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PDB: 1650 件

2O3J
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Structure of Caenorhabditis Elegans UDP-Glucose Dehydrogenase
分子名称: GLYCEROL, UDP-glucose 6-dehydrogenase
著者Zhang, Y, Zhan, C, Patskovsky, Y, Ramagopal, U, Shi, W, Toro, R, Wengerter, B.C, Milst, S, Vidal, M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC)
登録日2006-12-01
公開日2006-12-12
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Crystal Structure of Caenorhabditis Elegans Udp-Glucose Dehydrogenase
To be Published
7W3Z
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Cryo-EM Structure of Human Gastrin Releasing Peptide Receptor in complex with the agonist Gastrin Releasing Peptide and Gq heterotrimers
分子名称: Gastrin Releasing Peptide PRGNHWAVGHLM(NH2), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Zhan, Y, Peng, S, Zhang, H.
登録日2021-11-26
公開日2023-02-22
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structures of human gastrin-releasing peptide receptors bound to antagonist and agonist for cancer and itch therapy.
Proc.Natl.Acad.Sci.USA, 120, 2023
7W40
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Cryo-EM Structure of Human Gastrin Releasing Peptide Receptor in complex with the agonist Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] and Gq heterotrimers
分子名称: Bombesin, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Zhan, Y, Peng, S, Zhang, H.
登録日2021-11-26
公開日2023-02-22
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structures of human gastrin-releasing peptide receptors bound to antagonist and agonist for cancer and itch therapy.
Proc.Natl.Acad.Sci.USA, 120, 2023
8S55
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RNA polymerase II early elongation complex bound to TFIIE and TFIIF - state a (composite structure)
分子名称: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ...
著者Zhan, Y, Grabbe, F, Oberbeckmann, E, Dienemann, C, Cramer, P.
登録日2024-02-22
公開日2024-04-17
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Three-step mechanism of promoter escape by RNA polymerase II.
Mol.Cell, 84, 2024
8S5N
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RNA polymerase II core initially transcribing complex with an ordered RNA of 12 nt
分子名称: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ...
著者Zhan, Y, Grabbe, F, Oberbeckmann, E, Dienemann, C, Cramer, P.
登録日2024-02-24
公開日2024-04-10
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Three-step mechanism of promoter escape by RNA polymerase II.
Mol.Cell, 84, 2024
8S52
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RNA polymerase II core initially transcribing complex with an ordered RNA of 10 nt
分子名称: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ...
著者Zhan, Y, Grabbe, F, Oberbeckmann, E, Dienemann, C, Cramer, P.
登録日2024-02-22
公開日2024-04-17
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Three-step mechanism of promoter escape by RNA polymerase II.
Mol.Cell, 84, 2024
8S54
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RNA polymerase II early elongation complex bound to TFIIE and TFIIF - state b (composite structure)
分子名称: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ...
著者Zhan, Y, Grabber, F, Oberbeckmann, E, Dienemann, C, Cramer, P.
登録日2024-02-22
公開日2024-04-17
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Three-step mechanism of promoter escape by RNA polymerase II.
Mol.Cell, 84, 2024
8S51
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RNA polymerase II core initially transcribing complex with an ordered RNA of 8 nt
分子名称: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ...
著者Zhan, Y, Grabbe, F, Oberbeckmann, E, Dienemann, C, Cramer, P.
登録日2024-02-22
公開日2024-04-17
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Three-step mechanism of promoter escape by RNA polymerase II.
Mol.Cell, 84, 2024
6GFM
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Crystal structure of the Escherichia coli nucleosidase PpnN (pppGpp-form)
分子名称: Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase, guanosine 5'-(tetrahydrogen triphosphate) 3'-(trihydrogen diphosphate)
著者Zhang, Y, Baerentsen, R.L, Gerdes, K, Brodersen, D.E.
登録日2018-05-01
公開日2019-04-24
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.77 Å)
主引用文献(p)ppGpp Regulates a Bacterial Nucleosidase by an Allosteric Two-Domain Switch.
