1G6O
 
 | | CRYSTAL STRUCTURE OF THE HELICOBACTER PYLORI ATPASE, HP0525, IN COMPLEX WITH ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CAG-ALPHA, DI(HYDROXYETHYL)ETHER | | Authors: | Yeo, H.J, Savvides, S.N, Herr, A.B, Lanka, E, Waksman, G, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2000-11-07 | | Release date: | 2001-01-24 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of the hexameric traffic ATPase of the Helicobacter pylori type IV secretion system.
Mol.Cell, 6, 2000
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2KT6
 | | Structural homology between the C-terminal domain of the PapC usher and its plug | | Descriptor: | Outer membrane usher protein papC | | Authors: | Ford, B, Rego, A, Ragan, T.J, Pinkner, J, Dodson, K, Driscoll, P.C, Hultgren, S, Waksman, G. | | Deposit date: | 2010-01-19 | | Release date: | 2010-04-21 | | Last modified: | 2022-03-16 | | Method: | SOLUTION NMR | | Cite: | Structural Homology between the C-Terminal Domain of the PapC Usher and Its Plug.
J.Bacteriol., 192, 2010
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2OFQ
 | | NMR Solution Structure of a complex between the VirB9/VirB7 interaction domains of the pKM101 type IV secretion system | | Descriptor: | TraN, TraO | | Authors: | Harris, R, Bayliss, R, Driscoll, P.C, Waksman, G. | | Deposit date: | 2007-01-04 | | Release date: | 2007-01-23 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | NMR structure of a complex between the VirB9/VirB7 interaction domains of the pKM101 type IV secretion system
Proc.Natl.Acad.Sci.Usa, 104, 2007
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5NNY
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5O96
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2J7L
 | | E. coli P Pilus chaperone PapD in complex with a pilus biogenesis inhibitor, pilicide 2c | | Descriptor: | (3R)-8-CYCLOPROPYL-6-(MORPHOLIN-4-YLMETHYL)-7-(1-NAPHTHYLMETHYL)-5-OXO-2,3-DIHYDRO-5H-[1,3]THIAZOLO[3,2-A]PYRIDINE-3-CARBOXYLIC ACID, CHAPERONE PROTEIN PAPD | | Authors: | Remaut, H, Pinkner, J.S, Hultgren, S.J, Almqvist, F, Waksman, G. | | Deposit date: | 2006-10-12 | | Release date: | 2006-11-01 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Rationally Designed Small Compounds Inhibit Pilus Biogenesis in Uropathogenic Bacteria.
Proc.Natl.Acad.Sci.USA, 103, 2006
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1N0L
 | | Crystal structure of the PapD chaperone (C-terminally 6x histidine-tagged) bound to the PapE pilus subunit (N-terminal-deleted) from uropathogenic E. coli | | Descriptor: | Chaperone protein PapD, mature Fimbrial protein PapE | | Authors: | Sauer, F.G, Pinkner, J.S, Waksman, G, Hultgren, S.J. | | Deposit date: | 2002-10-14 | | Release date: | 2002-12-11 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Chaperone priming of pilus subunits facilitates a topological transition that drives fiber formation
Cell(Cambridge,Mass.), 111, 2002
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3CL3
 | | Crystal Structure of a vFLIP-IKKgamma complex: Insights into viral activation of the IKK signalosome | | Descriptor: | NF-kappa-B essential modulator, ORF K13 | | Authors: | Bagneris, C, Ageichik, A.V, Cronin, N, Boshoff, C, Waksman, G, Barrett, T. | | Deposit date: | 2008-03-18 | | Release date: | 2008-06-17 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Crystal structure of a vFlip-IKKgamma complex: insights into viral activation of the IKK signalosome.
Mol.Cell, 30, 2008
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1N12
 | | Crystal structure of the PapE (N-terminal-deleted) pilus subunit bound to a peptide corresponding to the N-terminal extension of the PapK pilus subunit (residues 1-11) from uropathogenic E. coli | | Descriptor: | Peptide corresponding to the N-terminal extension of protein PapK, mature Fimbrial protein PapE | | Authors: | Sauer, F.G, Pinkner, J.S, Waksman, G, Hultgren, S.J. | | Deposit date: | 2002-10-16 | | Release date: | 2002-12-11 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.87 Å) | | Cite: | Chaperone priming of pilus subunits facilitates a topological transition that drives fiber formation
Cell(Cambridge,Mass.), 111, 2002
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5N8O
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6EXC
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6EXD
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6EXB
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2THF
 | | STRUCTURE OF HUMAN ALPHA-THROMBIN Y225F MUTANT BOUND TO D-PHE-PRO-ARG-CHLOROMETHYLKETONE | | Descriptor: | D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, SODIUM ION, THROMBIN HEAVY CHAIN, ... | | Authors: | Caccia, S, Futterer, K, Di Cera, E, Waksman, G. | | Deposit date: | 1999-01-26 | | Release date: | 1999-03-07 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Unexpected crucial role of residue 225 in serine proteases.
