2Z39
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6GXD
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![BU of 6gxd by Molmil](/molmil-images/mine/6gxd) | The hit-and-return system enables efficient time-resolved serial synchrotron crystallography: FAcD752MS after reaction initiation | Descriptor: | CHLORIDE ION, fluoroacetate dehalogenase, fluoroacetic acid | Authors: | Schulz, E.C, Mehrabi, P, Mueller-Werkmeister, H, Tellkamp, F, Stuart, W, Persch, E, De Gasparo, R, Diederich, F, Pai, E.F, Miller, R.J.D. | Deposit date: | 2018-06-27 | Release date: | 2018-10-17 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The hit-and-return system enables efficient time-resolved serial synchrotron crystallography. Nat. Methods, 15, 2018
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2Z6G
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![BU of 2z6g by Molmil](/molmil-images/mine/2z6g) | Crystal Structure of a Full-Length Zebrafish Beta-Catenin | Descriptor: | B-catenin | Authors: | Xing, Y, Takemaru, K, Liu, J, Zheng, J, Moon, R, Xu, W. | Deposit date: | 2007-08-01 | Release date: | 2008-02-12 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Crystal Structure of a Full-Length beta-Catenin Structure, 16, 2008
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6GQM
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![BU of 6gqm by Molmil](/molmil-images/mine/6gqm) | Crystal structure of human c-KIT kinase domain in complex with a small molecule inhibitor, AZD3229 | Descriptor: | CHLORIDE ION, Mast/stem cell growth factor receptor Kit, ~{N}-[4-[[5-fluoranyl-7-(2-methoxyethoxy)quinazolin-4-yl]amino]phenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide | Authors: | Schimpl, M, Hardy, C.J, Ogg, D.J, Overman, R.C, Packer, M.J, Kettle, J.G, Anjum, R, Barry, E, Bhavsar, D, Brown, C, Campbell, A, Goldberg, K, Grondine, M, Guichard, S, Hunt, T, Jones, O, Li, X, Moleva, O, Pearson, S, Shao, W, Smith, A, Smith, J, Stead, D, Stokes, S, Tucker, M, Ye, Y. | Deposit date: | 2018-06-07 | Release date: | 2018-09-19 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors. J. Med. Chem., 61, 2018
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4IHA
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![BU of 4iha by Molmil](/molmil-images/mine/4iha) | Crystal structure of rice DWARF14 (D14) in complex with a GR24 hydrolysis intermediate | Descriptor: | (2R,3R)-2,4,4-trihydroxy-3-methylbutanal, Dwarf 88 esterase | Authors: | Zhou, X.E, Zhao, L.-H, Wu, Z.-S, Yi, W, Li, S, Li, Y, Xu, Y, Xu, T.-H, Liu, Y, Chen, R.-Z, Kovach, A, Kang, Y, Hou, L, He, Y, Zhang, C, Melcher, K, Xu, H.E. | Deposit date: | 2012-12-18 | Release date: | 2013-01-23 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Crystal structures of two phytohormone signal-transducing alpha / beta hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14. Cell Res., 23, 2013
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6GXH
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![BU of 6gxh by Molmil](/molmil-images/mine/6gxh) | The hit-and-return system enables efficient time-resolved serial synchrotron crystallography: FAcD 0MS after reaction initiation | Descriptor: | Fluoroacetate dehalogenase | Authors: | Schulz, E.C, Mehrabi, P, Mueller-Werkmeister, H, Tellkamp, F, Stuart, W, Persch, E, De Gasparo, R, Diederich, F, Pai, E.F, Miller, R.J.D. | Deposit date: | 2018-06-27 | Release date: | 2018-10-17 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.802 Å) | Cite: | The hit-and-return system enables efficient time-resolved serial synchrotron crystallography. Nat. Methods, 15, 2018
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2ZJB
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![BU of 2zjb by Molmil](/molmil-images/mine/2zjb) | Crystal structure of the human Dmc1-M200V polymorphic variant | Descriptor: | Meiotic recombination protein DMC1/LIM15 homolog | Authors: | Hikiba, J, Hirota, K, Kagawa, W, Ikawa, S, Kinebuchi, T, Sakane, I, Takizawa, Y, Yokoyama, S, Mandon-Pepin, B, Nicolas, A, Shibata, T, Ohta, K, Kurumizaka, H. | Deposit date: | 2008-03-02 | Release date: | 2008-08-12 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structural and functional analyses of the DMC1-M200V polymorphism found in the human population Nucleic Acids Res., 36, 2008
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6GZM
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![BU of 6gzm by Molmil](/molmil-images/mine/6gzm) | Crystal Structure of Human CKIdelta with A86 | Descriptor: | CITRIC ACID, Casein kinase I isoform delta, GLYCEROL, ... | Authors: | Ben-neriah, Y, Venkatachalam, A, Minzel, W, Fink, A, Snir-Alkalay, I, Vacca, J. | Deposit date: | 2018-07-04 | Release date: | 2018-08-29 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Small Molecules Co-targeting CKI alpha and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models. Cell, 175, 2018
