2O3J
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![BU of 2o3j by Molmil](/molmil-images/mine/2o3j) | Structure of Caenorhabditis Elegans UDP-Glucose Dehydrogenase | 分子名称: | GLYCEROL, UDP-glucose 6-dehydrogenase | 著者 | Zhang, Y, Zhan, C, Patskovsky, Y, Ramagopal, U, Shi, W, Toro, R, Wengerter, B.C, Milst, S, Vidal, M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | 登録日 | 2006-12-01 | 公開日 | 2006-12-12 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Crystal Structure of Caenorhabditis Elegans Udp-Glucose Dehydrogenase To be Published
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7W3Z
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![BU of 7w3z by Molmil](/molmil-images/mine/7w3z) | Cryo-EM Structure of Human Gastrin Releasing Peptide Receptor in complex with the agonist Gastrin Releasing Peptide and Gq heterotrimers | 分子名称: | Gastrin Releasing Peptide PRGNHWAVGHLM(NH2), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhan, Y, Peng, S, Zhang, H. | 登録日 | 2021-11-26 | 公開日 | 2023-02-22 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structures of human gastrin-releasing peptide receptors bound to antagonist and agonist for cancer and itch therapy. Proc.Natl.Acad.Sci.USA, 120, 2023
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7W40
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![BU of 7w40 by Molmil](/molmil-images/mine/7w40) | Cryo-EM Structure of Human Gastrin Releasing Peptide Receptor in complex with the agonist Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] and Gq heterotrimers | 分子名称: | Bombesin, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhan, Y, Peng, S, Zhang, H. | 登録日 | 2021-11-26 | 公開日 | 2023-02-22 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structures of human gastrin-releasing peptide receptors bound to antagonist and agonist for cancer and itch therapy. Proc.Natl.Acad.Sci.USA, 120, 2023
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8S55
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![BU of 8s55 by Molmil](/molmil-images/mine/8s55) | RNA polymerase II early elongation complex bound to TFIIE and TFIIF - state a (composite structure) | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ... | 著者 | Zhan, Y, Grabbe, F, Oberbeckmann, E, Dienemann, C, Cramer, P. | 登録日 | 2024-02-22 | 公開日 | 2024-04-17 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Three-step mechanism of promoter escape by RNA polymerase II. Mol.Cell, 84, 2024
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8S5N
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![BU of 8s5n by Molmil](/molmil-images/mine/8s5n) | RNA polymerase II core initially transcribing complex with an ordered RNA of 12 nt | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ... | 著者 | Zhan, Y, Grabbe, F, Oberbeckmann, E, Dienemann, C, Cramer, P. | 登録日 | 2024-02-24 | 公開日 | 2024-04-10 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Three-step mechanism of promoter escape by RNA polymerase II. Mol.Cell, 84, 2024
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8S52
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![BU of 8s52 by Molmil](/molmil-images/mine/8s52) | RNA polymerase II core initially transcribing complex with an ordered RNA of 10 nt | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ... | 著者 | Zhan, Y, Grabbe, F, Oberbeckmann, E, Dienemann, C, Cramer, P. | 登録日 | 2024-02-22 | 公開日 | 2024-04-17 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Three-step mechanism of promoter escape by RNA polymerase II. Mol.Cell, 84, 2024
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8S54
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![BU of 8s54 by Molmil](/molmil-images/mine/8s54) | RNA polymerase II early elongation complex bound to TFIIE and TFIIF - state b (composite structure) | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ... | 著者 | Zhan, Y, Grabber, F, Oberbeckmann, E, Dienemann, C, Cramer, P. | 登録日 | 2024-02-22 | 公開日 | 2024-04-17 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Three-step mechanism of promoter escape by RNA polymerase II. Mol.Cell, 84, 2024
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8S51
