2VWL
 
 | | Aminopyrrolidine Factor Xa inhibitor | | Descriptor: | 5-CHLORO-THIOPHENE-2-CARBOXYLIC ACID ((3R,5S)-1-{[2-FLUORO-4-(2-OXO-PYRIDIN-1-YL)-PHENYLCARBAMOYL]-METHYL}-5-HYDROXYMETHYL-PYRROLIDIN-3-YL)-AMIDE, ACTIVATED FACTOR XA HEAVY CHAIN, CALCIUM ION, ... | | Authors: | Groebke-Zbinden, K, Banner, D.W, Benz, J.M, Blasco, F, Decoret, G, Himber, J, Kuhn, B, Panday, N, Ricklin, F, Risch, P, Schlatter, D, Stahl, M, Unger, R, Haap, W. | | Deposit date: | 2008-06-26 | | Release date: | 2009-07-07 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Design of Novel Aminopyrrolidine Factor Xa Inhibitors from a Screening Hit.
Eur.J.Med.Chem., 44, 2009
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2E5R
 | | Solution structure of the ZZ domain of Dystrobrevin alpha (Dystrobrevin-alpha) | | Descriptor: | Dystrobrevin alpha, ZINC ION | | Authors: | Dang, W, Muto, Y, Inoue, M, Kigawa, T, Shirouzu, M, Terada, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2006-12-22 | | Release date: | 2007-06-26 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the ZZ domain of Dystrobrevin alpha (Dystrobrevin-alpha)
To be Published
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1CVI
 | | CRYSTAL STRUCTURE OF HUMAN PROSTATIC ACID PHOSPHATASE | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCINE, ... | | Authors: | Jakob, C.G, Lewinski, K, Kuciel, R, Ostrowski, W, Lebioda, L. | | Deposit date: | 1999-08-23 | | Release date: | 1999-08-31 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Crystal structure of human prostatic acid phosphatase .
Prostate, 42, 2000
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2E6N
 | | Solution structure of the TUDOR domain of Staphylococcal nuclease domain-containing protein 1 | | Descriptor: | Staphylococcal nuclease domain-containing protein 1 | | Authors: | Dang, W, Muto, Y, Inoue, M, Kigawa, T, Shirouzu, M, Terada, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2006-12-27 | | Release date: | 2007-07-03 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the TUDOR domain of Staphylococcal nuclease domain-containing protein 1
To be Published
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2EPP
 | | Solution structure of the first C2H2 type zinc finger domain of Zinc finger protein 278 | | Descriptor: | POZ-, AT hook-, and zinc finger-containing protein 1, ... | | Authors: | Tanabe, W, Suzuki, S, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-03-30 | | Release date: | 2008-02-12 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the first C2H2 type zinc finger domain of Zinc finger protein 278
To be Published
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1ASX
 | | APICAL DOMAIN OF THE CHAPERONIN FROM THERMOPLASMA ACIDOPHILUM | | Descriptor: | PHOSPHATE ION, THERMOSOME | | Authors: | Klumpp, M, Baumeister, W, Essen, L.-O. | | Deposit date: | 1997-08-11 | | Release date: | 1997-12-03 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structure of the substrate binding domain of the thermosome, an archaeal group II chaperonin.
Cell(Cambridge,Mass.), 91, 1997
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2EQY
 | | Solution structure of the ARID domain of Jarid1b protein | | Descriptor: | Jumonji, AT rich interactive domain 1B | | Authors: | Tanabe, W, Suzuki, S, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-03-30 | | Release date: | 2007-10-02 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the ARID domain of Jarid1b protein
To be Published
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2E5Q
 | | Solution structure of the TUDOR domain of PHD finger protein 19, isoform b [Homo sapiens] | | Descriptor: | PHD finger protein 19 | | Authors: | Dang, W, Muto, Y, Inoue, M, Kigawa, T, Shirouzu, M, Terada, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2006-12-22 | | Release date: | 2007-06-26 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the TUDOR domain of PHD finger protein 19,
isoform b [Homo sapiens]
To be Published
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2E70
 | | Solution structure of the fifth KOW motif of human transcription elongation factor SPT5 | | Descriptor: | Transcription elongation factor SPT5 | | Authors: | Tanabe, W, Suzuki, S, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-01-05 | | Release date: | 2007-07-10 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the fifth KOW motif of human transcription elongation factor SPT5
To be Published
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1BMV
 | | PROTEIN-RNA INTERACTIONS IN AN ICOSAHEDRAL VIRUS AT 3.0 ANGSTROMS RESOLUTION | | Descriptor: | PROTEIN (ICOSAHEDRAL VIRUS - A DOMAIN), PROTEIN (ICOSAHEDRAL VIRUS - B AND C DOMAIN), RNA (5'-R(*GP*GP*UP*CP*AP*AP*AP*AP*UP*GP*C)-3') | | Authors: | Chen, Z, Stauffacher, C, Li, Y, Schmidt, T, Bomu, W, Kamer, G, Shanks, M, Lomonossoff, G, Johnson, J.E. | | Deposit date: | 1989-10-09 | | Release date: | 1989-10-09 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Protein-RNA interactions in an icosahedral virus at 3.0 A resolution.
