8VI2
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![BU of 8vi2 by Molmil](/molmil-images/mine/8vi2) | TehA from Haemophilus influenzae purified in DDM | Descriptor: | Tellurite resistance protein TehA homolog | Authors: | Catalano, C, Senko, S, Tran, N.L, Lucier, K.W, Farwell, A.C, Silva, M.S, Dip, P.V, Poweleit, N, Scapin, G. | Deposit date: | 2024-01-03 | Release date: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | High-Resolution Cryo-Electron Microscopy Structure Determination of Haemophilus influenzae Tellurite-Resistance Protein A via 200 kV Transmission Electron Microscopy. Int J Mol Sci, 25, 2024
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8VE5
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![BU of 8ve5 by Molmil](/molmil-images/mine/8ve5) | (Biarylamine-FT2-WT)1(C10A)3-human transthyretin in the compressed conformation | Descriptor: | 2-[(3,5-DICHLORO-4-TRIOXIDANYLPHENYL)AMINO]BENZOIC ACID, Transthyretin | Authors: | Basanta, B, Nugroho, K, Yan, N, Kline, G.M, Tsai, F.J, Wu, M, Kelly, J.W, Lander, G.C. | Deposit date: | 2023-12-18 | Release date: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | The conformational landscape of human transthyretin revealed by cryo-EM To Be Published
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8VJ7
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![BU of 8vj7 by Molmil](/molmil-images/mine/8vj7) | GluA2 bound to GYKI-52466 and Glutamate, Inhibited State 2 | Descriptor: | 4-[(5S,8R)-8-methyl-6,7,8,9-tetrahydro-2H,5H-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-5-yl]aniline, GLUTAMIC ACID, Isoform Flip of Glutamate receptor 2 | Authors: | Hale, W.D, Montano Romero, A, Huganir, R.L, Twomey, E.C. | Deposit date: | 2024-01-05 | Release date: | 2024-06-05 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (4.85 Å) | Cite: | Allosteric competition and inhibition in AMPA receptors. Nat.Struct.Mol.Biol., 2024
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8XJ6
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![BU of 8xj6 by Molmil](/molmil-images/mine/8xj6) | The Cryo-EM structure of MPXV E5 apo conformation | Descriptor: | AMP PHOSPHORAMIDATE, Monkeypox virus E5, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Zhang, W, Liu, Y, Gao, H, Gan, J. | Deposit date: | 2023-12-20 | Release date: | 2024-05-01 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.32 Å) | Cite: | Structural and functional insights into the helicase protein E5 of Mpox virus. Cell Discov, 10, 2024
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8XN9
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![BU of 8xn9 by Molmil](/molmil-images/mine/8xn9) | Nipah virus fusion glycoprotein in complex with a broadly neutralizing antibody 1D6 | Descriptor: | 1D6 VH, 1D6 VL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Fan, P.F, Ren, Y, Yu, C.M, Chen, W. | Deposit date: | 2023-12-29 | Release date: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (1.99 Å) | Cite: | Nipah virus fusion glycoprotein in complex with a broadly neutralizing antibody 1D6 To Be Published
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8VE2
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![BU of 8ve2 by Molmil](/molmil-images/mine/8ve2) | Unliganded human transthyretin in the canonical conformation | Descriptor: | Transthyretin | Authors: | Basanta, B, Nugroho, K, Yan, N, Kline, G.M, Tsai, F.J, Wu, M, Kelly, J.W, Lander, G.C. | Deposit date: | 2023-12-18 | Release date: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | The conformational landscape of human transthyretin revealed by cryo-EM To Be Published
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8YHK
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![BU of 8yhk by Molmil](/molmil-images/mine/8yhk) | The Crystal Structure of P21-Activated Kinases Pak4 from Biortus | Descriptor: | Serine/threonine-protein kinase PAK 4, TRIETHYLENE GLYCOL | Authors: | Wang, F, Cheng, W, Lv, Z, Qi, J, Wu, B. | Deposit date: | 2024-02-28 | Release date: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | The Crystal Structure of P21-Activated Kinases Pak4 from Biortus To Be Published
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1HRP
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![BU of 1hrp by Molmil](/molmil-images/mine/1hrp) | CRYSTAL STRUCTURE OF HUMAN CHORIONIC GONADOTROPIN | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HUMAN CHORIONIC GONADOTROPIN | Authors: | Lapthorn, A.J, Harris, D.C, Isaacs, N.W. | Deposit date: | 1994-08-15 | Release date: | 1994-11-01 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of human chorionic gonadotropin. Nature, 369, 1994
