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PDB: 135 件
5ML4
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BU of 5ml4 by Molmil
The crystal structure of PDE6D in complex to inhibitor-7
分子名称: 4-[[[4-[(4-chlorophenyl)methyl-cyclopentyl-sulfamoyl]phenyl]sulfonyl-(piperidin-4-ylmethyl)amino]methyl]-2-(methylamino)benzoic acid, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
著者Fansa, E.K, Martin-Gago, P, waldmann, H, Wittinghofer, A.
登録日2016-12-06
公開日2017-02-01
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献A PDE6 delta-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2.
Angew. Chem. Int. Ed. Engl., 56, 2017
5ML6
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BU of 5ml6 by Molmil
The crystal structure of PDE6D in complex to inhibitor-8
分子名称: 2-azanyl-4-[[[4-[(4-chlorophenyl)methyl-cyclopentyl-sulfamoyl]phenyl]sulfonyl-(piperidin-4-ylmethyl)amino]methyl]benzoic acid, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
著者Fansa, E.K, Martin-gago, P, Waldmann, H, Wittinghofer, A.
登録日2016-12-06
公開日2017-02-01
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献A PDE6 delta-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2.
Angew. Chem. Int. Ed. Engl., 56, 2017
5ML2
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BU of 5ml2 by Molmil
The crystal structure of PDE6D in complex with inhibitor-3
分子名称: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, ~{N}1-[(4-chlorophenyl)methyl]-~{N}1-cyclopentyl-~{N}4-(phenylmethyl)benzene-1,4-disulfonamide
著者Fansa, E.K, Martin-Gago, P, Waldmann, H, Wittinghofer, A.
登録日2016-12-06
公開日2017-02-01
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献A PDE6 delta-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2.
Angew. Chem. Int. Ed. Engl., 56, 2017
4F0G
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BU of 4f0g by Molmil
Crystal Structure of the Roco4 Kinase Domain from D. discoideum
分子名称: Serine/threonine-protein kinase roco4
著者Gilsbach, B.K, Vetter, I.R, Wittinghofer, A, Kortholt, A.
登録日2012-05-04
公開日2012-06-27
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations.
Proc.Natl.Acad.Sci.USA, 109, 2012
4F0F
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BU of 4f0f by Molmil
Crystal Structure of the Roco4 Kinase Domain bound to AppCp from D. discoideum
分子名称: PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Serine/threonine-protein kinase roco4
著者Gilsbach, B.K, Vetter, I.R, Wittinghofer, A, Kortholt, A.
登録日2012-05-04
公開日2012-06-27
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations.
Proc.Natl.Acad.Sci.USA, 109, 2012
4F1O
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BU of 4f1o by Molmil
Crystal Structure of the L1180T mutant Roco4 Kinase Domain from D. discoideum bound to AppCp
分子名称: PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Serine/threonine-protein kinase roco4
著者Gilsbach, B.K, Vetter, I.R, Wittinghofer, A, Kortholt, A.
登録日2012-05-07
公開日2012-06-27
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations.
Proc.Natl.Acad.Sci.USA, 109, 2012
4F1T
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BU of 4f1t by Molmil
Crystal Structure of the Roco4 Kinase Domain from D. discoideum bound to the ROCK Inhibitor H1152
分子名称: (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE, Serine/threonine-protein kinase roco4
著者Gilsbach, B.K, Vetter, I.R, Wittinghofer, A, Kortholt, A.
登録日2012-05-07
公開日2012-06-27
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations.
Proc.Natl.Acad.Sci.USA, 109, 2012
1WER
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BU of 1wer by Molmil
RAS-GTPASE-ACTIVATING DOMAIN OF HUMAN P120GAP
分子名称: P120GAP
著者Scheffzek, K, Lautwein, A, Kabsch, W, Ahmadian, M.R, Wittinghofer, A.
登録日1996-11-20
公開日1997-12-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal structure of the GTPase-activating domain of human p120GAP and implications for the interaction with Ras.
Nature, 384, 1996
1PLK
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BU of 1plk by Molmil
CRYSTALLOGRAPHIC STUDIES ON P21H-RAS USING SYNCHROTRON LAUE METHOD: IMPROVEMENT OF CRYSTAL QUALITY AND MONITORING OF THE GTPASE REACTION AT DIFFERENT TIME POINTS
分子名称: C-H-RAS P21 PROTEIN, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
著者Scheidig, A, Sanchez-Llorente, A, Lautwein, A, Pai, E.F, Corrie, J.E.T, Reid, G.P, Wittinghofer, A, Goody, R.S.
