1LWV
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![BU of 1lwv by Molmil](/molmil-images/mine/1lwv) | Borohydride-trapped hOgg1 Intermediate Structure Co-Crystallized with 8-aminoguanine | Descriptor: | 5'-D(*GP*CP*GP*TP*CP*CP*AP*(PED)P*GP*TP*CP*TP*AP*CP*C)-3', 5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 8-AMINOGUANINE, ... | Authors: | Fromme, J.C, Bruner, S.D, Yang, W, Karplus, M, Verdine, G.L. | Deposit date: | 2002-06-03 | Release date: | 2003-02-25 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Product-Assisted Catalysis in Base Excision DNA Repair Nat.Struct.Biol., 10, 2003
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1LWY
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![BU of 1lwy by Molmil](/molmil-images/mine/1lwy) | hOgg1 Borohydride-Trapped Intermediate without 8-oxoguanine | Descriptor: | 5'-D(*GP*CP*GP*TP*CP*CP*AP*(PED)P*GP*TP*CP*TP*AP*CP*C)-3', 5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 8-OXOGUANINE DNA GLYCOSYLASE | Authors: | Fromme, J.C, Bruner, S.D, Yang, W, Karplus, M, Verdine, G.L. | Deposit date: | 2002-06-03 | Release date: | 2003-02-25 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Product-Assisted Catalysis in Base Excision DNA Repair Nat.Struct.Biol., 10, 2003
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1HU0
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![BU of 1hu0 by Molmil](/molmil-images/mine/1hu0) | CRYSTAL STRUCTURE OF AN HOGG1-DNA BOROHYDRIDE TRAPPED INTERMEDIATE COMPLEX | Descriptor: | 5'-D(*GP*CP*GP*TP*CP*CP*AP*(PED)P*GP*TP*CP*TP*AP*CP*C)-3', 5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 8-OXOGUANINE, ... | Authors: | Fromme, J.C, Bruner, S.D, Yang, W, Karplus, M, Verdine, G.L. | Deposit date: | 2001-01-03 | Release date: | 2003-02-25 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Product-Assisted Catalysis in base-excision DNA Repair Nat.Struct.Biol., 10, 2003
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3CDJ
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![BU of 3cdj by Molmil](/molmil-images/mine/3cdj) | Crystal structure of the E. coli KH/S1 domain truncated PNPase | Descriptor: | Polynucleotide phosphorylase | Authors: | Shi, Z, Yang, W.Z, Lin-Chao, S, Chak, K.F, Yuan, H.S. | Deposit date: | 2008-02-27 | Release date: | 2008-12-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of Escherichia coli PNPase: central channel residues are involved in processive RNA degradation. Rna, 14, 2008
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3CDI
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![BU of 3cdi by Molmil](/molmil-images/mine/3cdi) | Crystal structure of E. coli PNPase | Descriptor: | Polynucleotide phosphorylase | Authors: | Shi, Z, Yang, W.Z, Lin-Chao, S, Chak, K.F, Yuan, H.S. | Deposit date: | 2008-02-27 | Release date: | 2008-12-09 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of Escherichia coli PNPase: central channel residues are involved in processive RNA degradation. Rna, 14, 2008
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3LWO
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![BU of 3lwo by Molmil](/molmil-images/mine/3lwo) | Structure of H/ACA RNP bound to a substrate RNA containing 5BrU | Descriptor: | 5'-R(*GP*AP*GP*CP*GP*(5BU)P*GP*CP*GP*GP*UP*UP*U)-3', 50S ribosomal protein L7Ae, H/ACA RNA, ... | Authors: | Zhou, J, Liang, B, Lv, C, Yang, W, Li, H. | Deposit date: | 2010-02-24 | Release date: | 2010-07-14 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.855 Å) | Cite: | Glycosidic bond conformation preference plays a pivotal role in catalysis of RNA pseudouridylation: a combined simulation and structural study. J.Mol.Biol., 401, 2010
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3LWP
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![BU of 3lwp by Molmil](/molmil-images/mine/3lwp) | Structure of H/ACA RNP bound to a substrate RNA containing 5BrdU | Descriptor: | 5'-R(*GP*AP*GP*CP*GP*(BRU)P*GP*CP*GP*GP*UP*UP*U)-3, 50S ribosomal protein L7Ae, H/ACA RNA, ... | Authors: | Zhou, J, Liang, B, Lv, C, Yang, W, Li, H. | Deposit date: | 2010-02-24 | Release date: | 2010-07-14 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Glycosidic bond conformation preference plays a pivotal role in catalysis of RNA pseudouridylation: a combined simulation and structural study. J.Mol.Biol., 401, 2010
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3BSU
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![BU of 3bsu by Molmil](/molmil-images/mine/3bsu) | Hybrid-binding domain of human RNase H1 in complex with 12-mer RNA/DNA | Descriptor: | DNA (5'-D(*DGP*DAP*DAP*DTP*DCP*DAP*DGP*DGP*(5IU)P*DGP*DTP*DC)-3'), MAGNESIUM ION, RNA (5'-R(*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*C)-3'), ... | Authors: | Nowotny, M, Cerritelli, S.M, Ghirlando, R, Gaidamakov, S.A, Crouch, R.J, Yang, W. | Deposit date: | 2007-12-26 | Release date: | 2008-03-25 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Specific recognition of RNA/DNA hybrid and enhancement of human RNase H1 activity by HBD. Embo J., 27, 2008
