1G9U
| CRYSTAL STRUCTURE OF YOPM-LEUCINE RICH EFFECTOR PROTEIN FROM YERSINIA PESTIS | 分子名称: | ACETATE ION, CALCIUM ION, MERCURY (II) ION, ... | 著者 | Evdokimov, A.G, Anderson, D.E, Routzahn, K.M, Waugh, D.S. | 登録日 | 2000-11-28 | 公開日 | 2001-10-10 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Unusual molecular architecture of the Yersinia pestis cytotoxin YopM: a leucine-rich repeat protein with the shortest repeating unit. J.Mol.Biol., 312, 2001
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1HY5
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1HUF
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2YIQ
| Structural analysis of checkpoint kinase 2 in complex with inhibitor PV1322 | 分子名称: | (E)-5-(1-(2-CARBAMIMIDOYLHYDRAZONO)ETHYL)-N-(1H-INDOL-6-YL)-1H-INDOLE-2-CARBOXAMIDE, NITRATE ION, SERINE/THREONINE-PROTEIN KINASE CHK2 | 著者 | Lountos, G.T, Jobson, A.G, Tropea, J.E, Self, C, Zhang, G, Pommier, Y, Shoemaker, R.H, Waugh, D.S. | 登録日 | 2011-05-16 | 公開日 | 2011-09-07 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | X-Ray Structures of Checkpoint Kinase 2 in Complex with Inhibitors that Target its Gatekeeper-Dependent Hydrophobic Pocket. FEBS Lett., 585, 2011
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8SK1
| Bacillus anthracis HPPK in complex with bisubstrate inhibitor HP-73 | 分子名称: | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase, 5'-S-[(2R,4R)-1-{2-[(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridine-6-carbonyl)amino]ethyl}-2-carboxypiperidin-4-yl]-5'-thioadenosine | 著者 | Shaw, G.X, Tropea, J.E, Shi, G, Waugh, D.S, Ji, X. | 登録日 | 2023-04-18 | 公開日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of Bacillus anthracis HPPK in complex with bisubstrate inhibitor HP-73 To be published
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8SZE
| Crystal structure of Yersinia pestis dihydrofolate reductase in complex with Trimethoprim | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Dihydrofolate reductase, ... | 著者 | Shaw, G.X, Cherry, S, Tropea, J.E, Waugh, D.S, Ji, X. | 登録日 | 2023-05-29 | 公開日 | 2023-06-07 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structure of Yersinia pestis dihydrofolate reductase in complex with Trimethoprim To be published
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8SZD
| Crystal structure of Yersinia pestis dihydrofolate reductase at 1.25-A resolution | 分子名称: | CHLORIDE ION, Dihydrofolate reductase, MAGNESIUM ION, ... | 著者 | Shaw, G.X, Cherry, S, Tropea, J.E, Waugh, D.S, Ji, X. | 登録日 | 2023-05-29 | 公開日 | 2023-06-07 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Crystal structure of Yersinia pestis dihydrofolate reductase at 1.25-A resolution To be published
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2YIR
| Structural analysis of checkpoint kinase 2 in complex with inhibitor PV1352 | 分子名称: | (E)-N-(5-(2-CARBAMIMIDOYLHYDRAZONO)-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)-7-NITRO-1H-INDOLE-2-CARBOXAMIDE, NITRATE ION, SERINE/THREONINE-PROTEIN KINASE CHK2 | 著者 | Lountos, G.T, Jobson, A.G, Tropea, J.E, Self, C, Zhang, G, Pommier, Y, Shoemaker, R.H, Waugh, D.S. | 登録日 | 2011-05-16 | 公開日 | 2011-09-07 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | X-Ray Structures of Checkpoint Kinase 2 in Complex with Inhibitors that Target its Gatekeeper-Dependent Hydrophobic Pocket. FEBS Lett., 585, 2011
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2YIT
| Structural analysis of checkpoint kinase 2 in complex with PV1162, a novel inhibitor | 分子名称: | N-{4-[(1E)-N-carbamimidoylbutanehydrazonoyl]phenyl}-5-methoxy-1H-indole-2-carboxamide, NITRATE ION, SERINE/THREONINE-PROTEIN KINASE CHK2 | 著者 | Lountos, G.T, Jobson, A.G, Tropea, J.E, Self, C, Zhang, G, Pommier, Y, Shoemaker, R.H, Waugh, D.S. | 登録日 | 2011-05-16 | 公開日 | 2011-09-07 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | X-Ray Structures of Checkpoint Kinase 2 in Complex with Inhibitors that Target its Gatekeeper-Dependent Hydrophobic Pocket. FEBS Lett., 585, 2011
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6APX