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9EP4
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![BU of 9ep4 by Molmil](/molmil-images/mine/9ep4) | Structure of Integrator subcomplex INTS5/8/15 | Descriptor: | Integrator complex subunit 15, Integrator complex subunit 5, Integrator complex subunit 8 | Authors: | Razew, M, Galej, W.P. | Deposit date: | 2024-03-17 | Release date: | 2024-06-12 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis of the Integrator complex assembly and association with transcription factors. Mol.Cell, 84, 2024
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8VE6
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![BU of 8ve6 by Molmil](/molmil-images/mine/8ve6) | (Biarylamine-FT2-WT)1(C10A)3-human transthyretin in the frayed conformation | Descriptor: | 2-[(3,5-DICHLORO-4-TRIOXIDANYLPHENYL)AMINO]BENZOIC ACID, Transthyretin | Authors: | Basanta, B, Nugroho, K, Yan, N, Kline, G.M, Tsai, F.J, Wu, M, Kelly, J.W, Lander, G.C. | Deposit date: | 2023-12-18 | Release date: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | The conformational landscape of human transthyretin revealed by cryo-EM To Be Published
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9AUM
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![BU of 9aum by Molmil](/molmil-images/mine/9aum) | Structure of SARS-CoV-2 Mpro mutant (T21I,S144A,T304I) in complex with Nirmatrelvir (PF-07321332) | Descriptor: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 | Authors: | Gajiwala, K.S, Greasley, S.E, Ferre, R.A, Liu, W, Stewart, A.E. | Deposit date: | 2024-02-29 | Release date: | 2024-08-07 | Method: | X-RAY DIFFRACTION (1.539 Å) | Cite: | In vitro selection and analysis of SARS-CoV-2 nirmatrelvir resistance mutations contributing to clinical virus resistance surveillance. Sci Adv, 10, 2024
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8VI5
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![BU of 8vi5 by Molmil](/molmil-images/mine/8vi5) | TehA from Haemophilus influenzae purified in OG | Descriptor: | Tellurite resistance protein TehA homolog | Authors: | Catalano, C, Senko, S, Tran, N.L, Lucier, K.W, Farwell, A.C, Silva, M.S, Dip, P.V, Poweleit, N, Scapin, G. | Deposit date: | 2024-01-03 | Release date: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | High-Resolution Cryo-Electron Microscopy Structure Determination of Haemophilus influenzae Tellurite-Resistance Protein A via 200 kV Transmission Electron Microscopy. Int J Mol Sci, 25, 2024
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8W1I
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![BU of 8w1i by Molmil](/molmil-images/mine/8w1i) | Cryo-EM structure of BTV subcore | Descriptor: | Core protein VP3 | Authors: | Xia, X, Sung, P.Y, Martynowycz, M.W, Gonen, T, Roy, P, Zhou, Z.H. | Deposit date: | 2024-02-16 | Release date: | 2024-04-24 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (6.5 Å) | Cite: | RNA genome packaging and capsid assembly of bluetongue virus visualized in host cells. Cell, 187, 2024
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8W9B
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![BU of 8w9b by Molmil](/molmil-images/mine/8w9b) | CryoEM structure of human PI3K-alpha (P85/P110-H1047R) with QR-8557 binding at an allosteric site | Descriptor: | 1-[(1S)-1-(5-fluoranyl-3-methyl-1-benzofuran-2-yl)-2-methyl-propyl]-3-(1-oxidanylidene-2,3-dihydroisoindol-5-yl)urea, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Authors: | Huang, X, Ren, X, Zhong, W. | Deposit date: | 2023-09-05 | Release date: | 2024-04-17 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Cryo-EM structures reveal two allosteric inhibition modes of PI3K alpha H1047R involving a re-shaping of the activation loop. Structure, 32, 2024
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8WKY
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![BU of 8wky by Molmil](/molmil-images/mine/8wky) | Crystal structure of the Melanocortin-4 Receptor (MC4R) in complex with S25 | Descriptor: | CALCIUM ION, Melanocortin receptor 4, N-(2-aminoethyl)-5-(2-{[4-(morpholin-4-yl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)pyridine-3-carboxamide, ... | Authors: | Gimenez, L.E, Martin, C, Yu, J, Hollanders, C, Hernandez, C, Dahir, N.S, Wu, Y, Yao, D, Han, G.W, Wu, L, Poorten, O.V, Lamouroux, A, Mannes, M, Tourwe, D, Zhao, S, Stevens, R.C, Cone, R.D, Ballet, S. | Deposit date: | 2023-09-28 | Release date: | 2024-08-07 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design. J.Med.Chem., 67, 2024
