1SQ7
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![BU of 1sq7 by Molmil](/molmil-images/mine/1sq7) | Understanding protein lids: Structural analysis of active hinge mutants in triosephosphate isomerase | Descriptor: | Triosephosphate isomerase | Authors: | Kursula, I, Salin, M, Sun, J, Norledge, B.V, Haapalainen, A.M, Sampson, N.S, Wierenga, R.K. | Deposit date: | 2004-03-18 | Release date: | 2004-08-24 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Understanding protein lids: structural analysis of active hinge mutants in triosephosphate isomerase Protein Eng.Des.Sel., 17, 2004
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1SW0
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![BU of 1sw0 by Molmil](/molmil-images/mine/1sw0) | Triosephosphate isomerase from Gallus gallus, loop 6 hinge mutant K174L, T175W | Descriptor: | 2-PHOSPHOGLYCOLIC ACID, Triosephosphate isomerase | Authors: | Kursula, I, Salin, M, Sun, J, Norledge, B.V, Haapalainen, A.M, Sampson, N.S, Wierenga, R.K. | Deposit date: | 2004-03-30 | Release date: | 2004-08-24 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Understanding protein lids: structural analysis of active hinge mutants in triosephosphate isomerase Protein Eng.Des.Sel., 17, 2004
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1SW3
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![BU of 1sw3 by Molmil](/molmil-images/mine/1sw3) | Triosephosphate isomerase from Gallus gallus, loop 6 mutant T175V | Descriptor: | 2-PHOSPHOGLYCOLIC ACID, Triosephosphate isomerase | Authors: | Kursula, I, Salin, M, Sun, J, Norledge, B.V, Haapalainen, A.M, Sampson, N.S, Wierenga, R.K. | Deposit date: | 2004-03-30 | Release date: | 2004-08-24 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Understanding protein lids: structural analysis of active hinge mutants in triosephosphate isomerase Protein Eng.Des.Sel., 17, 2004
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1SSD
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![BU of 1ssd by Molmil](/molmil-images/mine/1ssd) | Understanding protein lids: Structural analysis of active hinge mutants in triosephosphate isomerase | Descriptor: | SULFATE ION, Triosephosphate isomerase | Authors: | Kursula, I, Salin, M, Sun, J, Norledge, B.V, Haapalainen, A.M, Sampson, N.S, Wierenga, R.K. | Deposit date: | 2004-03-24 | Release date: | 2004-08-24 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Understanding protein lids: structural analysis of active hinge mutants in triosephosphate isomerase Protein Eng.Des.Sel., 17, 2004
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1SU5
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![BU of 1su5 by Molmil](/molmil-images/mine/1su5) | Understanding protein lids: Structural analysis of active hinge mutants in triosephosphate isomerase | Descriptor: | 2-PHOSPHOGLYCOLIC ACID, GLYCEROL, SULFATE ION, ... | Authors: | Kursula, I, Salin, M, Sun, J, Norledge, B.V, Haapalainen, A.M, Sampson, N.S, Wierenga, R.K. | Deposit date: | 2004-03-26 | Release date: | 2004-08-24 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Understanding protein lids: structural analysis of active hinge mutants in triosephosphate isomerase Protein Eng.Des.Sel., 17, 2004
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1SW7
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![BU of 1sw7 by Molmil](/molmil-images/mine/1sw7) | Triosephosphate isomerase from Gallus gallus, loop 6 mutant K174N, T175S, A176S | Descriptor: | 2-PHOSPHOGLYCOLIC ACID, Triosephosphate isomerase | Authors: | Kursula, I, Salin, M, Sun, J, Norledge, B.V, Haapalainen, A.M, Sampson, N.S, Wierenga, R.K. | Deposit date: | 2004-03-30 | Release date: | 2004-08-24 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | Understanding protein lids: structural analysis of active hinge mutants in triosephosphate isomerase Protein Eng.Des.Sel., 17, 2004
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1SSG
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![BU of 1ssg by Molmil](/molmil-images/mine/1ssg) | Understanding protein lids: Structural analysis of active hinge mutants in triosephosphate isomerase | Descriptor: | 2-PHOSPHOGLYCOLIC ACID, GLYCEROL, SULFATE ION, ... | Authors: | Kursula, I, Salin, M, Sun, J, Norledge, B.V, Haapalainen, A.M, Sampson, N.S, Wierenga, R.K. | Deposit date: | 2004-03-24 | Release date: | 2004-08-24 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Understanding protein lids: structural analysis of active hinge mutants in triosephosphate isomerase Protein Eng.Des.Sel., 17, 2004
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1N55
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![BU of 1n55 by Molmil](/molmil-images/mine/1n55) | |
