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PDB: 176 件
6Q9J
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BU of 6q9j by Molmil
Crystal structure of reduced Aquifex aeolicus NADH-quinone oxidoreductase subunits NuoE G129S and NuoF bound to NADH
分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, ...
著者Wohlwend, D, Gerhardt, S, Gnandt, E, Friedrich, T.
登録日2018-12-18
公開日2019-06-26
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献A mechanism to prevent production of reactive oxygen species by Escherichia coli respiratory complex I.
Nat Commun, 10, 2019
6Q9K
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Crystal structure of reduced Aquifex aeolicus NADH-quinone oxidoreductase subunits NuoE and NuoF S96M bound to NADH
分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, ...
著者Wohlwend, D, Gerhardt, S, Gnandt, E, Friedrich, T.
登録日2018-12-18
公開日2019-06-26
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献A mechanism to prevent production of reactive oxygen species by Escherichia coli respiratory complex I.
Nat Commun, 10, 2019
6R7P
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BU of 6r7p by Molmil
Crystal structure of oxidized Aquifex aeolicus NADH-quinone oxidoreductase subunits NuoE and NuoF S96M
分子名称: CHLORIDE ION, FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, ...
著者Wohlwend, D, Gnandt, E, Friedrich, T.
登録日2019-03-29
公開日2019-06-26
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.22 Å)
主引用文献A mechanism to prevent production of reactive oxygen species by Escherichia coli respiratory complex I.
Nat Commun, 10, 2019
4LYI
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BU of 4lyi by Molmil
Crystal Structure of apo-BRD4(1)
分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, IODIDE ION, ...
著者Wohlwend, D.
登録日2013-07-31
公開日2014-01-15
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献4-Acyl pyrroles: mimicking acetylated lysines in histone code reading.
Angew.Chem.Int.Ed.Engl., 52, 2013
5C7Z
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BU of 5c7z by Molmil
AP2 Mu2 adaptin C-terminal domain complexed with integrin alpha-4 peptide
分子名称: AP-2 complex subunit mu, Integrin alpha-4
著者Owen, D.J, Evans, P.R, Wilson, T.A.
登録日2015-06-25
公開日2016-07-06
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.77 Å)
主引用文献AP2 Mu2 adaptin C-terminal domain complexed with integrin alpha-4 peptide
To Be Published
5D3J
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BU of 5d3j by Molmil
First bromodomain of BRD4 bound to inhibitor XD33
分子名称: 4-acetyl-N-[3-(diethylsulfamoyl)phenyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4
著者Wohlwend, D, Huegle, M.
登録日2015-08-06
公開日2016-01-20
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1).
J.Med.Chem., 59, 2016
5D3R
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BU of 5d3r by Molmil
First bromodomain of BRD4 bound to inhibitor XD42
分子名称: 4-acetyl-N-[3-(azepan-1-ylsulfonyl)phenyl]-5-methyl-3-propyl-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4
著者Wohlwend, D, Huegle, M.
登録日2015-08-06
公開日2016-01-20
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1).
J.Med.Chem., 59, 2016
5D3H
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BU of 5d3h by Molmil
First bromodomain of BRD4 bound to inhibitor XD29
分子名称: Bromodomain-containing protein 4, N-[5-(diethylsulfamoyl)-2-hydroxyphenyl]-3-ethyl-4-(hydroxyacetyl)-5-methyl-1H-pyrrole-2-carboxamide
著者Wohlwend, D, Huegle, M, Weitzel, G.
登録日2015-08-06
公開日2016-01-20
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1).
J.Med.Chem., 59, 2016
5D3L
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BU of 5d3l by Molmil
First bromodomain of BRD4 bound to inhibitor XD35
分子名称: 4-acetyl-N-[5-(diethylsulfamoyl)-2-hydroxy-4-methylphenyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4
著者Wohlwend, D, Huegle, M.
登録日2015-08-06
公開日2016-01-20
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1).