登録日1994-03-13
公開日1994-07-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystallographic studies on p21(H-ras) using the synchrotron Laue method: improvement of crystal quality and monitoring of the GTPase reaction at different time points.
Acta Crystallogr.,Sect.D, 50, 1994
1RVD
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BU of 1rvd by Molmil
H-RAS COMPLEXED WITH DIAMINOBENZOPHENONE-BETA,GAMMA-IMIDO-GTP
分子名称: 3-AMINOBENZOPHENONE-4-YL-AMINOHYDROXYPHOSPHINYLAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION, TRANSFORMING PROTEIN P21/H-RAS-1
著者Ahmadian, M.R, Zor, T, Vogt, D, Kabsch, W, Selinger, Z, Wittinghofer, A, Scheffzek, K.
登録日1999-05-03
公開日1999-05-28
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Guanosine triphosphatase stimulation of oncogenic Ras mutants.
Proc.Natl.Acad.Sci.USA, 96, 1999
1Z2C
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BU of 1z2c by Molmil
Crystal structure of mDIA1 GBD-FH3 in complex with RhoC-GMPPNP
分子名称: Diaphanous protein homolog 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Rose, R, Weyand, M, Lammers, M, Ishizaki, T, Ahmadian, M.R, Wittinghofer, A.
登録日2005-03-08
公開日2005-05-10
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural and mechanistic insights into the interaction between Rho and mammalian Dia.
Nature, 435, 2005
1PLJ
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BU of 1plj by Molmil
CRYSTALLOGRAPHIC STUDIES ON P21H-RAS USING SYNCHROTRON LAUE METHOD: IMPROVEMENT OF CRYSTAL QUALITY AND MONITORING OF THE GTPASE REACTION AT DIFFERENT TIME POINTS
分子名称: C-H-RAS P21 PROTEIN, GUANOSINE 5'-TRIPHOSPHATE P3-[1-(2-NITROPHENYL)ETHYL ESTER], MAGNESIUM ION
著者Scheidig, A, Sanchez-Llorente, A, Lautwein, A, Pai, E.F, Corrie, J.E.T, Reid, G.P, Wittinghofer, A, Goody, R.S.
登録日1994-03-13
公開日1994-07-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystallographic studies on p21(H-ras) using the synchrotron Laue method: improvement of crystal quality and monitoring of the GTPase reaction at different time points.
Acta Crystallogr.,Sect.D, 50, 1994
1PLL
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BU of 1pll by Molmil
CRYSTALLOGRAPHIC STUDIES ON P21H-RAS USING SYNCHROTRON LAUE METHOD: IMPROVEMENT OF CRYSTAL QUALITY AND MONITORING OF THE GTPASE REACTION AT DIFFERENT TIME POINTS
分子名称: C-H-RAS P21 PROTEIN, GUANOSINE-5'-DIPHOSPHATE
著者Scheidig, A, Sanchez-Llorente, A, Lautwein, A, Pai, E.F, Corrie, J.E.T, Reid, G.P, Wittinghofer, A, Goody, R.S.
登録日1994-03-13
公開日1994-07-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystallographic studies on p21(H-ras) using the synchrotron Laue method: improvement of crystal quality and monitoring of the GTPase reaction at different time points.
Acta Crystallogr.,Sect.D, 50, 1994
221P
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BU of 221p by Molmil
THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES
分子名称: H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
著者Krengel, U, Scherer, A, Kabsch, W, Wittinghofer, A, Pai, E.F.
登録日1991-06-06
公開日1994-01-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules.
Cell(Cambridge,Mass.), 62, 1990
2O98
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BU of 2o98 by Molmil
Structure of the 14-3-3 / H+-ATPase plant complex
分子名称: 14-3-3-like protein C, FUSICOCCIN, Plasma membrane H+ ATPase, ...
著者Ottmann, C, Weyand, M, Wittinghofer, A, Oecking, C.
登録日2006-12-13
公開日2007-04-03
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structure of a 14-3-3 coordinated hexamer of the plant plasma membrane H+ -ATPase by combining X-ray crystallography and electron cryomicroscopy
Mol.Cell, 25, 2007
2O02
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BU of 2o02 by Molmil
Phosphorylation independent interactions between 14-3-3 and Exoenzyme S: from structure to pathogenesis
分子名称: 14-3-3 protein zeta/delta, BENZOIC ACID, ExoS (416-430) peptide
著者Ottmann, C, Yasmin, L, Weyand, M, Hauser, A.R, Wittinghofer, A, Hallberg, B.
登録日2006-11-27
公開日2007-11-27
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Phosphorylation-independent interaction between 14-3-3 and exoenzyme S: from structure to pathogenesis
Embo J., 26, 2007
2HF9
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BU of 2hf9 by Molmil
Crystal structure of HypB from Methanocaldococcus jannaschii in the triphosphate form
分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, Probable hydrogenase nickel incorporation protein hypB, ...
