6W8Q
Co-crystal structures of CHIKV nsP3 macrodomain with pyrimidone fragments
Summary for 6W8Q
| Entry DOI | 10.2210/pdb6w8q/pdb |
| Descriptor | Nonstructural polyprotein, 2-oxo-1,2,5,6,7,8-hexahydroquinazoline-4-carboxylic acid (3 entities in total) |
| Functional Keywords | nsp3, macrodomain, pyrimidone fragments, viral protein |
| Biological source | Chikungunya virus (CHIKV) |
| Total number of polymer chains | 4 |
| Total formula weight | 74852.26 |
| Authors | Zhang, S.,Garzan, A.,Pathak, A.K.,Augelli-Szafran, C.E.,Wu, M. (deposition date: 2020-03-21, release date: 2021-01-13, Last modification date: 2023-10-18) |
| Primary citation | Zhang, S.,Garzan, A.,Haese, N.,Bostwick, R.,Martinez-Gzegozewska, Y.,Rasmussen, L.,Streblow, D.N.,Haise, M.T.,Pathak, A.K.,Augelli-Szafran, C.E.,Wu, M. Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design. Plos One, 16:e0245013-e0245013, 2021 Cited by PubMed: 33482665DOI: 10.1371/journal.pone.0245013 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.34 Å) |
Structure validation
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