6PMI
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![BU of 6pmi by Molmil](/molmil-images/mine/6pmi) | Sigm28-transcription initiation complex with specific promoter at the state 1 | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Liu, B, Shi, W. | Deposit date: | 2019-07-02 | Release date: | 2020-05-13 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.86 Å) | Cite: | Structural basis of bacterial sigma28-mediated transcription reveals roles of the RNA polymerase zinc-binding domain. Embo J., 39, 2020
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5UAL
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![BU of 5ual by Molmil](/molmil-images/mine/5ual) | Escherichia coli RNA polymerase and Rifampin complex, RpoB S531L mutant | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Molodtsov, V, Scharf, N.T, Stefan, M.A, Garcia, G.A, Murakami, K.S. | Deposit date: | 2016-12-19 | Release date: | 2017-01-11 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3.887 Å) | Cite: | Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis. Mol. Microbiol., 103, 2017
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6PSU
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![BU of 6psu by Molmil](/molmil-images/mine/6psu) | Escherichia coli RNA polymerase promoter unwinding intermediate (TRPi2) with TraR and rpsT P2 promoter | Descriptor: | CHAPSO, DNA (85-MER), DNA-directed RNA polymerase subunit alpha, ... | Authors: | Chen, J, Chiu, C.E, Campbell, E.A, Darst, S.A. | Deposit date: | 2019-07-13 | Release date: | 2020-03-25 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Stepwise Promoter Melting by Bacterial RNA Polymerase. Mol.Cell, 78, 2020
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6Z9P
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![BU of 6z9p by Molmil](/molmil-images/mine/6z9p) | Transcription termination intermediate complex 1 | Descriptor: | 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ... | Authors: | Said, N, Hilal, T, Loll, B, Wahl, M.C. | Deposit date: | 2020-06-04 | Release date: | 2020-11-04 | Last modified: | 2021-02-03 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Steps toward translocation-independent RNA polymerase inactivation by terminator ATPase rho. Science, 371, 2021
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8G7E
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![BU of 8g7e by Molmil](/molmil-images/mine/8g7e) | Cryo-EM structure of 3DVA component 0 of Escherichia coli que-PEC (paused elongation complex) RNA Polymerase plus preQ1 ligand | Descriptor: | 7-DEAZA-7-AMINOMETHYL-GUANINE, DNA (31-MER), DNA (39-mer), ... | Authors: | Porta, J.C, Chauvier, A, Deb, I, Ellinger, E, Frank, A.T, Meze, K, Ohi, M.D, Walter, N.G. | Deposit date: | 2023-02-16 | Release date: | 2023-06-21 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural basis for control of bacterial RNA polymerase pausing by a riboswitch and its ligand. Nat.Struct.Mol.Biol., 30, 2023
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4JK1
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![BU of 4jk1 by Molmil](/molmil-images/mine/4jk1) | |
6XH7
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![BU of 6xh7 by Molmil](/molmil-images/mine/6xh7) | CueR-TAC without RNA | Descriptor: | COPPER (II) ION, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Liu, B, Shi, W, Yang, Y. | Deposit date: | 2020-06-18 | Release date: | 2021-04-14 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural basis of copper-efflux-regulator-dependent transcription activation. Iscience, 24, 2021
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6RI7
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![BU of 6ri7 by Molmil](/molmil-images/mine/6ri7) | Cryo-EM structure of E. coli RNA polymerase elongation complex bound to GreB transcription factor | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Abdelkareem, M, Saint-Andre, C, Takacs, M, Papai, G, Crucifix, C, Guo, X, Ortiz, J, Weixlbaumer, A. | Deposit date: | 2019-04-23 | Release date: | 2019-07-03 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural Basis of Transcription: RNA Polymerase Backtracking and Its Reactivation. Mol.Cell, 75, 2019
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7PY5
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![BU of 7py5 by Molmil](/molmil-images/mine/7py5) | CryoEM structure of E.coli RNA polymerase elongation complex bound to NusA and NusG (the consensus NusA-NusG-EC) | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Zhu, C, Guo, X, Weixlbaumer, A. | Deposit date: | 2021-10-09 | Release date: | 2022-03-23 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Transcription factors modulate RNA polymerase conformational equilibrium. Nat Commun, 13, 2022
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6UU0
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![BU of 6uu0 by Molmil](/molmil-images/mine/6uu0) | E. coli sigma-S transcription initiation complex with a 3-nt RNA and a mismatching GTP ("Fresh" crystal soaked with GTP for 1 hour) | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Zuo, Y, De, S, Steitz, T.A. | Deposit date: | 2019-10-30 | Release date: | 2020-08-26 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.9 Å) | Cite: | Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
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8EH9
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![BU of 8eh9 by Molmil](/molmil-images/mine/8eh9) | Cryo-EM structure of his-elemental paused elongation complex with a folded TL and a rotated RH-FL (2) | Descriptor: | CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Kang, J.Y, Chen, J, Llewellyn, E, Landick, R, Darst, S.A. | Deposit date: | 2022-09-13 | Release date: | 2023-03-01 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | An ensemble of interconverting conformations of the elemental paused transcription complex creates regulatory options. Proc.Natl.Acad.Sci.USA, 120, 2023
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6X2N
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![BU of 6x2n by Molmil](/molmil-images/mine/6x2n) | Mfd-bound E.coli RNA polymerase elongation complex - I state | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DNA (64-MER), DNA-directed RNA polymerase subunit alpha, ... | Authors: | Llewellyn, E, Chen, J, Kang, J.Y, Darst, S.A. | Deposit date: | 2020-05-20 | Release date: | 2021-02-03 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural basis for transcription complex disruption by the Mfd translocase. Elife, 10, 2021
