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PDB: 50 件

6MBT
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BU of 6mbt by Molmil
Crystal structure of wild-type KRAS bound to GDP and Mg (Space group C2)
分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
著者Dharmaiah, S, Tran, T.H, Yan, W, Simanshu, D.K.
登録日2018-08-30
公開日2019-07-31
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Structures of N-terminally processed KRAS provide insight into the role of N-acetylation.
Sci Rep, 9, 2019
6M9W
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BU of 6m9w by Molmil
Structure of Mg-free KRAS4b (2-169) bound to GDP with the switch-I in fully open conformation
分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE
著者Dharmaiah, S, Tran, T.H, Yan, W, Simanshu, D.K.
登録日2018-08-24
公開日2019-07-31
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structures of N-terminally processed KRAS provide insight into the role of N-acetylation.
Sci Rep, 9, 2019
6NZS
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BU of 6nzs by Molmil
Dextranase AoDex KQ11
分子名称: Dextranase
著者Ren, W, Yan, W, Gu, L, Feng, Y, Dong, D, Wang, S, Wang, C, Lyu, M.
登録日2019-02-14
公開日2019-02-27
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Crystal structure of thermophilic dextranase from Thermoanaerobacter pseudethanolicus
To Be Published
6MBU
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BU of 6mbu by Molmil
Crystal structure of wild-type KRAS (1-169) bound to GDP and Mg (Space group P3)
分子名称: GLYCEROL, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
著者Dharmaiah, S, Tran, T.H, Yan, W, Simanshu, D.K.
登録日2018-08-30
公開日2019-07-31
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Structures of N-terminally processed KRAS provide insight into the role of N-acetylation.
Sci Rep, 9, 2019
6BOF
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BU of 6bof by Molmil
Crystal structure of KRAS A146T-GDP demonstrating open switch 1 conformation
分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE
著者Bera, A.K, Yan, W, Westover, K.D.
登録日2017-11-20
公開日2019-05-22
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.401 Å)
主引用文献Tissue-Specific Oncogenic Activity of KRASA146T.
Cancer Discov, 9, 2019
3JU5
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BU of 3ju5 by Molmil
Crystal Structure of Dimeric Arginine Kinase at 1.75-A Resolution
分子名称: Arginine kinase, MAGNESIUM ION
著者Wu, X, Ye, S, Guo, S, Yan, W, Bartlam, M, Rao, Z.
登録日2009-09-14
公開日2009-09-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural basis for a reciprocating mechanism of negative cooperativity in dimeric phosphagen kinase activity
Faseb J., 24, 2010
8KHQ
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BU of 8khq by Molmil
Bifunctional sulfoxide synthase OvoA_Th2 in complex with histidine and cysteine
分子名称: 5-histidylcysteine sulfoxide synthase/putative 4-mercaptohistidine N1-methyltranferase, COBALT (II) ION, CYSTEINE, ...
著者Wang, J, Ye, K, Wang, X.Y, Yan, W.P.
登録日2023-08-22
公開日2023-12-06
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.69 Å)
主引用文献Biochemical and Structural Characterization of OvoA Th2 : A Mononuclear Nonheme Iron Enzyme from Hydrogenimonas thermophila for Ovothiol Biosynthesis.
Acs Catalysis, 13, 2023
3JU6
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BU of 3ju6 by Molmil
Crystal Structure of Dimeric Arginine Kinase in Complex with AMPPNP and Arginine
分子名称: ARGININE, Arginine kinase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
著者Wu, X, Ye, S, Guo, S, Yan, W, Bartlam, M, Rao, Z.
登録日2009-09-14
公開日2009-09-29
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Structural basis for a reciprocating mechanism of negative cooperativity in dimeric phosphagen kinase activity
Faseb J., 24, 2010
8SAI
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BU of 8sai by Molmil
Cryo-EM structure of GPR34-Gi complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
著者Yong, X.H, Zhao, C, Yan, W, Shao, Z.H.
登録日2023-04-01
公開日2023-10-04
実験手法ELECTRON MICROSCOPY (3.27 Å)
主引用文献Cryo-EM structures of human GPR34 enable the identification of selective antagonists.