| Crystal structure of human dual specificity phosphatase 1 catalytic domain (C258S) as a maltose binding protein fusion in complex with the monobody YSX1 | 分子名称: | GLYCEROL, Maltose-binding periplasmic protein,Dual specificity protein phosphatase 1, Monobody YSX1, ... | 著者 | Gumpena, R, Lountos, G.T, Sreejith, R.K, Tropea, J.E, Cherry, S, Waugh, D.S. | 登録日 | 2017-08-18 | 公開日 | 2017-11-01 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.491 Å) | 主引用文献 | Crystal structure of the human dual specificity phosphatase 1 catalytic domain. Protein Sci., 27, 2018
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4Y2E
| Crystal structure of the catalytic domain of human dual-specificity phosphatase 7 (C232S) | 分子名称: | Dual specificity protein phosphatase 7, PHOSPHATE ION | 著者 | Lountos, G.T, Austin, B.P, Tropea, J.E, Waugh, D.S. | 登録日 | 2015-02-09 | 公開日 | 2015-06-03 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | Structure of human dual-specificity phosphatase 7, a potential cancer drug target. Acta Crystallogr.,Sect.F, 71, 2015
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6D3F
| Crystal Structure of the PTP epsilon D2 domain | 分子名称: | Receptor-type tyrosine-protein phosphatase epsilon | 著者 | Lountos, G.T, Raran-Kurussi, S, Zhao, B.M, Dyas, B.K, Austin, B.P, Burke Jr, T.R, Ulrich, R.G, Waugh, D.S. | 登録日 | 2018-04-16 | 公開日 | 2018-10-17 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.271 Å) | 主引用文献 | High-resolution crystal structures of the D1 and D2 domains of protein tyrosine phosphatase epsilon for structure-based drug design. Acta Crystallogr D Struct Biol, 74, 2018
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4WOH
| Structure of of human dual-specificity phosphatase 22 (E24A/K28A/K30A/C88S) complexed with 4-nitrophenolphosphate | 分子名称: | 1,2-ETHANEDIOL, 4-NITROPHENYL PHOSPHATE, DI(HYDROXYETHYL)ETHER, ... | 著者 | Lountos, G.T, Cherry, S, Tropea, J.E, Waugh, D.S. | 登録日 | 2014-10-15 | 公開日 | 2015-02-18 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.34 Å) | 主引用文献 | Structural analysis of human dual-specificity phosphatase 22 complexed with a phosphotyrosine-like substrate. Acta Crystallogr.,Sect.F, 71, 2015
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6D65
| Crystal structure of the human dual specificity phosphatase 1 catalytic domain (C258S) as a maltose binding protein fusion in complex with the designed AR protein off7 | 分子名称: | Designed AR protein off7, ETHANOL, GLYCEROL, ... | 著者 | Gumpena, R, Lountos, G.T, Waugh, D.S. | 登録日 | 2018-04-20 | 公開日 | 2018-09-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.348 Å) | 主引用文献 | MBP-binding DARPins facilitate the crystallization of an MBP fusion protein. Acta Crystallogr F Struct Biol Commun, 74, 2018
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6D4F
| Crystal structure of PTP epsilon D2 domain (A455N/V457Y/E597D) | 分子名称: | PENTAETHYLENE GLYCOL, Receptor-type tyrosine-protein phosphatase epsilon | 著者 | Lountos, G.T, Raran-Kurussi, S, Zhao, B.M, Dyas, B.K, Austin, B.P, Burke Jr, T.R, Ulrich, R.G, Waugh, D.S. | 登録日 | 2018-04-18 | 公開日 | 2018-10-17 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.909 Å) | 主引用文献 | High-resolution crystal structures of the D1 and D2 domains of protein tyrosine phosphatase epsilon for structure-based drug design. Acta Crystallogr D Struct Biol, 74, 2018
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6D4D
| Crystal structure of the PTP epsilon D1 domain | 分子名称: | Receptor-type tyrosine-protein phosphatase epsilon | 著者 | Lountos, G.T, Raran-Kurussi, S, Zhao, B.M, Dyas, B.K, Austin, B.P, Burke Jr, T.R, Ulrich, R.G, Waugh, D.S. | 登録日 | 2018-04-18 | 公開日 | 2018-10-17 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.765 Å) | 主引用文献 | High-resolution crystal structures of the D1 and D2 domains of protein tyrosine phosphatase epsilon for structure-based drug design. Acta Crystallogr D Struct Biol, 74, 2018
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6D66
| Crystal structure of the human dual specificity 1 catalytic domain (C258S) as a maltose binding protein fusion in complex with the designed AR protein mbp3_16 | 分子名称: | 1,2-ETHANEDIOL, D-ALANINE, DI(HYDROXYETHYL)ETHER, ... | 著者 | Gumpena, R, Waugh, D.S, Lountos, G.T. | 登録日 | 2018-04-20 | 公開日 | 2018-09-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.226 Å) | 主引用文献 | MBP-binding DARPins facilitate the crystallization of an MBP fusion protein. Acta Crystallogr F Struct Biol Commun, 74, 2018
