8AAK
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![BU of 8aak by Molmil](/molmil-images/mine/8aak) | Crystal structure of the PDZ tandem of syntenin in complex with compound 29 | Descriptor: | (2~{S})-2-[[(2~{S})-2-(3-oxidanylidene-1~{H}-isoindol-2-yl)-3-phenyl-propanoyl]amino]propanoic acid, GLYCEROL, Syntenin-1 | Authors: | Feracci, M, Barral, K. | Deposit date: | 2022-07-01 | Release date: | 2023-04-26 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.554 Å) | Cite: | Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein-Protein Interaction: A Semi-Automated "Hit Identification-to-Optimization" Approach. J.Med.Chem., 66, 2023
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8AAP
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![BU of 8aap by Molmil](/molmil-images/mine/8aap) | Crystal structure of the PDZ tandem of syntenin in complex with compound SYNTi | Descriptor: | (2S)-2-[[(2S)-2-(6-bromanyl-3-oxidanylidene-1H-isoindol-2-yl)-3-[4-(5-ethanoyl-2-fluoranyl-phenyl)phenyl]propanoyl]amino]propanoic acid, Syntenin-1 | Authors: | Feracci, M, Barral, K. | Deposit date: | 2022-07-01 | Release date: | 2023-04-26 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.174 Å) | Cite: | Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein-Protein Interaction: A Semi-Automated "Hit Identification-to-Optimization" Approach. J.Med.Chem., 66, 2023
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8AAO
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![BU of 8aao by Molmil](/molmil-images/mine/8aao) | Crystal structure of the PDZ tandem of syntenin in complex with compound 95 | Descriptor: | (2~{S})-2-[[(2~{S})-3-[4-(5-ethanoyl-2-fluoranyl-phenyl)phenyl]-2-(3-oxidanylidene-1~{H}-isoindol-2-yl)propanoyl]amino]propanoic acid, Syntenin-1 | Authors: | Feracci, M, Barral, K. | Deposit date: | 2022-07-01 | Release date: | 2023-04-26 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.469 Å) | Cite: | Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein-Protein Interaction: A Semi-Automated "Hit Identification-to-Optimization" Approach. J.Med.Chem., 66, 2023
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8AAI
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![BU of 8aai by Molmil](/molmil-images/mine/8aai) | Crystal structure of the PDZ tandem of syntenin in complex with fragment E5 | Descriptor: | (2~{S})-2-[[(2~{S})-3-methyl-2-(3-oxidanylidene-1~{H}-isoindol-2-yl)butanoyl]amino]propanoic acid, Syntenin-1 | Authors: | Feracci, M, Barral, K. | Deposit date: | 2022-07-01 | Release date: | 2023-04-26 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.76 Å) | Cite: | Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein-Protein Interaction: A Semi-Automated "Hit Identification-to-Optimization" Approach. J.Med.Chem., 66, 2023
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1GQ4
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![BU of 1gq4 by Molmil](/molmil-images/mine/1gq4) | |
5VWK
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![BU of 5vwk by Molmil](/molmil-images/mine/5vwk) | Crystal structure of human Scribble PDZ1:Beta-PIX complex | Descriptor: | Beta-PIX, Protein scribble homolog, SULFATE ION | Authors: | Lim, K.Y.B, Kvansakul, M. | Deposit date: | 2017-05-22 | Release date: | 2017-11-08 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural basis for the differential interaction of Scribble PDZ domains with the guanine nucleotide exchange factor beta-PIX. J. Biol. Chem., 292, 2017
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5VWI
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1GQ5
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![BU of 1gq5 by Molmil](/molmil-images/mine/1gq5) | |
1I16
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![BU of 1i16 by Molmil](/molmil-images/mine/1i16) | STRUCTURE OF INTERLEUKIN 16: IMPLICATIONS FOR FUNCTION, NMR, 20 STRUCTURES | Descriptor: | INTERLEUKIN 16 | Authors: | Muehlhahn, P, Zweckstetter, M, Georgescu, J, Ciosto, C, Renner, C, Lanzendoerfer, M, Lang, K, Ambrosius, D, Baier, M, Kurth, R, Holak, T.A. | Deposit date: | 1998-05-20 | Release date: | 1999-05-25 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure of interleukin 16 resembles a PDZ domain with an occluded peptide binding site. Nat.Struct.Biol., 5, 1998
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4G69
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1I92
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![BU of 1i92 by Molmil](/molmil-images/mine/1i92) | STRUCTURAL BASIS OF THE NHERF PDZ1-CFTR INTERACTION | Descriptor: | CHLORIDE ION, NA+/H+ EXCHANGE REGULATORY CO-FACTOR | Authors: | Karthikeyan, S, Leung, T, Ladias, J.A.A. | Deposit date: | 2001-03-16 | Release date: | 2001-06-27 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural basis of the Na+/H+ exchanger regulatory factor PDZ1 interaction with the carboxyl-terminal region of the cystic fibrosis transmembrane conductance regulator. J.Biol.Chem., 276, 2001
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4E35
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![BU of 4e35 by Molmil](/molmil-images/mine/4e35) | |
5WOU
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![BU of 5wou by Molmil](/molmil-images/mine/5wou) | |
4F8K
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![BU of 4f8k by Molmil](/molmil-images/mine/4f8k) | Molecular analysis of the interaction between the prostacyclin receptor and the first PDZ domain of PDZK1 | Descriptor: | Na(+)/H(+) exchange regulatory cofactor NHE-RF3, Prostacyclin receptor | Authors: | Kocher, O, Birrane, G, Kinsella, B.T, Mulvaney, E.P. | Deposit date: | 2012-05-17 | Release date: | 2013-02-27 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Molecular Analysis of the Prostacyclin Receptor's Interaction with the PDZ1 Domain of Its Adaptor Protein PDZK1. Plos One, 8, 2013
