7ZMB
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![BU of 7zmb by Molmil](/molmil-images/mine/7zmb) | CryoEM structure of mitochondrial complex I from Chaetomium thermophilum (state 2) | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... | 著者 | Laube, E, Kuehlbrandt, W. | 登録日 | 2022-04-19 | 公開日 | 2022-11-30 | 最終更新日 | 2022-12-07 | 実験手法 | ELECTRON MICROSCOPY (2.75 Å) | 主引用文献 | Conformational changes in mitochondrial complex I of the thermophilic eukaryote Chaetomium thermophilum. Sci Adv, 8, 2022
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7N4Z
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7N53
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![BU of 7n53 by Molmil](/molmil-images/mine/7n53) | Complex structure of PAP4 with papaverine | 分子名称: | 1-(3,4-DIMETHOXYBENZYL)-6,7-DIMETHOXYISOQUINOLINE, GLYCEROL, PAP4, ... | 著者 | Kim, W, Zhang, Y. | 登録日 | 2021-06-04 | 公開日 | 2022-06-29 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Using fungible biosensors to evolve improved alkaloid biosyntheses. Nat.Chem.Biol., 18, 2022
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7N54
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7N4W
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8WEX
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7N6F
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![BU of 7n6f by Molmil](/molmil-images/mine/7n6f) | Co-complex CYP46A1 with compound 3f | 分子名称: | (3-fluoroazetidin-1-yl){1-[4-(4-fluorophenyl)pyrimidin-5-yl]piperidin-4-yl}methanone, 1,2-ETHANEDIOL, Cholesterol 24-hydroxylase, ... | 著者 | Lane, W, Gay, S.C. | 登録日 | 2021-06-08 | 公開日 | 2022-07-27 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Design and synthesis of aryl-piperidine derivatives as potent and selective PET tracers for cholesterol 24-hydroxylase (CH24H) Eur.J.Med.Chem., 240, 2022
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7NTH
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![BU of 7nth by Molmil](/molmil-images/mine/7nth) | Structure of TAK1 in complex with compound 54 | 分子名称: | 2-[[5-[[2-[bis(fluoranyl)methoxy]phenyl]methyl-[(2~{R})-1-(methylamino)-1-oxidanylidene-propan-2-yl]carbamoyl]-1~{H}-imidazol-2-yl]carbonyl]isoindole-5-carboxamide, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Veerman, J.J.N, Bruseker, Y.B, Damen, E, Heijne, E.H, van Bruggen, W, Hekking, K.F.W, Winkel, R, Hupp, C.D, Keefe, A.D, Liu, J, Thomson, H.A, Zhang, Y, Cuozzo, J.W, McRiner, A.J, Mulvihill, M.J, van Rijnsbergen, P, Zech, B, Renzetti, L.M, Babiss, L, Mueller, G. | 登録日 | 2021-03-09 | 公開日 | 2021-04-07 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Discovery of 2,4-1 H -Imidazole Carboxamides as Potent and Selective TAK1 Inhibitors. Acs Med.Chem.Lett., 12, 2021
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7NTI
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![BU of 7nti by Molmil](/molmil-images/mine/7nti) | Structure of TAK1 in complex with compound 22 | 分子名称: | DIMETHYL SULFOXIDE, GLYCEROL, Mitogen-activated protein kinase 7,TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, ... | 著者 | Veerman, J.J.N, Bruseker, Y.B, Damen, E, Heijne, E.H, van Bruggen, W, Hekking, K.F.W, Winkel, R, Hupp, C.D, Keefe, A.D, Liu, J, Thomson, H.A, Zhang, Y, Cuozzo, J.W, McRiner, A.J, Mulvihill, M.J, van Rijnsbergen, P, Zech, B, Renzetti, L.M, Babiss, L, Mueller, G. | 登録日 | 2021-03-09 | 公開日 | 2021-04-07 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Discovery of 2,4-1 H -Imidazole Carboxamides as Potent and Selective TAK1 Inhibitors. Acs Med.Chem.Lett., 12, 2021
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7O2I
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![BU of 7o2i by Molmil](/molmil-images/mine/7o2i) | METTL3-METTL14 heterodimer bound to the SAM competitive small molecule inhibitor STM2457 | 分子名称: | DIMETHYL SULFOXIDE, N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit, ... | 著者 | Pilka, E.S, Blackaby, W, Hardick, D, Harper, C, Hewstone, D, Ridgill, M, Rotty, B, Rausch, O. | 登録日 | 2021-03-30 | 公開日 | 2021-04-14 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia. Nature, 593, 2021
