7W3I
| Structure of USP14-bound human 26S proteasome in substrate-inhibited state SB_USP14 | Descriptor: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | Authors: | Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. | Deposit date: | 2021-11-25 | Release date: | 2022-05-18 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
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7UPR
| Human mitochondrial AAA protein ATAD1 (with a catalytic dead mutation) in complex with a peptide substrate (closed conformation) | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Outer mitochondrial transmembrane helix translocase, ... | Authors: | Wang, L, Toutkoushian, H, Belyy, V, Kokontis, C, Walter, P. | Deposit date: | 2022-04-16 | Release date: | 2022-06-15 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Conserved structural elements specialize ATAD1 as a membrane protein extraction machine. Elife, 11, 2022
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7UPT
| Human mitochondrial AAA protein ATAD1 (with a catalytic dead mutation) in complex with a peptide substrate (open conformation) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Wang, L, Toutkoushian, H, Belyy, V, Kokontis, C, Walter, P. | Deposit date: | 2022-04-16 | Release date: | 2022-06-15 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Conserved structural elements specialize ATAD1 as a membrane protein extraction machine. Elife, 11, 2022
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7UIX
| ClpAP complex bound to ClpS N-terminal extension, class I | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpA, ATP-dependent Clp protease adapter protein ClpS, ... | Authors: | Kim, S, Fei, X, Sauer, R.T, Baker, T.A. | Deposit date: | 2022-03-29 | Release date: | 2022-11-09 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.24 Å) | Cite: | AAA+ protease-adaptor structures reveal altered conformations and ring specialization. Nat.Struct.Mol.Biol., 29, 2022
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7UIY
| ClpAP complex bound to ClpS N-terminal extension, class IIIa | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpA, ATP-dependent Clp protease adapter protein ClpS, ... | Authors: | Kim, S, Fei, X, Sauer, R.T, Baker, T.A. | Deposit date: | 2022-03-29 | Release date: | 2022-10-26 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.22 Å) | Cite: | AAA+ protease-adaptor structures reveal altered conformations and ring specialization. Nat.Struct.Mol.Biol., 29, 2022
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7UIW
| ClpAP complex bound to ClpS N-terminal extension, class IIb | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpA, ATP-dependent Clp protease adapter protein ClpS, ... | Authors: | Kim, S, Fei, X, Sauer, R.T, Baker, T.A. | Deposit date: | 2022-03-29 | Release date: | 2022-11-09 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.33 Å) | Cite: | AAA+ protease-adaptor structures reveal altered conformations and ring specialization. Nat.Struct.Mol.Biol., 29, 2022
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7UIZ
| ClpAP complex bound to ClpS N-terminal extension, class IIc | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpA, ATP-dependent Clp protease adapter protein ClpS, ... | Authors: | Kim, S, Fei, X, Sauer, R.T, Baker, T.A. | Deposit date: | 2022-03-29 | Release date: | 2022-11-09 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.24 Å) | Cite: | AAA+ protease-adaptor structures reveal altered conformations and ring specialization. Nat.Struct.Mol.Biol., 29, 2022
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7UIV
| ClpAP complex bound to ClpS N-terminal extension, class IIa | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpA, ATP-dependent Clp protease adapter protein ClpS, ... | Authors: | Kim, S, Fei, X, Sauer, R.T, Baker, T.A. | Deposit date: | 2022-03-29 | Release date: | 2022-11-09 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.38 Å) | Cite: | AAA+ protease-adaptor structures reveal altered conformations and ring specialization. Nat.Struct.Mol.Biol., 29, 2022
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7UJ0
| ClpAP complex bound to ClpS N-terminal extension, class IIIb | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpA, ATP-dependent Clp protease adapter protein ClpS, ... | Authors: | Kim, S, Fei, X, Sauer, R.T, Baker, T.A. | Deposit date: | 2022-03-29 | Release date: | 2022-11-09 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.26 Å) | Cite: | AAA+ protease-adaptor structures reveal altered conformations and ring specialization. Nat.Struct.Mol.Biol., 29, 2022
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7UQJ
| Cryo-EM structure of the S. cerevisiae chromatin remodeler Yta7 hexamer bound to ATPgS and histone H3 tail in state II | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATPase histone chaperone YTA7, Histone H3, ... | Authors: | Wang, F, Feng, X, Li, H. | Deposit date: | 2022-04-19 | Release date: | 2023-02-01 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | The Saccharomyces cerevisiae Yta7 ATPase hexamer contains a unique bromodomain tier that functions in nucleosome disassembly. J.Biol.Chem., 299, 2022
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7UQI
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7WBB
| Cryo-EM structure of substrate engaged Drg1 hexamer | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, AFG2 isoform 1, substrate | Authors: | Ma, C.Y, Wu, D.M, Chen, Q, Gao, N. | Deposit date: | 2021-12-16 | Release date: | 2022-12-28 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition. Nat Commun, 13, 2022
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7WD3
