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PDB: 134 件
6U1Q
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BU of 6u1q by Molmil
Crystal Structure of VpsO (VC0937) Kinase domain
分子名称: O-PHOSPHOTYROSINE, VpsO
著者Tripathi, S.M, Schwechheimer, C, Herbert, K, Porcella, M.E, Brown, E.R, Yildiz, F.H, Rubin, S.M.
登録日2019-08-16
公開日2020-08-19
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.87 Å)
主引用文献A tyrosine phosphoregulatory system controls exopolysaccharide biosynthesis and biofilm formation in Vibrio cholerae.
Plos Pathog., 16, 2020
6U1P
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BU of 6u1p by Molmil
Crystal structure of VpsU (VC0916) from Vibrio cholerae
分子名称: GLYCEROL, Low molecular weight phosphotyrosine protein phosphatase
著者Tripathi, S.M, Schwechheimer, C, Herbert, K, Osorio, J, Yildiz, F.H, Rubin, S.M.
登録日2019-08-16
公開日2020-08-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.201 Å)
主引用文献A tyrosine phosphoregulatory system controls exopolysaccharide biosynthesis and biofilm formation in Vibrio cholerae.
Plos Pathog., 16, 2020
4RIM
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BU of 4rim by Molmil
Native structure of intercalation-locked DNA tetraplex
分子名称: DNA (5'-D(*AP*CP*TP*CP*GP*GP*AP*TP*GP*AP*T)-3')
著者Tripathi, S.K, Zhang, D, Paukstelis, P.
登録日2014-10-06
公開日2015-02-11
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献An intercalation-locked parallel-stranded DNA tetraplex.
Nucleic Acids Res., 43, 2015
4RIP
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BU of 4rip by Molmil
BromoUracil substituted structure of intercalation-locked DNA tetraplex
分子名称: DNA (5'-D(*AP*CP*(BRU)P*CP*GP*GP*AP*(BRU)P*GP*AP*T)-3')
著者Tripathi, S.K, Zhang, D, Paukstelis, P.
登録日2014-10-07
公開日2015-02-11
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献An intercalation-locked parallel-stranded DNA tetraplex.
Nucleic Acids Res., 43, 2015
8CUR
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BU of 8cur by Molmil
Crystal structure of Cdk2 in complex with Cyclin A inhibitor 6-[(E)-2-(4-chlorophenyl)ethenyl]-2-{[(2R)-3-(4-hydroxyphenyl)-1-methoxy-1-oxopropan-2-yl]carbamoyl}quinoline-4-carboxylic acid
分子名称: 6-[(E)-2-(4-chlorophenyl)ethenyl]-2-{[(2R)-3-(4-hydroxyphenyl)-1-methoxy-1-oxopropan-2-yl]carbamoyl}quinoline-4-carboxylic acid, Cyclin-dependent kinase 2
著者Tripathi, S.M, Tambo, C.S, Kiss, G, Rubin, S.M.
登録日2022-05-17
公開日2023-04-05
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Biolayer Interferometry Assay for Cyclin-Dependent Kinase-Cyclin Association Reveals Diverse Effects of Cdk2 Inhibitors on Cyclin Binding Kinetics.
Acs Chem.Biol., 18, 2023
2VOE
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BU of 2voe by Molmil
Crystal structure of Rv2780 from M. tuberculosis H37Rv
分子名称: ALANINE DEHYDROGENASE
著者Tripathi, S.M, Ramachandran, R.
登録日2008-02-17
公開日2008-03-04
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal Structures of the Mycobacterium Tuberculosis Secretory Antigen Alanine Dehydrogenase (Rv2780) in Apo and Ternary Complex Forms Captures "Open" and "Closed" Enzyme Conformations.
Proteins, 72, 2008
2VOJ
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BU of 2voj by Molmil
Ternary complex of M. tuberculosis Rv2780 with NAD and pyruvate
分子名称: (2S)-2-HYDROXYPROPANOIC ACID, ALANINE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Tripathi, S.M, Ramachandran, R.
登録日2008-02-18
公開日2008-03-04
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal Structures of the Mycobacterium Tuberculosis Secretory Antigen Alanine Dehydrogenase (Rv2780) in Apo and Ternary Complex Forms Captures "Open" and "Closed" Enzyme Conformations.
Proteins: Struct., Funct., Bioinf., 72, 2008
7OY5
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BU of 7oy5 by Molmil
Crystal structure of GSK3Beta in complex with ARN25068
分子名称: CHLORIDE ION, Glycogen synthase kinase-3 beta, ~{N}4-(3-cyclopropyl-1~{H}-pyrazol-5-yl)-~{N}2-(phenylmethyl)thieno[3,2-d]pyrimidine-2,4-diamine
著者Tripathi, S.K, Balboni, B, Demuro, S, DiMartino, R, Giabbai, B, Storici, P, Ortega, J, Girotto, S, Cavalli, A.
登録日2021-06-23
公開日2022-03-02
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.57 Å)
主引用文献ARN25068, a versatile starting point towards triple GSK-3 beta /FYN/DYRK1A inhibitors to tackle tau-related neurological disorders.
Eur.J.Med.Chem., 229, 2022
7OY6
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BU of 7oy6 by Molmil
Crystal structure of human DYRK1A in complex with ARN25068
分子名称: Dual specificity tyrosine-phosphorylation-regulated kinase 1A, ~{N}4-(3-cyclopropyl-1~{H}-pyrazol-5-yl)-~{N}2-(phenylmethyl)thieno[3,2-d]pyrimidine-2,4-diamine
著者Tripathi, S.K, Balboni, B, Demuro, S, DiMartino, R, Ortega, J, Girotto, S, Cavalli, A.