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1NHH
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![BU of 1nhh by Molmil](/molmil-images/mine/1nhh) | Crystal structure of N-terminal 40KD MutL protein (LN40) complex with ADPnP and one Rubidium | Descriptor: | 1,2-ETHANEDIOL, DNA mismatch repair protein mutL, MAGNESIUM ION, ... | Authors: | Hu, X, Machius, M, Yang, W. | Deposit date: | 2002-12-19 | Release date: | 2003-06-10 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Monovalent cation dependence and preference of GHKL ATPases and kinases FEBS Lett., 544, 2003
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1NHJ
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![BU of 1nhj by Molmil](/molmil-images/mine/1nhj) | Crystal structure of N-terminal 40KD MutL/A100P mutant protein complex with ADPnP and one sodium | Descriptor: | DNA mismatch repair protein mutL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Hu, X, Machius, M, Yang, W. | Deposit date: | 2002-12-19 | Release date: | 2003-06-10 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Monovalent cation dependence and preference of GHKL ATPases and kinases FEBS Lett., 544, 2003
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4XVL
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![BU of 4xvl by Molmil](/molmil-images/mine/4xvl) | Binary complex of human polymerase nu and DNA with the finger domain open | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DNA (5'-D(*GP*AP*TP*CP*TP*GP*AP*CP*GP*CP*TP*AP*CP*G)-3'), DNA (5'-D(*TP*CP*GP*TP*AP*GP*CP*GP*TP*CP*A)-3'), ... | Authors: | Lee, Y.-S, Yang, W. | Deposit date: | 2015-01-27 | Release date: | 2015-03-11 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.301 Å) | Cite: | How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis. Nat.Struct.Mol.Biol., 22, 2015
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1FU1
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![BU of 1fu1 by Molmil](/molmil-images/mine/1fu1) | CRYSTAL STRUCTURE OF HUMAN XRCC4 | Descriptor: | ACETIC ACID, DNA REPAIR PROTEIN XRCC4 | Authors: | Junop, M, Modesti, M, Guarne, A, Gellert, M, Yang, W. | Deposit date: | 2000-09-13 | Release date: | 2000-12-11 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of the Xrcc4 DNA repair protein and implications for end joining. EMBO J., 19, 2000
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2YOJ
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![BU of 2yoj by Molmil](/molmil-images/mine/2yoj) | HCV NS5B polymerase complexed with pyridonylindole compound | Descriptor: | 4-fluoranyl-6-[(7-fluoranyl-4-oxidanylidene-3H-quinazolin-6-yl)methyl]-8-(2-oxidanylidene-1H-pyridin-3-yl)furo[2,3-e]indole-7-carboxylic acid, PHOSPHATE ION, RNA-DIRECTED RNA POLYMERASE | Authors: | Chen, K.X, Venkatraman, S, Anilkumar, G.N, Zeng, Q, Lesburg, C.A, Vibulbhan, B, Yang, W, Velazquez, F, Chan, T.-Y, Bennett, F, Sannigrahi, M, Jiang, Y, Duca, J.S, Pinto, P, Gavalas, S, Huang, Y, Wu, W, Selyutin, O, Agrawal, S, Feld, B, Huang, H.-C, Li, C, Cheng, K.-C, Shih, N.-Y, Kozlowski, J.A, Rosenblum, S.B, Njoroge, F.G. | Deposit date: | 2012-10-24 | Release date: | 2013-10-09 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Discovery of Sch 900188: A Potent Hepatitis C Virus Ns5B Polymerase Inhibitor Prodrug as a Development Candidate Acs Med.Chem.Lett., 5, 2014
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1FW6
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![BU of 1fw6 by Molmil](/molmil-images/mine/1fw6) | CRYSTAL STRUCTURE OF A TAQ MUTS-DNA-ADP TERNARY COMPLEX | Descriptor: | 5'-D(*GP*CP*GP*AP*CP*GP*CP*TP*AP*GP*CP*GP*TP*GP*CP*GP*GP*CP*TP*CP*GP*TP*C)-3', 5'-D(*GP*GP*AP*CP*GP*AP*GP*CP*CP*GP*CP*CP*GP*CP*TP*AP*GP*CP*GP*TP*CP*G)-3', ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Junop, M.S, Obmolova, G, Rausch, K, Hsieh, P, Yang, W. | Deposit date: | 2000-09-21 | Release date: | 2001-02-19 | Last modified: | 2018-01-31 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Composite active site of an ABC ATPase: MutS uses ATP to verify mismatch recognition and authorize DNA repair. Mol.Cell, 7, 2001
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3REZ
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![BU of 3rez by Molmil](/molmil-images/mine/3rez) | glycoprotein GPIb variant | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, Platelet glycoprotein Ib beta chain, ... | Authors: | McEwan, P.A, Yang, W, Carr, K.H, Mo, X, Zheng, X, Li, R, Emsley, J. | Deposit date: | 2011-04-05 | Release date: | 2012-02-15 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Quaternary organization of GPIb-IX complex and insights into Bernard-Soulier syndrome revealed by the structures of GPIb beta and a GPIb beta/GPIX chimera Blood, 118, 2011
