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PDB: 846 results

1L39
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CONTRIBUTIONS OF ENGINEERED SURFACE SALT BRIDGES TO THE STABILITY OF T4 LYSOZYME DETERMINED BY DIRECTED MUTAGENESIS
Descriptor: T4 LYSOZYME
Authors:Daopin, S, Matthews, B.W.
Deposit date:1991-01-28
Release date:1991-10-15
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Contributions of engineered surface salt bridges to the stability of T4 lysozyme determined by directed mutagenesis.
Biochemistry, 30, 1991
1L72
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MULTIPLE STABILIZING ALANINE REPLACEMENTS WITHIN ALPHA-HELIX 126-134 OF T4 LYSOZYME HAVE INDEPENDENT, ADDITIVE EFFECTS ON BOTH STRUCTURE AND STABILITY
Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME
Authors:Zhang, X, Matthews, B.W.
Deposit date:1991-09-23
Release date:1991-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Multiple alanine replacements within alpha-helix 126-134 of T4 lysozyme have independent, additive effects on both structure and stability.
Protein Sci., 1, 1992
1L88
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SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES
Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME
Authors:Eriksson, A.E, Matthews, B.W.
Deposit date:1992-01-21
Release date:1993-10-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Similar hydrophobic replacements of Leu99 and Phe153 within the core of T4 lysozyme have different structural and thermodynamic consequences.
J.Mol.Biol., 229, 1993
3GUK
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T4 lysozyme M102E/L99A mutant with buried charge in apolar cavity--Toluene binding
Descriptor: ACETATE ION, CALCIUM ION, CHLORIDE ION, ...
Authors:Liu, L, Matthews, B.W.
Deposit date:2009-03-30
Release date:2009-08-25
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Use of stabilizing mutations to engineer a charged group within a ligand-binding hydrophobic cavity in T4 lysozyme.
Biochemistry, 48, 2009
4PJZ
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CRYSTAL STRUCTURE OF T4 LYSOZYME-GSS-PEPTIDE IN COMPLEX WITH TEICOPLANIN-A2-2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-amino-2-deoxy-beta-D-glucopyranose, 8-METHYLNONANOIC ACID, ...
Authors:Han, S, Le, B.V, Hajare, H, Baxter, R.H.G, Miller, S.J.
Deposit date:2014-05-13
Release date:2014-09-10
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:X-ray Crystal Structure of Teicoplanin A2-2 Bound to a Catalytic Peptide Sequence via the Carrier Protein Strategy.
J.Org.Chem., 79, 2014
1CV5
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T4 LYSOZYME MUTANT L133M
Descriptor: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, LYSOZYME
Authors:Gassner, N.C, Baase, W.A, Lindstrom, J, Lu, J, Matthews, B.W.
Deposit date:1999-08-22
Release date:1999-11-10
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Methionine and alanine substitutions show that the formation of wild-type-like structure in the carboxy-terminal domain of T4 lysozyme is a rate-limiting step in folding.
Biochemistry, 38, 1999
3CDO
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Bacteriophage T4 lysozyme mutant R96V in wildtype background at low temperature
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, HEXANE-1,6-DIOL, Lysozyme, ...
Authors:Mooers, B.H.M.
Deposit date:2008-02-27
Release date:2009-02-17
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Contributions of all 20 amino acids at site 96 to the stability and structure of T4 lysozyme.
Protein Sci., 18, 2009
1KW7
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METHIONINE CORE MUTANT OF T4 LYSOZYME
Descriptor: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, LYSOZYME
Authors:Gassner, N.C, Baase, W.A, Mooers, B.H, Busam, R.D, Weaver, L.H, Lindstrom, J.D, Quillin, M.L, Matthews, B.W.
Deposit date:2002-01-28
Release date:2003-06-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Multiple methionine substitutions are tolerated in T4 lysozyme and have coupled effects on folding and stability
BIOPHYS.CHEM., 100, 2003
1CUP
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METHIONINE CORE MUTANT OF T4 LYSOZYME
Descriptor: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, LYSOZYME
Authors:Gassner, N.C, Baase, W.A, Lindstrom, J.D, Lu, J, Matthews, B.W.