Science, 245, 1989
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1BQB
 | | AUREOLYSIN, STAPHYLOCOCCUS AUREUS METALLOPROTEINASE | | Descriptor: | CALCIUM ION, PROTEIN (AUREOLYSIN), ZINC ION | | Authors: | Medrano, F.J, Banbula, A, Potempa, J, Travis, J, Bode, W. | | Deposit date: | 1998-07-14 | | Release date: | 1999-01-13 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.72 Å) | | Cite: | Amino-acid sequence and three-dimensional structure of the Staphylococcus aureus metalloproteinase at 1.72 A resolution.
Structure, 6, 1998
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2ECR
 | | Crystal structure of the ligand-free form of the flavin reductase component (HpaC) of 4-hydroxyphenylacetate 3-monooxygenase | | Descriptor: | flavin reductase component (HpaC) of 4-hydroxyphenylacetate 3-monooxygenase | | Authors: | Kim, S.H, Hisano, T, Iwasaki, W, Ebihara, A, Miki, K. | | Deposit date: | 2007-02-13 | | Release date: | 2008-01-15 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystal structure of the flavin reductase component (HpaC) of 4-hydroxyphenylacetate 3-monooxygenase from Thermus thermophilus HB8: Structural basis for the flavin affinity
Proteins, 70, 2008
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2VG2
 | | Rv2361 with IPP | | Descriptor: | 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, CHLORIDE ION, DIPHOSPHATE, ... | | Authors: | Naismith, J.H, Wang, W, Dong, C. | | Deposit date: | 2007-11-07 | | Release date: | 2007-11-13 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | The structural basis of chain length control in Rv1086.
J. Mol. Biol., 381, 2008
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2VDF
 | | Structure of the OpcA adhesion from Neisseria meningitidis determined by crystallization from the cubic mesophase | | Descriptor: | N-OCTANE, OUTER MEMBRANE PROTEIN, SULFATE ION | | Authors: | Cherezov, V, Liu, W, Derrick, J.P, Luan, B, Aksimentiev, A, Katritch, V, Caffrey, M. | | Deposit date: | 2007-10-05 | | Release date: | 2007-10-23 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | In meso crystal structure and docking simulations suggest an alternative proteoglycan binding site in the OpcA outer membrane adhesin.
Proteins, 71, 2008
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2VG3
 | | Rv2361 with citronellyl pyrophosphate | | Descriptor: | CHLORIDE ION, GERANYL DIPHOSPHATE, GLYCEROL, ... | | Authors: | Naismith, J.H, Wang, W, Dong, C. | | Deposit date: | 2007-11-08 | | Release date: | 2008-05-06 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The structural basis of chain length control in Rv1086.
J. Mol. Biol., 381, 2008
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2V11
 | | Crystal Structure of Renin with Inhibitor 6 | | Descriptor: | (2S,4S,5R,7R)-4-AMINO-8-(BUTYLAMINO)-5-HYDROXY-2,7-DIMETHYL-8-OXOOCTYL 1-BENZYL-1H-INDOLE-3-CARBOXYLATE, RENIN | | Authors: | Rahuel, J, Rasetti, V, Maibaum, J, Rueger, H, Goschke, R, Cohen, N.C, Stutz, S, Cumin, F, Fuhrer, W, Wood, J.M, Grutter, M.G. | | Deposit date: | 2007-05-21 | | Release date: | 2007-07-03 | | Last modified: | 2019-04-03 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structure-Based Drug Design: The Discovery of Novel Nonpeptide Orally Active Inhibitors of Human Renin
Chem.Biol., 7, 2000
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1C0K
 | | CRYSTAL STRUCTURE ANALYSIS OF D-AMINO ACID OXIDASE IN COMPLEX WITH L-LACTATE | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, LACTIC ACID, PROTEIN (D-AMINO ACID OXIDASE) | | Authors: | Umhau, S, Molla, G, Diederichs, K, Pilone, M.S, Ghisla, S, Welte, W, Pollegioni, L. | | Deposit date: | 1999-07-16 | | Release date: | 2000-11-22 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.46 Å) | | Cite: | The x-ray structure of D-amino acid oxidase at very high resolution identifies the chemical mechanism of flavin-dependent substrate dehydrogenation.