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2Z9A
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2ZBL
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![BU of 2zbl by Molmil](/molmil-images/mine/2zbl) | Functional annotation of Salmonella enterica yihS-encoded protein | Descriptor: | Putative isomerase, beta-D-mannopyranose | Authors: | Itoh, T, Mikami, B, Hashimoto, W, Murata, K. | Deposit date: | 2007-10-24 | Release date: | 2008-02-05 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal structure of YihS in complex with D-mannose: structural annotation of Escherichia coli and Salmonella enterica yihS-encoded proteins to an aldose-ketose isomerase J.Mol.Biol., 377, 2008
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2H3L
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![BU of 2h3l by Molmil](/molmil-images/mine/2h3l) | Crystal Structure of ERBIN PDZ | Descriptor: | LAP2 protein | Authors: | Appleton, B.A, Zhang, Y, Wu, P, Yin, J.P, Hunziker, W, Skelton, N.J, Sidhu, S.S, Wiesmann, C. | Deposit date: | 2006-05-22 | Release date: | 2006-06-13 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Comparative structural analysis of the Erbin PDZ domain and the first PDZ domain of ZO-1. Insights into determinants of PDZ domain specificity. J.Biol.Chem., 281, 2006
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2Z4S
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![BU of 2z4s by Molmil](/molmil-images/mine/2z4s) | Crystal structure of domain III from the Thermotoga maritima replication initiation protein DnaA | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Chromosomal replication initiator protein dnaA, MAGNESIUM ION | Authors: | Fujikawa, N, Ozaki, S, Kagawa, W, Park, S.-Y, Katayama, T, Kurumizaka, H, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-06-25 | Release date: | 2008-02-19 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | A Common Mechanism for the ATP-DnaA-dependent Formation of Open Complexes at the Replication Origin J.Biol.Chem., 283, 2008
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6GXL
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![BU of 6gxl by Molmil](/molmil-images/mine/6gxl) | The hit-and-return system enables efficient time-resolved serial synchrotron crystallography: RADDAM2 | Descriptor: | Fluoroacetate dehalogenase | Authors: | Schulz, E.C, Mehrabi, P, Mueller-Werkmeister, H, Tellkamp, F, Stuart, W, Persch, E, De Gasparo, R, Diederich, F, Pai, E.F, Miller, R.J.D. | Deposit date: | 2018-06-27 | Release date: | 2018-10-17 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The hit-and-return system enables efficient time-resolved serial synchrotron crystallography. Nat. Methods, 15, 2018
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2ZA9
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![BU of 2za9 by Molmil](/molmil-images/mine/2za9) | Crystal Structure of Alginate lyase A1-II' N141C/N199C | Descriptor: | Alginate lyase, SULFATE ION | Authors: | Ogura, K, Yamasaki, M, Mikami, B, Hashimoto, W, Murata, K. | Deposit date: | 2007-10-02 | Release date: | 2008-05-27 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Substrate Recognition in Tunnel of Family 7 Alginate Lyase from Sphingomonas sp. A1 To be Published
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2H2C
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![BU of 2h2c by Molmil](/molmil-images/mine/2h2c) | Crystal Structure of ZO-1 PDZ1 Bound to a Phage-Derived Ligand (WRRTTWV) | Descriptor: | Tight junction protein ZO-1 | Authors: | Appleton, B.A, Zhang, Y, Wu, P, Yin, J.P, Hunziker, W, Skelton, N.J, Sidhu, S.S, Wiesmann, C. | Deposit date: | 2006-05-18 | Release date: | 2006-06-13 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Comparative structural analysis of the Erbin PDZ domain and the first PDZ domain of ZO-1. Insights into determinants of PDZ domain specificity. J.Biol.Chem., 281, 2006
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4NOJ
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![BU of 4noj by Molmil](/molmil-images/mine/4noj) | Crystal structure of the mature form of asparaginyl endopeptidase (AEP)/Legumain activated at pH 3.5 | Descriptor: | Legumain | Authors: | Zhao, L, Hua, T, Ru, H, Ni, X, Shaw, N, Jiao, L, Ding, W, Qu, L, Ouyang, S, Liu, Z.J. | Deposit date: | 2013-11-19 | Release date: | 2014-02-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage. Cell Res., 24, 2014
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4NOL
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![BU of 4nol by Molmil](/molmil-images/mine/4nol) | Crystal structure of proenzyme asparaginyl endopeptidase (AEP)/Legumain mutant D233A at pH 7.5 | Descriptor: | Legumain | Authors: | Zhao, L, Hua, T, Ru, H, Ni, X, Shaw, N, Jiao, L, Ding, W, Qu, L, Ouyang, S, Liu, Z.J. | Deposit date: | 2013-11-19 | Release date: | 2014-02-19 | Last modified: | 2014-03-19 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage. Cell Res., 24, 2014