Mol.Cell, 74, 2019
5LG4
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Crystal structure of the Sec3/Sso2 complex at 2.9 angstrom resolution
分子名称: Exocyst complex component SEC3, Protein SSO2, SULFATE ION
著者Zhang, Y.B, Dong, G.
登録日2016-07-05
公開日2017-02-08
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Sec3 promotes the initial binary t-SNARE complex assembly and membrane fusion.
Nat Commun, 8, 2017
5E00
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Structure of HLA-A2 P130
分子名称: Beta-2-microglobulin, GLY-VAL-TRP-ILE-ARG-THR-PRO-PRO-ALA, HLA class I histocompatibility antigen, ...
著者Zhang, Y, Wu, Y, Qi, J, Liu, J, Gao, G.F, Meng, S.
登録日2015-09-26
公開日2017-01-18
最終更新日2019-01-23
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献CD8+T-Cell Response-Associated Evolution of Hepatitis B Virus Core Protein and Disease Progress.
J. Virol., 92, 2018
5M4Y
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BU of 5m4y by Molmil
Crystal structure of the Sec3/Sso2 complex at 2.20 angstrom resolution
分子名称: Exocyst complex component SEC3, GLYCEROL, Protein SSO2
著者Zhang, Y.B, Dong, G.
登録日2016-10-19
公開日2017-02-08
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Sec3 promotes the initial binary t-SNARE complex assembly and membrane fusion.
Nat Commun, 8, 2017
2R7K
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BU of 2r7k by Molmil
Crystal structure of FAICAR synthetase (PurP) from M. jannaschii complexed with AMPPCP and AICAR
分子名称: 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase, AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, CHLORIDE ION, ...
著者Zhang, Y, White, R.H, Ealick, S.E.
登録日2007-09-09
公開日2007-12-04
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii.
Biochemistry, 47, 2008
2R7M
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BU of 2r7m by Molmil
Crystal structure of FAICAR synthetase (PurP) from M. jannaschii complexed with AMP
分子名称: 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase, ADENOSINE MONOPHOSPHATE, CHLORIDE ION, ...
著者Zhang, Y, White, R.H, Ealick, S.E.
登録日2007-09-09
公開日2007-12-04
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii.
Biochemistry, 47, 2008
2R7L
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BU of 2r7l by Molmil
Crystal structure of FAICAR synthetase (PurP) from M. jannaschii complexed with ATP and AICAR
分子名称: 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase, ADENOSINE-5'-TRIPHOSPHATE, AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, ...
著者Zhang, Y, White, R.H, Ealick, S.E.
登録日2007-09-09
公開日2007-12-04
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii.
Biochemistry, 47, 2008
2R7N
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BU of 2r7n by Molmil
Crystal structure of FAICAR synthetase (PurP) from M. jannaschii complexed with ADP and FAICAR
分子名称: 5-(formylamino)-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazole-4-carboxamide, 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase, ADENOSINE-5'-DIPHOSPHATE, ...
著者Zhang, Y, White, R.H, Ealick, S.E.
登録日2007-09-09
公開日2007-12-04
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii.
Biochemistry, 47, 2008
5WAN
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BU of 5wan by Molmil
Crystal Structure of a flavoenzyme RutA in the pyrimidine catabolic pathway
分子名称: FLAVIN MONONUCLEOTIDE, GLYCEROL, Pyrimidine monooxygenase RutA, ...
著者Zhang, Y, Mukherjee, T, Abdelwahed, S, Begley, T.P, Ealick, S.E.
登録日2017-06-26
公開日2017-07-19
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.798 Å)
主引用文献Catalysis of a flavoenzyme-mediated amide hydrolysis.
J. Am. Chem. Soc., 132, 2010
5LS6
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Structure of Human Polycomb Repressive Complex 2 (PRC2) with inhibitor
分子名称: 1-[(1~{R})-1-[1-[2,2-bis(fluoranyl)propyl]piperidin-4-yl]ethyl]-~{N}-[(4-methoxy-6-methyl-2-oxidanylidene-3~{H}-pyridin-3-yl)methyl]-2-methyl-indole-3-carboxamide, Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2, Jarid2 K116me3, ...