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![BU of 8s51 by Molmil](/molmil-images/mine/8s51) | RNA polymerase II core initially transcribing complex with an ordered RNA of 8 nt | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ... | 著者 | Zhan, Y, Grabbe, F, Oberbeckmann, E, Dienemann, C, Cramer, P. | 登録日 | 2024-02-22 | 公開日 | 2024-04-17 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Three-step mechanism of promoter escape by RNA polymerase II. Mol.Cell, 84, 2024
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6GFM
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![BU of 6gfm by Molmil](/molmil-images/mine/6gfm) | Crystal structure of the Escherichia coli nucleosidase PpnN (pppGpp-form) | 分子名称: | Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase, guanosine 5'-(tetrahydrogen triphosphate) 3'-(trihydrogen diphosphate) | 著者 | Zhang, Y, Baerentsen, R.L, Gerdes, K, Brodersen, D.E. | 登録日 | 2018-05-01 | 公開日 | 2019-04-24 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | 主引用文献 | (p)ppGpp Regulates a Bacterial Nucleosidase by an Allosteric Two-Domain Switch. Mol.Cell, 74, 2019
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5LG4
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![BU of 5lg4 by Molmil](/molmil-images/mine/5lg4) | |
5E00
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![BU of 5e00 by Molmil](/molmil-images/mine/5e00) | Structure of HLA-A2 P130 | 分子名称: | Beta-2-microglobulin, GLY-VAL-TRP-ILE-ARG-THR-PRO-PRO-ALA, HLA class I histocompatibility antigen, ... | 著者 | Zhang, Y, Wu, Y, Qi, J, Liu, J, Gao, G.F, Meng, S. | 登録日 | 2015-09-26 | 公開日 | 2017-01-18 | 最終更新日 | 2019-01-23 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | CD8+T-Cell Response-Associated Evolution of Hepatitis B Virus Core Protein and Disease Progress. J. Virol., 92, 2018
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5M4Y
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![BU of 5m4y by Molmil](/molmil-images/mine/5m4y) | |
2R7K
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![BU of 2r7k by Molmil](/molmil-images/mine/2r7k) | Crystal structure of FAICAR synthetase (PurP) from M. jannaschii complexed with AMPPCP and AICAR | 分子名称: | 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase, AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, CHLORIDE ION, ... | 著者 | Zhang, Y, White, R.H, Ealick, S.E. | 登録日 | 2007-09-09 | 公開日 | 2007-12-04 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii. Biochemistry, 47, 2008
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2R7M
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![BU of 2r7m by Molmil](/molmil-images/mine/2r7m) | Crystal structure of FAICAR synthetase (PurP) from M. jannaschii complexed with AMP | 分子名称: | 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase, ADENOSINE MONOPHOSPHATE, CHLORIDE ION, ... | 著者 | Zhang, Y, White, R.H, Ealick, S.E. | 登録日 | 2007-09-09 | 公開日 | 2007-12-04 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii. Biochemistry, 47, 2008
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2R7L
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![BU of 2r7l by Molmil](/molmil-images/mine/2r7l) | Crystal structure of FAICAR synthetase (PurP) from M. jannaschii complexed with ATP and AICAR | 分子名称: | 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase, ADENOSINE-5'-TRIPHOSPHATE, AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, ... | 著者 | Zhang, Y, White, R.H, Ealick, S.E. | 登録日 | 2007-09-09 | 公開日 | 2007-12-04 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii. Biochemistry, 47, 2008
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2R7N
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![BU of 2r7n by Molmil](/molmil-images/mine/2r7n) | Crystal structure of FAICAR synthetase (PurP) from M. jannaschii complexed with ADP and FAICAR | 分子名称: | 5-(formylamino)-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazole-4-carboxamide, 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase, ADENOSINE-5'-DIPHOSPHATE, ... | 著者 | Zhang, Y, White, R.H, Ealick, S.E. | 登録日 | 2007-09-09 | 公開日 | 2007-12-04 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii. Biochemistry, 47, 2008
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5WAN
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![BU of 5wan by Molmil](/molmil-images/mine/5wan) | Crystal Structure of a flavoenzyme RutA in the pyrimidine catabolic pathway | 分子名称: | FLAVIN MONONUCLEOTIDE, GLYCEROL, Pyrimidine monooxygenase RutA, ... | 著者 | Zhang, Y, Mukherjee, T, Abdelwahed, S, Begley, T.P, Ealick, S.E. | 登録日 | 2017-06-26 | 公開日 | 2017-07-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.798 Å) | 主引用文献 | Catalysis of a flavoenzyme-mediated amide hydrolysis. J. Am. Chem. Soc., 132, 2010
