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PDB: 1631 results

4XV3
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B-Raf Kinase V600E oncogenic mutant in complex with PLX7922
Descriptor: N'-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}-N-ethyl-N-methylsulfuric diamide, Serine/threonine-protein kinase B-raf
Authors:Zhang, Y, Zhang, C.
Deposit date:2015-01-26
Release date:2015-10-28
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:RAF inhibitors that evade paradoxical MAPK pathway activation.
Nature, 526, 2015
4XV1
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BU of 4xv1 by Molmil
B-Raf Kinase V600E oncogenic mutant in complex with PLX7904
Descriptor: N'-(3-{[5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)-N-ethyl-N-methylsulfuric diamide, Serine/threonine-protein kinase B-raf
Authors:Zhang, Y, Zhang, C.
Deposit date:2015-01-26
Release date:2015-10-28
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:RAF inhibitors that evade paradoxical MAPK pathway activation.
Nature, 526, 2015
4XV2
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BU of 4xv2 by Molmil
B-Raf Kinase V600E oncogenic mutant in complex with Dabrafenib
Descriptor: Dabrafenib, Serine/threonine-protein kinase B-raf
Authors:zhang, Y, zhang, c.
Deposit date:2015-01-26
Release date:2015-10-28
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:RAF inhibitors that evade paradoxical MAPK pathway activation.
Nature, 526, 2015
5E9A
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BU of 5e9a by Molmil
Crystal structure analysis of the cold-adamped beta-galactosidase from Rahnella sp. R3
Descriptor: ACETATE ION, Beta-galactosidase, ZINC ION
Authors:Zhang, Y.Z, Fan, Y.T.
Deposit date:2015-10-14
Release date:2016-10-26
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.561 Å)
Cite:Cloning, expression and structural stability of a cold-adapted beta-galactosidase from Rahnella sp. R3.
Protein Expr.Purif., 115, 2015
8JNC
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BU of 8jnc by Molmil
Crystal structure of cytochrome P450 IkaD from Streptomyces sp. ZJ306, in complex with the substrate 10-epi-maltophilin
Descriptor: (1Z,3E,5S,8R,9S,10S,11R,13R,15R,16S,18Z,24S,25S)-11-ethyl-2,24-dihydroxy-10-methyl-21,26-diazapentacyclo[23.2.1.09,13.08,15.05,16]octacosa-1(2),3,18-triene-7,20,27,28-tetraone, Cytochrome P450, FORMIC ACID, ...
Authors:Zhang, Y.L, Zhang, L.P, Zhang, C.S.
Deposit date:2023-06-06
Release date:2023-11-15
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Mechanistic Understanding of the Distinct Regio- and Chemoselectivity of Multifunctional P450s by Structural Comparison of IkaD and CftA Complexed with Common Substrates.
Angew.Chem.Int.Ed.Engl., 62, 2023
1THD
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BU of 1thd by Molmil
COMPLEX ORGANIZATION OF DENGUE VIRUS E PROTEIN AS REVEALED BY 9.5 ANGSTROM CRYO-EM RECONSTRUCTION
Descriptor: Major envelope protein E
Authors:Zhang, Y, Zhang, W, Ogata, S, Clements, D, Strauss, J.H, Baker, T.S, Kuhn, R.J, Rossmann, M.G.
Deposit date:2004-06-01
Release date:2004-09-28
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (9.5 Å)
Cite:Conformational changes of the flavivirus e glycoprotein
Structure, 12, 2004
6O3Y
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BU of 6o3y by Molmil
Crystal structure of yeast Nrd1 CID in complex with Sen1 NIM3
Descriptor: CHLORIDE ION, Helicase SEN1, Protein NRD1
Authors:Zhang, Y, Tong, L.
Deposit date:2019-02-27
Release date:2019-06-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.799 Å)
Cite:Identification of Three Sequence Motifs in the Transcription Termination Factor Sen1 that Mediate Direct Interactions with Nrd1.