著者Gasper, R, Scrima, A, Wittinghofer, A.
登録日2006-06-23
公開日2006-07-04
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural insights into HypB, a GTP-binding protein that regulates metal binding.
J.Biol.Chem., 281, 2006
2GJ8
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BU of 2gj8 by Molmil
Structure of the MnmE G-domain in complex with GDP*AlF4-, Mg2+ and K+
分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, POTASSIUM ION, ...
著者Scrima, A, Wittinghofer, A.
登録日2006-03-30
公開日2006-07-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Dimerisation-dependent GTPase reaction of MnmE: how potassium acts as GTPase-activating element.
Embo J., 25, 2006
2GJA
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Structure of the MnmE G-domain in complex with GDP*AlF4-, Mg2+ and NH4+
分子名称: AMMONIUM ION, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Scrima, A, Wittinghofer, A.
登録日2006-03-30
公開日2006-07-04
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Dimerisation-dependent GTPase reaction of MnmE: how potassium acts as GTPase-activating element.
Embo J., 25, 2006
2GJ9
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BU of 2gj9 by Molmil
Structure of the MnmE G-domain in complex with GDP*AlF4-, Mg2+ and Rb+
分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, RUBIDIUM ION, ...
著者Scrima, A, Wittinghofer, A.
登録日2006-03-30
公開日2006-07-04
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Dimerisation-dependent GTPase reaction of MnmE: how potassium acts as GTPase-activating element.
Embo J., 25, 2006
2HF8
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BU of 2hf8 by Molmil
Crystal structure of HypB from Methanocaldococcus jannaschii in the triphosphate form, in complex with zinc
分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, Probable hydrogenase nickel incorporation protein hypB, ...
著者Gasper, R, Scrima, A, Wittinghofer, A.
登録日2006-06-23
公開日2006-07-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural insights into HypB, a GTP-binding protein that regulates metal binding.
J.Biol.Chem., 281, 2006
2BYV
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BU of 2byv by Molmil
Structure of the cAMP responsive exchange factor Epac2 in its auto- inhibited state
分子名称: RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 4
著者Rehmann, H, Wittinghofer, A, Bos, J.L.
登録日2005-08-08
公開日2006-02-02
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structure of the Cyclic-AMP Responsive Exchange Factor Epac2 in its Auto-Inhibited State
Nature, 439, 2006
1CLU
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BU of 1clu by Molmil
H-RAS COMPLEXED WITH DIAMINOBENZOPHENONE-BETA,GAMMA-IMIDO-GTP
分子名称: 3-AMINOBENZOPHENONE-4-YL-AMINOHYDROXYPHOSPHINYLAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION, TRANSFORMING PROTEIN P21/H-RAS-1
著者Ahmadian, M.R, Zor, T, Vogt, D, Kabsch, W, Selinger, Z, Wittinghofer, A, Scheffzek, K.
登録日1999-05-03
公開日1999-05-28
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Guanosine triphosphatase stimulation of oncogenic Ras mutants.
Proc.Natl.Acad.Sci.USA, 96, 1999
1RLF
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BU of 1rlf by Molmil
STRUCTURE DETERMINATION OF THE RAS-BINDING DOMAIN OF THE RAL-SPECIFIC GUANINE NUCLEOTIDE EXCHANGE FACTOR RLF, NMR, 10 STRUCTURES
分子名称: RLF
著者Esser, D, Bauer, B, Wolthuis, R.M.F, Wittinghofer, A, Cool, R.H, Bay, P.
登録日1998-07-09
公開日1999-02-16
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Structure determination of the Ras-binding domain of the Ral-specific guanine nucleotide exchange factor Rlf.
Biochemistry, 37, 1998
1GNQ
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BU of 1gnq by Molmil
X-RAY CRYSTAL STRUCTURE ANALYSIS OF THE CATALYTIC DOMAIN OF THE ONCOGENE PRODUCT P21H-RAS COMPLEXED WITH CAGED GTP AND MANT DGPPNHP
分子名称: C-H-RAS P21 PROTEIN, GUANOSINE 5'-TRIPHOSPHATE P3-[1-(2-NITROPHENYL)ETHYL ESTER], MAGNESIUM ION
著者Scheidig, A, Franken, S.M, Corrie, J.E.T, Reid, G.P, Wittinghofer, A, Pai, E.F, Goody, R.S.
登録日1995-05-11
公開日1995-07-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and mant dGppNHp.
J.Mol.Biol., 253, 1995

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