5C9D
| Crystal structure of a retropepsin-like aspartic protease from Rickettsia conorii | Descriptor: | ApRick protease, SODIUM ION | Authors: | Li, M, Gustchina, A, Cruz, R, Simoes, M, Curto, P, Martinez, J, Faro, C, Simoes, I, Wlodawer, A. | Deposit date: | 2015-06-26 | Release date: | 2015-10-14 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Structure of RC1339/APRc from Rickettsia conorii, a retropepsin-like aspartic protease Acta Crystallogr.,Sect.D, 71, 2015
|
|
1NAG
| CREVICE-FORMING MUTANTS IN THE RIGID CORE OF BOVINE PANCREATIC TRYPSIN INHIBITOR: CRYSTAL STRUCTURES OF F22A, Y23A, N43G, AND F45A | Descriptor: | BOVINE PANCREATIC TRYPSIN INHIBITOR, PHOSPHATE ION | Authors: | Danishefsky, A.T, Wlodawer, A, Kim, K.-S, Tao, F, Woodward, C. | Deposit date: | 1992-08-18 | Release date: | 1993-10-31 | Last modified: | 2019-08-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crevice-forming mutants in the rigid core of bovine pancreatic trypsin inhibitor: crystal structures of F22A, Y23A, N43G, and F45A. Protein Sci., 2, 1993
|
|
9ARQ
| Crystal structure of SARS-CoV-2 main protease (authentic protein) in complex with an inhibitor TKB-245 | Descriptor: | (1R,2S,5S)-N-{(1S,2S)-1-(4-fluoro-1,3-benzothiazol-2-yl)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 | Authors: | Bulut, H, Hattori, S, Hayashi, H, Hasegawa, K, Li, M, Wlodawer, A, Tamamura, H, Mitsuya, H. | Deposit date: | 2024-02-23 | Release date: | 2024-04-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural and virologic mechanism of emergence of main protease inhibitor-resistance in SARS-CoV-2 as selected with main protease inhibitors To Be Published
|
|
9AVQ
| Crystal structure of SARS-CoV-2 main protease A191T mutant in complex with an inhibitor Nirmatrelvir | Descriptor: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5, DI(HYDROXYETHYL)ETHER | Authors: | Bulut, H, Hattori, S, Hayashi, H, Hasegawa, K, Li, M, Wlodawer, A, Tamamura, H, Mitsuya, H. | Deposit date: | 2024-03-04 | Release date: | 2024-04-24 | Method: | X-RAY DIFFRACTION (2.58 Å) | Cite: | Structural and virologic mechanism of emergence of main protease inhibitor-resistance in SARS-CoV-2 as selected with main protease inhibitors To Be Published
|
|
6PAC
| |
6PAA
| |
6PA6
| |
6PA9
| |
6PA2
| |
6PA4
| |
1BG8
| |
3V1Q
| |
6RIX
| Crystal structure of MchDnaB-1 intein | Descriptor: | CHLORIDE ION, Replicative DNA helicase | Authors: | Beyer, H.M, Lountos, G.T, Mikula, M.K, Wlodawer, A, Iwai, H. | Deposit date: | 2019-04-25 | Release date: | 2020-05-13 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.655 Å) | Cite: | The Convergence of the Hedgehog/Intein Fold in Different Protein Splicing Mechanisms. Int J Mol Sci, 21, 2020
|
|
2B7F
| Crystal structure of human T-cell leukemia virus protease, a novel target for anti-cancer design | Descriptor: | (ACE)APQV(STA)VMHP peptide, HTLV protease, PHOSPHATE ION | Authors: | Li, M, Laco, G.S, Jaskolski, M, Rozycki, J, Alexandratos, J, Wlodawer, A, Gustchina, A. | Deposit date: | 2005-10-04 | Release date: | 2005-12-06 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of human T cell leukemia virus protease, a novel target for anticancer drug design Proc.Natl.Acad.Sci.Usa, 102, 2005
|
|
2FMB
| EIAV PROTEASE COMPLEXED WITH AN INHIBITOR LP-130 | Descriptor: | 4-[2-(2-ACETYLAMINO-3-NAPHTALEN-1-YL-PROPIONYLAMINO)-4-METHYL-PENTANOYLAMINO]-3-HYDROXY-6-METHYL-HEPTANOIC ACID [1-(1-CARBAMOYL-2-NAPHTHALEN-1-YL-ETHYLCARBAMOYL)-PROPYL]-AMIDE, EQUINE INFECTIOUS ANEMIA VIRUS PROTEASE | Authors: | Kervinen, J, Lubkowski, J, Zdanov, A, Wlodawer, A, Gustchina, A. | Deposit date: | 1998-07-13 | Release date: | 1999-01-13 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Toward a universal inhibitor of retroviral proteases: comparative analysis of the interactions of LP-130 complexed with proteases from HIV-1, FIV, and EIAV. Protein Sci., 7, 1998
|
|
6RIY
| Crystal structure of MchDnaB-1 intein (N145AA) | Descriptor: | CHLORIDE ION, Replicative DNA helicase | Authors: | Beyer, H.M, Lountos, G.T, Mikula, M.K, Wlodawer, A, Iwai, H. | Deposit date: | 2019-04-25 | Release date: | 2020-05-13 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | The Convergence of the Hedgehog/Intein Fold in Different Protein Splicing Mechanisms. Int J Mol Sci, 21, 2020
|
|
2ANE
| Crystal structure of N-terminal domain of E.Coli Lon Protease | Descriptor: | ATP-dependent protease La | Authors: | Li, M, Rasulova, F, Melnikov, E.E, Rotanova, T.V, Gustchina, A, Maurizi, M.R, Wlodawer, A. | Deposit date: | 2005-08-11 | Release date: | 2005-11-01 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Crystal structure of the N-terminal domain of E. coli Lon protease. Protein Sci., 14, 2005
|
|
2ILK
| |
4II0
| |
4IHZ
| |
4J2K
| Crystal structure of a plant trypsin inhibitor EcTI | Descriptor: | GLYCEROL, IMIDAZOLE, Trypsin inhibitor | Authors: | Zhou, D, Wlodawer, A. | Deposit date: | 2013-02-04 | Release date: | 2013-05-08 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Crystal Structures of a Plant Trypsin Inhibitor from Enterolobium contortisiliquum (EcTI) and of Its Complex with Bovine Trypsin. Plos One, 8, 2013
|
|
4J2Y
| |
6V25
| |
6V24
| |
6V2G
| |