5EEL
 
 | | Grb7 SH2 with bicyclic peptide inhibitor | | Descriptor: | Bicyclic Peptide Inhibitor, FORMIC ACID, Growth factor receptor-bound protein 7, ... | | Authors: | Watson, G.M, Gunzburg, M.J, Wilce, M.C.J, Wilce, J.A. | | Deposit date: | 2015-10-23 | | Release date: | 2016-06-15 | | Last modified: | 2018-12-26 | | Method: | X-RAY DIFFRACTION (2.47 Å) | | Cite: | Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.
Sci Rep, 6, 2016
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5U1Q
 | | Grb7-SH2 with bicyclic peptide inhibitor | | Descriptor: | CHLORIDE ION, Growth factor receptor-bound protein 7, LYS-PHE-GLU-GLY-TYR-ASP-ASN-GLU-CST | | Authors: | Watson, G.M, Wilce, M.C.J, Wilce, J.A. | | Deposit date: | 2016-11-28 | | Release date: | 2017-11-15 | | Last modified: | 2020-01-08 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target.
J. Med. Chem., 60, 2017
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5TYI
 | | Grb7 SH2 with bicyclic peptide containing pY mimetic | | Descriptor: | Growth factor receptor-bound protein 7, Peptide inhibitor | | Authors: | Watson, G.M, Wilce, M.C.J, Wilce, J.A. | | Deposit date: | 2016-11-20 | | Release date: | 2017-11-15 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target.
J. Med. Chem., 60, 2017
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1T3W
 | | Crystal Structure of the E.coli DnaG C-terminal domain (residues 434 to 581) | | Descriptor: | ACETIC ACID, DNA primase | | Authors: | Oakley, A.J, Loscha, K.V, Schaeffer, P.M, Liepinsh, E, Wilce, M.C.J, Otting, G, Dixon, N.E. | | Deposit date: | 2004-04-28 | | Release date: | 2004-11-02 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal and solution structures of the helicase-binding domain of Escherichia coli primase
J.Biol.Chem., 280, 2005
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1R0G
 | | mercury-substituted rubredoxin | | Descriptor: | MERCURY (II) ION, Rubredoxin | | Authors: | Maher, M, Cross, M, Wilce, M.C.J, Guss, J.M, Wedd, A.G. | | Deposit date: | 2003-09-22 | | Release date: | 2004-02-10 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Metal-substituted derivatives of the rubredoxin from Clostridium pasteurianum.
Acta Crystallogr.,Sect.D, 60, 2004
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1R0I
 | | cadmium-substituted rubredoxin | | Descriptor: | CADMIUM ION, Rubredoxin | | Authors: | Maher, M, Cross, M, Wilce, M.C.J, Guss, J.M, Wedd, A.G. | | Deposit date: | 2003-09-22 | | Release date: | 2004-02-10 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Metal-substituted derivatives of the rubredoxin from Clostridium pasteurianum.
Acta Crystallogr.,Sect.D, 60, 2004
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1R0J
 | | nickel-substituted rubredoxin | | Descriptor: | NICKEL (II) ION, Rubredoxin | | Authors: | Maher, M, Cross, M, Wilce, M.C.J, Guss, J.M, Wedd, A.G. | | Deposit date: | 2003-09-22 | | Release date: | 2004-02-10 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Metal-substituted derivatives of the rubredoxin from Clostridium pasteurianum.
Acta Crystallogr.,Sect.D, 60, 2004
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1R0F
 | | Gallium-substituted rubredoxin | | Descriptor: | GALLIUM (III) ION, Rubredoxin | | Authors: | Maher, M, Cross, M, Wilce, M.C.J, Guss, J.M, Wedd, A.G. | | Deposit date: | 2003-09-22 | | Release date: | 2004-02-10 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Metal-substituted derivatives of the rubredoxin from Clostridium pasteurianum.
Acta Crystallogr.,Sect.D, 60, 2004
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1R0H
 | | cobalt-substituted rubredoxin | | Descriptor: | COBALT (II) ION, Rubredoxin | | Authors: | Maher, M, Cross, M, Wilce, M.C.J, Guss, J.M, Wedd, A.G. | | Deposit date: | 2003-09-22 | | Release date: | 2004-02-10 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Metal-substituted derivatives of the rubredoxin from Clostridium pasteurianum.
Acta Crystallogr.,Sect.D, 60, 2004
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8FK6
 | | Crystal Structure of the Tick Evasin EVA-AAM1001(Y44A) Complexed to Human Chemokine CCL7 | | Descriptor: | C-C motif chemokine 7, Evasin P1243 | | Authors: | Devkota, S.R, Bhusal, R.P, Aryal, P, Wilce, M.C.J, Stone, M.J. | | Deposit date: | 2022-12-20 | | Release date: | 2023-03-29 | | Last modified: | 2023-08-02 | | Method: | X-RAY DIFFRACTION (1.74 Å) | | Cite: | Engineering broad-spectrum inhibitors of inflammatory chemokines from subclass A3 tick evasins.
Nat Commun, 14, 2023
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1RH9
 | | Family GH5 endo-beta-mannanase from Lycopersicon esculentum (tomato) | | Descriptor: | endo-beta-mannanase | | Authors: | Oakley, A.J, Bourgault, R, Bewley, J.D, Wilce, M.C.J. | | Deposit date: | 2003-11-14 | | Release date: | 2005-04-19 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Three-dimensional structure of (1,4)-beta-D-mannan mannanohydrolase from tomato fruit.