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8W1R
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![BU of 8w1r by Molmil](/molmil-images/mine/8w1r) | Cryo-EM structure of BTV core | Descriptor: | Core protein VP3, RNA-directed RNA polymerase | Authors: | Xia, X, Sung, P.Y, Martynowycz, M.W, Gonen, T, Roy, P, Zhou, Z.H. | Deposit date: | 2024-02-17 | Release date: | 2024-04-24 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | RNA genome packaging and capsid assembly of bluetongue virus visualized in host cells. Cell, 187, 2024
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4G6H
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![BU of 4g6h by Molmil](/molmil-images/mine/4g6h) | Crystal structure of NDH with NADH | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, MAGNESIUM ION, ... | Authors: | Li, W, Feng, Y, Ge, J, Yang, M. | Deposit date: | 2012-07-19 | Release date: | 2012-10-24 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.262 Å) | Cite: | Structural insight into the type-II mitochondrial NADH dehydrogenases. Nature, 491, 2012
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8Y4Z
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![BU of 8y4z by Molmil](/molmil-images/mine/8y4z) | Monomeric HERC5 HECT c-lobe structure in solution | Descriptor: | E3 ISG15--protein ligase HERC5 | Authors: | Dag, C, Lambert, M, Kahraman, K, Lohn, F, Lee, W, Gocenler, O, Guntert, P, Dotsch, V. | Deposit date: | 2024-01-31 | Release date: | 2024-02-14 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Monomeric HERC5 HECT c-lobe structure in solution To Be Published
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8Y7R
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![BU of 8y7r by Molmil](/molmil-images/mine/8y7r) | |
1HW4
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![BU of 1hw4 by Molmil](/molmil-images/mine/1hw4) | STRUCTURE OF THYMIDYLATE SYNTHASE SUGGESTS ADVANTAGES OF CHEMOTHERAPY WITH NONCOMPETITIVE INHIBITORS | Descriptor: | 1,2-ETHANEDIOL, SULFATE ION, THYMIDYLATE SYNTHASE | Authors: | Phan, J, Steadman, J.D, Koli, S, Ding, W.C, Minor, W, Dunlap, R.B, Berger, S.H, Lebioda, L. | Deposit date: | 2001-01-09 | Release date: | 2001-01-24 | Last modified: | 2022-04-13 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors. J.Biol.Chem., 276, 2001
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8W19
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![BU of 8w19 by Molmil](/molmil-images/mine/8w19) | Cryo-EM structure of BTV star-subcore | Descriptor: | Core protein VP3, VP6 | Authors: | Xia, X, Sung, P.Y, Martynowycz, M.W, Gonen, T, Roy, P, Zhou, Z.H. | Deposit date: | 2024-02-15 | Release date: | 2024-04-24 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | RNA genome packaging and capsid assembly of bluetongue virus visualized in host cells. Cell, 187, 2024
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9CA0
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![BU of 9ca0 by Molmil](/molmil-images/mine/9ca0) | Human TOP3B-TDRD3 core complex in DNA pre-cleavage state | Descriptor: | DNA (5'-D(*AP*TP*T)-3'), DNA (5'-D(P*TP*AP*CP*TP*AP*AP*A)-3'), DNA topoisomerase 3-beta-1, ... | Authors: | Yang, X, Chen, X, Yang, W, Pommier, Y. | Deposit date: | 2024-06-16 | Release date: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.48 Å) | Cite: | Structural Insights into human Topoisomerase 3-beta DNA and RNA catalytic cycles and topo-gate dynamics To Be Published
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9FA4
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![BU of 9fa4 by Molmil](/molmil-images/mine/9fa4) | |
9B90
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![BU of 9b90 by Molmil](/molmil-images/mine/9b90) | |
8VAE
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![BU of 8vae by Molmil](/molmil-images/mine/8vae) | Cryogenic electron microscopy structure of human serum albumin in complex with salicylic acid | Descriptor: | 2-HYDROXYBENZOIC ACID, Serum albumin | Authors: | Catalano, C, Lucier, K.W, To, D, Senko, S, Tran, N.L, Farwell, A.C, Silva, S.M, Dip, P.V, Poweleit, N, Scapin, G. | Deposit date: | 2023-12-11 | Release date: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | The CryoEM structure of human serum albumin in complex with ligands. J.Struct.Biol., 216, 2024
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