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PDB: 12895 件

7SIU
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Crystal structure of HPK1 (MAP4K1) complex with inhibitor A-745
分子名称: 6-[(5R)-5-benzamidocyclohex-1-en-1-yl]-3-[(1-methyl-1H-pyrazol-4-yl)amino]pyrazine-2-carboxamide, Mitogen-activated protein kinase kinase kinase kinase 1, SULFATE ION
著者Longenecker, K.L, Korepanova, A, Qiu, W.
登録日2021-10-14
公開日2022-03-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.786 Å)
主引用文献The HPK1 Inhibitor A-745 Verifies the Potential of Modulating T Cell Kinase Signaling for Immunotherapy.
Acs Chem.Biol., 17, 2022
2B6H
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Structure of human ADP-ribosylation factor 5
分子名称: ADP-ribosylation factor 5, CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, ...
著者Tempel, W, Atanassova, A, Sundarajan, E, Dimov, S, Shehab, I, Lew, J, Arrowsmith, C, Edwards, A, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
登録日2005-10-01
公開日2005-10-11
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.764 Å)
主引用文献Structure of human ADP-ribosylation factor 5
To be Published
6C54
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Ebola nucleoprotein nucleocapsid-like assembly and the asymmetric unit
分子名称: Nucleoprotein
著者Su, Z, Wu, C, Pintilie, G.D, Chiu, W, Amarasinghe, G.K, Leung, D.W.
登録日2018-01-13
公開日2018-03-07
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (5.8 Å)
主引用文献Electron Cryo-microscopy Structure of Ebola Virus Nucleoprotein Reveals a Mechanism for Nucleocapsid-like Assembly.
Cell, 172, 2018
5J3E
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Crystal Structure of Human THYN1 protein in complex with 5-methylcytosine containing DNA
分子名称: 5-methylcytosine containing DNA, Thymocyte nuclear protein 1, UNKNOWN ATOM OR ION
著者Halabelian, L, Tempel, W, Li, Y, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC)
登録日2016-03-30
公開日2016-04-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal Structure of Human THYN1 protein in complex with 5-methylcytosine containing DNA
To be published
2B90
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Crystal structure of the interleukin-4 variant T13DR85A
分子名称: Interleukin-4, SULFATE ION
著者Kraich, M, Klein, M, Patino, E, Harrer, H, Sebald, W, Mueller, T.D.
登録日2005-10-10
公開日2006-05-30
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
Bmc Biol., 4, 2006
2B8U
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Crystal structure of wildtype human Interleukin-4
分子名称: Interleukin-4, SULFATE ION
著者Kraich, M, Klein, M, Patino, E, Harrer, H, Sebald, W, Mueller, T.D.
登録日2005-10-10
公開日2006-05-30
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
Bmc Biol., 4, 2006
2B98
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Crystal Structure of an archaeal pentameric riboflavin synthase
分子名称: Riboflavin synthase
著者Ramsperger, A, Augustin, M, Schott, A.K, Gerhardt, S, Krojer, T, Eisenreich, W, Illarionov, B, Cushman, M, Bacher, A, Huber, R, Fischer, M.
登録日2005-10-11
公開日2005-11-08
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal Structure of an Archaeal Pentameric Riboflavin Synthase in Complex with a Substrate Analog Inhibitor: stereochemical implications
J.Biol.Chem., 281, 2006
2B8Y
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Crystal structure of the interleukin-4 variant T13DF82D
分子名称: Interleukin-4, SULFATE ION
著者Kraich, M, Klein, M, Patino, E, Harrer, H, Sebald, W, Mueller, T.D.
登録日2005-10-10
公開日2006-05-30
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
Bmc Biol., 4, 2006
2B91
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Crystal structure of the interleukin-4 variant F82DR85A
分子名称: Interleukin-4, SULFATE ION
著者Kraich, M, Klein, M, Patino, E, Harrer, H, Sebald, W, Mueller, T.D.
登録日2005-10-10
公開日2006-05-30
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
Bmc Biol., 4, 2006
2UYQ
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Crystal structure of ML2640c from Mycobacterium leprae in complex with S-adenosylmethionine
分子名称: HYPOTHETICAL PROTEIN ML2640, S-ADENOSYLMETHIONINE
著者Grana, M, Buschiazzo, A, Wehenkel, A, Haouz, A, Miras, I, Shepard, W, Alzari, P.M.
登録日2007-04-11
公開日2007-08-07
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The Crystal Structure of M. Leprae Ml2640C Defines a Large Family of Putative S-Adenosylmethionine- Dependent Methyltransferases in Mycobacteria.
