5KAO
 
 | | Crystal structure of wild type HIV-1 protease in complex with GRL-10413 | | Descriptor: | [(3~{a}~{S},4~{R},6~{a}~{R})-2,3,3~{a},4,5,6~{a}-hexahydrofuro[2,3-b]furan-4-yl] ~{N}-[(2~{S},3~{R})-1-(3-chloranyl-4-methoxy-phenyl)-4-[(4-methoxyphenyl)sulfonyl-(2-methylpropyl)amino]-3-oxidanyl-butan-2-yl]carbamate, protease | | Authors: | Yedidi, R.S, Delino, N.S, Das, D, Kaufman, J.D, Wingfield, P.T, Ghosh, A.K, Mitsuya, H. | | Deposit date: | 2016-06-01 | | Release date: | 2016-08-31 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | A Modified P1 Moiety Enhances In Vitro Antiviral Activity against Various Multidrug-Resistant HIV-1 Variants and In Vitro Central Nervous System Penetration Properties of a Novel Nonpeptidic Protease Inhibitor, GRL-10413.
Antimicrob.Agents Chemother., 60, 2016
|
|
2ARI
 | | Solution structure of micelle-bound fusion domain of HIV-1 gp41 | | Descriptor: | Envelope polyprotein GP160 | | Authors: | Jaroniec, C.P, Kaufman, J.D, Stahl, S.J, Viard, M, Blumenthal, R, Wingfield, P.T, Bax, A. | | Deposit date: | 2005-08-19 | | Release date: | 2005-12-20 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Structure and Dynamics of Micelle-Associated Human Immunodeficiency Virus gp41 Fusion Domain.
Biochemistry, 44, 2005
|
|
1BVG
 | | HIV-1 PROTEASE-DMP323 COMPLEX IN SOLUTION, NMR MINIMIZED AVERAGE STRUCTURE | | Descriptor: | HIV-1 PROTEASE, [4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-[1,3-BIS([4-HYDROXYMETHYL-PHENYL]METHYL)-4,7-BIS(PHEN YLMETHYL)]-2H-1,3-DIAZEPINONE | | Authors: | Yamazaki, T, Hinck, A.P, Wang, Y.-X, Nicholson, L.K, Torchia, D.A, Wingfield, P, Stahl, S.J, Kaufman, J.D, Chang, C, Domaille, P.J, Lam, P.Y.S. | | Deposit date: | 1996-01-16 | | Release date: | 1996-08-17 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Three-dimensional solution structure of the HIV-1 protease complexed with DMP323, a novel cyclic urea-type inhibitor, determined by nuclear magnetic resonance spectroscopy.
Protein Sci., 5, 1996
|
|
1BVE
 | | HIV-1 PROTEASE-DMP323 COMPLEX IN SOLUTION, NMR, 28 STRUCTURES | | Descriptor: | HIV-1 PROTEASE, [4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-[1,3-BIS([4-HYDROXYMETHYL-PHENYL]METHYL)-4,7-BIS(PHEN YLMETHYL)]-2H-1,3-DIAZEPINONE | | Authors: | Yamazaki, T, Hinck, A.P, Wang, Y.-X, Nicholson, L.K, Torchia, D.A, Wingfield, P, Stahl, S.J, Kaufman, J.D, Chang, C, Domaille, P.J, Lam, P.Y.S. | | Deposit date: | 1996-01-16 | | Release date: | 1996-08-17 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Three-dimensional solution structure of the HIV-1 protease complexed with DMP323, a novel cyclic urea-type inhibitor, determined by nuclear magnetic resonance spectroscopy.
Protein Sci., 5, 1996
|
|
5V4Y
 | | X-ray crystal structure of wild type HIV-1 protease in complex with GRL-09510 | | Descriptor: | (3S,3aR,5R,7aS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-yl [(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]carbamate, Protease | | Authors: | Yedidi, R.S, Delino, N.S, Das, D, Kaufman, J.D, Wingfield, P.T, Ghosh, A.K, Mitsuya, H. | | Deposit date: | 2017-03-11 | | Release date: | 2017-09-13 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | GRL-09510, a Unique P2-Crown-Tetrahydrofuranylurethane -Containing HIV-1 Protease Inhibitor, Maintains Its Favorable Antiviral Activity against Highly-Drug-Resistant HIV-1 Variants in vitro.
Sci Rep, 7, 2017
|
|
1QBZ
 | | THE CRYSTAL STRUCTURE OF THE SIV GP41 ECTODOMAIN AT 1.47 A | | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, CHLORIDE ION, MERCURY (II) ION, ... | | Authors: | Yang, Z.-N, Mueser, T.C, Kaufman, J, Stahl, S.J, Wingfield, P.T, Hyde, C.C. | | Deposit date: | 1999-04-28 | | Release date: | 1999-05-17 | | Last modified: | 2023-08-02 | | Method: | X-RAY DIFFRACTION (1.47 Å) | | Cite: | The crystal structure of the SIV gp41 ectodomain at 1.47 A resolution.
J.Struct.Biol., 126, 1999
|
|
1EY1
 | | SOLUTION STRUCTURE OF ESCHERICHIA COLI NUSB | | Descriptor: | ANTITERMINATION FACTOR NUSB | | Authors: | Altieri, A.S, Mazzulla, M.J, Horita, D.A, Coats, R.H, Wingfield, P.T, Byrd, R.A. | | Deposit date: | 2000-05-05 | | Release date: | 2000-06-14 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | The structure of the transcriptional antiterminator NusB from Escherichia coli.
Nat.Struct.Biol., 7, 2000
|
|
3V6F
 | | Crystal Structure of an anti-HBV e-antigen monoclonal Fab fragment (e6), unbound | | Descriptor: | Fab e6 Heavy Chain, Fab e6 Light Chain | | Authors: | Dimattia, M.A, Watts, N.R, Stahl, S.J, Grimes, J.M, Steven, A.C, Stuart, D.I, Wingfield, P.T. | | Deposit date: | 2011-12-19 | | Release date: | 2013-02-06 | | Method: | X-RAY DIFFRACTION (2.52 Å) | | Cite: | Antigenic switching of hepatitis B virus by alternative dimerization of the capsid protein.
Structure, 21, 2013
|
|
3V6Z
 | | Crystal Structure of Hepatitis B Virus e-antigen | | Descriptor: | Fab e6 Heavy Chain, Fab e6 Light Chain, e-antigen | | Authors: | Dimattia, M.A, Watts, N.R, Stahl, S.J, Grimes, J.M, Steven, A.C, Stuart, D.I, Wingfield, P.T. | | Deposit date: | 2011-12-20 | | Release date: | 2013-02-06 | | Last modified: | 2022-12-21 | | Method: | X-RAY DIFFRACTION (3.34 Å) | | Cite: | Antigenic switching of hepatitis B virus by alternative dimerization of the capsid protein.
Structure, 21, 2013
|
|