Deposit date:1999-08-20
Release date:1999-11-10
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Methionine and alanine substitutions show that the formation of wild-type-like structure in the carboxy-terminal domain of T4 lysozyme is a rate-limiting step in folding.
Biochemistry, 38, 1999
1D2W
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N-TERMINAL DOMAIN CORE METHIONINE MUTATION
Descriptor: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, LYSOZYME
Authors:Gassner, N.C, Matthews, B.W.
Deposit date:1999-09-28
Release date:1999-10-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Use of differentially substituted selenomethionine proteins in X-ray structure determination.
Acta Crystallogr.,Sect.D, 55, 1999
210L
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BU of 210l by Molmil
PROTEIN STRUCTURE PLASTICITY EXEMPLIFIED BY INSERTION AND DELETION MUTANTS IN T4 LYSOZYME
Descriptor: 2-HYDROXYETHYL DISULFIDE, T4 LYSOZYME
Authors:Vetter, I.R, Baase, W.A, Heinz, D.W, Xiong, J.-P, Snow, S, Matthews, B.W.
Deposit date:1996-09-23
Release date:1996-12-23
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Protein structural plasticity exemplified by insertion and deletion mutants in T4 lysozyme.
Protein Sci., 5, 1996
214L
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PROTEIN STRUCTURE PLASTICITY EXEMPLIFIED BY INSERTION AND DELETION MUTANTS IN T4 LYSOZYME
Descriptor: T4 LYSOZYME
Authors:Vetter, I.R, Baase, W.A, Heinz, D.W, Xiong, J.-P, Snow, S, Matthews, B.W.
Deposit date:1996-09-23
Release date:1996-12-23
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Protein structural plasticity exemplified by insertion and deletion mutants in T4 lysozyme.
Protein Sci., 5, 1996
4WTV
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BU of 4wtv by Molmil
Crystal structure of the phosphatidylinositol 4-kinase IIbeta
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Phosphatidylinositol 4-kinase type 2-beta,Endolysin,Phosphatidylinositol 4-kinase type 2-beta
Authors:Klima, M, Baumlova, A, Chalupska, D, Boura, E.
Deposit date:2014-10-30
Release date:2015-07-15
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The high-resolution crystal structure of phosphatidylinositol 4-kinase II beta and the crystal structure of phosphatidylinositol 4-kinase II alpha containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design.
Acta Crystallogr.,Sect.D, 71, 2015
1B6I
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T4 LYSOZYME MUTANT WITH CYS 54 REPLACED BY THR, CYS 97 REPLACED BY ALA, THR 21 REPLACED BY CYS AND LYS 124 REPLACED BY CYS (C54T,C97A,T21C,K124C)
Descriptor: 2-HYDROXYETHYL DISULFIDE, PROTEIN (LYSOZYME)
Authors:Vetter, I.R, Baase, W.A, Snow, S, Matthews, B.W.
Deposit date:1999-01-14
Release date:2000-01-12
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Solid-state synthesis and mechanical unfolding of polymers of T4 lysozyme.
Proc.Natl.Acad.Sci.USA, 97, 2000
1OWZ
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T4 Lysozyme Cavity Mutant L99A/M102Q Bound With 4-FluoroPhenEthyl Alcohol
Descriptor: 4-FLUOROPHENETHYL ALCOHOL, BETA-MERCAPTOETHANOL, CHLORIDE ION, ...
Authors:Wei, B.Q, Baase, W.A, Weaver, L.H, Matthews, B.W, Shoichet, B.K.
Deposit date:2003-03-31
Release date:2004-04-13
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Testing a Flexible-receptor Docking Algorithm in a Model Binding Site
J.Mol.Biol., 337, 2004
1JTM
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BU of 1jtm by Molmil
Alternative Structures of a Sequence Extended T4 Lysozyme Show that the Highly Conserved Beta-Sheet has Weak Intrinsic Folding Propensity
Descriptor: BETA-MERCAPTOETHANOL, LYSOZYME
Authors:Sagermann, M, Matthews, B.W.
