2E6G
 
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5M8R
 | | Crystal structure of human tyrosinase related protein 1 (T391V-R374S-Y362F) in complex with mimosine | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Lai, X, Soler-Lopez, M, Wichers, H.J, Dijkstra, B.W. | | 登録日 | 2016-10-29 | | 公開日 | 2017-07-12 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis.
Angew. Chem. Int. Ed. Engl., 56, 2017
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3OW3
 | | Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors | | 分子名称: | (2R)-3-(1H-indol-3-yl)-1-{4-[(5S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]piperazin-1-yl}-1-oxopropan-2-amine, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha | | 著者 | Dizon, F, Wu, W, Vigers, G.P.A, Brandhuber, B.J. | | 登録日 | 2010-09-17 | | 公開日 | 2010-11-10 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
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3JSD
 | | Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus | | 分子名称: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | | 著者 | Weiss, M.A, Wan, Z.L, Dodson, E.J, Liu, M, Xu, B, Hua, Q.X, Turkenburg, M, Whittingham, J, Nakagawa, S.H, Huang, K, Hu, S.Q, Jia, W.H, Wang, S.H, Brange, J, Whittaker, J, Arvan, P, Katsoyannis, P.G, Dodson, G.G. | | 登録日 | 2009-09-10 | | 公開日 | 2010-09-15 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
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5LI8
 | | Crystal structure of Mycobacterium tuberculosis CYP126A1 in complex with ketoconazole | | 分子名称: | 1-acetyl-4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine, PROTOPORPHYRIN IX CONTAINING FE, Putative cytochrome P450 126 | | 著者 | Levy, C, Munro, A.W, Leys, D. | | 登録日 | 2016-07-14 | | 公開日 | 2016-12-21 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1.
J. Biol. Chem., 292, 2017
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1Y1N
 | | Identification of SH3 motif in M. Tuberculosis methionine aminopeptidase suggests a mode of interaction with the ribosome | | 分子名称: | Methionine aminopeptidase 1B, POTASSIUM ION | | 著者 | Addlagatta, A, Quillin, M.L, Omotoso, O, Liu, J.O, Matthews, B.W. | | 登録日 | 2004-11-18 | | 公開日 | 2005-05-24 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | | 主引用文献 | Identification of an SH3-Binding Motif in a New Class of Methionine Aminopeptidases from Mycobacterium tuberculosis Suggests a Mode of Interaction with the Ribosome
Biochemistry, 44, 2005
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5ZE0
 | | Hairpin Forming Complex, RAG1/2-Nicked(with Dideoxy) 12RSS/23RSS complex in Mg2+ | | 分子名称: | 1,2-ETHANEDIOL, DNA (30-MER), DNA (39-MER), ... | | 著者 | Kim, M.S, Chuenchor, W, Chen, X, Gellert, M, Yang, W. | | 登録日 | 2018-02-25 | | 公開日 | 2018-04-25 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Cracking the DNA Code for V(D)J Recombination
Mol. Cell, 70, 2018
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2I7P
 | | Crystal structure of human PANK3 in complex with AcCoA | | 分子名称: | ACETYL COENZYME *A, Pantothenate kinase 3 | | 著者 | Hong, B.S, Wang, L, Shen, L, Tempel, W, Loppnau, P, Finerty, P, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H.W, Structural Genomics Consortium (SGC) | | 登録日 | 2006-08-31 | | 公開日 | 2006-12-26 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder.
J.Biol.Chem., 282, 2007
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3DSU
 | | Crystal structure of RabGGTase(DELTA LRR; DELTA IG)in complex with farnesyl pyrophosphate | | 分子名称: | CALCIUM ION, FARNESYL DIPHOSPHATE, Geranylgeranyl transferase type-2 subunit alpha, ... | | 著者 | Guo, Z, Yu, S, Goody, R.S, Alexandrov, K, Blankenfeldt, W. | | 登録日 | 2008-07-14 | | 公開日 | 2008-09-09 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation
Embo J., 27, 2008
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6RDI
 | | Cryo-EM structure of Polytomella F-ATP synthase, Rotary substate 1A, monomer-masked refinement | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ASA-10: Polytomella F-ATP synthase associated subunit 10, ... | | 著者 | Murphy, B.J, Klusch, N, Yildiz, O, Kuhlbrandt, W. | | 登録日 | 2019-04-12 | | 公開日 | 2019-07-03 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Rotary substates of mitochondrial ATP synthase reveal the basis of flexible F 1 -F o coupling.