Protein Sci., 16, 2007
2B8X
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Crystal structure of the interleukin-4 variant F82D
分子名称: Interleukin-4, SULFATE ION
著者Kraich, M, Klein, M, Patino, E, Harrer, H, Sebald, W, Mueller, T.D.
登録日2005-10-10
公開日2006-05-30
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
Bmc Biol., 4, 2006
2VBD
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Isopenicillin N synthase with substrate analogue L,L,L-ACOMP (unexposed)
分子名称: FE (II) ION, ISOPENICILLIN N SYNTHETASE, N^6^-[(1R)-2-[(1R)-1-carboxy-2-(methylsulfanyl)ethoxy]-2-oxo-1-(sulfanylmethyl)ethyl]-6-oxo-L-lysine
著者Ge, W, Clifton, I.J, Adlington, R.M, Baldwin, J.E, Rutledge, P.J.
登録日2007-09-10
公開日2008-09-23
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The Crystal Structure of an Lll-Configured Depsipeptide Substrate Analogue Bound to Isopenicillin N Synthase.
Org.Biomol.Chem., 8, 2010
2BCO
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BU of 2bco by Molmil
X-ray structure of succinylglutamate desuccinalase from Vibrio Parahaemolyticus (RIMD 2210633) at the resolution 2.3 A, Northeast Structural Genomics Target Vpr14
分子名称: Succinylglutamate desuccinylase, ZINC ION
著者Kuzin, A.P, Abashidze, M, Forouhar, F, Benach, J, Zhou, W, Acton, T, Northeast Structural Genomics Consortium (NESG)
登録日2005-10-19
公開日2005-10-25
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.33 Å)
主引用文献X-ray structure of succinylglutamate desuccinalase from Vibrio Parahaemolyticus (RIMD 2210633) at the resolution 2.3 A, Northeast Structural Genomics Target Vpr14
To be Published
2WJG
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BU of 2wjg by Molmil
Structure and function of the FeoB G-domain from Methanococcus jannaschii
分子名称: FERROUS IRON TRANSPORT PROTEIN B HOMOLOG, GUANOSINE-5'-DIPHOSPHATE, POLYALANINE
著者Koester, S, Wehner, M, Herrmann, C, Kuehlbrandt, W, Yildiz, O.
登録日2009-05-26
公開日2009-07-28
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure and Function of the Feob G-Domain from Methanococcus Jannaschii.
J.Mol.Biol., 392, 2009
2B8Z
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BU of 2b8z by Molmil
Crystal structure of the interleukin-4 variant R85A
分子名称: Interleukin-4, SULFATE ION
著者Kraich, M, Klein, M, Patino, E, Harrer, H, Sebald, W, Mueller, T.D.
登録日2005-10-10
公開日2006-05-30
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
Bmc Biol., 4, 2006
2X4F
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BU of 2x4f by Molmil
The Crystal Structure of the human myosin light chain kinase LOC340156.
分子名称: 1,2-ETHANEDIOL, 4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(3-dioxaziridin-3-ylphenyl)pyrimidin-2-amine, MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4, ...
著者Muniz, J.R.C, Mahajan, P, Rellos, P, Fedorov, O, Shrestha, B, Wang, J, Elkins, J.M, Daga, N, Cocking, R, Chaikuad, A, Krojer, T, Ugochukwu, E, Yue, W, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Gileadi, O, Knapp, S.
登録日2010-01-29
公開日2010-02-09
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.67 Å)
主引用文献The Crystal Structure of the Human Myosin Light Chain Kinase Loc340156
To be Published
2ARG
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BU of 2arg by Molmil
FORMATION OF AN AMINO ACID BINDING POCKET THROUGH ADAPTIVE ZIPPERING-UP OF A LARGE DNA HAIRPIN LOOP, NMR, 9 STRUCTURES
分子名称: ARGININEAMIDE, DNA APTAMER [5'-D (*TP*GP*AP*CP*CP*AP*GP*GP*GP*CP*AP*AP*AP*CP*GP*GP*TP*AP* GP*GP*TP*GP*AP*GP*TP*GP*GP*TP*CP*A)-3']
著者Lin, C.H, Wang, W, Jones, R.A, Patel, D.J.
登録日1998-08-19
公開日1999-03-23
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Formation of an amino-acid-binding pocket through adaptive zippering-up of a large DNA hairpin loop.
