6CGO
 
 | | Molecular basis for condensation domain-mediated chain release from the enacyloxin polyketide synthase | | 分子名称: | Condensation domain protein, PHOSPHATE ION | | 著者 | Valentic, T.R, Tsai, S.C, Challis, G.L, Lewandowski, J.R, Kosol, S, Gallo, A, Griffiths, D, Masschelein, J.L, Jenner, M, De los Santos, E. | | 登録日 | 2018-02-20 | | 公開日 | 2019-02-27 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural basis for chain release from the enacyloxin polyketide synthase.
Nat.Chem., 11, 2019
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5THQ
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5INI
 | | Structural basis for acyl-CoA carboxylase-mediated assembly of unusual polyketide synthase extender units incorporated into the stambomycin antibiotics | | 分子名称: | HEXANOYL-COENZYME A, Putative carboxyl transferase | | 著者 | Valentic, T.R, Ray, L, Miyazawa, T, Withall, D.M, Song, L, Milligan, J.C, Osada, H, Tsai, S.C, Challis, G.L. | | 登録日 | 2016-03-07 | | 公開日 | 2016-12-28 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units.
Nat Commun, 7, 2016
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5ING
 | | A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender unit | | 分子名称: | Putative carboxyl transferase | | 著者 | Valentic, T.R, Ray, L, Miyazawa, T, Song, L, Withall, D.M, Milligan, J.C, Takahashi, S, Osada, H, Tsai, S.C, Challis, G.L. | | 登録日 | 2016-03-07 | | 公開日 | 2016-12-28 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units.
Nat Commun, 7, 2016
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5INF
 | | Structural basis for acyl-CoA carboxylase-mediated assembly of unusual polyketide synthase extender units incorporated into the stambomycin antibiotics | | 分子名称: | Carboxyl transferase, HEXANOYL-COENZYME A | | 著者 | Valentic, T.R, Ray, L, Miyazawa, T, Withall, D.M, Song, L, Osada, H, Tsai, S.C, Challis, G.L. | | 登録日 | 2016-03-07 | | 公開日 | 2016-12-28 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.751 Å) | | 主引用文献 | A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units.
Nat Commun, 7, 2016
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5TII
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6NEI
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6NEG
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6NEH
 | | N191D, F205S mutant of scoulerine 9-O-methyltransferase from Thalictrum flavum complexed with (13aS)-3,10-dimethoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline-2,9-diol and S-ADENOSYL-L-HOMOCYSTEINE | | 分子名称: | (13aS)-3,10-dimethoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline-2,9-diol, (S)-scoulerine 9-O-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | | 著者 | Valentic, T.R, Smolke, C.D, Payne, J.T. | | 登録日 | 2018-12-17 | | 公開日 | 2019-12-18 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | | 主引用文献 | Structural and functional characterization of the scoulerine 9-O methyltransferase from Thalictrum flavum.
To Be Published
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6NEJ
 | | scoulerine 9-O-methyltransferase from Thalictrum flavum complexed (13aS)-3,10-dimethoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline-2,9-diol and with S-ADENOSYL-L-HOMOCYSTEINE | | 分子名称: | (13aS)-3,10-dimethoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline-2,9-diol, (S)-scoulerine 9-O-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | | 著者 | Valentic, T.R, Smolke, C.D, Payne, J.T. | | 登録日 | 2018-12-17 | | 公開日 | 2019-12-18 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural and functional characterization of the scoulerine 9-O methyltransferase from Thalictrum flavum.
