5NOO
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![BU of 5noo by Molmil](/molmil-images/mine/5noo) | Crystal Structure of C.elegans Thymidylate Synthase in Complex with dUMP and Tomudex | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, TOMUDEX, Thymidylate synthase | 著者 | Wilk, P, Jarmula, A, Maj, P, Dowiercial, A, Banaszak, K, Rypniewski, W, Rode, W. | 登録日 | 2017-04-12 | 公開日 | 2017-05-03 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Crystal structures of nematode (parasitic T. spiralis and free living C. elegans), compared to mammalian, thymidylate synthases (TS). Molecular docking and molecular dynamics simulations in search for nematode-specific inhibitors of TS. J. Mol. Graph. Model., 77, 2017
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5M4Q
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![BU of 5m4q by Molmil](/molmil-images/mine/5m4q) | Crystal Structure of Wild-Type Human Prolidase with Mn ions and Pro ligand | 分子名称: | GLYCEROL, HYDROXIDE ION, MANGANESE (II) ION, ... | 著者 | Wilk, P, Weiss, M.S, Mueller, U, Dobbek, H. | 登録日 | 2016-10-18 | 公開日 | 2017-07-12 | 最終更新日 | 2020-04-22 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Substrate specificity and reaction mechanism of human prolidase. FEBS J., 284, 2017
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5MBY
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![BU of 5mby by Molmil](/molmil-images/mine/5mby) | Crystal Structure of Arg184Gln mutant of Human Prolidase with Mn ions and GlyPro ligand | 分子名称: | GLYCEROL, GLYCINE, HYDROXIDE ION, ... | 著者 | Wilk, P, Piwowarczyk, R, Mueller, U, Dobbek, H, Weiss, M.S. | 登録日 | 2016-11-09 | 公開日 | 2017-12-20 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Structural basis for prolidase deficiency disease mechanisms. FEBS J., 285, 2018
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5MC5
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![BU of 5mc5 by Molmil](/molmil-images/mine/5mc5) | Crystal Structure of delGlu452 mutant of Human Prolidase with Mn ions and GlyPro ligand | 分子名称: | GLYCEROL, GLYCINE, HYDROXIDE ION, ... | 著者 | Wilk, P, Mueller, U, Dobbek, H, Weiss, M.S. | 登録日 | 2016-11-09 | 公開日 | 2017-12-20 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural basis for prolidase deficiency disease mechanisms. FEBS J., 285, 2018
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5MC3
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![BU of 5mc3 by Molmil](/molmil-images/mine/5mc3) | Crystal Structure of Glu412Lys mutant of Human Prolidase with Mn ions and GlyPro ligand | 分子名称: | GLYCEROL, GLYCINE, HYDROXIDE ION, ... | 著者 | Wilk, P, Mueller, U, Dobbek, H, Weiss, M.S. | 登録日 | 2016-11-09 | 公開日 | 2017-12-20 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | Structural basis for prolidase deficiency disease mechanisms. FEBS J., 285, 2018
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5MC4
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![BU of 5mc4 by Molmil](/molmil-images/mine/5mc4) | Crystal Structure of Gly448Arg mutant of Human Prolidase with Mn ions and GlyPro ligand | 分子名称: | GLYCEROL, GLYCINE, HYDROXIDE ION, ... | 著者 | Wilk, P, Mueller, U, Dobbek, H, Weiss, M.S. | 登録日 | 2016-11-09 | 公開日 | 2017-12-20 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural basis for prolidase deficiency disease mechanisms. FEBS J., 285, 2018
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5MC0
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![BU of 5mc0 by Molmil](/molmil-images/mine/5mc0) | Crystal Structure of delTyr231 mutant of Human Prolidase with Mn ions and GlyPro ligand | 分子名称: | CHLORIDE ION, GLYCEROL, GLYCINE, ... | 著者 | Wilk, P, Mueller, U, Dobbek, H, Weiss, M.S. | 登録日 | 2016-11-09 | 公開日 | 2017-12-20 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Structural basis for prolidase deficiency disease mechanisms. FEBS J., 285, 2018
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5M4G
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![BU of 5m4g by Molmil](/molmil-images/mine/5m4g) | Crystal Structure of Wild-Type Human Prolidase with Mn ions | 分子名称: | GLYCEROL, HYDROXIDE ION, MANGANESE (II) ION, ... | 著者 | Wilk, P, Weiss, M.S, Mueller, U, Dobbek, H. | 登録日 | 2016-10-18 | 公開日 | 2017-07-12 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | Substrate specificity and reaction mechanism of human prolidase. FEBS J., 284, 2017
