 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Tubulin acetyltransferases access and modify the microtubule luminal K40 residue through anchors in taxane-binding pockets.
Nat.Struct.Mol.Biol., 32, 2025
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8YAL
 | | ATAT-2 bound K40Q MEC-12/MEC-7 microtubule | | Descriptor: | ACETYL COENZYME *A, Alpha-tubulin N-acetyltransferase 2, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Lam, W.H, Yu, D, Zhai, Y, Ti, S. | | Deposit date: | 2024-02-09 | | Release date: | 2024-11-06 | | Last modified: | 2025-03-05 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Tubulin acetyltransferases access and modify the microtubule luminal K40 residue through anchors in taxane-binding pockets.
Nat.Struct.Mol.Biol., 32, 2025
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8Y9F
 | | ATAT-2 bound MEC-12/MEC-7 microtubule | | Descriptor: | Alpha-tubulin N-acetyltransferase 2, GUANOSINE-5'-TRIPHOSPHATE, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... | | Authors: | Lam, W.H, Yu, D, Zhai, Y, Ti, S. | | Deposit date: | 2024-02-06 | | Release date: | 2024-11-06 | | Last modified: | 2025-03-05 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Tubulin acetyltransferases access and modify the microtubule luminal K40 residue through anchors in taxane-binding pockets.
Nat.Struct.Mol.Biol., 32, 2025
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8OU0
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4AQW
 | | Model of human kinesin-5 motor domain (1II6, 3HQD) and mammalian tubulin heterodimer (1JFF) docked into the 9.5-angstrom cryo-EM map of microtubule-bound kinesin-5 motor domain in the rigor state. | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, ... | | Authors: | Goulet, A, Behnke-Parks, W.M, Sindelar, C.V, Rosenfeld, S.S, Moores, C.A. | | Deposit date: | 2012-04-19 | | Release date: | 2012-11-21 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (9.5 Å) | | Cite: | The Structural Basis of Force Generation by the Mitotic Motor Kinesin-5.
J.Biol.Chem., 287, 2012
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8IXG
 | | GMPCPP-Alpha4A/Beta2A-microtubule decorated with kinesin seam region | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-1 heavy chain, ... | | Authors: | Zheng, W, Zhao, Q.Y, Diao, L, Bao, L, Cong, Y. | | Deposit date: | 2023-03-31 | | Release date: | 2023-08-16 | | Last modified: | 2023-10-25 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Cryo-EM of alpha-tubulin isotype-containing microtubules revealed a contracted structure of alpha 4A/ beta 2A microtubules.
Acta Biochim.Biophys.Sin., 55, 2023
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8IXE
 | | GMPCPP-Alpha1C/Beta2A-microtubule decorated with kinesin seam region | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-1 heavy chain, ... | | Authors: | Zheng, W, Zhao, Q.Y, Diao, L, Bao, L, Cong, Y. | | Deposit date: | 2023-03-31 | | Release date: | 2023-08-16 | | Last modified: | 2023-10-25 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Cryo-EM of alpha-tubulin isotype-containing microtubules revealed a contracted structure of alpha 4A/ beta 2A microtubules.
Acta Biochim.Biophys.Sin., 55, 2023
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8IXB
 | | GMPCPP-Alpha1A/Beta2A-microtubule decorated with kinesin seam region | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-1 heavy chain, ... | | Authors: | Zheng, W, Zhao, Q.Y, Diao, L, Bao, L, Cong, Y. | | Deposit date: | 2023-03-31 | | Release date: | 2023-08-16 | | Last modified: | 2025-07-16 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Cryo-EM of alpha-tubulin isotype-containing microtubules revealed a contracted structure of alpha 4A/ beta 2A microtubules.
Acta Biochim.Biophys.Sin., 55, 2023
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8IXA
 | | GMPCPP-Alpha1A/Beta2A-microtubule decorated with kinesin non-seam region | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-1 heavy chain, ... | | Authors: | Zheng, W, Zhao, Q.Y, Diao, L, Bao, L, Cong, Y. | | Deposit date: | 2023-03-31 | | Release date: | 2023-08-16 | | Last modified: | 2023-10-25 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Cryo-EM of alpha-tubulin isotype-containing microtubules revealed a contracted structure of alpha 4A/ beta 2A microtubules.
Acta Biochim.Biophys.Sin., 55, 2023
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8IXD
 | | GMPCPP-Alpha1C/Beta2A-microtubule decorated with kinesin non-seam region | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-1 heavy chain, ... | | Authors: | Zheng, W, Zhao, Q.Y, Diao, L, Bao, L, Cong, Y. | | Deposit date: | 2023-03-31 | | Release date: | 2023-08-16 | | Last modified: | 2023-10-25 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Cryo-EM of alpha-tubulin isotype-containing microtubules revealed a contracted structure of alpha 4A/ beta 2A microtubules.
Acta Biochim.Biophys.Sin., 55, 2023
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8IXF
 | | GMPCPP-Alpha4A/Beta2A-microtubule decorated with kinesin non-seam region | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-1 heavy chain, ... | | Authors: | Zheng, W, Zhao, Q.Y, Diao, L, Bao, L, Cong, Y. | | Deposit date: | 2023-03-31 | | Release date: | 2023-08-16 | | Last modified: | 2023-10-25 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Cryo-EM of alpha-tubulin isotype-containing microtubules revealed a contracted structure of alpha 4A/ beta 2A microtubules.
Acta Biochim.Biophys.Sin., 55, 2023
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