2PQE
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![BU of 2pqe by Molmil](/molmil-images/mine/2pqe) | Solution structure of proline-free mutant of staphylococcal nuclease | Descriptor: | Thermonuclease | Authors: | Shan, L, Tong, Y, Xie, T, Wang, M, Wang, J. | Deposit date: | 2007-05-01 | Release date: | 2007-06-19 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Restricted backbone conformational and motional flexibilities of loops containing peptidyl-proline bonds dominate the enzyme activity of staphylococcal nuclease. Biochemistry, 46, 2007
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5YB1
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![BU of 5yb1 by Molmil](/molmil-images/mine/5yb1) | Structure and function of human serum albumin-metal agent complex | Descriptor: | PALMITIC ACID, Serum albumin, ~{N},~{N},12-trimethyl-3$l^{3}-thia-1$l^{4},5,6$l^{4}-triaza-2$l^{3}-cupratricyclo[6.4.0.0^{2,6}]dodeca-1(8),3,6,9,11-pentaen-4-amine | Authors: | Yang, F, Wang, T, Wang, J, Gou, Y, Zhang, Z.L. | Deposit date: | 2017-09-02 | Release date: | 2018-09-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.616 Å) | Cite: | Developing an Anticancer Copper(II) Multitarget Pro-Drug Based on the His146 Residue in the IB Subdomain of Modified Human Serum Albumin. Mol. Pharm., 15, 2018
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4ID7
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![BU of 4id7 by Molmil](/molmil-images/mine/4id7) | ACK1 kinase in complex with the inhibitor cis-3-[8-amino-1-(4-phenoxyphenyl)imidazo[1,5-a]pyrazin-3-yl]cyclobutanol | Descriptor: | Activated CDC42 kinase 1, SULFATE ION, cis-3-[8-amino-1-(4-phenoxyphenyl)imidazo[1,5-a]pyrazin-3-yl]cyclobutanol | Authors: | Jin, M, Wang, J, Kleinberg, A, Kadalbajoo, M, Siu, K, Cooke, A, Bittner, M, Yao, Y, Thelemann, A, Ji, Q, Bhagwat, S, Crew, A.P, Pachter, J, Epstein, D, Mulvihill, M.J. | Deposit date: | 2012-12-11 | Release date: | 2013-01-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Discovery of potent, selective and orally bioavailable imidazo[1,5-a]pyrazine derived ACK1 inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
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3P5N
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5GPH
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3P49
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![BU of 3p49 by Molmil](/molmil-images/mine/3p49) | Crystal Structure of a Glycine Riboswitch from Fusobacterium nucleatum | Descriptor: | GLYCINE, GLYCINE RIBOSWITCH, MAGNESIUM ION, ... | Authors: | Butler, E.B, Wang, J, Xiong, Y, Strobel, S. | Deposit date: | 2010-10-06 | Release date: | 2011-04-06 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.55 Å) | Cite: | Structural basis of cooperative ligand binding by the glycine riboswitch. Chem.Biol., 18, 2011
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3QER
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![BU of 3qer by Molmil](/molmil-images/mine/3qer) | RB69 DNA Polymerase (L561A/S565G/Y567A) Ternary Complex with dATP Opposite Difluorotoluene Nucleoside | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*(DOC))-3'), ... | Authors: | Xia, S, Konigsberg, W.H, Wang, J. | Deposit date: | 2011-01-20 | Release date: | 2012-01-25 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Structural Basis for Differential Insertion Kinetics of dNMPs Opposite a Difluorotoluene Nucleotide Residue. Biochemistry, 51, 2012
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8WIG
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![BU of 8wig by Molmil](/molmil-images/mine/8wig) | Crystal structure of E. coli ThrS catalytic domain mutant G463S/Q484A | Descriptor: | Threonine--tRNA ligase, ZINC ION | Authors: | Qiao, H, Wang, Z, Wang, J, Fang, P. | Deposit date: | 2023-09-24 | Release date: | 2024-07-24 | Method: | X-RAY DIFFRACTION (3.22 Å) | Cite: | Specific glycine-dependent enzyme motion determines the potency of conformation selective inhibitors of threonyl-tRNA synthetase. Commun Biol, 7, 2024
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8WII
