8E9Y
 
 | | CryoEM structure of miniGq-coupled hM3Dq in complex with CNO | | 分子名称: | 8-chloro-11-(4-methyl-4-oxo-4lambda~5~-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Zhang, S, Fay, J.F, Roth, B.L. | | 登録日 | 2022-08-27 | | 公開日 | 2022-11-30 | | 最終更新日 | 2022-12-21 | | 実験手法 | ELECTRON MICROSCOPY (2.79 Å) | | 主引用文献 | Molecular basis for selective activation of DREADD-based chemogenetics.
Nature, 612, 2022
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8E9Z
 | | CryoEM structure of miniGq-coupled hM3R in complex with Iperoxo | | 分子名称: | 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Zhang, S, Fay, J.F, Roth, B.L. | | 登録日 | 2022-08-27 | | 公開日 | 2022-11-30 | | 最終更新日 | 2022-12-21 | | 実験手法 | ELECTRON MICROSCOPY (2.69 Å) | | 主引用文献 | Molecular basis for selective activation of DREADD-based chemogenetics.
Nature, 612, 2022
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8J2F
 | | Human neutral shpingomyelinase | | 分子名称: | HEPTANE, MAGNESIUM ION, Sphingomyelin phosphodiesterase 2, ... | | 著者 | Zhang, S.S. | | 登録日 | 2023-04-14 | | 公開日 | 2023-12-06 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | | 主引用文献 | Molecular basis for the catalytic mechanism of human neutral sphingomyelinases 1 (hSMPD2).
Nat Commun, 14, 2023
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7BXU
 | | CLC-7/Ostm1 membrane protein complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, H(+)/Cl(-) exchange transporter 7, Osteopetrosis-associated transmembrane protein 1 | | 著者 | Zhang, S.S, Yang, M.J. | | 登録日 | 2020-04-20 | | 公開日 | 2020-09-16 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Molecular insights into the human CLC-7/Ostm1 transporter.
Sci Adv, 6, 2020
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8HAT
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8HAS
 | | NARROW LEAF 1-close from Japonica | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Protein NARROW LEAF 1 | | 著者 | Zhang, S.J, He, Y.J, Wang, N, Zhang, W.J, Liu, C.M. | | 登録日 | 2022-10-26 | | 公開日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | | 主引用文献 | NARROW LEAF 1-close from Japonica
To Be Published
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8HAU
 | | NARROW LEAF 1 from Indica | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Protein NARROW LEAF 1 | | 著者 | Zhang, S.J, He, Y.J, Wang, N, Zhang, W.J, Liu, C.M. | | 登録日 | 2022-10-26 | | 公開日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.02 Å) | | 主引用文献 | NARROW LEAF 1 from Indica
To Be Published
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8JSC
 | | Structure of the FSP1 protein from Human | | 分子名称: | 6-HYDROXY-FLAVIN-ADENINE DINUCLEOTIDE, Ferroptosis suppressor protein 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Zhang, S.T, Jia, D. | | 登録日 | 2023-06-19 | | 公開日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | | 主引用文献 | FSP1 oxidizes NADPH to suppress ferroptosis.
Cell Res., 33, 2023
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5H32
 | | Cryo-EM structure of zika virus complexed with Fab C10 at pH 5.0 | | 分子名称: | C10 IgG heavy chain variable region, C10 IgG light chain variable region, structural protein E | | 著者 | Zhang, S, Kostyuchenko, V, Ng, T.-S, Lok, S.-M. | | 登録日 | 2016-10-20 | | 公開日 | 2016-11-30 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (12 Å) | | 主引用文献 | Neutralization mechanism of a highly potent antibody against Zika virus
Nat Commun, 7, 2016
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5H37
 | | Cryo-EM structure of zika virus complexed with Fab C10 at pH 8.0 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, C10 IgG heavy chain variable region, C10 IgG light chain variable region, ... | | 著者 | Zhang, S, Kostyuchenko, V, Ng, T.-S, Lim, X.-N, Ooi, J.S.G, Lambert, S, Tan, T.Y, Widman, D, Shi, J, Baric, R.S, Lok, S.-M. | | 登録日 | 2016-10-20 | | 公開日 | 2016-11-30 | | 最終更新日 | 2022-03-23 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Neutralization mechanism of a highly potent antibody against Zika virus
Nat Commun, 7, 2016
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5H30
 | | Cryo-EM structure of zika virus complexed with Fab C10 at pH 6.5 | | 分子名称: | IgG C10 heavy chain, IgG C10 light chain, structural protein E, ... | | 著者 | Zhang, S, Kostyuchenko, V, Ng, T.-S, Lok, S.-M. | | 登録日 | 2016-10-19 | | 公開日 | 2016-11-30 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | | 主引用文献 | Neutralization mechanism of a highly potent antibody against Zika virus
Nat Commun, 7, 2016
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5ZHH
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6O3N
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8J64
 | | Crystal structure of Toxoplasma gondii MIC2-M2AP complex | | 分子名称: | MIC2-associated protein, Micronemal protein MIC2 | | 著者 | Zhang, S, Wang, F.F, Zhang, D.J, Song, G.J, Springer, T.A. | | 登録日 | 2023-04-24 | | 公開日 | 2023-08-30 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural insights into MIC2 recognition by MIC2-associated protein in Toxoplasma gondii.
