7OB0
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![BU of 7ob0 by Molmil](/molmil-images/mine/7ob0) | Structure of RsLOV d2 variant | Descriptor: | ACETATE ION, CALCIUM ION, FLAVIN MONONUCLEOTIDE, ... | Authors: | Moeglich, A, Krafft, T.G.A, Weyand, M. | Deposit date: | 2021-04-20 | Release date: | 2021-06-30 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A Light-Oxygen-Voltage Receptor Integrates Light and Temperature. J.Mol.Biol., 433, 2021
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1RD5
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![BU of 1rd5 by Molmil](/molmil-images/mine/1rd5) | Crystal structure of Tryptophan synthase alpha chain homolog BX1: a member of the chemical plant defense system | Descriptor: | MALONIC ACID, Tryptophan synthase alpha chain, chloroplast | Authors: | Kulik, V, Hartmann, E, Weyand, M, Frey, M, Gierl, A, Niks, D, Dunn, M.F, Schlichting, I. | Deposit date: | 2003-11-05 | Release date: | 2004-12-28 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | On the structural basis of the catalytic mechanism and the regulation of the alpha subunit of tryptophan synthase from Salmonella typhimurium and BX1 from maize, two evolutionarily related enzymes. J.Mol.Biol., 352, 2005
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7PGX
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![BU of 7pgx by Molmil](/molmil-images/mine/7pgx) | Structure of dark-adapted AsLOV2 wild type | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ... | Authors: | Gelfert, R, Weyand, M, Moeglich, A. | Deposit date: | 2021-08-16 | Release date: | 2022-05-11 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.001 Å) | Cite: | Signal transduction in light-oxygen-voltage receptors lacking the active-site glutamine. Nat Commun, 13, 2022
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7PGZ
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![BU of 7pgz by Molmil](/molmil-images/mine/7pgz) | Structure of dark-adapted AsLOV2 Q513L | Descriptor: | 1,2-ETHANEDIOL, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... | Authors: | Gelfert, R, Weyand, M, Moeglich, A. | Deposit date: | 2021-08-16 | Release date: | 2022-05-11 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (0.9 Å) | Cite: | Signal transduction in light-oxygen-voltage receptors lacking the active-site glutamine. Nat Commun, 13, 2022
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7PH0
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![BU of 7ph0 by Molmil](/molmil-images/mine/7ph0) | Structure of light-adapted AsLOV2 Q513L | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... | Authors: | Gelfert, R, Weyand, M, Moeglich, A. | Deposit date: | 2021-08-16 | Release date: | 2022-05-11 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (0.979 Å) | Cite: | Signal transduction in light-oxygen-voltage receptors lacking the active-site glutamine. Nat Commun, 13, 2022
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7PGY
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![BU of 7pgy by Molmil](/molmil-images/mine/7pgy) | Structure of light-adapted AsLOV2 wild type | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ... | Authors: | Gelfert, R, Weyand, M, Moeglich, A. | Deposit date: | 2021-08-16 | Release date: | 2022-05-11 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.09 Å) | Cite: | Signal transduction in light-oxygen-voltage receptors lacking the active-site glutamine. Nat Commun, 13, 2022
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3RBB
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![BU of 3rbb by Molmil](/molmil-images/mine/3rbb) | HIV-1 NEF protein in complex with engineered HCK SH3 domain | Descriptor: | 1,2-ETHANEDIOL, Protein Nef, Tyrosine-protein kinase HCK | Authors: | Horenkamp, F.A, Schulte, A, Weyand, M, Geyer, M. | Deposit date: | 2011-03-29 | Release date: | 2011-04-27 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Conformation of the Dileucine-Based Sorting Motif in HIV-1 Nef Revealed by Intermolecular Domain Assembly. Traffic, 12, 2011
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3GNU
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![BU of 3gnu by Molmil](/molmil-images/mine/3gnu) | Toxin fold as basis for microbial attack and plant defense | Descriptor: | 25 kDa protein elicitor, CHLORIDE ION, GUANIDINE | Authors: | Ottmann, C, Luberacki, B, Kuefner, I, Koch, W, Brunner, F, Weyand, M, Mattinen, L, Pirhonen, M, Anderluh, G, Seitz, H.U, Nuernberger, T, Oecking, C. | Deposit date: | 2009-03-18 | Release date: | 2009-06-09 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A common toxin fold mediates microbial attack and plant defense Proc.Natl.Acad.Sci.USA, 106, 2009
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3GNZ