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6D67
| Crystal structure of the human dual specificity phosphatase 1 catalytic domain (C258S) as a maltose binding protein fusion (maltose bound form) in complex with the designed AR protein mbp3_16 | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Designed AR protein mbp3_16, ... | 著者 | Gumpena, R, Lountos, G.T, Waugh, D.S. | 登録日 | 2018-04-20 | 公開日 | 2018-09-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | MBP-binding DARPins facilitate the crystallization of an MBP fusion protein. Acta Crystallogr F Struct Biol Commun, 74, 2018
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2JLH
| Crystal Structure of the Cytoplasmic domain of Yersinia Pestis YscU N263A mutant | 分子名称: | PENTAETHYLENE GLYCOL, YOP PROTEINS TRANSLOCATION PROTEIN U | 著者 | Lountos, G.T, Austin, B.P, Nallamsetty, S, Waugh, D.S. | 登録日 | 2008-09-09 | 公開日 | 2009-02-03 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | 主引用文献 | Atomic Resolution Structure of the Cytoplasmic Domain of Yersinia Pestis Yscu, a Regulatory Switch Involved in Type III Secretion. Protein Sci., 18, 2009
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2IF5
| Structure of the POZ domain of human LRF, a master regulator of oncogenesis | 分子名称: | PRASEODYMIUM ION, Zinc finger and BTB domain-containing protein 7A | 著者 | Schubot, F.D, Waugh, D.S, Tropea, J. | 登録日 | 2006-09-20 | 公開日 | 2006-11-21 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of the POZ domain of human LRF, a master regulator of oncogenesis. Biochem.Biophys.Res.Commun., 351, 2006
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2JLI
| Atomic resolution structure of the cytoplasmic domain of Yersinia pestis YscU, a regulatory switch involved in type III secretion | 分子名称: | YOP PROTEINS TRANSLOCATION PROTEIN | 著者 | Lountos, G.T, Austin, B.P, Nallamsetty, S, Waugh, D.S. | 登録日 | 2008-09-09 | 公開日 | 2009-02-03 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.13 Å) | 主引用文献 | Atomic Resolution Structure of the Cytoplasmic Domain of Yersinia Pestis Yscu, a Regulatory Switch Involved in Type III Secretion. Protein Sci., 18, 2009
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2JLJ
| Crystal Structure of the cytoplasmic domain of Yersinia pestis YscU N263A P264A mutant | 分子名称: | YOP PROTEINS TRANSLOCATION PROTEIN U | 著者 | Lountos, G.T, Austin, B.P, Nallamsetty, S, Waugh, D.S. | 登録日 | 2008-09-09 | 公開日 | 2009-02-03 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Atomic Resolution Structure of the Cytoplasmic Domain of Yersinia Pestis Yscu, a Regulatory Switch Involved in Type III Secretion. Protein Sci., 18, 2009
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2JR0
| Solution structure of NusB from Aquifex Aeolicus | 分子名称: | N utilization substance protein B homolog | 著者 | Das, R, Loss, S, Li, J, Tarasov, S, Wingfield, P, Waugh, D.S, Byrd, R.A, Altieri, A.S. | 登録日 | 2007-06-18 | 公開日 | 2008-02-19 | 最終更新日 | 2024-05-08 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural biophysics of the NusB:NusE antitermination complex. J.Mol.Biol., 376, 2008
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2YCR
| Crystal structure of checkpoint kinase 2 in complex with inhibitor PV976 | 分子名称: | 1,3-BIS{4-[(1E)-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)ETHANEHYDRAZONOYL]PHENYL}UREA, NITRATE ION, SERINE/THREONINE-PROTEIN KINASE CHK2 | 著者 | Lountos, G.T, Jobson, A.G, Tropea, J.E, Self, C.R, Pommier, Y, Shoemaker, R.H, Zhang, G, Waugh, D.S. | 登録日 | 2011-03-16 | 公開日 | 2011-11-16 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural Characterization of Inhibitor Complexes with Checkpoint Kinase 2 (Chk2), a Drug Target for Cancer Therapy. J.Struct.Biol., 176, 2011
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1ORJ
| FLAGELLAR EXPORT CHAPERONE | 分子名称: | flagellar protein FliS | 著者 | Evdokimov, A.G, Phan, J, Tropea, J.E, Routzahn, K.M, Peters III, H.K, Pokross, M, Waugh, D.S. | 登録日 | 2003-03-13 | 公開日 | 2003-09-16 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Similar modes of polypeptide recognition by export chaperones in flagellar biosynthesis and type III secretion Nat.Struct.Biol., 10, 2003
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