Proc.Natl.Acad.Sci.USA, 97, 2000
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2V6V
 | | The structure of the Bem1p PX domain | | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, BUD EMERGENCE PROTEIN 1 | | Authors: | Stahelin, R.V, Karathanassis, D, Murray, D, Williams, R.L, Cho, W. | | Deposit date: | 2007-07-21 | | Release date: | 2007-07-31 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structural and Membrane Binding Analysis of the Phox Homology Domain of Bem1P: Basis of Phosphatidylinositol 4-Phosphate Specificity.
J.Biol.Chem., 282, 2007
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2BU8
 | | crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DICHLORO-ACETIC ACID, MAGNESIUM ION, ... | | Authors: | Knoechel, T.R, Tucker, A.D, Robinson, C.M, Phillips, C, Taylor, W, Bungay, P.J, Kasten, S.A, Roche, T.E, Brown, D.G. | | Deposit date: | 2005-06-08 | | Release date: | 2006-02-02 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Regulatory Roles of the N-Terminal Domain Based on Crystal Structures of Human Pyruvate Dehydrogenase Kinase 2 Containing Physiological and Synthetic Ligands.
Biochemistry, 45, 2006
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2WPA
 | | Optimisation of 6,6-Dimethyl Pyrrolo 3,4-c pyrazoles: Identification of PHA-793887, a Potent CDK Inhibitor Suitable for Intravenous Dosing | | Descriptor: | CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, N-{6,6-DIMETHYL-5-[(1-METHYLPIPERIDIN-4-YL)CARBONYL]-1,4,5,6-TETRAHYDROPYRROLO[3,4-C]PYRAZOL-3-YL}-3-METHYLBUTANAMIDE, ... | | Authors: | Brasca, M.G, Albanese, C, Alzani, R, Amici, R, Avanzi, N, Ballinari, D, Bischoff, J, Borghi, D, Casale, E, Croci, V, Fiorentini, F, Isacchi, A, Mercurio, C, Nesi, M, Orsini, P, Pastori, W, Pesenti, E, Pevarello, P, Roussel, P, Varasi, M, Volpi, D, Vulpetti, A, Ciomei, M. | | Deposit date: | 2009-08-03 | | Release date: | 2010-02-23 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.51 Å) | | Cite: | Optimization of 6,6-Dimethyl Pyrrolo[3,4-C]Pyrazoles: Identification of Pha-793887, a Potent Cdk Inhibitor Suitable for Intravenous Dosing.
Bioorg.Med.Chem., 18, 2010
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1BV8
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1BPR
 | | NMR STRUCTURE OF THE SUBSTRATE BINDING DOMAIN OF DNAK, MINIMIZED AVERAGE STRUCTURE | | Descriptor: | DNAK | | Authors: | Wang, H, Kurochkin, A.V, Pang, Y, Hu, W, Flynn, G.C, Zuiderweg, E.R.P. | | Deposit date: | 1998-08-11 | | Release date: | 1999-03-02 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | NMR solution structure of the 21 kDa chaperone protein DnaK substrate binding domain: a preview of chaperone-protein interaction.
Biochemistry, 37, 1998
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2BNW
 | | Structural basis for cooperative binding of Ribbon-Helix-Helix Omega repressor to direct DNA heptad repeats | | Descriptor: | 5'-D(*CP*TP*TP*GP*TP*GP*AP*TP*TP*TP *GP*TP*GP*AP*TP*TP*CP*G)-3', 5'-D(*GP*AP*AP*TP*CP*AP*CP*AP*AP*AP *TP*CP*AP*CP*AP*AP*GP*C)-3', ORF OMEGA | | Authors: | Weihofen, W.A, Cicek, A, Pratto, F, Alonso, J.C, Saenger, W. | | Deposit date: | 2005-04-05 | | Release date: | 2006-03-15 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Structures of Omega Repressors Bound to Direct and Inverted DNA Repeats Explain Modulation of Transcription.
Nucleic Acids Res., 34, 2006
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2WVN
 | | Structure of the HET-s N-terminal domain | | Descriptor: | SMALL S PROTEIN | | Authors: | Greenwald, J, Buhtz, C, Ritter, C, Kwiatkowski, W, Choe, S, Saupe, S.J, Riek, R. | | Deposit date: | 2009-10-19 | | Release date: | 2010-07-28 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.62 Å) | | Cite: | The Mechanism of Prion Inhibition by Het-S.
Mol.Cell, 38, 2010
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1C6O
 | | CRYSTAL STRUCTURE OF OXIDIZED CYTOCHROME C6 FROM THE GREEN ALGAE SCENEDESMUS OBLIQUUS | | Descriptor: | CYTOCHROME C6, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Schnackenberg, J, Than, M.E, Mann, K, Wiegand, G, Huber, R, Reuter, W. | | Deposit date: | 1999-04-07 | | Release date: | 2000-04-12 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Amino acid sequence, crystallization and structure determination of reduced and oxidized cytochrome c6 from the green alga Scenedesmus obliquus.
J.Mol.Biol., 290, 1999
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