8EI4
| Crystal structure of the WWP1 HECT domain in complex with H302, a Helicon Polypeptide | Descriptor: | 1,2-ETHANEDIOL, H302, N,N'-(1,4-phenylene)diacetamide, ... | Authors: | Li, K, Tokareva, O.S, Thomson, T.M, Verdine, G.L, McGee, J.H. | Deposit date: | 2022-09-14 | Release date: | 2023-10-25 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.43 Å) | Cite: | Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides. Nat Commun, 14, 2023
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8EI7
| Crystal structure of the WWP2 HECT domain in complex with H304, a Helicon Polypeptide | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | Authors: | Li, K, Tokareva, O.S, Thomson, T.M, Verdine, G.L, McGee, J.H. | Deposit date: | 2022-09-14 | Release date: | 2023-10-25 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides. Nat Commun, 14, 2023
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8EI0
| Crystal structure of the STUB1 TPR domain in complex with H318, a Helicon Polypeptide | Descriptor: | 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase CHIP, H318, ... | Authors: | Li, K, Swiecicki, J.-M, Tokareva, O.S, Thomson, T.M, Verdine, G.L, McGee, J.H. | Deposit date: | 2022-09-14 | Release date: | 2023-10-25 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides. Nat Commun, 14, 2023
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8EI6
| Crystal structure of the WWP2 HECT domain in complex with H305, a Helicon Polypeptide | Descriptor: | H305, N,N'-(1,4-phenylene)diacetamide, NEDD4-like E3 ubiquitin-protein ligase WWP2 | Authors: | Li, K, Tokareva, O.S, Thomson, T.M, Verdine, G.L, McGee, J.H. | Deposit date: | 2022-09-14 | Release date: | 2023-10-25 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.62 Å) | Cite: | Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides. Nat Commun, 14, 2023
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8EIB
| Crystal structure of beta-catenin and the MDM2 p53-binding domain in complex with H329, a Helicon Polypeptide | Descriptor: | Catenin beta-1, E3 ubiquitin-protein ligase Mdm2, H329, ... | Authors: | Li, K, Travaline, T.L, Swiecicki, J.-M, Tokareva, O.S, Thomson, T.M, Verdine, G.L, McGee, J.H. | Deposit date: | 2022-09-14 | Release date: | 2023-10-25 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.76 Å) | Cite: | Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides. Nat Commun, 14, 2023
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8EI1
| Crystal structure of the N-terminal domain of CUL4B in complex with H316, a Helicon Polypeptide | Descriptor: | Cullin-4B, H316, N,N'-(1,4-phenylene)diacetamide | Authors: | Li, K, Tokareva, O.S, Thomson, T.M, Verdine, G.L, McGee, J.H. | Deposit date: | 2022-09-14 | Release date: | 2023-10-25 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides. Nat Commun, 14, 2023
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8EIA
| Crystal structure of beta-catenin and the MDM2 p53-binding domain in complex with H333, a Helicon Polypeptide | Descriptor: | Catenin beta-1, E3 ubiquitin-protein ligase Mdm2, H333, ... | Authors: | Li, K, Travaline, T.L, Swiecicki, J.-M, Tokareva, O.S, Thomson, T.M, Verdine, G.L, McGee, J.H. | Deposit date: | 2022-09-14 | Release date: | 2023-10-25 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides. Nat Commun, 14, 2023
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1ADN
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1DCT
| DNA (CYTOSINE-5) METHYLASE FROM HAEIII COVALENTLY BOUND TO DNA | Descriptor: | CALCIUM ION, DNA (5'-D(*AP*CP*CP*AP*GP*CP*AP*GP*GP*(C49)P*CP*AP*CP*CP*AP*GP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*CP*TP*GP*GP*TP*GP*GP*(C5M)P*CP*TP*GP*CP*TP*GP*G)-3'), ... | Authors: | Reinisch, K.M, Chen, L, Verdine, G.L, Lipscomb, W.N. | Deposit date: | 1995-05-17 | Release date: | 1995-09-15 | Last modified: | 2019-11-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The crystal structure of HaeIII methyltransferase convalently complexed to DNA: an extrahelical cytosine and rearranged base pairing. Cell(Cambridge,Mass.), 82, 1995
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2NOF
