4HLU
 
 | | Structure of the EcfA-A' heterodimer bound to ADP | | Descriptor: | ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, Energy-coupling factor transporter ATP-binding protein EcfA, ... | | Authors: | Wang, D.N, Karpowich, N.K. | | Deposit date: | 2012-10-17 | | Release date: | 2013-02-06 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.7003 Å) | | Cite: | Assembly and mechanism of a group II ECF transporter.
Proc.Natl.Acad.Sci.USA, 110, 2013
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3KLY
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3KLZ
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8TTF
 | | NorA double mutant - E222QD307N at pH 7.5 | | Descriptor: | Heavy Chain of FabDA1 Variable Domain, Light Chain of FabDA1 Variable Domain, Quinolone resistance protein NorA | | Authors: | Li, J.P, Li, Y, Koide, A, Kuang, H.H, Torres, V.J, Koide, S, Wang, D.N, Traaseth, N.J. | | Deposit date: | 2023-08-13 | | Release date: | 2024-05-29 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (3.61 Å) | | Cite: | Proton-coupled transport mechanism of the efflux pump NorA.
Nat Commun, 15, 2024
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8TTH
 | | NorA single mutant - D307N at pH 7.5 | | Descriptor: | Heavy Chain of FabDA1 Variable Domain, Light Chain of FabDA1 Variable Domain, Quinolone resistance protein NorA | | Authors: | Li, J.P, Li, Y, Koide, A, Kuang, H.H, Torres, V.J, Koide, S, Wang, D.N, Traaseth, N.J. | | Deposit date: | 2023-08-13 | | Release date: | 2024-05-29 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.54 Å) | | Cite: | Proton-coupled transport mechanism of the efflux pump NorA.
Nat Commun, 15, 2024
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8TTE
 | | Protonated state of NorA at pH 5.0 | | Descriptor: | FabDA1 CDRH3 loop, Quinolone resistance protein NorA | | Authors: | Li, J.P, Li, Y, Koide, A, Kuang, H.H, Torres, V.J, Koide, S, Wang, D.N, Traaseth, N.J. | | Deposit date: | 2023-08-13 | | Release date: | 2024-05-29 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.26 Å) | | Cite: | Proton-coupled transport mechanism of the efflux pump NorA.
Nat Commun, 15, 2024
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8TTG
 | | NorA single mutant - E222Q at pH 7.5 | | Descriptor: | FabDA1 CDRH3 loop, Quinolone resistance protein NorA | | Authors: | Li, J.P, Li, Y, Koide, A, Kuang, H.H, Torres, V.J, Koide, S, Wang, D.N, Traaseth, N.J. | | Deposit date: | 2023-08-13 | | Release date: | 2024-05-29 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.35 Å) | | Cite: | Proton-coupled transport mechanism of the efflux pump NorA.
Nat Commun, 15, 2024
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7T9F
 | | Structure of VcINDY-apo | | Descriptor: | DASS family sodium-coupled anion symporter | | Authors: | Sauer, D.B, Marden, J.J, Song, J.M, Wang, D.N. | | Deposit date: | 2021-12-19 | | Release date: | 2022-05-25 | | Last modified: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (3.23 Å) | | Cite: | Structural basis of ion - substrate coupling in the Na + -dependent dicarboxylate transporter VcINDY.
Nat Commun, 13, 2022
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7T9G
 | | Structure of VcINDY-Na+ | | Descriptor: | DASS family sodium-coupled anion symporter, SODIUM ION | | Authors: | Sauer, D.B, Marden, J.J, Song, J.M, Wang, D.N. | | Deposit date: | 2021-12-19 | | Release date: | 2022-05-25 | | Last modified: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (2.83 Å) | | Cite: | Structural basis of ion - substrate coupling in the Na + -dependent dicarboxylate transporter VcINDY.
Nat Commun, 13, 2022
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4ZIR
 | | Crystal structure of EcfAA' heterodimer bound to AMPPNP | | Descriptor: | CHLORIDE ION, Energy-coupling factor transporter ATP-binding protein EcfA1, Energy-coupling factor transporter ATP-binding protein EcfA2, ... | | Authors: | Karpowich, N.K, Cocco, N, Song, J.M, Wang, D.N. | | Deposit date: | 2015-04-28 | | Release date: | 2015-06-10 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | ATP binding drives substrate capture in an ECF transporter by a release-and-catch mechanism.
Nat.Struct.Mol.Biol., 22, 2015
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7LO8
 | | NorA in complex with Fab36 | | Descriptor: | Fab36 Heavy Chain, Fab36 Light Chain, Quinolone resistance protein NorA | | Authors: | Brawley, D.N, Sauer, D.B, Song, J.M, Koide, A, Koide, S, Traaseth, N.J, Wang, D.N. | | Deposit date: | 2021-02-09 | | Release date: | 2022-04-20 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.16 Å) | | Cite: | Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus.
Nat.Chem.Biol., 18, 2022
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7LO7
 | | NorA in complex with Fab25 | | Descriptor: | Fab25 Heavy Chain, Fab25 Light Chain, Quinolone resistance protein NorA | | Authors: | Brawley, D.N, Sauer, D.B, Song, J.M, Koide, A, Koide, S, Traaseth, N.J, Wang, D.N. | | Deposit date: | 2021-02-09 | | Release date: | 2022-04-20 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.74 Å) | | Cite: | Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus.
