2FM2
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![BU of 2fm2 by Molmil](/molmil-images/mine/2fm2) | HCV NS3-4A protease domain complexed with a ketoamide inhibitor, SCH446211 | Descriptor: | BETA-MERCAPTOETHANOL, NS3 protease/helicase, NS4a protein, ... | Authors: | Yi, M, Tong, X, Skelton, A, Chase, R, Chen, T, Prongay, A, Bogen, S.L, Saksena, A.K, Njoroge, F.G, Veselenak, R.L, Pyles, R.B, Bourne, N, Malcolm, B.A, Lemon, S.M. | Deposit date: | 2006-01-06 | Release date: | 2006-02-07 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Mutations conferring resistance to SCH6, a novel hepatitis C virus NS3/4A protease inhibitor. Reduced RNA replication fitness and partial rescue by second-site mutations J.Biol.Chem., 281, 2006
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