J.Med.Chem., 59, 2016
4LZR
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BU of 4lzr by Molmil
Crystal Structure of BRD4(1) bound to Colchicine
分子名称: Bromodomain-containing protein 4, N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide
著者Wohlwend, D, Gerhardt, S, Einsle, O, Huegle, M.
登録日2013-08-01
公開日2014-01-15
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献4-Acyl pyrroles: mimicking acetylated lysines in histone code reading.
Angew.Chem.Int.Ed.Engl., 52, 2013
1B9K
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BU of 1b9k by Molmil
ALPHA-ADAPTIN APPENDAGE DOMAIN, FROM CLATHRIN ADAPTOR AP2
分子名称: PROTEIN (ALPHA-ADAPTIN APPENDAGE DOMAIN)
著者Owen, D.J, Evans, P.R.
登録日1999-02-11
公開日1999-07-06
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A structural explanation for the binding of multiple ligands by the alpha-adaptin appendage domain.
Cell(Cambridge,Mass.), 97, 1999
5D3N
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BU of 5d3n by Molmil
First bromodomain of BRD4 bound to inhibitor XD40
分子名称: 4-acetyl-3-ethyl-5-methyl-N-[2-methyl-5-(methylsulfamoyl)phenyl]-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4
著者Wohlwend, D, Huegle, M.
登録日2015-08-06
公開日2016-01-20
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1).
J.Med.Chem., 59, 2016
5D26
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BU of 5d26 by Molmil
First bromodomain of BRD4 bound to inhibitor XD28
分子名称: (R,R)-2,3-BUTANEDIOL, 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ...
著者Wohlwend, D, Huegle, M.
登録日2015-08-05
公開日2016-01-20
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1).
J.Med.Chem., 59, 2016
5D25
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BU of 5d25 by Molmil
First bromodomain of BRD4 bound to inhibitor XD27
分子名称: (R,R)-2,3-BUTANEDIOL, 4-acetyl-N-[5-(diethylsulfamoyl)-2-hydroxyphenyl]-3,5-dimethyl-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4, ...
著者Wohlwend, D, Huegle, M, Gerhardt, S.
登録日2015-08-05
公開日2016-01-20
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1).
J.Med.Chem., 59, 2016
5D24
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BU of 5d24 by Molmil
First bromodomain of BRD4 bound to inhibitor XD26
分子名称: 1,2-ETHANEDIOL, 4-acetyl-N-[3-(2-amino-2-oxoethoxy)phenyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4
著者Wohlwend, D, Huegle, M, Gerhardt, S.
登録日2015-08-05
公開日2016-01-20
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1).
J.Med.Chem., 59, 2016
5D3P
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BU of 5d3p by Molmil
First bromodomain of BRD4 bound to inhibitor XD41
分子名称: 1-[(4-acetyl-3-ethyl-5-methyl-1H-pyrrol-2-yl)carbonyl]-N-methyl-1H-indole-6-sulfonamide, Bromodomain-containing protein 4, NICKEL (II) ION
著者Wohlwend, D, Huegle, M.
登録日2015-08-06
公開日2016-01-20
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1).
J.Med.Chem., 59, 2016
5D3S
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BU of 5d3s by Molmil
First bromodomain of BRD4 bound to inhibitor XD44
分子名称: (R,R)-2,3-BUTANEDIOL, 4-acetyl-3-ethyl-N-[4-fluoro-3-(morpholin-4-ylsulfonyl)phenyl]-5-methyl-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4, ...
著者Wohlwend, D, Huegle, M.
登録日2015-08-06
公開日2016-01-20
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1).
J.Med.Chem., 59, 2016
1BXX
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BU of 1bxx by Molmil
MU2 ADAPTIN SUBUNIT (AP50) OF AP2 ADAPTOR (SECOND DOMAIN), COMPLEXED WITH TGN38 INTERNALIZATION PEPTIDE DYQRLN
分子名称: PROTEIN (AP50), PROTEIN (TGN38 PEPTIDE)
著者Owen, D.J, Evans, P.R.