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8RED
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![BU of 8red by Molmil](/molmil-images/mine/8red) | |
6ZTN
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![BU of 6ztn by Molmil](/molmil-images/mine/6ztn) | E. coli 70S-RNAP expressome complex in NusG-coupled state (42 nt intervening mRNA) | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Webster, M.W, Takacs, M, Weixlbaumer, A. | Deposit date: | 2020-07-20 | Release date: | 2020-09-16 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural basis of transcription-translation coupling and collision in bacteria. Science, 369, 2020
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8FIX
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![BU of 8fix by Molmil](/molmil-images/mine/8fix) | Cryo-EM structure of E. coli RNA polymerase backtracked elongation complex harboring a terminal mismatch | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Florez Ariza, A, Wee, L, Tong, A, Canari, C, Grob, P, Nogales, E, Bustamante, C. | Deposit date: | 2022-12-17 | Release date: | 2023-03-29 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | A trailing ribosome speeds up RNA polymerase at the expense of transcript fidelity via force and allostery. Cell, 186, 2023
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6B6H
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![BU of 6b6h by Molmil](/molmil-images/mine/6b6h) | The cryo-EM structure of a bacterial class I transcription activation complex | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Liu, B, Hong, C, Huang, R, Yu, Z, Steitz, T.A. | Deposit date: | 2017-10-02 | Release date: | 2017-11-15 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural basis of bacterial transcription activation. Science, 358, 2017
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4MEX
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![BU of 4mex by Molmil](/molmil-images/mine/4mex) | Crystal structure of Escherichia coli RNA polymerase in complex with salinamide A | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Feng, Y, Zhang, Y, Arnold, E, Ebright, R.H. | Deposit date: | 2013-08-27 | Release date: | 2014-05-21 | Last modified: | 2014-06-25 | Method: | X-RAY DIFFRACTION (3.902 Å) | Cite: | Transcription inhibition by the depsipeptide antibiotic salinamide A. Elife, 3, 2014
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6PMJ
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![BU of 6pmj by Molmil](/molmil-images/mine/6pmj) | Sigm28-transcription initiation complex with specific promoter at the state 2 | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Liu, B, Shi, W. | Deposit date: | 2019-07-02 | Release date: | 2020-05-13 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.91 Å) | Cite: | Structural basis of bacterial sigma28-mediated transcription reveals roles of the RNA polymerase zinc-binding domain. Embo J., 39, 2020
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5UAJ
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![BU of 5uaj by Molmil](/molmil-images/mine/5uaj) | Escherichia coli RNA polymerase RpoB S531L mutant | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Molodtsov, V, Scharf, N.T, Stefan, M.A, Garcia, G.A, Murakami, K.S. | Deposit date: | 2016-12-19 | Release date: | 2017-01-11 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.915 Å) | Cite: | Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis. Mol. Microbiol., 103, 2017
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4MEY
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![BU of 4mey by Molmil](/molmil-images/mine/4mey) | Crystal structure of Escherichia coli RNA polymerase holoenzyme | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Feng, Y, Zhang, Y, Arnold, E, Ebright, R.H. | Deposit date: | 2013-08-27 | Release date: | 2014-05-21 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.948 Å) | Cite: | Transcription inhibition by the depsipeptide antibiotic salinamide A. Elife, 3, 2014
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6UUB
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![BU of 6uub by Molmil](/molmil-images/mine/6uub) | E. coli sigma-S transcription initiation complex with a mismatching UTP ("Fresh" crystal soaked with UTP for 2 hours) | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Zuo, Y, De, S, Steitz, T.A. | Deposit date: | 2019-10-30 | Release date: | 2020-08-26 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.955 Å) | Cite: | Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
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4KN4
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![BU of 4kn4 by Molmil](/molmil-images/mine/4kn4) | |
8Y6U
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![BU of 8y6u by Molmil](/molmil-images/mine/8y6u) | |
4ZH4
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![BU of 4zh4 by Molmil](/molmil-images/mine/4zh4) | Crystal structure of Escherichia coli RNA polymerase in complex with CBRP18 | Descriptor: | 5-(4-fluorophenyl)-4-[4-fluoro-3-(trifluoromethyl)phenyl]-1H-pyrazole, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Feng, Y, Ebright, R.H. | Deposit date: | 2015-04-24 | Release date: | 2015-08-05 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.993 Å) | Cite: | Structural Basis of Transcription Inhibition by CBR Hydroxamidines and CBR Pyrazoles. Structure, 23, 2015
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7VWZ
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![BU of 7vwz by Molmil](/molmil-images/mine/7vwz) | Cryo-EM structure of Rob-dependent transcription activation complex in a unique conformation | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Lin, W, Feng, Y, Shi, J. | Deposit date: | 2021-11-12 | Release date: | 2022-06-08 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structural basis of transcription activation by Rob, a pleiotropic AraC/XylS family regulator. Nucleic Acids Res., 50, 2022
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