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3BXN
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![BU of 3bxn by Molmil](/molmil-images/mine/3bxn) | The high resolution crystal structure of HLA-B*1402 complexed with a Cathepsin A signal sequence peptide, pCatA | Descriptor: | Cathepsin A signal sequence octapeptide, GLYCEROL, HLA-B*1402 extracellular domain, ... | Authors: | Kumar, P, Vahedi-Faridi, A, Saenger, W, Uchanska-Ziegler, B, Ziegler, A. | Deposit date: | 2008-01-14 | Release date: | 2009-02-03 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.864 Å) | Cite: | Structural basis for T cell alloreactivity among three HLA-B14 and HLA-B27 antigens J.Biol.Chem., 284, 2009
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3BZP
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![BU of 3bzp by Molmil](/molmil-images/mine/3bzp) | Crystal structural of the mutated N262A EscU C-terminal domain | Descriptor: | EscU | Authors: | Zarivach, R, Deng, W, Vuckovic, M, Felise, H.B, Nguyen, H.V, Miller, S.I, Finlay, B.B, Strynadka, N.C.J. | Deposit date: | 2008-01-18 | Release date: | 2008-04-22 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.499 Å) | Cite: | Structural analysis of the essential self-cleaving type III secretion proteins EscU and SpaS. Nature, 453, 2008
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4CDX
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![BU of 4cdx by Molmil](/molmil-images/mine/4cdx) | Crystal structure of human Enterovirus 71 in complex with the uncoating inhibitor GPP12 | Descriptor: | 1-(5-((3'-METHYL-[1,1'-BIPHENYL]-4-YL)OXY)PENTYL)-3-(, SODIUM ION, VP1, ... | Authors: | De Colibus, L, Wang, X, Spyrou, J.A.B, Kelly, J, Ren, J, Grimes, J, Puerstinger, G, Stonehouse, N, Walter, T.S, Hu, Z, Wang, J, Li, X, Peng, W, Rowlands, D, Fry, E.E, Rao, Z, Stuart, D.I. | Deposit date: | 2013-11-07 | Release date: | 2014-02-12 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | More-Powerful Virus Inhibitors from Structure-Based Analysis of Hev71 Capsid-Binding Molecules. Nat.Struct.Mol.Biol., 21, 2014
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3BPJ
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![BU of 3bpj by Molmil](/molmil-images/mine/3bpj) | Crystal structure of human translation initiation factor 3, subunit 1 alpha | Descriptor: | Eukaryotic translation initiation factor 3 subunit J, UNKNOWN ATOM OR ION | Authors: | Tempel, W, Nedyalkova, L, Hong, B, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2007-12-18 | Release date: | 2008-01-15 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Crystal structure of human translation initiation factor 3, subunit 1 alpha. To be Published
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4CDW
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![BU of 4cdw by Molmil](/molmil-images/mine/4cdw) | Crystal structure of human Enterovirus 71 in complex with the uncoating inhibitor GPP4 | Descriptor: | 1-[(3S)-5-(4-iodanylphenoxy)-3-methyl-pentyl]-3-pyridin-4-yl-imidazolidin-2-one, SODIUM ION, VP1, ... | Authors: | De Colibus, L, Wang, X, Spyrou, J.A.B, Kelly, J, Ren, J, Grimes, J, Puerstinger, G, Stonehouse, N, Walter, T.S, Hu, Z, Wang, J, Li, X, Peng, W, Rowlands, D, Fry, E.E, Rao, Z, Stuart, D.I. | Deposit date: | 2013-11-06 | Release date: | 2014-02-12 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | More-Powerful Virus Inhibitors from Structure-Based Analysis of Hev71 Capsid-Binding Molecules Nat.Struct.Mol.Biol., 21, 2014
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3BQJ
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![BU of 3bqj by Molmil](/molmil-images/mine/3bqj) | VA387 polypeptide | Descriptor: | va387 polypeptide | Authors: | Bu, W, Mamedova, A, Tan, M, Jiang, J, Hegde, R. | Deposit date: | 2007-12-20 | Release date: | 2008-04-22 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis for the receptor binding specificity of Norwalk virus. J.Virol., 82, 2008
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1PTK
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3BZR
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![BU of 3bzr by Molmil](/molmil-images/mine/3bzr) | Crystal structure of EscU C-terminal domain with N262D mutation, Space group P 41 21 2 | Descriptor: | EscU | Authors: | Zarivach, R, Deng, W, Vuckovic, M, Felise, H.B, Nguyen, H.V, Miller, S.I, Finlay, B.B, Strynadka, N.C.J. | Deposit date: | 2008-01-18 | Release date: | 2008-04-22 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.646 Å) | Cite: | Structural analysis of the essential self-cleaving type III secretion proteins EscU and SpaS. Nature, 453, 2008
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