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1EA6
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![BU of 1ea6 by Molmil](/molmil-images/mine/1ea6) | |
1ETQ
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![BU of 1etq by Molmil](/molmil-images/mine/1etq) | |
4BAC
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![BU of 4bac by Molmil](/molmil-images/mine/4bac) | prototype foamy virus strand transfer complexes on product DNA | Descriptor: | 5'-D(*AP*GP*GP*AP*GP*CP*CP*AP*AP*GP*AP*CP*GP*GP *AP*TP*CP)-3', 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP *TP*TP*GP*TP*AP)-3', DNA (38-MER), ... | Authors: | Yin, Z, Lapkouski, M, Yang, W, Craigie, R. | Deposit date: | 2012-09-12 | Release date: | 2012-10-10 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.263 Å) | Cite: | Assembly of Prototype Foamy Virus Strand Transfer Complexes on Product DNA Bypassing Catalysis of Integration. Protein Sci., 21, 2012
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7M7R
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![BU of 7m7r by Molmil](/molmil-images/mine/7m7r) | Human DNA Pol eta S113A with rA-ended primer and dAMPNPP | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*CP*AP*TP*TP*TP*TP*GP*AP*CP*GP*CP*T)-3'), DNA polymerase eta, ... | Authors: | Gregory, M.T, Gao, Y, Yang, W. | Deposit date: | 2021-03-28 | Release date: | 2021-06-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction. Proc.Natl.Acad.Sci.USA, 118, 2021
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7M87
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![BU of 7m87 by Molmil](/molmil-images/mine/7m87) | Human DNA Pol eta S113A with dA-ended primer and dATP: in crystallo reaction for 230 s | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ... | Authors: | Gregory, M.T, Gao, Y, Yang, W. | Deposit date: | 2021-03-29 | Release date: | 2021-06-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction. Proc.Natl.Acad.Sci.USA, 118, 2021
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7M85
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![BU of 7m85 by Molmil](/molmil-images/mine/7m85) | Human DNA Pol eta S113A with dA-ended primer and dATP: in crystallo reaction for 80 s | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*A)-3'), ... | Authors: | Gregory, M.T, Gao, Y, Yang, W. | Deposit date: | 2021-03-29 | Release date: | 2021-06-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction. Proc.Natl.Acad.Sci.USA, 118, 2021
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7M88
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![BU of 7m88 by Molmil](/molmil-images/mine/7m88) | Human DNA Pol eta S113A with dA-ended primer and dATP: in crystallo reaction for 300 s | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ... | Authors: | Gregory, M.T, Gao, Y, Yang, W. | Deposit date: | 2021-03-29 | Release date: | 2021-06-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction. Proc.Natl.Acad.Sci.USA, 118, 2021
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7M7S
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![BU of 7m7s by Molmil](/molmil-images/mine/7m7s) | Human DNA Pol eta S113A with dT-ended primer and 0.1 mM dAMPNPP | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*TP*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... | Authors: | Gregory, M.T, Gao, Y, Yang, W. | Deposit date: | 2021-03-28 | Release date: | 2021-06-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction. Proc.Natl.Acad.Sci.USA, 118, 2021
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7M89
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![BU of 7m89 by Molmil](/molmil-images/mine/7m89) | Human DNA Pol eta S113A with rA-ended primer and dATP: in crystallo reaction for 0 s | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*CP*AP*TP*TP*TP*TP*GP*AP*CP*GP*CP*T)-3'), ... | Authors: | Gregory, M.T, Gao, Y, Yang, W. | Deposit date: | 2021-03-29 | Release date: | 2021-06-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction. Proc.Natl.Acad.Sci.USA, 118, 2021
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7M7Q
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![BU of 7m7q by Molmil](/molmil-images/mine/7m7q) | Human DNA Pol eta S113A with dT-ended primer and dAMPNPP | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*TP*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... | Authors: | Gregory, M.T, Gao, Y, Yang, W. | Deposit date: | 2021-03-28 | Release date: | 2021-06-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction. Proc.Natl.Acad.Sci.USA, 118, 2021
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