Nat.Chem.Biol., 18, 2022
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5KBW
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5KC4
 | | Structure of TmRibU, orthorhombic crystal form | | Descriptor: | RIBOFLAVIN, Riboflavin transporter RibU, nonyl beta-D-glucopyranoside | | Authors: | Karpowich, N.K, Wang, D.N, Song, J.M. | | Deposit date: | 2016-06-04 | | Release date: | 2016-06-29 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | An Aromatic Cap Seals the Substrate Binding Site in an ECF-Type S Subunit for Riboflavin.
J.Mol.Biol., 428, 2016
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5KC0
 | | Crystal structure of TmRibU, hexagonal crystal form | | Descriptor: | RIBOFLAVIN, Riboflavin transporter RibU, nonyl beta-D-glucopyranoside | | Authors: | Karpowich, N.K, Wang, D.N, Song, J.M. | | Deposit date: | 2016-06-03 | | Release date: | 2016-06-29 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.2001 Å) | | Cite: | An Aromatic Cap Seals the Substrate Binding Site in an ECF-Type S Subunit for Riboflavin.
J.Mol.Biol., 428, 2016
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2QJU
 | | Crystal Structure of an NSS Homolog with Bound Antidepressant | | Descriptor: | 3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE, CHLORIDE ION, LEUCINE, ... | | Authors: | Zhou, Z, Karpowich, N.K, Wang, D.N, New York Consortium on Membrane Protein Structure (NYCOMPS) | | Deposit date: | 2007-07-09 | | Release date: | 2007-08-21 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake.
Science, 317, 2007
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7JSJ
 | | Structure of the NaCT-PF2 complex | | Descriptor: | (2R)-2-[2-(4-tert-butylphenyl)ethyl]-2-hydroxybutanedioic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, ... | | Authors: | Sauer, D.B, Wang, B, Song, J, Rice, W.J, Wang, D.N. | | Deposit date: | 2020-08-14 | | Release date: | 2021-02-24 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.12 Å) | | Cite: | Structure and inhibition mechanism of the human citrate transporter NaCT.
Nature, 591, 2021
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7JSK
 | | Structure of the NaCT-Citrate complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CITRIC ACID, SODIUM ION, ... | | Authors: | Sauer, D.B, Wang, B, Song, J, Rice, W.J, Wang, D.N. | | Deposit date: | 2020-08-14 | | Release date: | 2021-02-24 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.04 Å) | | Cite: | Structure and inhibition mechanism of the human citrate transporter NaCT.
Nature, 591, 2021
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7EW5
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3GWU
 | | Leucine transporter LeuT in complex with sertraline | | Descriptor: | (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine, LEUCINE, SODIUM ION, ... | | Authors: | Zhou, Z, Zhen, J, Karpowich, N.K, Law, C.J, Reith, M.E.A, Wang, D.N. | | Deposit date: | 2009-04-01 | | Release date: | 2009-05-12 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.14 Å) | | Cite: | Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.
Nat.Struct.Mol.Biol., 16, 2009
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3GWW
 | | Leucine transporter LeuT in complex with S-fluoxetine | | Descriptor: | (3S)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, LEUCINE, SODIUM ION, ... | | Authors: | Zhou, Z, Zhen, J, Karpowich, N.K, Law, C.J, Reith, M.E.A, Wang, D.N. | | Deposit date: | 2009-04-01 | | Release date: | 2009-05-12 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.46 Å) | | Cite: | Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.
Nat.Struct.Mol.Biol., 16, 2009
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1PW4
 | | Crystal Structure of the Glycerol-3-Phosphate Transporter from E.Coli | | Descriptor: | Glycerol-3-phosphate transporter | | Authors: | Huang, Y, Lemieux, M.J, Song, J, Auer, M, Wang, D.N. | | Deposit date: | 2003-06-30 | | Release date: | 2003-08-05 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Structure and Mechanism of the Glycerol-3-Phosphate Transporter from Escherichia Coli
Science, 301, 2003
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3GWV
 | | Leucine transporter LeuT in complex with R-fluoxetine | | Descriptor: | (3R)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, LEUCINE, SODIUM ION, ... | | Authors: | Zhou, Z, Zhen, J, Karpowich, N.K, Law, C.J, Reith, M.E.A, Wang, D.N. | | Deposit date: | 2009-04-01 | | Release date: | 2009-05-12 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.
Nat.Struct.Mol.Biol., 16, 2009
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7F8I
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6OL0
 | | Structure of VcINDY bound to Malate | | Descriptor: | (2S)-2-hydroxybutanedioic acid, SODIUM ION, Transporter, ... | | Authors: | Sauer, D.B, Marden, J.J, Wang, D.N. | | Deposit date: | 2019-04-15 | | Release date: | 2020-10-28 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.502 Å) | | Cite: | Elevator mechanism dynamics in a sodium-coupled dicarboxylate transporter
Biorxiv, 2022
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