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5M4L
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![BU of 5m4l by Molmil](/molmil-images/mine/5m4l) | Crystal Structure of Wild-Type Human Prolidase with Mg ions and LeuPro ligand | 分子名称: | GLYCEROL, HYDROXIDE ION, LEUCINE, ... | 著者 | Wilk, P, Weiss, M.S, Mueller, U, Dobbek, H. | 登録日 | 2016-10-18 | 公開日 | 2017-07-12 | 最終更新日 | 2020-04-22 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Substrate specificity and reaction mechanism of human prolidase. FEBS J., 284, 2017
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5MBZ
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![BU of 5mbz by Molmil](/molmil-images/mine/5mbz) | Crystal Structure of Ser202Phe mutant of Human Prolidase with Mn ions and GlyPro ligand | 分子名称: | CHLORIDE ION, GLYCEROL, GLYCINE, ... | 著者 | Wilk, P, Mueller, U, Dobbek, H, Weiss, M.S. | 登録日 | 2016-11-09 | 公開日 | 2017-12-20 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structural basis for prolidase deficiency disease mechanisms. FEBS J., 285, 2018
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5MC1
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![BU of 5mc1 by Molmil](/molmil-images/mine/5mc1) | Crystal Structure of Asp276Asn mutant of Human Prolidase with Mn ions and GlyPro ligand | 分子名称: | GLYCEROL, GLYCINE, MANGANESE (II) ION, ... | 著者 | Wilk, P, Mueller, U, Dobbek, H, Weiss, M.S. | 登録日 | 2016-11-09 | 公開日 | 2017-12-20 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | 主引用文献 | Structural basis for prolidase deficiency disease mechanisms. FEBS J., 285, 2018
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5MC2
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![BU of 5mc2 by Molmil](/molmil-images/mine/5mc2) | Crystal Structure of Gly278Asp mutant of Human Prolidase with Mn ions and GlyPro ligand | 分子名称: | GLYCEROL, GLYCINE, MANGANESE (II) ION, ... | 著者 | Wilk, P, Mueller, U, Dobbek, H, Weiss, M.S. | 登録日 | 2016-11-09 | 公開日 | 2017-12-20 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural basis for prolidase deficiency disease mechanisms. FEBS J., 285, 2018
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5M4J
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![BU of 5m4j by Molmil](/molmil-images/mine/5m4j) | Crystal Structure of Wild-Type Human Prolidase with GlyPro ligand | 分子名称: | GLYCEROL, GLYCINE, PROLINE, ... | 著者 | Wilk, P, Weiss, M.S, Mueller, U, Dobbek, H. | 登録日 | 2016-10-18 | 公開日 | 2017-07-12 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Substrate specificity and reaction mechanism of human prolidase. FEBS J., 284, 2017
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6XXI
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![BU of 6xxi by Molmil](/molmil-images/mine/6xxi) | Crystal Structure of Human Deoxyhypusine Synthase in complex with NAD | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, 1,2-ETHANEDIOL, ACETATE ION, ... | 著者 | Wator, E, Wilk, P, Grudnik, P. | 登録日 | 2020-01-27 | 公開日 | 2020-04-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.679 Å) | 主引用文献 | Half Way to Hypusine-Structural Basis for Substrate Recognition by Human Deoxyhypusine Synthase. Biomolecules, 10, 2020
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6XXK
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![BU of 6xxk by Molmil](/molmil-images/mine/6xxk) | Crystal Structure of Human Deoxyhypusine Synthase in complex with spermidine | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, 1,2-ETHANEDIOL, ACETATE ION, ... | 著者 | Wator, E, Wilk, P, Grudnik, P. | 登録日 | 2020-01-27 | 公開日 | 2020-04-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Half Way to Hypusine-Structural Basis for Substrate Recognition by Human Deoxyhypusine Synthase. Biomolecules, 10, 2020
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8QZX
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![BU of 8qzx by Molmil](/molmil-images/mine/8qzx) | |
5BY6