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![BU of 3gnz by Molmil](/molmil-images/mine/3gnz) | Toxin fold for microbial attack and plant defense | Descriptor: | 25 kDa protein elicitor, MAGNESIUM ION | Authors: | Ottmann, C, Luberacki, B, Kuefner, I, Koch, W, Brunner, F, Weyand, M, Mattinen, L, Pirhonen, M, Anderluh, G, Seitz, H.U, Nuernberger, T, Oecking, C. | Deposit date: | 2009-03-18 | Release date: | 2009-06-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | A common toxin fold mediates microbial attack and plant defense Proc.Natl.Acad.Sci.USA, 106, 2009
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2WBL
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![BU of 2wbl by Molmil](/molmil-images/mine/2wbl) | Three-dimensional structure of a binary ROP-PRONE complex | Descriptor: | RAC-LIKE GTP-BINDING PROTEIN ARAC2, RHO OF PLANTS GUANINE NUCLEOTIDE EXCHANGE FACTOR 8 | Authors: | Thomas, C, Fricke, I, Weyand, M, Berken, A. | Deposit date: | 2009-03-02 | Release date: | 2009-04-14 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | 3D Structure of a Binary Rop-Prone Complex: The Final Intermediate for a Complete Set of Molecular Snapshots of the Ropgef Reaction. Biol.Chem., 390, 2009
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3UBW
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![BU of 3ubw by Molmil](/molmil-images/mine/3ubw) | Complex of 14-3-3 isoform epsilon, a Mlf1 phosphopeptide and a small fragment hit from a FBDD screen | Descriptor: | (3S)-pyrrolidin-3-ol, 14-3-3 protein epsilon, Myeloid leukemia factor 1, ... | Authors: | Molzan, M, Weyand, M, Rose, R, Ottmann, C. | Deposit date: | 2011-10-25 | Release date: | 2012-01-25 | Last modified: | 2012-02-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural insights of the MLF1/14-3-3 interaction. Febs J., 279, 2012
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3CU8
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![BU of 3cu8 by Molmil](/molmil-images/mine/3cu8) | Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome | Descriptor: | 14-3-3 protein zeta/delta, MAGNESIUM ION, PROPANOIC ACID, ... | Authors: | Schumacher, B, Weyand, M, Kuhlmann, J, Ottmann, C. | Deposit date: | 2008-04-16 | Release date: | 2009-05-05 | Last modified: | 2017-10-25 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. Mol. Cell. Biol., 30, 2010
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3IQU
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![BU of 3iqu by Molmil](/molmil-images/mine/3iqu) | |
3IQJ
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![BU of 3iqj by Molmil](/molmil-images/mine/3iqj) | Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (10mer) | Descriptor: | 10-mer peptide from RAF proto-oncogene serine/threonine-protein kinase, 14-3-3 protein sigma, CHLORIDE ION, ... | Authors: | Ottmann, C, Weyand, M. | Deposit date: | 2009-08-20 | Release date: | 2010-09-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. Mol.Cell.Biol., 30, 2010
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3IQV
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2CLE
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![BU of 2cle by Molmil](/molmil-images/mine/2cle) | Tryptophan Synthase in complex with N-(4'-trifluoromethoxybenzoyl)-2- amino-1-ethylphosphate (F6) - lowF6 complex | Descriptor: | 2-{[4-(TRIFLUOROMETHOXY)BENZOYL]AMINO}ETHYL DIHYDROGEN PHOSPHATE, PYRIDOXAL-5'-PHOSPHATE, SODIUM ION, ... | Authors: | Ngo, H, Harris, R, Kimmich, N, Casino, P, Niks, D, Blumenstein, L, Barends, T.R, Kulik, V, Weyand, M, Schlichting, I, Dunn, M.F. | Deposit date: | 2006-04-27 | Release date: | 2007-06-12 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Synthesis and Characterization of Allosteric Probes of Substrate Channeling in the Tryptophan Synthase Bienzyme Complex. Biochemistry, 46, 2007
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2CLK
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![BU of 2clk by Molmil](/molmil-images/mine/2clk) | Tryptophan Synthase in complex with D-glyceraldehyde 3-phosphate (G3P) | Descriptor: | GLYCERALDEHYDE-3-PHOSPHATE, PYRIDOXAL-5'-PHOSPHATE, SODIUM ION, ... | Authors: | Ngo, H, Harris, R, Kimmich, N, Casino, P, Niks, D, Blumenstein, L, Barends, T.R, Kulik, V, Weyand, M, Schlichting, I, Dunn, M.F. | Deposit date: | 2006-04-27 | Release date: | 2007-06-12 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Synthesis and Characterization of Allosteric Probes of Substrate Channeling in the Tryptophan Synthase Bienzyme Complex. Biochemistry, 46, 2007
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2CLF
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![BU of 2clf by Molmil](/molmil-images/mine/2clf) | Tryptophan Synthase in complex with N-(4'-trifluoromethoxybenzoyl)-2- amino-1-ethylphosphate (F6) - highF6 complex | Descriptor: | 2-{[4-(TRIFLUOROMETHOXY)BENZOYL]AMINO}ETHYL DIHYDROGEN PHOSPHATE, PYRIDOXAL-5'-PHOSPHATE, SODIUM ION, ... | Authors: | Ngo, H, Harris, R, Kimmich, N, Casino, P, Niks, D, Blumenstein, L, Barends, T.R, Kulik, V, Weyand, M, Schlichting, I, Dunn, M.F. | Deposit date: | 2006-04-27 | Release date: | 2007-06-26 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Synthesis and Characterization of Allosteric Probes of Substrate Channeling in the Tryptophan Synthase Bienzyme Complex. Biochemistry, 46, 2007