Proc.Natl.Acad.Sci.USA, 96, 1999
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6GEF
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2UY6
 | | Crystal structure of the P pilus rod subunit PapA | | Descriptor: | PAP FIMBRIAL MAJOR PILIN PROTEIN, PERIPLASMID CHAPERONE PAPD PROTEIN | | Authors: | Verger, D, Bullitt, E, Hultgren, S.J, Waksman, G. | | Deposit date: | 2007-04-02 | | Release date: | 2007-05-29 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal Structure of the P Pilus Rod Subunit Papa.
Plos Pathog., 3, 2007
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1IS0
 | | Crystal Structure of a Complex of the Src SH2 Domain with Conformationally Constrained Peptide Inhibitor | | Descriptor: | AY0 GLU GLU ILE peptide, Tyrosine-protein kinase transforming protein SRC | | Authors: | Davidson, J.P, Lubman, O, Rose, T, Waksman, G, Martin, S.F. | | Deposit date: | 2001-11-02 | | Release date: | 2002-02-06 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Calorimetric and structural studies of 1,2,3-trisubstituted cyclopropanes as conformationally constrained peptide inhibitors of Src SH2 domain binding.
J.Am.Chem.Soc., 124, 2002
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1PDK
 | | PAPD-PAPK CHAPERONE-PILUS SUBUNIT COMPLEX FROM E.COLI P PILUS | | Descriptor: | PROTEIN (CHAPERONE PROTEIN PAPD), PROTEIN (PROTEIN PAPK) | | Authors: | Fuetterer, K, Sauer, F.G, Hultgren, S.J, Waksman, G. | | Deposit date: | 1999-03-29 | | Release date: | 1999-08-17 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural basis of chaperone function and pilus biogenesis.
Science, 285, 1999
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2BHM
 | | Crystal structure of VirB8 from Brucella suis | | Descriptor: | TYPE IV SECRETION SYSTEM PROTEIN VIRB8 | | Authors: | Bayliss, R, Baron, C, Waksman, G. | | Deposit date: | 2005-01-14 | | Release date: | 2005-03-16 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structures of Two Core Subunits of the Bacterial Type Iv Secretion System, Virb8 from Brucella Suis and Comb10 from Helicobacter Pylori
Proc.Natl.Acad.Sci.USA, 102, 2005
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3CRF
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5O95
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5N6X
 | | Crystal structure of the Legionella effector WipA | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, BETA-MERCAPTOETHANOL, BROMIDE ION, ... | | Authors: | Pinotsis, N, Waksman, G. | | Deposit date: | 2017-02-16 | | Release date: | 2017-04-19 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Structure of the WipA protein reveals a novel tyrosine protein phosphatase effector from Legionella pneumophila.
J. Biol. Chem., 292, 2017
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3CRE
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2BHV
 | | Structure of ComB10 of the Com Type IV secretion system of Helicobacter pylori | | Descriptor: | COMB10 | | Authors: | Terradot, L, Oomen, C, Bayliss, R, Leonard, G, Waksman, G. | | Deposit date: | 2005-01-18 | | Release date: | 2005-03-16 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structures of Two Core Subunits of the Bacterial Type Iv Secretion System, Virb8 from Brucella Suis and Comb10 from Helicobacter Pylori
Proc.Natl.Acad.Sci.USA, 102, 2005
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1KA8
 | | Crystal Structure of the Phage P4 Origin-Binding Domain | | Descriptor: | putative P4-specific DNA primase | | Authors: | Yeo, H.J, Ziegelin, G, Korolev, S, Calendar, R, Lanka, E, Waksman, G. | | Deposit date: | 2001-10-31 | | Release date: | 2002-04-17 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Phage P4 origin-binding domain structure reveals a mechanism for regulation of DNA-binding activity by homo- and heterodimerization of winged helix proteins.
Mol.Microbiol., 43, 2002
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