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4H11
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![BU of 4h11 by Molmil](/molmil-images/mine/4h11) | Interaction partners of PSD-93 studied by X-ray crystallography and fluorescent polarization spectroscopy | Descriptor: | ACETATE ION, Disks large homolog 2, SULFATE ION | Authors: | Fiorentini, M, Kastrup, J.S, Gajhede, M. | Deposit date: | 2012-09-10 | Release date: | 2013-04-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Interaction partners of PSD-93 studied by X-ray crystallography and fluorescence polarization spectroscopy. Acta Crystallogr.,Sect.D, 69, 2013
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1IU2
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![BU of 1iu2 by Molmil](/molmil-images/mine/1iu2) | The first PDZ domain of PSD-95 | Descriptor: | PSD-95 | Authors: | Long, J.-F, Tochio, H, Wang, P, Sala, C, Niethammer, M, Sheng, M, Zhang, M. | Deposit date: | 2002-02-19 | Release date: | 2003-03-11 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Supramodular structure and synergistic target binding of the N-terminal tandem PDZ domains of PSD-95 J.MOL.BIOL., 327, 2003
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4GVD
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![BU of 4gvd by Molmil](/molmil-images/mine/4gvd) | Crystal Structure of T-cell Lymphoma Invasion and Metastasis-1 PDZ in complex with Syndecan1 Peptide | Descriptor: | 5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID), CHLORIDE ION, SODIUM ION, ... | Authors: | Liu, X, Shepherd, T.R, Murray, A.M, Xu, Z, Fuentes, E.J. | Deposit date: | 2012-08-30 | Release date: | 2013-03-13 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | The structure of the Tiam1 PDZ domain/ phospho-syndecan1 complex reveals a ligand conformation that modulates protein dynamics. Structure, 21, 2013
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1IHJ
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![BU of 1ihj by Molmil](/molmil-images/mine/1ihj) | |
5V6B
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![BU of 5v6b by Molmil](/molmil-images/mine/5v6b) | Crystal structure of GIPC1 | Descriptor: | PDZ domain-containing protein GIPC1 | Authors: | Shang, G, Zhang, X. | Deposit date: | 2017-03-16 | Release date: | 2017-05-31 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure analyses reveal a regulated oligomerization mechanism of the PlexinD1/GIPC/myosin VI complex. Elife, 6, 2017
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5VWC
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![BU of 5vwc by Molmil](/molmil-images/mine/5vwc) | Crystal structure of human Scribble PDZ1 domain | Descriptor: | 1,2-ETHANEDIOL, Protein scribble homolog | Authors: | Lim, K.Y.B, Kvansakul, M. | Deposit date: | 2017-05-21 | Release date: | 2017-11-08 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.911 Å) | Cite: | Structural basis for the differential interaction of Scribble PDZ domains with the guanine nucleotide exchange factor beta-PIX. J. Biol. Chem., 292, 2017
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5W72
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4GVC
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![BU of 4gvc by Molmil](/molmil-images/mine/4gvc) | Crystal Structure of T-cell Lymphoma Invasion and Metastasis-1 PDZ in complex with phosphorylated Syndecan1 Peptide | Descriptor: | 5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID), CHLORIDE ION, SODIUM ION, ... | Authors: | Liu, X, Shepherd, T.R, Murray, A.M, Xu, Z, Fuentes, E.J. | Deposit date: | 2012-08-30 | Release date: | 2013-03-13 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | The structure of the Tiam1 PDZ domain/ phospho-syndecan1 complex reveals a ligand conformation that modulates protein dynamics. Structure, 21, 2013
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4HOP
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![BU of 4hop by Molmil](/molmil-images/mine/4hop) | Crystal structure of the computationally designed NNOS-Syntrophin complex | Descriptor: | Alpha-1-syntrophin, Nitric oxide synthase, brain | Authors: | Harwood, I.M, Melero, C, Ollikainen, N, Kortemme, T. | Deposit date: | 2012-10-22 | Release date: | 2013-11-06 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Quantification of the transferability of a designed protein specificity switch reveals extensive epistasis in molecular recognition. Proc.Natl.Acad.Sci.USA, 111, 2014
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1GM1
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![BU of 1gm1 by Molmil](/molmil-images/mine/1gm1) | Second PDZ Domain (PDZ2) of PTP-BL | Descriptor: | PROTEIN TYROSINE PHOSPHATASE | Authors: | Walma, T, Tessari, M, Aelen, J, Schepens, J, Hendriks, W, Vuister, G.W. | Deposit date: | 2001-09-06 | Release date: | 2002-03-08 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structure, dynamics and binding characteristics of the second PDZ domain of PTP-BL. J. Mol. Biol., 316, 2002
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1IU0
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![BU of 1iu0 by Molmil](/molmil-images/mine/1iu0) | The first PDZ domain of PSD-95 | Descriptor: | PSD-95 | Authors: | Long, J.-F, Tochio, H, Wang, P, Sala, C, Niethammer, M, Sheng, M, Zhang, M. | Deposit date: | 2002-02-18 | Release date: | 2003-03-11 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Supramodular structure and synergistic target binding of the N-terminal tandem PDZ domains of PSD-95 J.MOL.BIOL., 327, 2003
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