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5LS6
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![BU of 5ls6 by Molmil](/molmil-images/mine/5ls6) | Structure of Human Polycomb Repressive Complex 2 (PRC2) with inhibitor | 分子名称: | 1-[(1~{R})-1-[1-[2,2-bis(fluoranyl)propyl]piperidin-4-yl]ethyl]-~{N}-[(4-methoxy-6-methyl-2-oxidanylidene-3~{H}-pyridin-3-yl)methyl]-2-methyl-indole-3-carboxamide, Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2, Jarid2 K116me3, ... | 著者 | Zhang, Y, Justin, N, Chen, S, Wilson, J, Gamblin, S. | 登録日 | 2016-08-22 | 公開日 | 2017-02-22 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.47 Å) | 主引用文献 | Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas. J. Med. Chem., 59, 2016
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2R85
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![BU of 2r85 by Molmil](/molmil-images/mine/2r85) | Crystal structure of PurP from Pyrococcus furiosus complexed with AMP | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE MONOPHOSPHATE, CHLORIDE ION, ... | 著者 | Zhang, Y, White, R.H, Ealick, S.E. | 登録日 | 2007-09-10 | 公開日 | 2007-12-04 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii. Biochemistry, 47, 2008
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2R86
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![BU of 2r86 by Molmil](/molmil-images/mine/2r86) | Crystal structure of PurP from Pyrococcus furiosus complexed with ATP | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, PHOSPHATE ION, ... | 著者 | Zhang, Y, White, R.H, Ealick, S.E. | 登録日 | 2007-09-10 | 公開日 | 2007-12-04 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii. Biochemistry, 47, 2008
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2R84
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![BU of 2r84 by Molmil](/molmil-images/mine/2r84) | Crystal structure of PurP from Pyrococcus furiosus complexed with AMP and AICAR | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE MONOPHOSPHATE, AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, ... | 著者 | Zhang, Y, White, R.H, Ealick, S.E. | 登録日 | 2007-09-10 | 公開日 | 2007-12-04 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii. Biochemistry, 47, 2008
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6GFL
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![BU of 6gfl by Molmil](/molmil-images/mine/6gfl) | |
5E18
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![BU of 5e18 by Molmil](/molmil-images/mine/5e18) | |
8JOO
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![BU of 8joo by Molmil](/molmil-images/mine/8joo) | Crystal structure of cytochrome P450 IkaD from Streptomyces sp. ZJ306, in complex with the substrate ikarugamycin | 分子名称: | (1Z,3E,5S,7R,8R,10R,11R,12S,15R,16S,18Z,25S)-11-ethyl-2-hydroxy-10-methyl-21,26-diazapentacyclo[23.2.1.05,16.07,15.08,12]octacosa-1(2),3,13,18-tetraene-20,27,28-trione, Cytochrome P450, FORMIC ACID, ... | 著者 | Zhang, Y.L, Zhang, L.P, Zhang, C.S. | 登録日 | 2023-06-08 | 公開日 | 2023-11-15 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | A Mechanistic Understanding of the Distinct Regio- and Chemoselectivity of Multifunctional P450s by Structural Comparison of IkaD and CftA Complexed with Common Substrates. Angew.Chem.Int.Ed.Engl., 62, 2023
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8JNO
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![BU of 8jno by Molmil](/molmil-images/mine/8jno) | Crystal structure of cytochrome P450 IkaD from Streptomyces sp. ZJ306, in complex with the substrate 10-epi-deOH-HSAF | 分子名称: | (1Z,3E,5S,7S,8R,9S,10S,11R,13R,15R,16S,18Z,25S)-11-ethyl-2,7-dihydroxy-10-methyl-21,26-diazapentacyclo[23.2.1.09,13.08,15.05,16]octacosa-1(2),3,18-triene-20,27,28-trione, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Zhang, Y.L, Zhang, L.P, Zhang, C.S. | 登録日 | 2023-06-06 | 公開日 | 2023-11-22 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A Mechanistic Understanding of the Distinct Regio- and Chemoselectivity of Multifunctional P450s by Structural Comparison of IkaD and CftA Complexed with Common Substrates. Angew.Chem.Int.Ed.Engl., 62, 2023
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