7SIU

Crystal structure of HPK1 (MAP4K1) complex with inhibitor A-745

Summary for 7SIU

• Entry DOI: 10.2210/pdb7siu/pdb
• Descriptor: Mitogen-activated protein kinase kinase kinase kinase 1, 6-[(5R)-5-benzamidocyclohex-1-en-1-yl]-3-[(1-methyl-1H-pyrazol-4-yl)amino]pyrazine-2-carboxamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: protein kinase, signaling protein, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 70318.95

Authors

Longenecker, K.L.,Korepanova, A.,Qiu, W. (deposition date: 2021-10-14, release date: 2022-03-02, Last modification date: 2023-10-18)

• Primary citation: Malchow, S.,Korepanova, A.,Panchal, S.C.,McClure, R.A.,Longenecker, K.L.,Qiu, W.,Zhao, H.,Cheng, M.,Guo, J.,Klinge, K.L.,Trusk, P.,Pratt, S.D.,Li, T.,Kurnick, M.D.,Duan, L.,Shoemaker, A.R.,Gopalakrishnan, S.M.,Warder, S.E.,Shotwell, J.B.,Lai, A.,Sun, C.,Osuma, A.T.,Pappano, W.N.; The HPK1 Inhibitor A-745 Verifies the Potential of Modulating T Cell Kinase Signaling for Immunotherapy.; Acs Chem.Biol., 17:556-566, 2022; PubMed: 35188729; DOI: 10.1021/acschembio.1c00819

Experimental method

X-RAY DIFFRACTION (1.786 Å)