Commun Biol, 6, 2023
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8EA0
 | | CryoEM structure of miniGq-coupled hM3R in complex with iperoxo (local refinement) | | 分子名称: | 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, CHOLESTEROL HEMISUCCINATE, Muscarinic acetylcholine receptor M3 | | 著者 | Zhang, S, Fay, J.F, Roth, B.L. | | 登録日 | 2022-08-27 | | 公開日 | 2022-11-30 | | 最終更新日 | 2022-12-21 | | 実験手法 | ELECTRON MICROSCOPY (2.56 Å) | | 主引用文献 | Molecular basis for selective activation of DREADD-based chemogenetics.
Nature, 612, 2022
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6W8Y
 | | Co-crystal structures of CHIKV nsP3 macrodomain with pyrimidone fragments | | 分子名称: | 2-oxo-2,3-dihydropyrimidine-4-carboxylic acid, Nonstructural polyprotein | | 著者 | Zhang, S, Garzan, A, Pathak, A.K, Augelli-Szafran, C.E, Wu, M. | | 登録日 | 2020-03-21 | | 公開日 | 2021-01-13 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design.
Plos One, 16, 2021
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6W8Z
 | | Co-crystal structures of CHIKV nsP3 macrodomain with pyrimidone fragments | | 分子名称: | Nonstructural polyprotein, methyl 2-oxo-1,2-dihydroquinazoline-4-carboxylate | | 著者 | Zhang, S, Garzan, A, Pathak, A.K, Augelli-Szafran, C.E, Wu, M. | | 登録日 | 2020-03-21 | | 公開日 | 2021-01-13 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design.
Plos One, 16, 2021
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6W91
 | | Co-crystal structures of CHIKV nsP3 macrodomain with pyrimidone fragments | | 分子名称: | Nonstructural polyprotein, methyl 2-oxo-2,5-dihydropyrimidine-4-carboxylate | | 著者 | Zhang, S, Garzan, A, Pathak, A.K, Augelli-Szafran, C.E, Wu, M. | | 登録日 | 2020-03-21 | | 公開日 | 2021-01-13 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | | 主引用文献 | Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design.
Plos One, 16, 2021
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6W7H
 | | Co-crystal structures of CHIKV nsP3 macrodomain with pyrimidone fragments | | 分子名称: | 6-methyl-2-oxo-2,5-dihydropyrimidine-4-carboxylic acid, Nonstructural polyprotein | | 著者 | Zhang, S, Garzan, A, Augelli-Szafran, C.E, Pathak, A.K, Wu, M. | | 登録日 | 2020-03-19 | | 公開日 | 2021-01-13 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design.
Plos One, 16, 2021
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6W8Q
 | | Co-crystal structures of CHIKV nsP3 macrodomain with pyrimidone fragments | | 分子名称: | 2-oxo-1,2,5,6,7,8-hexahydroquinazoline-4-carboxylic acid, Nonstructural polyprotein | | 著者 | Zhang, S, Garzan, A, Pathak, A.K, Augelli-Szafran, C.E, Wu, M. | | 登録日 | 2020-03-21 | | 公開日 | 2021-01-13 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | | 主引用文献 | Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design.
Plos One, 16, 2021
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6W8M
 | | Co-crystal structures of CHIKV nsP3 macrodomain with pyrimidone fragments | | 分子名称: | 2-oxo-1,2-dihydroquinazoline-4-carboxylic acid, Nonstructural polyprotein | | 著者 | Zhang, S, Garzan, A, Pathak, A.K, Augelli-Szafran, C.E, Wu, M. | | 登録日 | 2020-03-20 | | 公開日 | 2021-01-13 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design.
Plos One, 16, 2021
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6W8K
 | | Co-crystal structures of CHIKV nsP3 macrodomain with pyrimidone fragments | | 分子名称: | 5,6-dimethyl-2-oxo-2,3-dihydropyrimidine-4-carboxylic acid, Nonstructural polyprotein | | 著者 | Zhang, S, Garzan, A, Augelli-Szafran, C.E, Pathak, A.K, Wu, M. | | 登録日 | 2020-03-20 | | 公開日 | 2021-01-13 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design.
Plos One, 16, 2021
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8JPR
 | | Cryo-EM structure of Y553C human ClC-6 | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, H(+)/Cl(-) exchange transporter 6, ... | | 著者 | Zhang, S.S. | | 登録日 | 2023-06-12 | | 公開日 | 2023-09-20 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Molecular basis of ClC-6 function and its impairment in human disease
Sci Adv, 2023
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8JPO
 | | Cryo-EM structure of ATP bound human ClC-6 | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, H(+)/Cl(-) exchange transporter 6, ... | | 著者 | Zhang, S.S. | | 登録日 | 2023-06-12 | | 公開日 | 2023-09-20 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Molecular basis of ClC-6 function and its impairment in human disease
Sci Adv, 2023
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8JPJ
 | | Cryo-EM structure of ClC-6 apo state | | 分子名称: | CHLORIDE ION, H(+)/Cl(-) exchange transporter 6 | | 著者 | Zhang, S.S. | | 登録日 | 2023-06-12 | | 公開日 | 2023-09-20 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Molecular basis of ClC-6 function and its impairment in human disease
Sci Adv, 2023
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