Structure, 27, 2019
3OG7
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B-Raf Kinase V600E oncogenic mutant in complex with PLX4032
Descriptor: AKAP9-BRAF fusion protein, N-(3-{[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide
Authors:Zhang, Y, Zhang, K.Y, Zhang, C.
Deposit date:2010-08-16
Release date:2010-09-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma.
Nature, 467, 2010
4XZ6
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TmoX in complex with TMAO
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, GLYCEROL, ...
Authors:Zhang, Y.Z, Li, C.Y.
Deposit date:2015-02-04
Release date:2015-08-19
Last modified:2015-10-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mechanistic Insight into Trimethylamine N-Oxide Recognition by the Marine Bacterium Ruegeria pomeroyi DSS-3
J.Bacteriol., 197, 2015
7XED
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BU of 7xed by Molmil
Crystal Structure of OsCIE1-Ubox and OsUBC8 complex
Descriptor: U-box domain-containing protein 12, UBC core domain-containing protein
Authors:Zhang, Y, Yu, C.Z.
Deposit date:2022-03-30
Release date:2023-10-04
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Release of a ubiquitin brake activates OsCERK1-triggered immunity in rice.
Nature, 629, 2024
6O7G
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BU of 6o7g by Molmil
Solution structure of MLL4 PHD6 domain in complex with histone H4K16ac peptide
Descriptor: Histone H4, Histone-lysine N-methyltransferase 2D, ZINC ION
Authors:Zhang, Y, Kutateladze, T.G.
Deposit date:2019-03-07
Release date:2019-05-22
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF.
Nat Commun, 10, 2019
4HVS
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BU of 4hvs by Molmil
Crystal structure of KIT kinase domain with a small molecule inhibitor, PLX647
Descriptor: 5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-N-[4-(trifluoromethyl)benzyl]pyridin-2-amine, Mast/stem cell growth factor receptor Kit
Authors:Zhang, Y, Zhang, C.
Deposit date:2012-11-06
Release date:2013-03-27
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HW7
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BU of 4hw7 by Molmil
Crystal structure of FMS kinase domain with a small molecular inhibitor, PLX647-OME
Descriptor: 5-[(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-[4-(trifluoromethyl)benzyl]pyridin-2-amine, Macrophage colony-stimulating factor 1 receptor
Authors:Zhang, Y, Zhang, C.
Deposit date:2012-11-07
Release date:2013-03-27
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.9001 Å)
Cite:Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor.
Proc.Natl.Acad.Sci.USA, 110, 2013
5E1R
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BU of 5e1r by Molmil
Crystal structure of pecan (carya illinoinensis) vicilin, a new food allergen
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 7S vicilin, COPPER (II) ION
Authors:Zhang, Y.Z.
Deposit date:2015-09-30
Release date:2016-08-10
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.651 Å)
Cite:Identification and Characterization of a New Pecan [Carya illinoinensis (Wangenh.) K. Koch] Allergen, Car i 2.
J.Agric.Food Chem., 64, 2016
1N6G
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BU of 1n6g by Molmil
The structure of immature Dengue-2 prM particles
Descriptor: major envelope protein E
Authors:Zhang, Y, Corver, J, Chipman, P.R, Zhang, W, Pletnev, S.V, Sedlak, D, Baker, T.S, Strauss, J.H, Kuhn, R.J, Rossmann, M.G.
Deposit date:2002-11-10
Release date:2003-06-03
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (16 Å)
Cite:Structures of Immature flavivirus particles
EMBO J., 22, 2003
1NA4
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BU of 1na4 by Molmil
The structure of immature Yellow Fever virus particle
Descriptor: major envelope protein E
Authors:Zhang, Y, Corver, J, Chipman, P.R, Lenches, E, Zhang, W, Pletnev, S.V, Sedlak, D, Baker, T.S, Strauss, J.H, Kuhn, R.J, Rossmann, M.G.
Deposit date:2002-11-26
Release date:2003-12-09
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY
Cite:Structures of immature flavivirus particles
EMBO J., 22, 2003
6O3W
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BU of 6o3w by Molmil
Crystal structure of yeast Nrd1 CID in complex with Sen1 NIM1
Descriptor: Helicase SEN1, Protein NRD1
Authors:Zhang, Y, Tong, L.