Deposit date:2001-08-21
Release date:2002-03-20
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structures of a T4-lysozyme Duplication-extension Mutant Demonstrate that the Highly Conserved beta-Sheet Region has Low Intrinsic Folding Propensity
J.Mol.Biol., 316, 2002
1DYF
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DETERMINATION OF ALPHA-HELIX PROPENSITY WITHIN THE CONTEXT OF A FOLDED PROTEIN: SITES 44 AND 131 IN BACTERIOPHAGE T4 LYSOZYME
Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME
Authors:Zhou, H.-J, Matthews, B.W.
Deposit date:1993-05-13
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Determination of alpha-helix propensity within the context of a folded protein. Sites 44 and 131 in bacteriophage T4 lysozyme.
J.Mol.Biol., 235, 1994
1I6S
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T4 LYSOZYME MUTANT C54T/C97A/N101A
Descriptor: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, LYSOZYME
Authors:Kovall, R.A, Baldwin, E.P, Matthews, B.W.
Deposit date:2001-03-04
Release date:2001-05-09
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and thermodynamic analysis of the binding of solvent at internal sites in T4 lysozyme.
Protein Sci., 10, 2001
1C6E
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T4 LYSOZYME MUTANT C54T/C97A/L99A IN THE PRESENCE OF 2 ATM XENON
Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, PROTEIN (LYSOZYME), ...
Authors:Quillin, M.L, Matthews, B.W.
Deposit date:1999-12-21
Release date:2000-10-04
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Size versus polarizability in protein-ligand interactions: binding of noble gases within engineered cavities in phage T4 lysozyme.
J.Mol.Biol., 302, 2000
1C6P
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T4 LYSOZYME MUTANT C54T/C97A IN THE PRESENCE OF 8 ATM ARGON
Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, PROTEIN (LYSOZYME)
Authors:Quillin, M.L, Matthews, B.W.
Deposit date:1999-12-21
Release date:2000-10-04
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Size versus polarizability in protein-ligand interactions: binding of noble gases within engineered cavities in phage T4 lysozyme.
J.Mol.Biol., 302, 2000
1C6G
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T4 LYSOZYME MUTANT C54T/C97A/L99A IN THE PRESENCE OF 4 ATM KRYPTON
Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, KRYPTON, ...
Authors:Quillin, M.L, Matthews, B.W.
Deposit date:1999-12-21
Release date:2000-10-04
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Size versus polarizability in protein-ligand interactions: binding of noble gases within engineered cavities in phage T4 lysozyme.
J.Mol.Biol., 302, 2000
1C6Q
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T4 LYSOZYME MUTANT C54T/C97A IN THE PRESENCE OF 8 ATM KRYPTON
Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, KRYPTON, ...
Authors:Quillin, M.L, Matthews, B.W.
Deposit date:1999-12-21
Release date:2000-10-04
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Size versus polarizability in protein-ligand interactions: binding of noble gases within engineered cavities in phage T4 lysozyme.
J.Mol.Biol., 302, 2000
1C6H
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T4 LYSOZYME MUTANT C54T/C97A/L99A IN THE PRESENCE OF 4 ATM XENON
Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, PROTEIN (LYSOZYME), ...
Authors:Quillin, M.L, Matthews, B.W.
Deposit date:1999-12-21
Release date:2000-10-04
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Size versus polarizability in protein-ligand interactions: binding of noble gases within engineered cavities in phage T4 lysozyme.
J.Mol.Biol., 302, 2000
1G0G
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CRYSTAL STRUCTURE OF T4 LYSOZYME MUTANT T152A
Descriptor: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, PROTEIN (LYSOZYME)
Authors:Xu, J, Baase, W.A, Quillin, M.L, Matthews, B.W.
Deposit date:2000-10-06
Release date:2001-05-23
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and thermodynamic analysis of the binding of solvent at internal sites in T4 lysozyme.
Protein Sci., 10, 2001
1G1V
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T4 LYSOZYME MUTANT C54T/C97A/I58T
Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME
Authors:Quillin, M.L, Matthews, B.W.
Deposit date:2000-10-13
Release date:2001-05-09
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and thermodynamic analysis of the binding of solvent at internal sites in T4 lysozyme.
Protein Sci., 10, 2001

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