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![BU of 5by6 by Molmil](/molmil-images/mine/5by6) | Crystal structure of Trichinella spiralis thymidylate synthase complexed with dUMP | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, GLYCEROL, ... | 著者 | Dowiercial, A, Jarmula, A, Rypniewski, W, Fraczyk, T, Wilk, P, Rode, W. | 登録日 | 2015-06-10 | 公開日 | 2015-06-17 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structures of nematode (parasitic T. spiralis and free living C. elegans), compared to mammalian, thymidylate synthases (TS). Molecular docking and molecular dynamics simulations in search for nematode-specific inhibitors of TS. J. Mol. Graph. Model., 77, 2017
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8QZW
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![BU of 8qzw by Molmil](/molmil-images/mine/8qzw) | |
8QZV
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![BU of 8qzv by Molmil](/molmil-images/mine/8qzv) | |
5FCT
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![BU of 5fct by Molmil](/molmil-images/mine/5fct) | Mouse thymidylate synthase in ternary complex with FdUMP and methylenetetrahydrofolate. | 分子名称: | 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID, Thymidylate synthase | 著者 | Dowiercial, A, Wilk, P, Jarmula, A, Rode, W. | 登録日 | 2015-12-15 | 公開日 | 2016-10-26 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Mouse thymidylate synthase does not show the inactive conformation, observed for the human enzyme Struct Chem, 2016
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8P61
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![BU of 8p61 by Molmil](/molmil-images/mine/8p61) | Crystal structure of O'nyong'nyong virus capsid protease (106-256) | 分子名称: | Capsid protein, GLYCEROL, SULFATE ION | 著者 | Plewka, J, Chykunova, Y, Wilk, P, Sienczyk, M, Dubin, G, Pyrc, K. | 登録日 | 2023-05-24 | 公開日 | 2024-03-06 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Autoinhibition of suicidal capsid protease from O'nyong'nyong virus. Int.J.Biol.Macromol., 262, 2024
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7A6S
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![BU of 7a6s by Molmil](/molmil-images/mine/7a6s) | Crystal Structure of Asn173Ser variant of Human Deoxyhypusine Synthase | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Deoxyhypusine synthase, ... | 著者 | Wator, E, Wilk, P, Grudnik, P. | 登録日 | 2020-08-26 | 公開日 | 2022-03-23 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders. Nat Commun, 14, 2023
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7A6T
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![BU of 7a6t by Molmil](/molmil-images/mine/7a6t) | Crystal Structure of Asn173Ser variant of Human Deoxyhypusine Synthase in complex with NAD and spermidine | 分子名称: | 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, Deoxyhypusine synthase, ... | 著者 | Wator, E, Wilk, P, Grudnik, P. | 登録日 | 2020-08-26 | 公開日 | 2022-03-23 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders. Nat Commun, 14, 2023
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6GKO
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![BU of 6gko by Molmil](/molmil-images/mine/6gko) | Mouse thymidylate synthase cocrystallized with dUMP and soaked in phenolphthalein | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 3,3-bis(4-hydroxyphenyl)-2-benzofuran-1-one, DIMETHYL SULFOXIDE, ... | 著者 | Maj, P, Wilk, P, Jarmula, A, Weiss, M.S, Rode, W. | 登録日 | 2018-05-21 | 公開日 | 2019-06-05 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.839 Å) | 主引用文献 | Thymidylate synthase fragment screening To Be Published
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6GYJ
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![BU of 6gyj by Molmil](/molmil-images/mine/6gyj) | Mouse thymidylate synthase crystal soaked in phenolphthalein | 分子名称: | 3,3-bis(4-hydroxyphenyl)-2-benzofuran-1-one, DIMETHYL SULFOXIDE, SULFATE ION, ... | 著者 | Maj, P, Jarmula, A, Wilk, P, Weiss, M.S, Rode, W. | 登録日 | 2018-06-30 | 公開日 | 2019-08-28 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Thymidylate synthase fragment screening To be published
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