著者Zhang, Y, Justin, N, Chen, S, Wilson, J, Gamblin, S.
登録日2016-08-22
公開日2017-02-22
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.47 Å)
主引用文献Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas.
J. Med. Chem., 59, 2016
2R85
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Crystal structure of PurP from Pyrococcus furiosus complexed with AMP
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE MONOPHOSPHATE, CHLORIDE ION, ...
著者Zhang, Y, White, R.H, Ealick, S.E.
登録日2007-09-10
公開日2007-12-04
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii.
Biochemistry, 47, 2008
2R86
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BU of 2r86 by Molmil
Crystal structure of PurP from Pyrococcus furiosus complexed with ATP
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, PHOSPHATE ION, ...
著者Zhang, Y, White, R.H, Ealick, S.E.
登録日2007-09-10
公開日2007-12-04
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii.
Biochemistry, 47, 2008
2R84
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BU of 2r84 by Molmil
Crystal structure of PurP from Pyrococcus furiosus complexed with AMP and AICAR
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE MONOPHOSPHATE, AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, ...
著者Zhang, Y, White, R.H, Ealick, S.E.
登録日2007-09-10
公開日2007-12-04
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii.
Biochemistry, 47, 2008
6GFL
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BU of 6gfl by Molmil
Crystal structure of the Escherichia coli nucleosidase PpnN (apo form)
分子名称: Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase
著者Zhang, Y, Baerentsen, R.L, Gerdes, K, Brodersen, D.E.
登録日2018-05-01
公開日2019-04-24
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献(p)ppGpp Regulates a Bacterial Nucleosidase by an Allosteric Two-Domain Switch.
Mol.Cell, 74, 2019
5E18
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T. thermophilus transcription initiation complex having a YYY discriminator sequence and a nontemplate-strand length corresponding to TSS selection at position 8 (RPo-CCC-8)
分子名称: DNA (28-MER), DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3'), DNA-directed RNA polymerase subunit alpha, ...
著者Zhang, Y, Ebright, R.H.
登録日2015-09-29
公開日2016-03-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Multiplexed protein-DNA cross-linking: Scrunching in transcription start site selection.
Science, 351, 2016
8JOO
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Crystal structure of cytochrome P450 IkaD from Streptomyces sp. ZJ306, in complex with the substrate ikarugamycin
分子名称: (1Z,3E,5S,7R,8R,10R,11R,12S,15R,16S,18Z,25S)-11-ethyl-2-hydroxy-10-methyl-21,26-diazapentacyclo[23.2.1.05,16.07,15.08,12]octacosa-1(2),3,13,18-tetraene-20,27,28-trione, Cytochrome P450, FORMIC ACID, ...
著者Zhang, Y.L, Zhang, L.P, Zhang, C.S.
登録日2023-06-08
公開日2023-11-15
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献A Mechanistic Understanding of the Distinct Regio- and Chemoselectivity of Multifunctional P450s by Structural Comparison of IkaD and CftA Complexed with Common Substrates.
Angew.Chem.Int.Ed.Engl., 62, 2023
8JNO
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Crystal structure of cytochrome P450 IkaD from Streptomyces sp. ZJ306, in complex with the substrate 10-epi-deOH-HSAF
分子名称: (1Z,3E,5S,7S,8R,9S,10S,11R,13R,15R,16S,18Z,25S)-11-ethyl-2,7-dihydroxy-10-methyl-21,26-diazapentacyclo[23.2.1.09,13.08,15.05,16]octacosa-1(2),3,18-triene-20,27,28-trione, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Zhang, Y.L, Zhang, L.P, Zhang, C.S.
登録日2023-06-06
公開日2023-11-22
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A Mechanistic Understanding of the Distinct Regio- and Chemoselectivity of Multifunctional P450s by Structural Comparison of IkaD and CftA Complexed with Common Substrates.
Angew.Chem.Int.Ed.Engl., 62, 2023

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件を2024-07-03に公開中

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