登録日1998-10-08
公開日1998-11-25
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献A structural explanation for the recognition of tyrosine-based endocytotic signals.
Science, 282, 1998
2QNA
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BU of 2qna by Molmil
Crystal structure of human Importin-beta (127-876) in complex with the IBB-domain of Snurportin1 (1-65)
分子名称: Importin subunit beta-1, SULFATE ION, Snurportin-1
著者Wohlwend, D, Strasser, A, Dickmanns, A, Ficner, R.
登録日2007-07-18
公開日2008-04-08
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.84 Å)
主引用文献Structural basis for RanGTP independent entry of spliceosomal U snRNPs into the nucleus.
J.Mol.Biol., 374, 2007
5D3T
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BU of 5d3t by Molmil
First bromodomain of BRD4 bound to inhibitor XD47
分子名称: 1,2-ETHANEDIOL, 4-acetyl-N-(3-carbamoylbenzyl)-3-ethyl-N,5-dimethyl-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4, ...
著者Wohlwend, D, Huegle, M.
登録日2015-08-06
公開日2016-01-20
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1).
J.Med.Chem., 59, 2016
4C7N
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BU of 4c7n by Molmil
Crystal Structure of the synthetic peptide iM10 in complex with the coiled-coil region of MITF
分子名称: MERCURY (II) ION, MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR, SYNTHETIC ALPHA-HELIX, ...
著者Wohlwend, D, Gerhardt, S, Kuekenshoener, T, Einsle, O.
登録日2013-09-23
公開日2014-04-02
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Improving Coiled Coil Stability While Maintaining Specificity by a Bacterial Hitchhiker Selection System.
J.Struct.Biol., 186, 2014
1BW8
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BU of 1bw8 by Molmil
MU2 ADAPTIN SUBUNIT (AP50) OF AP2 ADAPTOR (SECOND DOMAIN), COMPLEXED WITH EGFR INTERNALIZATION PEPTIDE FYRALM
分子名称: PROTEIN (INTERNALIZATION SIGNAL FROM EGFR), PROTEIN (MU2 ADAPTIN SUBUNIT)
著者Owen, D.J, Evans, P.R.
登録日1998-09-30
公開日1998-11-25
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献A structural explanation for the recognition of tyrosine-based endocytotic signals.
Science, 282, 1998
2V8S
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BU of 2v8s by Molmil
VTI1B HABC DOMAIN - EPSINR ENTH DOMAIN COMPLEX
分子名称: CLATHRIN INTERACTOR 1, GLYCEROL, VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1B
著者Owen, D.J, McCoy, A.J, Collins, B.M, Miller, S.E.
登録日2007-08-14
公開日2007-11-27
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献A Snare-Adaptor Interaction is a New Mode of Cargo Recognition in Clathrin Coated Vesicles
Nature, 450, 2007
2VGL
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BU of 2vgl by Molmil
AP2 CLATHRIN ADAPTOR CORE
分子名称: ADAPTOR PROTEIN COMPLEX AP-2, ALPHA 2 SUBUNIT, AP-2 COMPLEX SUBUNIT BETA-1, ...
著者Owen, D.J, Collins, B.M, McCoy, A.J, Evans, P.R.
登録日2007-11-14
公開日2007-12-25
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Molecular Architecture and Functional Model of the Endocytic Ap2 Complex
Cell(Cambridge,Mass.), 109, 2002
1BB9
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BU of 1bb9 by Molmil
CRYSTAL STRUCTURE OF THE SH3 DOMAIN FROM RAT AMPHIPHYSIN 2
分子名称: AMPHIPHYSIN 2
著者Owen, D.J, Mcmahon, H.T, Evans, P.R.
登録日1998-04-29
公開日1998-06-17
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of the amphiphysin-2 SH3 domain and its role in the prevention of dynamin ring formation.
EMBO J., 17, 1998

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