Science, 364, 2019
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6RDX
 | | Cryo-EM structure of Polytomella F-ATP synthase, Rotary substate 1F, monomer-masked refinement | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ASA-10: Polytomella F-ATP synthase associated subunit 10, ... | | 著者 | Murphy, B.J, Klusch, N, Yildiz, O, Kuhlbrandt, W. | | 登録日 | 2019-04-12 | | 公開日 | 2019-07-03 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Rotary substates of mitochondrial ATP synthase reveal the basis of flexible F 1 -F o coupling.
Science, 364, 2019
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1KW7
 | | METHIONINE CORE MUTANT OF T4 LYSOZYME | | 分子名称: | 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, LYSOZYME | | 著者 | Gassner, N.C, Baase, W.A, Mooers, B.H, Busam, R.D, Weaver, L.H, Lindstrom, J.D, Quillin, M.L, Matthews, B.W. | | 登録日 | 2002-01-28 | | 公開日 | 2003-06-03 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | Multiple methionine substitutions are tolerated in T4 lysozyme and have coupled effects on folding and stability
BIOPHYS.CHEM., 100, 2003
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6RDK
 | | Cryo-EM structure of Polytomella F-ATP synthase, Rotary substate 1B, composite map | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ASA-10: Polytomella F-ATP synthase associated subunit 10, ... | | 著者 | Murphy, B.J, Klusch, N, Yildiz, O, Kuhlbrandt, W. | | 登録日 | 2019-04-12 | | 公開日 | 2019-07-03 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Rotary substates of mitochondrial ATP synthase reveal the basis of flexible F 1 -F o coupling.
Science, 364, 2019
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6RE0
 | | Cryo-EM structure of Polytomella F-ATP synthase, Rotary substate 2A, monomer-masked refinement | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ASA-10: Polytomella F-ATP synthase associated subunit 10, ... | | 著者 | Murphy, B.J, Klusch, N, Yildiz, O, Kuhlbrandt, W. | | 登録日 | 2019-04-12 | | 公開日 | 2019-07-03 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Rotary substates of mitochondrial ATP synthase reveal the basis of flexible F 1 -F o coupling.
Science, 364, 2019
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6REP
 | | Cryo-EM structure of Polytomella F-ATP synthase, Primary rotary state 3, composite map | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ASA-10: Polytomella F-ATP synthase associated subunit 10, ... | | 著者 | Murphy, B.J, Klusch, N, Yildiz, O, Kuhlbrandt, W. | | 登録日 | 2019-04-12 | | 公開日 | 2019-07-03 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Rotary substates of mitochondrial ATP synthase reveal the basis of flexible F 1 -F o coupling.
Science, 364, 2019
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5ZE1
 | | Hairpin Forming Complex, RAG1/2-Nicked 12RSS/23RSS complex in 2mM Mn2+ for 10 min at 4'C | | 分子名称: | 1,2-ETHANEDIOL, DNA, HMGB1 A-B box, ... | | 著者 | Kim, M.S, Chuenchor, W, Chen, X, Gellert, M, Yang, W. | | 登録日 | 2018-02-25 | | 公開日 | 2018-04-25 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Cracking the DNA Code for V(D)J Recombination
Mol. Cell, 70, 2018
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8UTG
 | | An RNA G-Quadruplex from the NS5 gene in the West Nile Virus Genome | | 分子名称: | AMMONIUM ION, POTASSIUM ION, RNA (5'-R(*UP*AP*UP*GP*GP*AP*AP*GP*AP*GP*GP*CP*GP*GP*UP*UP*GP*GP*UP*AP*U)-3') | | 著者 | Terrell, J.R, Le, T.T, Wilson, W.D, Siemer, J.L. | | 登録日 | 2023-10-31 | | 公開日 | 2024-06-19 | | 最終更新日 | 2024-07-17 | | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | | 主引用文献 | Structure of an RNA G-quadruplex from the West Nile virus genome.