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4ZJ0
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![BU of 4zj0 by Molmil](/molmil-images/mine/4zj0) | The crystal structure of monomer Q108K:K40L:Y60W CRBPII bound to all-trans-retinal | 分子名称: | ACETATE ION, RETINAL, Retinol-binding protein 2 | 著者 | Nossoni, Z, Assar, Z, Wang, W, Vasileiou, C, Borhan, B, Geiger, J.H. | 登録日 | 2015-04-28 | 公開日 | 2016-05-11 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Domain-Swapped Dimers of Intracellular Lipid-Binding Proteins: Evidence for Ordered Folding Intermediates. Structure, 24, 2016
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7OJ5
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3J03
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![BU of 3j03 by Molmil](/molmil-images/mine/3j03) | Lidless Mm-cpn in the closed state with ATP/AlFx | 分子名称: | Lidless Mm-cpn | 著者 | Zhang, J, Ma, B, DiMaio, F, Douglas, N.R, Joachimiak, L, Baker, D, Frydman, J, Levitt, M, Chiu, W. | 登録日 | 2011-02-10 | 公開日 | 2011-05-18 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | Cryo-EM structure of a group II chaperonin in the prehydrolysis ATP-bound state leading to lid closure. Structure, 19, 2011
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3JBH
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![BU of 3jbh by Molmil](/molmil-images/mine/3jbh) | TWO HEAVY MEROMYOSIN INTERACTING-HEADS MOTIFS FLEXIBLE DOCKED INTO TARANTULA THICK FILAMENT 3D-MAP ALLOWS IN DEPTH STUDY OF INTRA- AND INTERMOLECULAR INTERACTIONS | 分子名称: | MYOSIN 2 ESSENTIAL LIGHT CHAIN STRIATED MUSCLE, MYOSIN 2 HEAVY CHAIN STRIATED MUSCLE, MYOSIN 2 REGULATORY LIGHT CHAIN STRIATED MUSCLE | 著者 | Alamo, L, Qi, D, Wriggers, W, Pinto, A, Zhu, J, Bilbao, A, Gillilan, R.E, Hu, S, Padron, R. | 登録日 | 2015-09-01 | 公開日 | 2016-03-09 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (20 Å) | 主引用文献 | Conserved Intramolecular Interactions Maintain Myosin Interacting-Heads Motifs Explaining Tarantula Muscle Super-Relaxed State Structural Basis. J. Mol. Biol., 428, 2016
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2IEA
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![BU of 2iea by Molmil](/molmil-images/mine/2iea) | E. coli pyruvate dehydrogenase | 分子名称: | MAGNESIUM ION, Pyruvate dehydrogenase E1 component, THIAMINE DIPHOSPHATE | 著者 | Furey, W, Arjunan, P. | 登録日 | 2006-09-18 | 公開日 | 2006-10-03 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structure of the pyruvate dehydrogenase multienzyme complex E1 component from Escherichia coli at 1.85 A resolution. Biochemistry, 41, 2002
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2HF6
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![BU of 2hf6 by Molmil](/molmil-images/mine/2hf6) | Solution structure of human zeta-COP | 分子名称: | Coatomer subunit zeta-1 | 著者 | Yu, W, Jin, C, Xia, B. | 登録日 | 2006-06-23 | 公開日 | 2007-06-12 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of human zeta-COP: direct evidences for structural similarity between COP I and clathrin-adaptor coats J.Mol.Biol., 386, 2009
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7OI3
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![BU of 7oi3 by Molmil](/molmil-images/mine/7oi3) | Cryo-EM structure of the Cetacean morbillivirus nucleoprotein-RNA complex | 分子名称: | Cetacean morbillivirus nucleoprotein, poly-A 6-mer | 著者 | Zinzula, L, Beck, F, Klumpe, S, Bohn, S, Pfeifer, G, Bollschweiler, D, Nagy, I, Plitzko, J.M, Baumeister, W. | 登録日 | 2021-05-11 | 公開日 | 2021-06-23 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Cryo-EM structure of the cetacean morbillivirus nucleoprotein-RNA complex. J.Struct.Biol., 213, 2021
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7OC5