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![BU of 8wii by Molmil](/molmil-images/mine/8wii) | Crystal structure of E. coli ThrS catalytic domain mutant G463A in complex with Obafluorin | Descriptor: | Threonine--tRNA ligase, ZINC ION, ~{N}-[(2~{R},3~{S})-2-[(4-nitrophenyl)methyl]-4-oxidanylidene-oxetan-3-yl]-2,3-bis(oxidanyl)benzamide | Authors: | Qiao, H, Wang, Z, Wang, J, Fang, P. | Deposit date: | 2023-09-24 | Release date: | 2024-07-24 | Method: | X-RAY DIFFRACTION (2.98 Å) | Cite: | Specific glycine-dependent enzyme motion determines the potency of conformation selective inhibitors of threonyl-tRNA synthetase. Commun Biol, 7, 2024
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8WIJ
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![BU of 8wij by Molmil](/molmil-images/mine/8wij) | Crystal structure of E. coli ThrS catalytic domain mutant L489M in complex with Obafluorin | Descriptor: | N-(2,3-dihydroxybenzoyl)-4-(4-nitrophenyl)-L-threonine, Threonine--tRNA ligase, ZINC ION | Authors: | Qiao, H, Wang, Z, Wang, J, Fang, P. | Deposit date: | 2023-09-24 | Release date: | 2024-07-24 | Method: | X-RAY DIFFRACTION (3.08 Å) | Cite: | Specific glycine-dependent enzyme motion determines the potency of conformation selective inhibitors of threonyl-tRNA synthetase. Commun Biol, 7, 2024
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8WIA
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![BU of 8wia by Molmil](/molmil-images/mine/8wia) | Crystal structure of E. coli ThrS catalytic domain mutant G463S | Descriptor: | Threonine--tRNA ligase, ZINC ION | Authors: | Qiao, H, Wang, Z, Wang, J, Fang, P. | Deposit date: | 2023-09-24 | Release date: | 2024-07-24 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Specific glycine-dependent enzyme motion determines the potency of conformation selective inhibitors of threonyl-tRNA synthetase. Commun Biol, 7, 2024
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3QET
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3QEV
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3QEI
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![BU of 3qei by Molmil](/molmil-images/mine/3qei) | RB69 DNA Polymerase (L561A/S565G/Y567A) Ternary Complex with dCTP Opposite Difluorotoluene Nucleoside | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*(DOC))-3'), ... | Authors: | Xia, S, Konigsberg, W.H, Wang, J. | Deposit date: | 2011-01-20 | Release date: | 2012-01-25 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.178 Å) | Cite: | Structural Basis for Differential Insertion Kinetics of dNMPs Opposite a Difluorotoluene Nucleotide Residue. Biochemistry, 51, 2012
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3QEW
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3QES
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![BU of 3qes by Molmil](/molmil-images/mine/3qes) | RB69 DNA Polymerase (L561A/S565G/Y567A) Ternary Complex with dGTP Opposite Difluorotoluene Nucleoside | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*(DOC))-3'), ... | Authors: | Xia, S, Konigsberg, W.H, Wang, J. | Deposit date: | 2011-01-20 | Release date: | 2012-01-25 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Structural Basis for Differential Insertion Kinetics of dNMPs Opposite a Difluorotoluene Nucleotide Residue. Biochemistry, 51, 2012
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3P22
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![BU of 3p22 by Molmil](/molmil-images/mine/3p22) | Crystal structure of the ENE, a viral RNA stability element, in complex with A9 RNA | Descriptor: | Core ENE hairpin from KSHV PAN RNA, oligo(A)9 RNA | Authors: | Mitton-Fry, R.M, DeGregorio, S.J, Wang, J, Steitz, T.A, Steitz, J.A. | Deposit date: | 2010-10-01 | Release date: | 2010-12-08 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.501 Å) | Cite: | Poly(A) tail recognition by a viral RNA element through assembly of a triple helix. Science, 330, 2010
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8WIH