1TJ7
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![BU of 1tj7 by Molmil](/molmil-images/mine/1tj7) | Structure determination and refinement at 2.44 A resolution of Argininosuccinate lyase from E. coli | Descriptor: | Argininosuccinate lyase, GLYCEROL, PHOSPHATE ION | Authors: | Bhaumik, P, Koski, M.K, Bergman, U, Wierenga, R.K. | Deposit date: | 2004-06-03 | Release date: | 2004-10-26 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.44 Å) | Cite: | Structure determination and refinement at 2.44 A resolution of argininosuccinate lyase from Escherichia coli. Acta Crystallogr.,Sect.D, 60, 2004
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1DLU
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![BU of 1dlu by Molmil](/molmil-images/mine/1dlu) | UNLIGANDED BIOSYNTHETIC THIOLASE FROM ZOOGLOEA RAMIGERA | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, BIOSYNTHETIC THIOLASE, SULFATE ION | Authors: | Modis, Y, Wierenga, R.K. | Deposit date: | 1999-12-12 | Release date: | 2000-04-24 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Crystallographic analysis of the reaction pathway of Zoogloea ramigera biosynthetic thiolase. J.Mol.Biol., 297, 2000
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1DM3
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![BU of 1dm3 by Molmil](/molmil-images/mine/1dm3) | |
1DLV
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![BU of 1dlv by Molmil](/molmil-images/mine/1dlv) | |
1E2X
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![BU of 1e2x by Molmil](/molmil-images/mine/1e2x) | FadR, fatty acid responsive transcription factor from E. coli | Descriptor: | FATTY ACID METABOLISM REGULATOR PROTEIN, SULFATE ION | Authors: | Van Aalten, D.M.F, Dirusso, C.C, Knudsen, J, Wierenga, R.K. | Deposit date: | 2000-05-30 | Release date: | 2000-12-03 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structure of Fadr, a Fatty Acid-Responsive Transcription Factor with a Novel Acyl Coenzyme A-Binding Fold Embo J., 19, 2000
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2X58
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![BU of 2x58 by Molmil](/molmil-images/mine/2x58) | The crystal structure of MFE1 liganded with CoA | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, COENZYME A, GLYCEROL, ... | Authors: | Kasaragod, P, Venkatesan, R, Kiema, T.R, Hiltunen, J.K, Wierenga, R.K. | Deposit date: | 2010-02-05 | Release date: | 2010-05-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The Crystal Structure of Liganded Rat Peroxisomal Multifunctional Enzyme Type 1: A Flexible Molecule with Two Interconnected Active Sites J.Biol.Chem., 285, 2010
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2WL6
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![BU of 2wl6 by Molmil](/molmil-images/mine/2wl6) | |
1TTI
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![BU of 1tti by Molmil](/molmil-images/mine/1tti) | |
2VU1
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![BU of 2vu1 by Molmil](/molmil-images/mine/2vu1) | Biosynthetic thiolase from Z. ramigera. Complex of with O-pantheteine- 11-pivalate. | Descriptor: | ACETYL-COA ACETYLTRANSFERASE, PANTOTHENYL-AMINOETHANOL-11-PIVALIC ACID, SODIUM ION, ... | Authors: | Kursula, P, Schmitz, W, Wierenga, R.K. | Deposit date: | 2008-05-19 | Release date: | 2008-10-28 | Last modified: | 2019-07-24 | Method: | X-RAY DIFFRACTION (1.51 Å) | Cite: | The Sulfur Atoms of the Substrate Coa and the Catalytic Cysteine are Required for a Productive Mode of Substrate Binding in Bacterial Biosynthetic Thiolase, a Thioester-Dependent Enzyme. FEBS J., 275, 2008
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2VU0
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2VU2
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![BU of 2vu2 by Molmil](/molmil-images/mine/2vu2) | Biosynthetic thiolase from Z. ramigera. Complex with S-pantetheine-11- pivalate. | Descriptor: | (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)butyl 2,2-dimethylpropanoate, ACETYL-COA ACETYLTRANSFERASE, SULFATE ION | Authors: | Kursula, P, Merilainen, G, Schmitz, W, Wierenga, R.K. | Deposit date: | 2008-05-19 | Release date: | 2008-10-28 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | The Sulfur Atoms of the Substrate Coa and the Catalytic Cysteine are Required for a Productive Mode of Substrate Binding in Bacterial Biosynthetic Thiolase, a Thioester-Dependent Enzyme. FEBS J., 275, 2008
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2VTZ
