5HV2
| |
6KI2
| |
6KI1
| |
8JES
| Cryo-EM structure of DltB homo-tetramer | 分子名称: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, DIACYL GLYCEROL, DODECYL-BETA-D-MALTOSIDE, ... | 著者 | Zhang, P, Liu, Z. | 登録日 | 2023-05-16 | 公開日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.42 Å) | 主引用文献 | Structural insights into the transporting and catalyzing mechanism of DltB in LTA D-alanylation. Nat Commun, 15, 2024
|
|
8JF2
| Cryo-EM structure of tetrameric DltB/DltC complex | 分子名称: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, D-alanyl carrier protein, DIACYL GLYCEROL, ... | 著者 | Zhang, P, Liu, Z. | 登録日 | 2023-05-17 | 公開日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural insights into the transporting and catalyzing mechanism of DltB in LTA D-alanylation. Nat Commun, 15, 2024
|
|
8JEM
| DltB tetramer in complex with inhibitor m-AMSA | 分子名称: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, DIACYL GLYCEROL, DODECYL-BETA-D-MALTOSIDE, ... | 著者 | Zhang, P, Liu, Z. | 登録日 | 2023-05-16 | 公開日 | 2024-05-15 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | 主引用文献 | Structural insights into the transporting and catalyzing mechanism of DltB in LTA D-alanylation. Nat Commun, 15, 2024
|
|
8KGC
| |
3P5N
| |
3EPC
| CryoEM structure of poliovirus receptor bound to poliovirus type 1 | 分子名称: | MYRISTIC ACID, Poliovirus receptor, Protein VP1, ... | 著者 | Zhang, P, Mueller, S, Morais, M.C, Bator, C.M, Bowman, V.D, Hafenstein, S, Wimmer, E, Rossmann, M.G. | 登録日 | 2008-09-29 | 公開日 | 2008-11-11 | 最終更新日 | 2024-04-17 | 実験手法 | ELECTRON MICROSCOPY (8 Å) | 主引用文献 | Crystal structure of CD155 and electron microscopic studies of its complexes with polioviruses. Proc.Natl.Acad.Sci.USA, 105, 2008
|
|
3EPF
| CryoEM structure of poliovirus receptor bound to poliovirus type 2 | 分子名称: | 1[2-CHLORO-4-METHOXY-PHENYL-OXYMETHYL]-4-[2,6-DICHLORO-PHENYL-OXYMETHYL]-BENZENE, MYRISTIC ACID, Poliovirus receptor, ... | 著者 | Zhang, P, Mueller, S, Morais, M.C, Bator, C.M, Bowman, V.D, Hafenstein, S, Wimmer, E, Rossmann, M.G. | 登録日 | 2008-09-29 | 公開日 | 2008-11-11 | 最終更新日 | 2024-04-17 | 実験手法 | ELECTRON MICROSCOPY (9 Å) | 主引用文献 | Crystal structure of CD155 and electron microscopic studies of its complexes with polioviruses. Proc.Natl.Acad.Sci.USA, 105, 2008
|
|
3EPD
| CryoEM structure of poliovirus receptor bound to poliovirus type 3 | 分子名称: | MYRISTIC ACID, Poliovirus Type3 peptide, Poliovirus receptor, ... | 著者 | Zhang, P, Mueller, S, Morais, M.C, Bator, C.M, Bowman, V.D, Hafenstein, S, Wimmer, E, Rossmann, M.G. | 登録日 | 2008-09-29 | 公開日 | 2008-11-11 | 最終更新日 | 2024-04-17 | 実験手法 | ELECTRON MICROSCOPY (9 Å) | 主引用文献 | Crystal structure of CD155 and electron microscopic studies of its complexes with polioviruses. Proc.Natl.Acad.Sci.USA, 105, 2008
|
|
4PO2
| Crystal Structure of the Stress-Inducible Human Heat Shock Protein HSP70 Substrate-Binding Domain in Complex with Peptide Substrate | 分子名称: | HSP70 substrate peptide, Heat shock 70 kDa protein 1A/1B, PHOSPHATE ION, ... | 著者 | Zhang, P, Leu, J.I, Murphy, M.E, George, D.L, Marmorstein, R. | 登録日 | 2014-02-24 | 公開日 | 2014-08-20 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with Peptide substrate. Plos One, 9, 2014
|
|
4GJH
| Crystal Structure of the TRAF domain of TRAF5 | 分子名称: | TNF receptor-associated factor 5 | 著者 | Zhang, P, Reichardt, A, Liang, H, Wang, Y, Cheng, D, Aliyari, R, Cheng, G, Liu, Y. | 登録日 | 2012-08-09 | 公開日 | 2012-11-28 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.805 Å) | 主引用文献 | Single Amino Acid Substitutions Confer the Antiviral Activity of the TRAF3 Adaptor Protein onto TRAF5 Sci.Signal., 5, 2012
|
|
4GHU
| Crystal structure of TRAF3/Cardif | 分子名称: | Mitochondrial antiviral-signaling protein, TNF receptor-associated factor 3 | 著者 | Zhang, P. | 登録日 | 2012-08-08 | 公開日 | 2012-11-28 | 実験手法 | X-RAY DIFFRACTION (2.199 Å) | 主引用文献 | Single Amino Acid Substitutions Confer the Antiviral Activity of the TRAF3 Adaptor Protein onto TRAF5 Sci.Signal., 5, 2012
|
|
2F5J
| |
3TNQ
| Structure and Allostery of the PKA RIIb Tetrameric Holoenzyme | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Protein kinase, ... | 著者 | Zhang, P, Smith-Nguyen, E.V, Keshwani, M.M, Deal, M.S, Kornev, A.P, Taylor, S.S. | 登録日 | 2011-09-01 | 公開日 | 2012-02-01 | 最終更新日 | 2012-09-26 | 実験手法 | X-RAY DIFFRACTION (3.097 Å) | 主引用文献 | Structure and allostery of the PKA RIIbeta tetrameric holoenzyme Science, 335, 2012