| Structure of Q315F human 8-oxoguanine glycosylase proximal crosslink to 8-oxoguanine DNA | Descriptor: | 5'-D(*GP*CP*GP*TP*C*CP*AP*(G42)P*GP*TP*CP*TP*AP*CP*C)-3', 5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', CALCIUM ION, ... | Authors: | Radom, C.T, Banerjee, A, Verdine, G.L. | Deposit date: | 2006-10-25 | Release date: | 2006-11-21 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural characterization of human 8-oxoguanine DNA glycosylase variants bearing active site mutations. J.Biol.Chem., 282, 2007
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2NOZ
| Structure of Q315F human 8-oxoguanine glycosylase distal crosslink to 8-oxoguanine DNA | Descriptor: | 5'-D(*G*CP*GP*TP*CP*CP*AP*(G42)P*GP*TP*CP*TP*AP*CP*C)-3', 5'-D(*GP*G*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', CALCIUM ION, ... | Authors: | Radom, C.T, Banerjee, A, Verdine, G.L. | Deposit date: | 2006-10-26 | Release date: | 2006-11-21 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.43 Å) | Cite: | Structural characterization of human 8-oxoguanine DNA glycosylase variants bearing active site mutations. J.Biol.Chem., 282, 2007
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2NOI
| Structure of G42A human 8-oxoguanine glycosylase crosslinked to undamaged G-containing DNA | Descriptor: | 5'-D(*GP*CP*GP*TP*C*CP*AP*GP*GP*TP*CP*TP*AP*CP*C)-3', 5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', CALCIUM ION, ... | Authors: | Radom, C.T, Banerjee, A, Verdine, G.L. | Deposit date: | 2006-10-25 | Release date: | 2006-11-21 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural characterization of human 8-oxoguanine DNA glycosylase variants bearing active site mutations. J.Biol.Chem., 282, 2007
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2NOB
| Structure of catalytically inactive H270A human 8-oxoguanine glycosylase crosslinked to 8-oxoguanine DNA | Descriptor: | 5'-D(*G*CP*GP*TP*CP*CP*AP*(G42)P*GP*TP*CP*TP*AP*CP*C)-3', 5'-D(*T*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', CALCIUM ION, ... | Authors: | Radom, C.T, Banerjee, A, Verdine, G.L. | Deposit date: | 2006-10-25 | Release date: | 2006-11-21 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural characterization of human 8-oxoguanine DNA glycosylase variants bearing active site mutations. J.Biol.Chem., 282, 2007
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2NOE
| Structure of catalytically inactive G42A human 8-oxoguanine glycosylase complexed to 8-oxoguanine DNA | Descriptor: | 5'-D(*G*CP*GP*TP*CP*CP*AP*(G42)P*GP*TP*CP*TP*AP*CP*C)-3', 5'-D(*G*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', CALCIUM ION, ... | Authors: | Radom, C.T, Banerjee, A, Verdine, G.L. | Deposit date: | 2006-10-25 | Release date: | 2006-11-21 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural characterization of human 8-oxoguanine DNA glycosylase variants bearing active site mutations. J.Biol.Chem., 282, 2007
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2NOL
| Structure of catalytically inactive human 8-oxoguanine glycosylase distal crosslink to oxoG DNA | Descriptor: | 5'-D(*GP*CP*GP*TP*CP*CP*AP*(G42)P*GP*TP*CP*TP*AP*CP*C)-3', 5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', CALCIUM ION, ... | Authors: | Banerjee, A, Radom, C.T, Verdine, G.L. | Deposit date: | 2006-10-25 | Release date: | 2006-11-21 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | Structural characterization of human 8-oxoguanine DNA glycosylase variants bearing active site mutations. J.Biol.Chem., 282, 2007
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2NOH
| Structure of catalytically inactive Q315A human 8-oxoguanine glycosylase complexed to 8-oxoguanine DNA | Descriptor: | 5'-D(*GP*CP*GP*TP*CP*CP*AP*(G42)P*GP*TP*CP*TP*AP*CP*C)-3', 5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', CALCIUM ION, ... | Authors: | Radom, C.T, Banerjee, A, Verdine, G.L. | Deposit date: | 2006-10-25 | Release date: | 2006-11-21 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Structural characterization of human 8-oxoguanine DNA glycosylase variants bearing active site mutations. J.Biol.Chem., 282, 2007
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3GPP
| MutM encountering an intrahelical 8-oxoguanine (oxoG) lesion in EC3-T224P complex | Descriptor: | DNA (5'-D(P*CP*GP*TP*CP*CP*(8OG)P*GP*AP*TP*CP*TP*AP*C)-3'), DNA (5'-D(P*GP*GP*TP*AP*GP*AP*TP*CP*CP*GP*GP*AP*C)-3'), DNA glycosylase, ... | Authors: | Spong, M.C, Qi, Y, Verdine, G.L. | Deposit date: | 2009-03-23 | Release date: | 2009-11-10 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme. Nature, 462, 2009