| Cryo-EM structure of Drg1 hexamer treated with ATP and benzo-diazaborine | Descriptor: | 2-(TOLUENE-4-SULFONYL)-2H-BENZO[D][1,2,3]DIAZABORININ-1-OL, ADENOSINE-5'-TRIPHOSPHATE, ATPase family gene 2 protein | Authors: | Ma, C.Y, Wu, D.M, Chen, Q, Gao, N. | Deposit date: | 2021-12-21 | Release date: | 2022-12-14 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition. Nat Commun, 13, 2022
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7VCT
| Human p97 single hexamer conformer III with D1-ATPgammaS and D2-ADP bound | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | Authors: | Gao, H, Li, F, Shi, Z, Li, Y, Yu, H. | Deposit date: | 2021-09-04 | Release date: | 2022-03-02 | Last modified: | 2022-03-09 | Method: | ELECTRON MICROSCOPY (3.21 Å) | Cite: | Cryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state. Cell Discov, 8, 2022
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7VCS
| Human p97 double hexamer conformer II with ATPgammaS bound | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | Authors: | Gao, H, Li, F, Shi, Z, Li, Y, Yu, H. | Deposit date: | 2021-09-03 | Release date: | 2022-03-02 | Last modified: | 2022-03-09 | Method: | ELECTRON MICROSCOPY (3.32 Å) | Cite: | Cryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state. Cell Discov, 8, 2022
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7VCX
| Human p97 single hexamer conformer II with ATPgammaS bound | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | Authors: | Gao, H, Li, F, Shi, Z, Li, Y, Yu, H. | Deposit date: | 2021-09-04 | Release date: | 2022-03-02 | Last modified: | 2022-03-09 | Method: | ELECTRON MICROSCOPY (3.24 Å) | Cite: | Cryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state. Cell Discov, 8, 2022
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7VCU
| Human p97 double hexamer conformer I with D1-ATPgammaS and D2-ADP bound | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | Authors: | Gao, H, Li, F, Shi, Z, Li, Y, Yu, H. | Deposit date: | 2021-09-04 | Release date: | 2022-03-02 | Last modified: | 2022-03-09 | Method: | ELECTRON MICROSCOPY (3.15 Å) | Cite: | Cryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state. Cell Discov, 8, 2022
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7VCV
| Human p97 single hexamer conformer I with ATPgammaS bound | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | Authors: | Gao, H, Li, F, Shi, Z, Li, Y, Yu, H. | Deposit date: | 2021-09-04 | Release date: | 2022-03-02 | Last modified: | 2022-03-09 | Method: | ELECTRON MICROSCOPY (3.21 Å) | Cite: | Cryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state. Cell Discov, 8, 2022
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7VHP
| Structural insights into the membrane microdomain organization by SPFH family proteins | Descriptor: | ATP-dependent zinc metalloprotease FtsH, Modulator of FtsH protease HflC, Protein HflK | Authors: | Ma, C.Y, Wang, C.K, Luo, D.Y, Yan, L, Yang, W.X, Li, N.N, Gao, N. | Deposit date: | 2021-09-22 | Release date: | 2022-03-23 | Method: | ELECTRON MICROSCOPY (3.27 Å) | Cite: | Structural insights into the membrane microdomain organization by SPFH family proteins. Cell Res., 32, 2022
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7YKL
| Cryo-EM structure of Drg1 hexamer treated with AMPPNP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ATPase family gene 2 protein | Authors: | Ma, C.Y, Wu, D.M, Chen, Q, Gao, N. | Deposit date: | 2022-07-22 | Release date: | 2022-12-14 | Method: | ELECTRON MICROSCOPY (5.6 Å) | Cite: | Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition. Nat Commun, 13, 2022
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7YKZ
| Cryo-EM structure of Drg1 hexamer in the planar state treated with ADP/AMPPNP/Diazaborine | Descriptor: | 2-(TOLUENE-4-SULFONYL)-2H-BENZO[D][1,2,3]DIAZABORININ-1-OL, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Ma, C.Y, Wu, D.M, Chen, Q, Gao, N. | Deposit date: | 2022-07-25 | Release date: | 2022-12-14 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition. Nat Commun, 13, 2022
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7YKK
| Cryo-EM structure of Drg1 hexamer treated with ADP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ATPase family gene 2 protein | Authors: | Ma, C.Y, Wu, D.M, Chen, Q, Gao, N. | Deposit date: | 2022-07-22 | Release date: | 2022-12-14 | Method: | ELECTRON MICROSCOPY (5.9 Å) | Cite: | Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition. Nat Commun, 13, 2022
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7YKT
| Cryo-EM structure of Drg1 hexamer in helical state treated with ADP/AMPPNP/benzo-diazaborine | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATPase family gene 2 protein | Authors: | Ma, C.Y, Wu, D.M, Chen, Q, Gao, N. | Deposit date: | 2022-07-23 | Release date: | 2022-12-14 | Method: | ELECTRON MICROSCOPY (5.9 Å) | Cite: | Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition. Nat Commun, 13, 2022
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7WI4
| Cryo-EM structure of E.Coli FtsH protease cytosolic domains | Descriptor: | ATP-dependent zinc metalloprotease FtsH, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Qiao, Z, Gao, Y.G. | Deposit date: | 2022-01-02 | Release date: | 2022-06-01 | Last modified: | 2022-06-15 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM structure of the entire FtsH-HflKC AAA protease complex. Cell Rep, 39, 2022
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7WI3
| Cryo-EM structure of E.Coli FtsH-HflkC AAA protease complex | Descriptor: | ATP-dependent zinc metalloprotease FtsH, Modulator of FtsH protease HflC, Modulator of FtsH protease HflK | Authors: | Qiao, Z, Gao, Y.G. | Deposit date: | 2022-01-02 | Release date: | 2022-06-01 | Last modified: | 2022-06-15 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Cryo-EM structure of the entire FtsH-HflKC AAA protease complex. Cell Rep, 39, 2022
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