Protein Sci., 14, 2005
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2DPU
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2DPD
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2DQR
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2EFW
 | | Crystal structure of the RTP:nRB complex from Bacillus subtilis | | Descriptor: | DNA (5'-D(*DCP*DT*DAP*DTP*DGP*DTP*DAP*DCP*DCP*DAP*DAP*DAP*DTP*DGP*DTP*DTP*DCP*DAP*DGP*DTP*DC)-3'), DNA (5'-D(*DGP*DAP*DCP*DTP*DGP*DAP*DAP*DCP*DAP*DTP*DTP*DTP*DGP*DGP*DTP*DAP*DCP*DAP*DTP*DAP*DG)-3'), Replication termination protein | | Authors: | Vivian, J.P, Porter, C.J, Wilce, J.A, Wilce, M.C.J. | | Deposit date: | 2007-02-26 | | Release date: | 2008-02-26 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | An asymmetric structure of the Bacillus subtilis replication terminator protein in complex with DNA
J.Mol.Biol., 370, 2007
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3BJX
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1R7O
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4TZG
 | | Crystal structure of eCGP123, an extremely thermostable green fluorescent protein | | Descriptor: | Fluorescent Protein | | Authors: | Close, D.W, Don Paul, C, Traore, D.A.K, Wilce, M.C.J, Prescott, M, Bradbury, A.R.M. | | Deposit date: | 2014-07-10 | | Release date: | 2014-10-22 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Thermal green protein, an extremely stable, nonaggregating fluorescent protein created by structure-guided surface engineering.
Proteins, 83, 2015
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2QMS
 | | Crystal structure of a signaling molecule | | Descriptor: | Growth factor receptor-bound protein 7, SULFATE ION | | Authors: | Porter, C.J, Wilce, M.C, Wilce, J.A. | | Deposit date: | 2007-07-16 | | Release date: | 2008-07-22 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Grb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferation.
Bmc Struct.Biol., 7, 2007
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2ZNM
 | | Oxidoreductase NmDsbA3 from Neisseria meningitidis | | Descriptor: | Thiol:disulfide interchange protein DsbA | | Authors: | Vivian, J.P, Scoullar, J, Robertson, A.L, Bottomley, S.P, Horne, J, Chin, Y, Velkov, T, Wielens, J, Thompson, P.E, Piek, S, Byres, E, Beddoe, T, Wilce, M.C.J, Kahler, C, Rossjohn, J, Scanlon, M.J. | | Deposit date: | 2008-04-30 | | Release date: | 2008-08-19 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural and Biochemical Characterization of the Oxidoreductase NmDsbA3 from Neisseria meningitidis
J.Biol.Chem., 283, 2008
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8FJ0
 | | Crystal Structure of the Tick Evasin EVA-AAM1001(Y44A) Complexed to Human Chemokine CCL2 | | Descriptor: | C-C motif chemokine 2, Evasin P1243 | | Authors: | Devkota, S.R, Bhusal, R.P, Aryal, P, Wilce, M.C.J, Stone, M.J. | | Deposit date: | 2022-12-18 | | Release date: | 2023-03-29 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.91 Å) | | Cite: | Engineering broad-spectrum inhibitors of inflammatory chemokines from subclass A3 tick evasins.
Nat Commun, 14, 2023
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8FK8
 | | Crystal Structure of the Tick Evasin EVA-AAM1001(L39P) Complexed to Human Chemokine CCL7 | | Descriptor: | C-C motif chemokine 7, Evasin P1243 | | Authors: | Devkota, S.R, Bhusal, R.P, Aryal, P, Wilce, M.C.J, Stone, M.J. | | Deposit date: | 2022-12-20 | | Release date: | 2023-03-29 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.96 Å) | | Cite: | Engineering broad-spectrum inhibitors of inflammatory chemokines from subclass A3 tick evasins.
Nat Commun, 14, 2023
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8FJ3
 | | Crystal Structure of the Tick Evasin EVA-AAM1001 Complexed to Human Chemokine CCL7(Y13A) | | Descriptor: | C-C motif chemokine 7, Evasin P1243 | | Authors: | Devkota, S.R, Bhusal, R.P, Aryal, P, Wilce, M.C.J, Stone, M.J. | | Deposit date: | 2022-12-19 | | Release date: | 2023-03-29 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.07 Å) | | Cite: | Engineering broad-spectrum inhibitors of inflammatory chemokines from subclass A3 tick evasins.
Nat Commun, 14, 2023
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8FJ2
 | | Crystal Structure of the Tick Evasin EVA-AAM1001(C8) Complexed to Human Chemokine CCL17 | | Descriptor: | C-C motif chemokine 17, Evasin P1243 | | Authors: | Devkota, S.R, Bhusal, R.P, Aryal, P, Wilce, M.C.J, Stone, M.J. | | Deposit date: | 2022-12-19 | | Release date: | 2023-03-29 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.07 Å) | | Cite: | Engineering broad-spectrum inhibitors of inflammatory chemokines from subclass A3 tick evasins.
Nat Commun, 14, 2023
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8FK9
 | | Crystal Structure of the Tick Evasin EVA-ACA1001 Complexed to Human Chemokine CCL16 | | Descriptor: | C-C motif chemokine 16, Evasin P991 | | Authors: | Devkota, S.R, Bhusal, R.P, Aryal, P, Wilce, M.C.J, Stone, M.J. | | Deposit date: | 2022-12-21 | | Release date: | 2024-01-17 | | Last modified: | 2024-07-31 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural basis of chemokine recognition by the class A3 tick evasin EVA-ACA1001.
Protein Sci., 33, 2024
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