4OD6
| Structure of Smr domain of MutS2 from Deinococcus radiodurans, Mn2+ soaked | Descriptor: | Endonuclease MutS2 | Authors: | Zhang, H, Zhao, Y, Xu, Q, Hua, Y.J. | Deposit date: | 2014-01-10 | Release date: | 2014-06-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.199 Å) | Cite: | Structural and functional studies of MutS2 from Deinococcus radiodurans. Dna Repair, 21, 2014
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4KTC
| NS3/NS4A protease with inhibitor | Descriptor: | (2R,6S,13aR,14aR,16aS)-6-{[(cyclopentyloxy)carbonyl]amino}-14a-[(cyclopropylsulfonyl)carbamoyl]-5,16-dioxooctadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 3,4-dihydroisoquinoline-2(1H)-carboxylate, NS4A peptide, Serine protease NS3, ... | Authors: | Zhang, H, Ballard, J, Vigers, G.P.A, Brandhuber, B.J. | Deposit date: | 2013-05-20 | Release date: | 2013-08-07 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Discovery of Danoprevir (ITMN-191/R7227), a Highly Selective and Potent Inhibitor of Hepatitis C Virus (HCV) NS3/4A Protease. J.Med.Chem., 57, 2014
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5YAT
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5ZGE
| Crystal structure of NDM-1 at pH5.5 (Bis-Tris) in complex with hydrolyzed ampicillin | Descriptor: | (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, HYDROXIDE ION, Metallo-beta-lactamase type 2, ... | Authors: | Zhang, H, Hao, Q. | Deposit date: | 2018-03-08 | Release date: | 2018-08-22 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1. Antimicrob. Agents Chemother., 62, 2018
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5E09
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5H21
| Trimethoxy-ring inhibitor in complex with the first bromodomain of BRD4 | Descriptor: | 3,4,5-trimethoxy-~{N}-(2-thiophen-2-ylethyl)benzamide, Bromodomain-containing protein 4 | Authors: | Zhang, H, Luo, C. | Deposit date: | 2016-10-13 | Release date: | 2017-07-05 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.591 Å) | Cite: | Discovery of novel trimethoxy-ring BRD4 bromodomain inhibitors: AlphaScreen assay, crystallography and cell-based assay. Medchemcomm, 8, 2017
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5F1K
| human CD38 in complex with nanobody MU1053 | Descriptor: | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, nanobody MU1053 | Authors: | Zhang, H, Hao, Q. | Deposit date: | 2015-11-30 | Release date: | 2016-06-15 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Immuno-targeting the multifunctional CD38 using nanobody Sci Rep, 6, 2016
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6M10
| Crystal structure of PA4853 (Fis) from Pseudomonas aeruginosa | Descriptor: | Putative Fis-like DNA-binding protein | Authors: | Zhang, H, Gao, Z, Zhou, J, Dong, Y. | Deposit date: | 2020-02-24 | Release date: | 2020-05-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.985 Å) | Cite: | Crystal structure of the nucleoid-associated protein Fis (PA4853) from Pseudomonas aeruginosa. Acta Crystallogr.,Sect.F, 76, 2020
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5NBG
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6NIG
| Crystal structure of the human TLR2-Diprovocim complex | Descriptor: | (3S,4S,3'S,4'S)-1,1'-(1,4-phenylenedicarbonyl)bis{N~3~,N~4~-bis[(1S,2R)-2-phenylcyclopropyl]pyrrolidine-3,4-dicarboxami de}, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Zhang, H, Beutler, B.A, Tomchick, D.R, Su, L. | Deposit date: | 2018-12-27 | Release date: | 2019-04-17 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural Basis of TLR2/TLR1 Activation by the Synthetic Agonist Diprovocim. J. Med. Chem., 62, 2019
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3ROK
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5F1O
| human CD38 in complex with nanobody MU551 | Descriptor: | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, nanobody MU551 | Authors: | Zhang, H, Hao, Q. | Deposit date: | 2015-11-30 | Release date: | 2016-06-15 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Immuno-targeting the multifunctional CD38 using nanobody Sci Rep, 6, 2016
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5XP6
| native structure of NDM-1 crystallized at pH5.5 | Descriptor: | 1,2-ETHANEDIOL, HYDROXIDE ION, Metallo-beta-lactamase type 2, ... | Authors: | Zhang, H, Ma, G, Lai, J, Sun, H. | Deposit date: | 2017-06-01 | Release date: | 2018-03-07 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (0.95 Å) | Cite: | Bismuth antimicrobial drugs serve as broad-spectrum metallo-beta-lactamase inhibitors Nat Commun, 9, 2018