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3GPY
| Sequence-matched MutM Lesion Recognition Complex 3 (LRC3) | Descriptor: | DNA (5'-D(*AP*GP*GP*TP*AP*GP*AP*TP*CP*CP*GP*GP*AP*CP*GP*C)-3'), DNA (5'-D(*T*GP*CP*GP*TP*CP*CP*(8OG)P*GP*AP*TP*CP*TP*AP*CP*C)-3'), DNA glycosylase, ... | Authors: | Qi, Y, Verdine, G.L. | Deposit date: | 2009-03-23 | Release date: | 2009-11-10 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme. Nature, 462, 2009
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3GQ4
| Sequence-matched MutM Lesion Recognition Complex 5 (LRC5) | Descriptor: | DNA (5'-D(*AP*GP*GP*TP*AP*GP*AP*CP*CP*CP*GP*GP*AP*CP*GP*C)-3'), DNA (5'-D(*TP*GP*CP*GP*TP*CP*CP*GP*(8OG)P*GP*TP*CP*TP*AP*CP*C)-3'), DNA glycosylase, ... | Authors: | Spong, M.C, Qi, Y, Verdine, G.L. | Deposit date: | 2009-03-23 | Release date: | 2009-11-10 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme. Nature, 462, 2009
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3GO8
| MutM encountering an intrahelical 8-oxoguanine (oxoG) lesion in EC3-loop deletion complex | Descriptor: | 5'-D(*GP*CP*GP*TP*CP*CP*(8OG)P*GP*AP*TP*CP*TP*AP*C)-3', 5'-D(P*GP*GP*TP*AP*GP*AP*TP*CP*CP*GP*GP*AP*CP*G)-3', Formamidopyrimidine-DNA glycosylase, ... | Authors: | Spong, M.C, Qi, Y, Verdine, G.L. | Deposit date: | 2009-03-18 | Release date: | 2009-12-15 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme Nature, 462, 2009
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3GPU
| MutM encountering an intrahelical 8-oxoguanine (oxoG) lesion in EC4-loop deletion complex | Descriptor: | DNA (5'-D(*AP*GP*GP*TP*AP*GP*AP*CP*TP*CP*GP*GP*AP*CP*GP*C)-3'), DNA (5'-D(*TP*GP*CP*GP*TP*CP*CP*(8OG)P*AP*GP*TP*CP*TP*AP*CP*C)-3'), DNA glycosylase, ... | Authors: | Banerjee, A, Qi, Y, Verdine, G.L. | Deposit date: | 2009-03-23 | Release date: | 2009-11-10 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme. Nature, 462, 2009
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3GQ3
| MutM encountering an intrahelical 8-oxoguanine (oxoG) lesion in EC5-loop deletion complex | Descriptor: | DNA (5'-D(*AP*GP*GP*TP*AP*GP*AP*CP*CP*CP*GP*GP*AP*CP*GP*C)-3'), DNA (5'-D(*TP*GP*CP*GP*TP*CP*CP*GP*(8OG)P*GP*TP*CP*TP*AP*CP*C)-3'), DNA glycosylase, ... | Authors: | Banerjee, A, Qi, Y, Verdine, G.L. | Deposit date: | 2009-03-23 | Release date: | 2009-11-10 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme. Nature, 462, 2009
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1R2Z
| MutM (Fpg) bound to 5,6-dihydrouracil (DHU) containing DNA | Descriptor: | 5'-D(*AP*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 5'-D(*TP*GP*CP*GP*TP*CP*CP*AP*(DHU)P*GP*TP*CP*TP*AP*CP*C)-3', MutM, ... | Authors: | Fromme, J.C, Verdine, G.L. | Deposit date: | 2003-09-30 | Release date: | 2003-10-14 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | DNA Lesion Recognition by the Bacterial Repair Enzyme MutM. J.Biol.Chem., 278, 2003
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1U8B
| Crystal structure of the methylated N-ADA/DNA complex | Descriptor: | 5'-D(*AP*AP*TP*CP*TP*TP*GP*CP*GP*CP*TP*TP*T)-3', 5'-D(*TP*AP*AP*AP*TP*T)-3', 5'-D(P*AP*AP*AP*GP*CP*GP*CP*AP*AP*GP*AP*T)-3', ... | Authors: | He, C, Hus, J.-C, Sun, L.J, Zhou, P, Norman, D.P.G, Dotsch, V, Gross, J.D, Lane, W.S, Wagner, G, Verdine, G.L. | Deposit date: | 2004-08-05 | Release date: | 2005-10-11 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A methylation-dependent electrostatic switch controls DNA repair and transcriptional activation by E. coli ada. Mol.Cell, 20, 2005
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3JR4
| MutM interrogating an extrahelical G | Descriptor: | DNA (5'-D(*AP*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3'), DNA (5'-D(*TP*G*CP*GP*TP*CP*CP*AP*(GX1)P*GP*TP*CP*TP*AP*CP*C)-3'), DNA glycosylase, ... | Authors: | Qi, Y, Spong, M.C, Verdine, G.L. | Deposit date: | 2009-09-08 | Release date: | 2009-11-03 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.601 Å) | Cite: | Entrapment and structure of an extrahelical guanine attempting to enter the active site of a bacterial DNA glycosylase, MutM. J.Biol.Chem., 285, 2010
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