PDB Search results for query - Protein Data Bank Japan

PDB: 3 results

Ortho-substituted phenyl sulfonyl fluoride and fluorosulfate as potent elastase inhibitory fragments
Descriptor:	2-(fluorosulfonyl)benzene-1-sulfonic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Wolan, D.W, Woehl, J.L, Kitamura, S.
Deposit date:	2018-07-24
Release date:	2019-07-24
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.33 Å)
Cite:	SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase. Proc.Natl.Acad.Sci.USA, 116, 2019

Co-complex of S. pyogenes 10782 streptopain bound with a nitrile-based specific covalent inhibitor
Descriptor:	NITRATE ION, Streptopain, benzyl [(2S)-1-(3-nitrophenyl)-3-oxobutan-2-yl]carbamate
Authors:	Wolan, D.W, Woehl, J.L, Kitamura, S.
Deposit date:	2019-10-04
Release date:	2020-09-09
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.589 Å)
Cite:	An Irreversible Inhibitor to Probe the Role ofStreptococcus pyogenesCysteine Protease SpeB in Evasion of Host Complement Defenses. Acs Chem.Biol., 15, 2020

Co-complex of S. pyogenes 10782 streptopain bound with a SuFEx-based optimized small molecule inhibitor
Descriptor:	Streptopain, benzyl [(1S)-2-(3-{[(4-carbamoylpiperidin-1-yl)(fluoro)oxo-lambda~6~-sulfanylidene]amino}phenyl)-1-cyanoethyl]carbamate
Authors:	Wolan, D.W, Woehl, J.L, Kitamura, S.
Deposit date:	2019-10-18
Release date:	2020-08-26
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.02 Å)
Cite:	Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry. J.Am.Chem.Soc., 142, 2020