To Be Published
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5TT4
 | | Determining the Molecular Basis For Starter Unit Selection During Daunorubicin Biosynthesis | | 分子名称: | Daunorubicin-doxorubicin polyketide synthase | | 著者 | Jackson, D.R, Valentic, T.R, Patel, A, Tsai, S.C, Mohammed, L, Vasilakis, K, Wattana-amorn, P, Long, P.F, Crump, M.P, Crosby, J. | | 登録日 | 2016-11-01 | | 公開日 | 2016-11-23 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Determining the Molecular Basis For Starter Unit Selection During Daunorubicin Biosynthesis
To Be Published
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5MTI
 | | Bamb_5917 Acyl-Carrier Protein | | 分子名称: | Phosphopantetheine-binding protein | | 著者 | Gallo, A, Kosol, S, Griffiths, D, Masschelein, J, Alkhalaf, L, Smith, H, Valentic, T, Tsai, S, Challis, G, Lewandowski, J.R. | | 登録日 | 2017-01-09 | | 公開日 | 2018-08-01 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural basis for chain release from the enacyloxin polyketide synthase
Nat.Chem., 2019
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4XRT
 | | Crystal structure of the di-domain ARO/CYC StfQ from the steffimycin biosynthetic pathway | | 分子名称: | FORMIC ACID, StfQ Aromatase/Cyclase | | 著者 | Tsai, S.C, Caldara-Festin, G.M, Jackson, D.R, Aguilar, S, Patel, A, Nguyen, M, Sasaki, E, Valentic, T.R, Barajas, J.F, Vo, M, Khanna, A, Liu, H.-W. | | 登録日 | 2015-01-21 | | 公開日 | 2015-12-02 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.952 Å) | | 主引用文献 | Structural and functional analysis of two di-domain aromatase/cyclases from type II polyketide synthases.
Proc.Natl.Acad.Sci.USA, 112, 2015
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4XRW
 | | Crystal structure of the di-domain ARO/CYC BexL from the BE-7585A biosynthetic pathway | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, BexL | | 著者 | Tsai, S.C, Caldara-Festin, G.M, Jackson, D.R, Aguilar, S, Patel, A, Nguyen, M, Sasaki, E, Valentic, T.R, Barajas, J.F, Vo, M, Khanna, A, Liu, H.-W. | | 登録日 | 2015-01-21 | | 公開日 | 2015-12-02 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Structural and functional analysis of two di-domain aromatase/cyclases from type II polyketide synthases.
Proc.Natl.Acad.Sci.USA, 112, 2015
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4XSA
 | | Determining the Molecular Basis for Starter Unit Selection During Daunorubicin Biosynthesis | | 分子名称: | Daunorubicin-doxorubicin polyketide synthase | | 著者 | Jackson, D.R, Valentic, T.R, Tsai, S.C, Patel, A, Mohammed, L, Vasilakis, K, Wattana-amorn, P, Long, P.F, Crump, M.P, Crosby, J. | | 登録日 | 2015-01-22 | | 公開日 | 2016-01-27 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.204 Å) | | 主引用文献 | Determining the Molecular Basis for Starter Unit Selection During Daunorubicin Biosynthesis
To Be Published
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4XS7
 | | Determining the Molecular Basis for Starter Unit Selection During Daunorubicin Biosynthesis | | 分子名称: | Daunorubicin-doxorubicin polyketide synthase | | 著者 | Jackson, D.R, Valentic, T.R, Tsai, S.C, Patel, A, Mohammed, L, Vasilakis, K, Wattana-amorn, P, Long, P.F, Crump, M.P, Crosby, J. | | 登録日 | 2015-01-22 | | 公開日 | 2016-01-27 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Determining the Molecular Basis for Starter Unit Selection During Daunorubicin Biosynthesis
To Be Published
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4XSB
 | | Determining the Molecular Basis for Starter Unit Selection During Daunorubicin Biosynthesis | | 分子名称: | Daunorubicin-doxorubicin polyketide synthase | | 著者 | Jackson, D.R, Valentic, T.R, Tsai, S.C, Patel, A, Mohammed, L, Vasilakis, K, Wattana-amorn, P, Long, P.F, Crump, M.P, Crosby, J. | | 登録日 | 2015-01-22 | | 公開日 | 2016-01-27 | | 最終更新日 | 2019-12-25 | | 実験手法 | X-RAY DIFFRACTION (2.203 Å) | | 主引用文献 | Determining the Molecular Basis for Starter Unit Selection During Daunorubicin Biosynthesis
To Be Published
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4XS9
 | | Determining the Molecular Basis for Starter Unit Selection During Daunorubicin Biosynthesis | | 分子名称: | Daunorubicin-doxorubicin polyketide synthase, N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-[2-(propanoylamino)ethyl]-beta-alaninamide | | 著者 | Jackson, D.R, Valentic, T.R, Tsai, S.C, Patel, A, Mohammed, L, Vasilakis, K, Wattana-amorn, P, Long, P.F, Crump, M.P, Crosby, J. | | 登録日 | 2015-01-22 | | 公開日 | 2016-01-27 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.002 Å) | | 主引用文献 | Determining the Molecular Basis for Starter Unit Selection During Daunorubicin Biosynthesis
To Be Published
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