Chem.Biol., 5, 1998
2X4D
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Crystal structure of human phospholysine phosphohistidine inorganic pyrophosphate phosphatase LHPP
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, MAGNESIUM ION, ...
著者Vollmar, M, Gileadi, C, Guo, K, Savitsky, P, Muniz, J.R.C, Yue, W, Allerston, C, von Delft, F, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Kavanagh, K.L, Oppermann, U.
登録日2010-01-29
公開日2010-03-16
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Crystal Structure of Human Phospholysine Phosphohistidine Inorganic Pyrophosphate Phosphatase Lhpp
To be Published
5JE7
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Human carbonic anhydrase II (F131Y) complexed with benzo[d]thiazole-2-sulfonamide
分子名称: 1,3-benzothiazole-2-sulfonamide, Carbonic anhydrase 2, ZINC ION
著者Fox, J.M, Kang, K, Sastry, M, Sherman, W, Sankaran, B, Zwart, P.H, Whitesides, G.M.
登録日2016-04-17
公開日2017-01-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Water-Restructuring Mutations Can Reverse the Thermodynamic Signature of Ligand Binding to Human Carbonic Anhydrase.
Angew. Chem. Int. Ed. Engl., 56, 2017
5JGL
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Crystal structure of GtmA in complex with S-Adenosylmethionine
分子名称: S-ADENOSYLMETHIONINE, SODIUM ION, UbiE/COQ5 family methyltransferase, ...
著者Dolan, S.K, Bock, T, Hering, V, Jones, G.W, Blankenfeldt, W, Doyle, S.
登録日2016-04-20
公開日2017-03-01
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Structural, mechanistic and functional insight into gliotoxinbis-thiomethylation inAspergillus fumigatus.
Open Biol, 7, 2017
2AZO
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BU of 2azo by Molmil
DNA MISMATCH REPAIR PROTEIN MUTH FROM E. COLI
分子名称: MUTH
著者Yang, W.
登録日1997-11-20
公開日1998-05-20
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis for MutH activation in E.coli mismatch repair and relationship of MutH to restriction endonucleases.
EMBO J., 17, 1998
1C58
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CRYSTAL STRUCTURE OF CYCLOAMYLOSE 26
分子名称: Cyclohexacosakis-(1-4)-(alpha-D-glucopyranose)
著者Gessler, K, Saenger, W, Nimz, O.
登録日1999-11-04
公開日1999-11-10
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (0.99 Å)
主引用文献V-Amylose at atomic resolution: X-ray structure of a cycloamylose with 26 glucose residues (cyclomaltohexaicosaose).
Proc.Natl.Acad.Sci.USA, 96, 1999
5JG5
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Human carbonic anhydrase II (V121T/F131Y) complexed with benzo[d]thiazole-2-sulfonamide
分子名称: 1,3-benzothiazole-2-sulfonamide, Carbonic anhydrase 2, ZINC ION
著者Fox, J.M, Kang, K, Sastry, M, Sherman, W, Sankaran, B, Zwart, P.H, Whitesides, G.M.
登録日2016-04-19
公開日2017-01-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.19 Å)
主引用文献Water-Restructuring Mutations Can Reverse the Thermodynamic Signature of Ligand Binding to Human Carbonic Anhydrase.
Angew. Chem. Int. Ed. Engl., 56, 2017
5JGT
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Human carbonic anhydrase II (F131Y/L198A) complexed with 1,3-thiazole-2-sulfonamide
分子名称: 1,3-thiazole-2-sulfonamide, Carbonic anhydrase 2, ZINC ION
著者Fox, J.M, Kang, K, Sastry, M, Sherman, W, Sankaran, B, Zwart, P.H, Whitesides, G.M.
登録日2016-04-20
公開日2017-01-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Water-Restructuring Mutations Can Reverse the Thermodynamic Signature of Ligand Binding to Human Carbonic Anhydrase.
Angew. Chem. Int. Ed. Engl., 56, 2017
1FSI
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CRYSTAL STRUCTURE OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASE OF APPR>P FROM ARABIDOPSIS THALIANA
分子名称: CYCLIC PHOSPHODIESTERASE, SULFATE ION
著者Hofmann, A, Zdanov, A, Genschik, P, Filipowicz, W, Ruvinov, S, Wlodawer, A.
登録日2000-09-10
公開日2000-11-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure and mechanism of activity of the cyclic phosphodiesterase of Appr>p, a product of the tRNA splicing reaction.
EMBO J., 19, 2000

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件を2024-07-10に公開中

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