Proc.Natl.Acad.Sci.USA, 120, 2023
3SHV
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BU of 3shv by Molmil
Crystal structure of human MCPH1 tandem BRCT domains-gamma H2AX complex
分子名称: Histone H2A.x, Microcephalin
著者Shao, Z.H, Li, F.D, Yan, W.
登録日2011-06-17
公開日2011-12-28
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Specific recognition of phosphorylated tail of H2AX by the tandem BRCT domains of MCPH1 revealed by complex structure
J.Struct.Biol., 177, 2012
8JII
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BU of 8jii by Molmil
Cryo-EM structure of compound 9n and niacin bound ketone body receptor HCAR2-Gi signaling complex
分子名称: 7-methyl-N-[(2R)-1-phenoxypropan-2-yl]-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Zhao, C, Tian, X.W, Liu, Y, Cheng, L, Yan, W, Shao, Z.H.
登録日2023-05-26
公開日2023-09-06
最終更新日2023-09-27
実験手法ELECTRON MICROSCOPY (3.17 Å)
主引用文献Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation.
Mol.Cell, 83, 2023
8JIM
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BU of 8jim by Molmil
Cryo-EM structure of MMF bound ketone body receptor HCAR2-Gi signaling complex
分子名称: (2Z)-4-methoxy-4-oxobut-2-enoic acid, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Zhao, C, Tian, X.W, Liu, Y, Cheng, L, Yan, W, Shao, Z.H.
登録日2023-05-26
公開日2023-09-06
最終更新日2023-09-27
実験手法ELECTRON MICROSCOPY (2.98 Å)
主引用文献Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation.
Mol.Cell, 83, 2023
8JHY
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BU of 8jhy by Molmil
Cryo-EM structure of compound 9n bound ketone body receptor HCAR2-Gi signaling complex
分子名称: 7-methyl-N-[(2R)-1-phenoxypropan-2-yl]-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Zhao, C, Tian, X.W, Liu, Y, Cheng, L, Yan, W, Shao, Z.H.
登録日2023-05-25
公開日2023-09-06
最終更新日2023-09-27
実験手法ELECTRON MICROSCOPY (2.87 Å)
主引用文献Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation.
Mol.Cell, 83, 2023
8JIL
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BU of 8jil by Molmil
Cryo-EM structure of niacin bound ketone body receptor HCAR2-Gi signaling complex
分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Zhao, C, Tian, X.W, Liu, Y, Cheng, L, Yan, W, Shao, Z.H.
登録日2023-05-26
公開日2023-09-06
最終更新日2023-09-27
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation.
Mol.Cell, 83, 2023
8JZ7
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BU of 8jz7 by Molmil
Cryo-EM structure of MK-6892-bound HCAR2 in complex with Gi protein
分子名称: 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Zhao, C, Tian, X.W, Liu, Y, Cheng, L, Yan, W, Shao, Z.H.
登録日2023-07-04
公開日2023-10-04
実験手法ELECTRON MICROSCOPY (2.6 Å)
主引用文献Orthosteric ligand selectivity and allosteric probe dependence at Hydroxycarboxylic acid receptor HCAR2.
Signal Transduct Target Ther, 8, 2023
3SHT
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BU of 3sht by Molmil
Crystal structure of human MCPH1 tandem BRCT domains
分子名称: Microcephalin
著者Shao, Z.H, Li, F.D, Yan, W.
登録日2011-06-17
公開日2011-12-28
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Specific recognition of phosphorylated tail of H2AX by the tandem BRCT domains of MCPH1 revealed by complex structure
J.Struct.Biol., 177, 2012
8JRL
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BU of 8jrl by Molmil
Crystal structure of P450 TleB with an indole alkaloid
分子名称: (2~{S})-~{N}-[(2~{S})-1-(4-fluoranyl-1~{H}-indol-3-yl)-3-oxidanyl-propan-2-yl]-3-methyl-2-sulfanyl-butanamide, Cytochrome P-450, PROTOPORPHYRIN IX CONTAINING FE
著者Wang, J, Yan, W.P.