Nat Commun, 15, 2024
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5MD2
 | | The structure of the mature HIV-1 CA hexameric lattice with curvature parameters: tilt=5, twist=-6 | | 分子名称: | Capsid protein p24 C-terminal domain, Capsid protein p24 N-terminal domain | | 著者 | Mattei, S, Glass, B, Hagen, W.J.H, Kraeusslich, H.-G, Briggs, J.A.G. | | 登録日 | 2016-11-10 | | 公開日 | 2016-12-28 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (8.6 Å) | | 主引用文献 | The structure and flexibility of conical HIV-1 capsids determined within intact virions.
Science, 354, 2016
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5MDC
 | | The structure of the mature HIV-1 CA hexameric lattice with curvature parameters: tilt=17, twist=-12 | | 分子名称: | Gag protein | | 著者 | Mattei, S, Glass, B, Hagen, W.J.H, Kraeusslich, H.-G, Briggs, J.A.G. | | 登録日 | 2016-11-10 | | 公開日 | 2016-12-28 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (8.4 Å) | | 主引用文献 | The structure and flexibility of conical HIV-1 capsids determined within intact virions.
Science, 354, 2016
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5ZFJ
 | | Crystal structure of a cyclase Filc from Fischerella sp. in complex with 4-(1H-Indol-3-yl)butan-2-one | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-(1~{H}-indol-3-yl)butan-2-one, CALCIUM ION, ... | | 著者 | Hu, X.Y, Liu, W.D, Chen, C.C, Guo, R.T. | | 登録日 | 2018-03-06 | | 公開日 | 2018-12-19 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | The Crystal Structure of a Class of Cyclases that Catalyze the Cope Rearrangement
Angew. Chem. Int. Ed. Engl., 57, 2018
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3HS0
 | | Cobra Venom Factor (CVF) in complex with human factor B | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cobra venom factor, ... | | 著者 | Janssen, B.J.C, Gomes, L, Koning, R.I, Svergun, D.I, Koster, A.J, Fritzinger, D.C, Vogel, C.-W, Gros, P. | | 登録日 | 2009-06-10 | | 公開日 | 2009-07-07 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex
Embo J., 28, 2009
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6R86
 | | Yeast Vms1-60S ribosomal subunit complex (post-state) | | 分子名称: | 25S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | | 著者 | Su, T, Izawa, T, Cheng, J, Yamashita, Y, Berninghausen, O, Inada, T, Neupert, W, Beckmann, R. | | 登録日 | 2019-03-31 | | 公開日 | 2019-07-31 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structure and function of Vms1 and Arb1 in RQC and mitochondrial proteome homeostasis.
Nature, 570, 2019
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4RVS
 | | The native structure of mycobacterial quinone oxidoreductase Rv154c. | | 分子名称: | Probable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) | | 著者 | Zhou, W.H, Zheng, Q.Q, Song, Y.L, Zhang, W, Shaw, N, Rao, Z. | | 登録日 | 2014-11-27 | | 公開日 | 2015-06-24 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.8464 Å) | | 主引用文献 | Structural views of quinone oxidoreductase from Mycobacterium tuberculosis reveal large conformational changes induced by the co-factor.
Febs J., 282, 2015
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6WLL
 | | Apo F. nucleatum glycine riboswitch models, 10.0 Angstrom resolution | | 分子名称: | RNA (171-MER) | | 著者 | Kappel, K, Zhang, K, Su, Z, Watkins, A.M, Kladwang, W, Li, S, Pintilie, G, Topkar, V.V, Rangan, R, Zheludev, I.N, Yesselman, J.D, Chiu, W, Das, R. | | 登録日 | 2020-04-20 | | 公開日 | 2020-07-08 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (10 Å) | | 主引用文献 | Accelerated cryo-EM-guided determination of three-dimensional RNA-only structures.
Nat.Methods, 17, 2020
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5MK5
 | | Structures of DHBN domain of human BLM helicase | | 分子名称: | Bloom syndrome protein, IODIDE ION, POTASSIUM ION | | 著者 | Shi, J, Chen, W.-F, Zhang, B, Fan, S.-H, Ai, X, Liu, N.-N, Rety, S, Xi, X.-G. | | 登録日 | 2016-12-02 | | 公開日 | 2017-03-01 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | | 主引用文献 | A helical bundle in the N-terminal domain of the BLM helicase mediates dimer and potentially hexamer formation.
J. Biol. Chem., 292, 2017
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