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2O98
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![BU of 2o98 by Molmil](/molmil-images/mine/2o98) | Structure of the 14-3-3 / H+-ATPase plant complex | Descriptor: | 14-3-3-like protein C, FUSICOCCIN, Plasma membrane H+ ATPase, ... | Authors: | Ottmann, C, Weyand, M, Wittinghofer, A, Oecking, C. | Deposit date: | 2006-12-13 | Release date: | 2007-04-03 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure of a 14-3-3 coordinated hexamer of the plant plasma membrane H+ -ATPase by combining X-ray crystallography and electron cryomicroscopy Mol.Cell, 25, 2007
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2CLI
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![BU of 2cli by Molmil](/molmil-images/mine/2cli) | Tryptophan Synthase in complex with N-(4'- trifluoromethoxybenzenesulfonyl)-2-amino-1-ethylphosphate (F9) | Descriptor: | 2-({[4-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}AMINO)ETHYL DIHYDROGEN PHOSPHATE, PYRIDOXAL-5'-PHOSPHATE, SODIUM ION, ... | Authors: | Ngo, H, Harris, R, Kimmich, N, Casino, P, Niks, D, Blumenstein, L, Barends, T.R, Kulik, V, Weyand, M, Schlichting, I, Dunn, M.F. | Deposit date: | 2006-04-27 | Release date: | 2007-06-12 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Synthesis and Characterization of Allosteric Probes of Substrate Channeling in the Tryptophan Synthase Bienzyme Complex. Biochemistry, 46, 2007
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2CLH
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![BU of 2clh by Molmil](/molmil-images/mine/2clh) | Tryptophan Synthase in complex with (naphthalene-2'-sulfonyl)-2-amino- 1-ethylphosphate (F19) | Descriptor: | 2-[(2-NAPHTHYLSULFONYL)AMINO]ETHYL DIHYDROGEN PHOSPHATE, PYRIDOXAL-5'-PHOSPHATE, SODIUM ION, ... | Authors: | Ngo, H, Harris, R, Kimmich, N, Casino, P, Niks, D, Blumenstein, L, Barends, T.R, Kulik, V, Weyand, M, Schlichting, I, Dunn, M.F. | Deposit date: | 2006-04-27 | Release date: | 2007-06-12 | Last modified: | 2019-04-24 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Synthesis and characterization of allosteric probes of substrate channeling in the tryptophan synthase bienzyme complex. Biochemistry, 46, 2007
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3DPU
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![BU of 3dpu by Molmil](/molmil-images/mine/3dpu) | RocCOR domain tandem of Rab family protein (Roco) | Descriptor: | Rab family protein | Authors: | Gotthardt, K, Weyand, M, Kortholt, A, Van Haastert, P.J.M, Wittinghofer, A. | Deposit date: | 2008-07-09 | Release date: | 2008-08-12 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure of the Roc-COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase Embo J., 27, 2008
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3DPT
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![BU of 3dpt by Molmil](/molmil-images/mine/3dpt) | COR domain of Rab family protein (Roco) | Descriptor: | Rab family protein | Authors: | Gotthardt, K, Weyand, M, Kortholt, A, Van Haastert, P.J.M, Wittinghofer, A. | Deposit date: | 2008-07-09 | Release date: | 2008-08-12 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure of the Roc-COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase Embo J., 27, 2008
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3E6Y
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![BU of 3e6y by Molmil](/molmil-images/mine/3e6y) | Structure of 14-3-3 in complex with the differentiation-inducing agent Cotylenin A | Descriptor: | 14-3-3-like protein C, CHLORIDE ION, Cotylenin A, ... | Authors: | Ottmann, C, Weyand, M, Wittinghofer, A, Oecking, C. | Deposit date: | 2008-08-17 | Release date: | 2009-03-10 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A structural rationale for selective stabilization of anti-tumor interactions of 14-3-3 proteins by cotylenin A J.Mol.Biol., 386, 2009
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2O02
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![BU of 2o02 by Molmil](/molmil-images/mine/2o02) | Phosphorylation independent interactions between 14-3-3 and Exoenzyme S: from structure to pathogenesis | Descriptor: | 14-3-3 protein zeta/delta, BENZOIC ACID, ExoS (416-430) peptide | Authors: | Ottmann, C, Yasmin, L, Weyand, M, Hauser, A.R, Wittinghofer, A, Hallberg, B. | Deposit date: | 2006-11-27 | Release date: | 2007-11-27 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Phosphorylation-independent interaction between 14-3-3 and exoenzyme S: from structure to pathogenesis Embo J., 26, 2007
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