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![BU of 8wih by Molmil](/molmil-images/mine/8wih) | Crystal structure of E. coli ThrS catalytic domain mutant G463A in complex with ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Threonine--tRNA ligase, ZINC ION | Authors: | Qiao, H, Wang, Z, Wang, J, Fang, P. | Deposit date: | 2023-09-24 | Release date: | 2024-07-24 | Method: | X-RAY DIFFRACTION (2.44 Å) | Cite: | Specific glycine-dependent enzyme motion determines the potency of conformation selective inhibitors of threonyl-tRNA synthetase. Commun Biol, 7, 2024
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3NS2
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![BU of 3ns2 by Molmil](/molmil-images/mine/3ns2) | High-resolution structure of pyrabactin-bound PYL2 | Descriptor: | 4-bromo-N-(pyridin-2-ylmethyl)naphthalene-1-sulfonamide, Abscisic acid receptor PYL2 | Authors: | Hao, Q, Yin, P, Yan, C, Yuan, X, Wang, J, Yan, N. | Deposit date: | 2010-07-01 | Release date: | 2010-07-21 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.634 Å) | Cite: | Single amino acid alteration between Valine and Isoleucine determines the distinct pyrabactin selectivity by PYL1 and PYL2 J.Biol.Chem., 285, 2010
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3QEP
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![BU of 3qep by Molmil](/molmil-images/mine/3qep) | RB69 DNA Polymerase (L561A/S565G/Y567A) Ternary Complex with dTTP Opposite Difluorotoluene Nucleoside | Descriptor: | CALCIUM ION, DNA (5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*(DOC))-3'), DNA (5'-D(*TP*CP*GP*(DFT)P*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3'), ... | Authors: | Xia, S, Konigsberg, W.H, Wang, J. | Deposit date: | 2011-01-20 | Release date: | 2011-08-31 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Hydrogen-bonding capability of a templating difluorotoluene nucleotide residue in an RB69 DNA polymerase ternary complex. J.Am.Chem.Soc., 133, 2011
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3QEX
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7E2B
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![BU of 7e2b by Molmil](/molmil-images/mine/7e2b) | GDPD mutant complex from Pyrococcus furiosus DSM 3638 | Descriptor: | CHOLINE ION, Glycerophosphodiester phosphodiesterase, MAGNESIUM ION, ... | Authors: | Wang, Y.H, Wang, J, Wang, F.H. | Deposit date: | 2021-02-05 | Release date: | 2022-02-09 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Observation of the GPC production during hydrolysis of LPC by GDPD D60A from Pyrococcus furiosus DSM 3638 To Be Published
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7E0V
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![BU of 7e0v by Molmil](/molmil-images/mine/7e0v) | GDPD from Pyrococcus furiosus DSM 3638 | Descriptor: | Glycerophosphodiester phosphodiesterase | Authors: | Wang, Y.H, Wang, J, Wang, F.H. | Deposit date: | 2021-01-28 | Release date: | 2022-02-09 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Crystal structure of Bomgl, a monoacylglycerol lipase from marine Bacillus To Be Published
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7E2A
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![BU of 7e2a by Molmil](/molmil-images/mine/7e2a) | GDPD mutant from Pyrococcus furiosus DSM 3638 | Descriptor: | Glycerophosphodiester phosphodiesterase | Authors: | Wang, Y.H, Wang, J, Wang, F.H. | Deposit date: | 2021-02-05 | Release date: | 2022-02-09 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Crystal structure of glycerophoshphodiester phospodiesterase D60A mutant from Pyrococcus furiosus DSM To Be Published
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3RC8
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![BU of 3rc8 by Molmil](/molmil-images/mine/3rc8) | Human Mitochondrial Helicase Suv3 in Complex with Short RNA Fragment | Descriptor: | ATP-dependent RNA helicase SUPV3L1, mitochondrial, RNA fragment | Authors: | Dauter, Z, Jedrzejczak, R, Dauter, M, Wang, J, Szczesny, R, Stepien, P. | Deposit date: | 2011-03-30 | Release date: | 2011-05-11 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Human Suv3 protein reveals unique features among SF2 helicases. Acta Crystallogr.,Sect.D, 67, 2011
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