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3ROQ
| Crystal structure of human CD38 in complex with compound CZ-46 | Descriptor: | (2R,3R,4S,5S)-4-fluoro-3,5-dihydroxytetrahydrofuran-2-yl 2-phenylethyl hydrogen (S)-phosphate, ADP-ribosyl cyclase 1 | Authors: | Zhang, H, Lee, H.C, Hao, Q. | Deposit date: | 2011-04-26 | Release date: | 2011-12-21 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Catalysis-based inhibitors of the calcium signaling function of CD38. Biochemistry, 51, 2012
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3ROM
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3ROP
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8Z0L
| Cryo-EM structure of Cas8-HNH system at partial R-loop state | Descriptor: | DNA (32-MER), DNA (5'-D(P*GP*TP*GP*CP*GP*GP*A)-3'), HNH endonuclease, ... | Authors: | Zhang, H, Zhu, H, Li, X, Liu, Y. | Deposit date: | 2024-04-09 | Release date: | 2024-10-02 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (2.57 Å) | Cite: | Structural basis for the type I-F Cas8-HNH system. Embo J., 2024
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8ZDY
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8Z0K
| Cryo-EM structure of Cas8-HNH system at full R-loop state | Descriptor: | DNA (37-MER), DNA (5'-D(P*GP*TP*GP*CP*GP*GP*A)-3'), HNH endonuclease, ... | Authors: | Zhang, H, Zhu, H, Li, X, Liu, Y. | Deposit date: | 2024-04-09 | Release date: | 2024-10-02 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (2.51 Å) | Cite: | Structural basis for the type I-F Cas8-HNH system. Embo J., 2024
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8ZNR
| Cryo-EM structure of Cas8-HNH system at ssDNA-bound state | Descriptor: | DNA (35-MER), RNA (56-MER), protein structure | Authors: | Zhang, H, Zhu, H, Li, X, Liu, Y. | Deposit date: | 2024-05-28 | Release date: | 2024-10-02 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis for the type I-F Cas8-HNH system. Embo J., 2024
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8Z9C
| Cryo-EM structure of NTR-bound type VII CRISPR-Cas complex at substrate-engaged state I | Descriptor: | Protein structure, RNA (41-MER), RNA (48-MER), ... | Authors: | Zhang, H, Deng, Z, Li, X. | Deposit date: | 2024-04-23 | Release date: | 2024-08-21 | Last modified: | 2024-09-25 | Method: | ELECTRON MICROSCOPY (3.01 Å) | Cite: | Structural basis for the activity of the type VII CRISPR-Cas system. Nature, 633, 2024
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8Z4L
| Cryo-EM structure of CTR-bound type VII CRISPR-Cas complex at substrate-engaged state I | Descriptor: | RNA (40-MER), RNA (49-MER), ZINC ION, ... | Authors: | Zhang, H, Deng, Z, Li, X. | Deposit date: | 2024-04-17 | Release date: | 2024-08-21 | Last modified: | 2024-09-25 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Structural basis for the activity of the type VII CRISPR-Cas system. Nature, 633, 2024
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8Z4J
| Cryo-EM structure of CTR-bound type VII CRISPR-Cas complex at substrate-engaged state II | Descriptor: | Protein structure, RNA (34-MER), RNA (38-MER), ... | Authors: | Zhang, H, Deng, Z, Li, X. | Deposit date: | 2024-04-17 | Release date: | 2024-08-21 | Last modified: | 2024-09-25 | Method: | ELECTRON MICROSCOPY (2.97 Å) | Cite: | Structural basis for the activity of the type VII CRISPR-Cas system. Nature, 633, 2024
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8Z9E
| Cryo-EM structure of NTR-bound type VII CRISPR-Cas complex at substrate-engaged state II | Descriptor: | Protein structure, RNA (34-MER), RNA (39-MER), ... | Authors: | Zhang, H, Deng, Z, Li, X. | Deposit date: | 2024-04-23 | Release date: | 2024-08-21 | Last modified: | 2024-09-25 | Method: | ELECTRON MICROSCOPY (3.13 Å) | Cite: | Structural basis for the activity of the type VII CRISPR-Cas system. Nature, 633, 2024
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8YHE
| Cryo-EM structure of CTR-bound type VII CRISPR-Cas complex at post-state II | Descriptor: | RNA (29-MER), RNA (46-MER), ZINC ION, ... | Authors: | Zhang, H, Deng, Z, Li, X. | Deposit date: | 2024-02-28 | Release date: | 2024-08-21 | Last modified: | 2024-09-25 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | Structural basis for the activity of the type VII CRISPR-Cas system. Nature, 633, 2024
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