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PDB: 7 件
6Y20
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BU of 6y20 by Molmil
Crystal structure of Protein Scalloped (222-440) bound to Protein Vestigial (298-337)
分子名称: MYRISTIC ACID, Protein scalloped, Protein vestigial
著者Scheufler, C, Villard, F, Bokhovchuk, F.
登録日2020-02-14
公開日2020-10-21
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.849 Å)
主引用文献A new perspective on the interaction between the Vg/VGLL1-3 proteins and the TEAD transcription factors.
Sci Rep, 10, 2020
6Z10
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BU of 6z10 by Molmil
Crystal structure of a humanized (K18E, K269N) rat succinate receptor SUCNR1 (GPR91) in complex with a nanobody and antagonist
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-[2-[[3-[4-chloranyl-2-fluoranyl-5-[(3~{R})-piperidin-3-yl]oxy-phenyl]-2-fluoranyl-phenyl]carbonylamino]-5-fluoranyl-phenyl]ethanoic acid, CHLORIDE ION, ...
著者Haffke, M, Villard, F.
登録日2020-05-11
公開日2020-09-16
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.269 Å)
主引用文献Discovery and Optimization of Novel SUCNR1 Inhibitors: Design of Zwitterionic Derivatives with a Salt Bridge for the Improvement of Oral Exposure.
J.Med.Chem., 63, 2020
6SEO
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BU of 6seo by Molmil
TEAD4 bound to a FAM181B peptide
分子名称: Protein FAM181B, Transcriptional enhancer factor TEF-3
著者Scheufler, C, Villard, F.
登録日2019-07-30
公開日2019-11-20
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Identification of FAM181A and FAM181B as new interactors with the TEAD transcription factors.
Protein Sci., 29, 2020
6SEN
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BU of 6sen by Molmil
TEAD4 bound to a FAM181A peptide
分子名称: Protein FAM181A, SULFATE ION, Transcriptional enhancer factor TEF-3
著者Scheufler, C, Villard, F.
登録日2019-07-30
公開日2019-11-20
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Identification of FAM181A and FAM181B as new interactors with the TEAD transcription factors.
Protein Sci., 29, 2020
8A8Q
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BU of 8a8q by Molmil
Crystal structure of Protein Scalloped in complex with YAP peptide
分子名称: ACETATE ION, Isoform 7 of Transcriptional coactivator YAP1, Protein scalloped
著者Scheufler, C, Villard, F.
登録日2022-06-23
公開日2022-12-28
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.465 Å)
主引用文献N-terminal beta-strand in YAP is critical for stronger binding to scalloped relative to TEAD transcription factor.
Protein Sci., 32, 2023
8PFP
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BU of 8pfp by Molmil
Crystal structure of WRN helicase domain in complex with ATPgammaS
分子名称: Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ZINC ION
著者Scheufler, C, Villard, F.
登録日2023-06-16
公開日2024-04-24
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers.
Nature, 629, 2024
8P0M
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BU of 8p0m by Molmil
Crystal structure of TEAD3 in complex with IAG933
分子名称: 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, 4-[(2~{S})-5-chloranyl-6-fluoranyl-2-phenyl-2-[(2~{S})-pyrrolidin-2-yl]-3~{H}-1-benzofuran-4-yl]-5-fluoranyl-6-(2-hydroxyethyloxy)-~{N}-methyl-pyridine-3-carboxamide, DIMETHYL SULFOXIDE, ...
著者Scheufler, C, Villard, F, Chau, S.
登録日2023-05-10
公開日2024-04-10
最終更新日2024-08-07
実験手法X-RAY DIFFRACTION (1.961 Å)
主引用文献Direct and selective pharmacological disruption of the YAP-TEAD interface by IAG933 inhibits Hippo-dependent and RAS-MAPK-altered cancers.
Nat Cancer, 5, 2024

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件を2024-10-30に公開中

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