Deposit date:2019-02-27
Release date:2019-06-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Identification of Three Sequence Motifs in the Transcription Termination Factor Sen1 that Mediate Direct Interactions with Nrd1.
Structure, 27, 2019
3OMX
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BU of 3omx by Molmil
Crystal structure of Ssu72 with vanadate complex
Descriptor: CG14216, VANADATE ION
Authors:Zhang, Y, Zhang, M, Zhang, Y.
Deposit date:2010-08-27
Release date:2011-01-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3366 Å)
Cite:Crystal structure of Ssu72, an essential eukaryotic phosphatase specific for the C-terminal domain of RNA polymerase II, in complex with a transition state analogue.
Biochem.J., 434, 2011
3OMW
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BU of 3omw by Molmil
Crystal structure of Ssu72, an essential eukaryotic phosphatase specific for the C-terminal domain of RNA polymerase II
Descriptor: CG14216
Authors:Zhang, Y, Zhang, M, Zhang, Y.
Deposit date:2010-08-27
Release date:2011-01-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.8701 Å)
Cite:Crystal structure of Ssu72, an essential eukaryotic phosphatase specific for the C-terminal domain of RNA polymerase II, in complex with a transition state analogue.
Biochem.J., 434, 2011
6O3X
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BU of 6o3x by Molmil
Crystal structure of yeast Nrd1 CID in complex with Sen1 NIM2
Descriptor: CHLORIDE ION, Helicase SEN1, Protein NRD1
Authors:Zhang, Y, Tong, L.
Deposit date:2019-02-27
Release date:2019-06-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.994 Å)
Cite:Identification of Three Sequence Motifs in the Transcription Termination Factor Sen1 that Mediate Direct Interactions with Nrd1.
Structure, 27, 2019
5BW0
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BU of 5bw0 by Molmil
The crystal structure of minor pseudopilin binary complex of XcpV and XcpW from the Type 2 secretion system of Pseudomonas aeruginosa
Descriptor: SULFATE ION, Type II secretion system protein I, Type II secretion system protein J
Authors:Zhang, Y, Faucher, F, Poole, K, Jia, Z.
Deposit date:2015-06-05
Release date:2016-07-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-guided disruption of the pseudopilus tip complex inhibits the Type II secretion in Pseudomonas aeruginosa.
PLoS Pathog., 14, 2018
1TG8
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BU of 1tg8 by Molmil
The structure of Dengue virus E glycoprotein
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose, envelope glycoprotein
Authors:Zhang, Y, Zhang, W, Ogata, S, Clements, D, Strauss, J.H, Baker, T.S, Rossmann, M.G.
Deposit date:2004-05-28
Release date:2004-09-28
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Conformational changes of the flavivirus e glycoprotein
Structure, 12, 2004
5T0X
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BU of 5t0x by Molmil
Solution NMR-derived structure of calmodulin bound with ER alpha peptides
Descriptor: CALCIUM ION, Calmodulin, Estrogen receptor peptide
Authors:Zhang, Y, Ames, J.B.
Deposit date:2016-08-16
Release date:2017-02-15
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Solution NMR-derived structure of calmodulin bound with ER alpha peptides
To Be Published
8XAJ
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Cryo-EM structure of OSCA1.2-liposome-inside-in open state
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Calcium permeable stress-gated cation channel 1
Authors:Zhang, Y, Han, Y.
Deposit date:2023-12-04
Release date:2024-04-10
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.29 Å)
Cite:Mechanical activation opens a lipid-lined pore in OSCA ion channels.
Nature, 628, 2024
8XNG
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Cryo-EM structure of OSCA1.2-liposome-inside-out closed state
Descriptor: Calcium permeable stress-gated cation channel 1
Authors:Zhang, Y, Han, Y.
Deposit date:2023-12-29
Release date:2024-04-10
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.56 Å)
Cite:Mechanical activation opens a lipid-lined pore in OSCA ion channels.
Nature, 628, 2024

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