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![BU of 2vtz by Molmil](/molmil-images/mine/2vtz) | Biosynthetic thiolase from Z. ramigera. Complex of the C89A mutant with coenzyme A. | Descriptor: | ACETYL-COA ACETYLTRANSFERASE, COENZYME A, SULFATE ION | Authors: | Kursula, P, Merilainen, G, Wierenga, R.K. | Deposit date: | 2008-05-19 | Release date: | 2008-10-28 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The Sulfur Atoms of the Substrate Coa and the Catalytic Cysteine are Required for a Productive Mode of Substrate Binding in Bacterial Biosynthetic Thiolase, a Thioester-Dependent Enzyme. FEBS J., 275, 2008
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2V4A
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![BU of 2v4a by Molmil](/molmil-images/mine/2v4a) | Crystal structure of the SeMet-labeled prolyl-4 hydroxylase (P4H) type I from green algae Chlamydomonas reinhardtii. | Descriptor: | CHLORIDE ION, DIMETHYL SULFOXIDE, GLYCEROL, ... | Authors: | Koski, M.K, Hieta, R, Bollner, C, Kivirikko, K.I, Myllyharju, J, Wierenga, R.K. | Deposit date: | 2007-06-28 | Release date: | 2007-10-30 | Last modified: | 2019-07-24 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | The Active Site of an Algal Prolyl 4-Hydroxylase Has a Large Structural Plasticity. J.Biol.Chem., 282, 2007
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2V0T
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![BU of 2v0t by Molmil](/molmil-images/mine/2v0t) | The A178L mutation in the C-terminal hinge of the flexible loop-6 of triosephosphate isomerase (TIM) induces a more closed conformation of this hinge region in dimeric and monomeric TIM | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, SULFATE ION, TRIOSEPHOSPHATE ISOMERASE GLYCOSOMAL | Authors: | Alahuhta, M, Casteleijn, M.G, Neubauer, P, Wierenga, R.K. | Deposit date: | 2007-05-18 | Release date: | 2008-02-19 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural studies show that the A178L mutation in the C-terminal hinge of the catalytic loop-6 of triosephosphate isomerase (TIM) induces a closed-like conformation in dimeric and monomeric TIM. Acta Crystallogr. D Biol. Crystallogr., 64, 2008
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2VEK
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![BU of 2vek by Molmil](/molmil-images/mine/2vek) | Structure-based enzyme engineering efforts with an inactive monomeric TIM variant: the importance of a single point mutation for generating an active site with suitable binding properties | Descriptor: | 3-(BUTYLSULPHONYL)-PROPANOIC ACID, CITRIC ACID, TERTIARY-BUTYL ALCOHOL, ... | Authors: | Alahuhta, M, Salin, M, Casteleijn, M.G, Kemmer, C, El-Sayed, I, Augustyns, K, Neubauer, P, Wierenga, R.K. | Deposit date: | 2007-10-24 | Release date: | 2008-02-19 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure-Based Protein Engineering Efforts with a Monomeric Tim Variant: The Importance of a Single Point Mutation for Generating an Active Site with Suitable Binding Properties. Protein Eng.Des.Sel., 21, 2008
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2VEN
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![BU of 2ven by Molmil](/molmil-images/mine/2ven) | Structure-based enzyme engineering efforts with an inactive monomeric TIM variant: the importance of a single point mutation for generating an active site with suitable binding properties | Descriptor: | CITRIC ACID, GLYCOSOMAL TRIOSEPHOSPHATE ISOMERASE | Authors: | Alahuhta, M, Salin, M, Casteleijn, M.G, Kemmer, C, El-Sayed, I, Augustyns, K, Neubauer, P, Wierenga, R.K. | Deposit date: | 2007-10-25 | Release date: | 2008-02-19 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-Based Protein Engineering Efforts with a Monomeric Tim Variant: The Importance of a Single Point Mutation for Generating an Active Site with Suitable Binding Properties. Protein Eng.Des.Sel., 21, 2008
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2V2C
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![BU of 2v2c by Molmil](/molmil-images/mine/2v2c) | The A178L mutation in the C-terminal hinge of the flexible loop-6 of triosephosphate isomerase (TIM) induces a more closed conformation of this hinge region in dimeric and monomeric TIM | Descriptor: | 2-PHOSPHOGLYCOLIC ACID, SULFATE ION, TRIOSEPHOSPHATE ISOMERASE GLYCOSOMAL | Authors: | Alahuhta, M, Casteleijn, M.G, Neubauer, P, Wierenga, R.K. | Deposit date: | 2007-06-05 | Release date: | 2008-02-19 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Structural Studies Show that the A178L Mutation in the C-Terminal Hinge of the Catalytic Loop-6 of Triosephosphate Isomerase (Tim) Induces a Closed-Like Conformation in Dimeric and Monomeric Tim. Acta Crystallogr.,Sect.D, 64, 2008
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