登録日2023-06-17
公開日2024-04-17
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献Regulation of P450 TleB catalytic flow for the synthesis of sulfur-containing indole alkaloids by substrate structure-directed strategy. and protein engineering.
Sci China Chem, 66, 2023
7WSB
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BU of 7wsb by Molmil
The ternary complex structure of FtmOx1 with a-ketoglutarate and 13-oxo-fumitremorgin B
分子名称: 13-Oxofumitremorgin B, 2-OXOGLUTARIC ACID, COBALT (II) ION, ...
著者Wang, J, Wang, X.Y, Wang, Y.Y, Yan, W.P.
登録日2022-01-28
公開日2022-07-06
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.87 Å)
主引用文献Dissecting the Mechanism of the Nonheme Iron Endoperoxidase FtmOx1 Using Substrate Analogues.
Jacs Au, 2, 2022
7CBZ
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BU of 7cbz by Molmil
Crystal structure of T2R-TTL-A31 complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-[5-[4-[2-[4-(2-cyclopropylethanoyl)piperazin-1-yl]ethoxy]phenyl]pyridin-2-yl]-N-(phenylmethyl)ethanamide, CALCIUM ION, ...
著者Yang, J.H, Yan, W.
登録日2020-06-15
公開日2021-06-23
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.61 Å)
主引用文献Design, Synthesis, and Bioactivity Evaluation of Dual-Target Inhibitors of Tubulin and Src Kinase Guided by Crystal Structure.
J.Med.Chem., 64, 2021
7EXC
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BU of 7exc by Molmil
Crystal structure of T2R-TTL-1129A2 complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ...
著者Yang, J.H, Yan, W.
登録日2021-05-26
公開日2022-06-01
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献Structure-Based Design and Synthesis of N-Substituted 3-Amino-beta-Carboline Derivatives as Potent alpha beta-Tubulin Degradation Agents
J.Med.Chem., 65, 2022
7EMJ
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BU of 7emj by Molmil
Crystal structure of T2R-TTL-Barbigerone complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 8,8-dimethyl-3-(2,4,5-trimethoxyphenyl)pyrano[2,3-f]chromen-4-one, CALCIUM ION, ...
著者Yang, J.H, Yan, W.
登録日2021-04-14
公開日2022-04-20
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.33 Å)
主引用文献Crystal structure of T2R-TTL-barbigerone complex
To Be Published
7Y65
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BU of 7y65 by Molmil
Cryo-EM structure of C5a peptide-bound C5aR1 in complex with Gi protein
分子名称: C5a anaphylatoxin chemotactic receptor 1, C5apep peptide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H.
登録日2022-06-18
公開日2023-03-01
最終更新日2023-04-19
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Mechanism of activation and biased signaling in complement receptor C5aR1.
Cell Res., 33, 2023
7Y64
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BU of 7y64 by Molmil
Cryo-EM structure of C5a-bound C5aR1 in complex with Gi protein
分子名称: C5a anaphylatoxin, C5a anaphylatoxin chemotactic receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H.
登録日2022-06-18
公開日2023-03-01
最終更新日2023-04-19
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Mechanism of activation and biased signaling in complement receptor C5aR1.
Cell Res., 33, 2023
7Y66
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BU of 7y66 by Molmil
Cryo-EM structure of BM213-bound C5aR1 in complex with Gi protein
分子名称: BM213 peptide, C5a anaphylatoxin chemotactic receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H.
登録日2022-06-18
公開日2023-03-01
最終更新日2023-04-19
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Mechanism of activation and biased signaling in complement receptor C5aR1.
Cell Res., 33, 2023
7Y67
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BU of 7y67 by Molmil
Cryo-EM structure of C089-bound C5aR1(I116A) mutant in complex with Gi protein
分子名称: C089 peptide, C5a anaphylatoxin chemotactic receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H.
登録日2022-06-18
公開日2023-03-01
最終更新日2023-04-19
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Mechanism of activation and biased signaling in complement receptor C5aR1.
Cell Res., 33, 2023
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