|
|
3TNP
| Structure and Allostery of the PKA RIIb Tetrameric Holoenzyme | 分子名称: | cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase type II-beta regulatory subunit | 著者 | Zhang, P, Smith-Nguyen, E.V, Keshwani, M.M, Deal, M.S, Kornev, A.P, Taylor, S.S. | 登録日 | 2011-09-01 | 公開日 | 2012-02-01 | 最終更新日 | 2013-02-27 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure and allostery of the PKA RIIbeta tetrameric holoenzyme Science, 335, 2012
|
|
2F5K
| |
7FHA
| Crystal structure of the ATP sulfurylase domain of human PAPSS2 in complex with APS | 分子名称: | ADENOSINE-5'-PHOSPHOSULFATE, Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2, POTASSIUM ION, ... | 著者 | Zhang, P, Zhang, L, Zhang, L. | 登録日 | 2021-07-29 | 公開日 | 2021-12-01 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis for the substrate recognition mechanism of ATP-sulfurylase domain of human PAPS synthase 2. Biochem.Biophys.Res.Commun., 586, 2022
|
|
7FH3
| |
7V1A
| Stapled TBS peptide from RIAM bound to talin R7R8 domains | 分子名称: | 1,2-ETHANEDIOL, ASP-ILE-ASP-GLN-MET-PHE-SER-THR-LEU-LEU-GLY-GLU-MK8-ASP-LEU-LEU-MK8-GLN-SER, Talin-1 | 著者 | Zhang, P, Gao, T, Wu, J. | 登録日 | 2022-05-11 | 公開日 | 2023-06-14 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.845 Å) | 主引用文献 | Inhibition of talin-induced integrin activation by a double-hit stapled peptide. Structure, 31, 2023
|
|
8B56
| Crystal structure of SARS-CoV-2 main protease (MPro) in complex with the inhibitor GD-9 | 分子名称: | (2~{S})-4-(2-chloranylethanoyl)-1-(3,4-dichlorophenyl)-~{N}-(thiophen-2-ylmethyl)piperazine-2-carboxamide, 3C-like proteinase nsp5, BROMIDE ION, ... | 著者 | Straeter, N, Muller, C.E, Claff, T, Sylvester, K, Weisse, R, Gao, S, Song, L, Liu, X, Zhan, P. | 登録日 | 2022-09-21 | 公開日 | 2023-08-09 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.823 Å) | 主引用文献 | Discovery and Crystallographic Studies of Nonpeptidic Piperazine Derivatives as Covalent SARS-CoV-2 Main Protease Inhibitors. J.Med.Chem., 65, 2022
|
|
8Q71
| Crystal structure of SARS-CoV-2 main protease (MPro) in complex with the inhibitor GC-67 | 分子名称: | (2~{S})-1-(3,4-dichlorophenyl)-4-(4-methoxypyridin-3-yl)carbonyl-~{N}-(thiophen-2-ylmethyl)piperazine-2-carboxamide, 3C-like proteinase nsp5 | 著者 | Strater, N, Muller, C.E, Sylvester, K, Weisse, R.H, Useini, A, Gao, S, Song, L, Liu, Z, Zhan, P. | 登録日 | 2023-08-15 | 公開日 | 2023-12-06 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.322 Å) | 主引用文献 | Design, Synthesis, and Biological Evaluation of Trisubstituted Piperazine Derivatives as Noncovalent Severe Acute Respiratory Syndrome Coronavirus 2 Main Protease Inhibitors with Improved Antiviral Activity and Favorable Druggability. J.Med.Chem., 66, 2023
|
|
7QHE
| Human Butyrylcholinesterase in complex with (S)-1-(4-((naphthalen-1-yl)carbamoyl)benzyl)-N-(3-((1,2,3,4-tetrahydroacridin-9-yl)amino)propyl)piperidine-3-carboxamide | 分子名称: | (3~{S})-1-[[4-(naphthalen-1-ylcarbamoyl)phenyl]methyl]-~{N}-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]piperidine-3-carboxamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Brazzolotto, X, Jing, L, Zhan, P, Liu, X, Nachon, F. | 登録日 | 2021-12-12 | 公開日 | 2022-12-21 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | 主引用文献 | Rapid discovery and crystallography study of highly potent and selective butylcholinesterase inhibitors based on oxime-containing libraries and conformational restriction strategies. Bioorg.Chem., 134, 2023
|
|
7QHD
| Human Butyrylcholinesterase in complex with (S)-1-(4-((2-(1H-indol-3-yl)ethyl)carbamoyl)benzyl)-N-(3-((1,2,3,4-tetrahydroacridin-9-yl)amino)propyl)piperidine-3-carboxamide | 分子名称: | (3~{S})-1-[[4-[2-(1~{H}-indol-3-yl)ethylcarbamoyl]phenyl]methyl]-~{N}-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]piperidine-3-carboxamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Brazzolotto, X, Jing, L, Zhan, P, Liu, X, Nachon, F. | 登録日 | 2021-12-12 | 公開日 | 2022-12-21 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Rapid discovery and crystallography study of highly potent and selective butylcholinesterase inhibitors based on oxime-containing libraries and conformational restriction strategies. Bioorg.Chem., 134, 2023
|
|