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![BU of 7oc5 by Molmil](/molmil-images/mine/7oc5) | Alpha-humulene synthase AsR6 from Sarocladium schorii | 分子名称: | Alpha-humulene synthase AsR6, MAGNESIUM ION, ZINC ION | 著者 | Schotte, C, Lukat, P, Deuschmann, A, Blankenfeldt, W, Cox, R.J. | 登録日 | 2021-04-26 | 公開日 | 2021-07-07 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Understanding and Engineering the Stereoselectivity of Humulene Synthase. Angew.Chem.Int.Ed.Engl., 60, 2021
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7OC6
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![BU of 7oc6 by Molmil](/molmil-images/mine/7oc6) | Selenomethionine derivative of alpha-humulene synthase AsR6 from Sarocladium schorii | 分子名称: | Alpha-humulene synthase asR6, GLYCEROL, SULFATE ION, ... | 著者 | Schotte, C, Lukat, P, Deuschmann, A, Blankenfeldt, W, Cox, R.J. | 登録日 | 2021-04-26 | 公開日 | 2021-07-07 | 最終更新日 | 2021-09-15 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Understanding and Engineering the Stereoselectivity of Humulene Synthase. Angew.Chem.Int.Ed.Engl., 60, 2021
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7OC4
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![BU of 7oc4 by Molmil](/molmil-images/mine/7oc4) | Alpha-humulene synthase AsR6 from Sarocladium schorii in complex with thiolodiphosphate and a cyclized reaction product. | 分子名称: | (1E,4E,8E)-2,6,6,9-Tetramethyl-1,4-8-cycloundecatriene, (R,R)-2,3-BUTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | 著者 | Schotte, C, Lukat, P, Deuschmann, A, Blankenfeldt, W, Cox, R.J. | 登録日 | 2021-04-26 | 公開日 | 2021-07-07 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Understanding and Engineering the Stereoselectivity of Humulene Synthase. Angew.Chem.Int.Ed.Engl., 60, 2021
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8AZT
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![BU of 8azt by Molmil](/molmil-images/mine/8azt) | Type II amyloid-beta 42 filaments from high-spin supernatants of aqueous extracts from Alzheimer's disease brains | ABeta42 | 分子名称: | Amyloid-beta precursor protein | 著者 | Yang, Y, Stern, M.A, Meunier, L.A, Liu, W, Cai, Y.Q, Ericsson, M, Liu, L, Selkoe, J.D, Goedert, M, Scheres, H.W.S. | 登録日 | 2022-09-06 | 公開日 | 2022-11-02 | 最終更新日 | 2023-07-19 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Abundant A beta fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer's disease brains. Neuron, 111, 2023
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7M6C
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![BU of 7m6c by Molmil](/molmil-images/mine/7m6c) | Crystal structure of PLA2 from snake venom of peruvian Bothrops atrox | 分子名称: | Basic phospholipase A2, LAURIC ACID | 著者 | Leonardo, D.A, Chojnowski, G, Simpkin, A, Seifert-Davila, W, Vivas-Ruiz, D.E, Keegan, R, Rigden, D. | 登録日 | 2021-03-25 | 公開日 | 2022-01-12 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | findMySequence: a neural-network-based approach for identification of unknown proteins in X-ray crystallography and cryo-EM Iucrj, 9, 2022
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7M6K
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7MRY
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![BU of 7mry by Molmil](/molmil-images/mine/7mry) | Norovirus T=3 GII.4 HOV VLP | 分子名称: | VP1 | 著者 | Salmen, W, Hu, L, Prasad, B. | 登録日 | 2021-05-10 | 公開日 | 2022-03-02 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Atomic structure of the predominant GII.4 human norovirus capsid reveals novel stability and plasticity. Nat Commun, 13, 2022
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7MDP
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![BU of 7mdp by Molmil](/molmil-images/mine/7mdp) | KRas G12C in complex with G-2897 | 分子名称: | 1,2-ETHANEDIOL, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, 4-(trifluoromethyl)-1,3-benzothiazol-2-amine, ... | 著者 | Oh, A, Frank, Y, Wang, W. | 登録日 | 2021-04-05 | 公開日 | 2022-03-16 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors. Nat.Biotechnol., 40, 2022
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