登録日2021-06-23
公開日2022-03-02
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.38 Å)
主引用文献ARN25068, a versatile starting point towards triple GSK-3 beta /FYN/DYRK1A inhibitors to tackle tau-related neurological disorders.
Eur.J.Med.Chem., 229, 2022
6CPB
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BU of 6cpb by Molmil
Crystal structure of the heme domain of CooA from Carboxydothermus hydrogenoformans
分子名称: Carbon monoxide oxidation system transcription regulator CooA-1, GLYCEROL, SULFATE ION
著者Tripathi, S.M, Poulos, T.L.
登録日2018-03-13
公開日2018-05-16
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.155 Å)
主引用文献Testing the N-Terminal Velcro Model of CooA Carbon Monoxide Activation.
Biochemistry, 57, 2018
5CV2
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BU of 5cv2 by Molmil
Structural implications of homo-pyrimidine base pairs on the parallel-stranded d(GAY) motif
分子名称: DNA (5'-D(*AP*CP*TP*CP*GP*GP*AP*CP*GP*AP*CP*GP*AP*T)-3'), STRONTIUM ION
著者Tripathi, S, Paukstelis, P.
登録日2015-07-25
公開日2015-12-16
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.693 Å)
主引用文献Structural Implications of Homopyrimidine Base Pairs in the Parallel-Stranded d(YGA) Motif.
Chembiochem, 17, 2016
5IBN
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BU of 5ibn by Molmil
Ultra high resolution crystal structure of the apo- form of second bromodomain of BRD2.
分子名称: Bromodomain-containing protein 2, CHLORIDE ION, GLYCEROL, ...
著者Tripathi, S.K, Padmanabhan, B.
登録日2016-02-22
公開日2016-06-22
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (0.94 Å)
主引用文献A Novel Phenanthridionone Based Scaffold As a Potential Inhibitor of the BRD2 Bromodomain: Crystal Structure of the Complex
Plos One, 11, 2016
5IG6
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BU of 5ig6 by Molmil
Ultra-high resolution crystal structure of second bromodomain of BRD2 in complex with inhibitor 6B3
分子名称: 2'-[(6-oxo-5,6-dihydrophenanthridin-3-yl)carbamoyl][1,1'-biphenyl]-2-carboxylic acid, Bromodomain-containing protein 2, CHLORIDE ION, ...
著者Tripathi, S.K, Padmanabhan, B.
登録日2016-02-27
公開日2016-06-22
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (0.91 Å)
主引用文献A Novel Phenanthridionone Based Scaffold As a Potential Inhibitor of the BRD2 Bromodomain: Crystal Structure of the Complex
Plos One, 11, 2016
4IMH
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BU of 4imh by Molmil
Crystal Structure of Cytoplasmic Heme Binding Protein, PhuS, from Pseudomonas aeruginosa
分子名称: Hemin degrading factor
著者Tripathi, S.M, Poulos, T.L.
登録日2013-01-02
公開日2013-09-18
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.976 Å)
主引用文献Crystal structure of the Pseudomonas aeruginosa cytoplasmic heme binding protein, Apo-PhuS.
J.Inorg.Biochem., 128C, 2013
4ZYM
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BU of 4zym by Molmil
Structural implications of homo-pyrimidine base pairs on the parallel-stranded d(GAY) motif.
分子名称: DNA (5'-D(*AP*CP*TP*CP*GP*GP*AP*CP*GP*AP*T)-3'), MAGNESIUM ION
著者Tripathi, S.K, Paukstelis, P.
登録日2015-05-21
公開日2015-12-16
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.53 Å)
主引用文献Structural Implications of Homopyrimidine Base Pairs in the Parallel-Stranded d(YGA) Motif.
Chembiochem, 17, 2016
4JWS
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BU of 4jws by Molmil
Crystal structure of Cytochrome P450cam-putidaredoxin complex
分子名称: 1,1'-hexane-1,6-diyldipyrrolidine-2,5-dione, CALCIUM ION, Camphor 5-monooxygenase, ...
著者Tripathi, S.M, Li, H, Poulos, T.L.
登録日2013-03-27
公開日2013-06-19
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural basis for effector control and redox partner recognition in cytochrome P450.
Science, 340, 2013
4JWU
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BU of 4jwu by Molmil
Crystal structure of Cytochrome P450cam-putidaredoxin complex
分子名称: 1,1'-hexane-1,6-diyldipyrrolidine-2,5-dione, CALCIUM ION, Camphor 5-monooxygenase, ...
著者Tripathi, S.M, Li, H, Poulos, T.L.
登録日2013-03-27
公開日2013-06-19
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural basis for effector control and redox partner recognition in cytochrome P450.
Science, 340, 2013
4JX1
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BU of 4jx1 by Molmil
Crystal structure of reduced Cytochrome P450cam-putidaredoxin complex bound to camphor and 5-exo-hydroxycamphor
分子名称: 1,1'-hexane-1,6-diyldipyrrolidine-2,5-dione, 5-EXO-HYDROXYCAMPHOR, CALCIUM ION, ...
著者Tripathi, S.M, Li, H, Poulos, T.L.
登録日2013-03-27
公開日2013-06-19
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.087 Å)
主引用文献Structural basis for effector control and redox partner recognition in cytochrome P450.
Science, 340, 2013
2CIN
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BU of 2cin by Molmil
Lysine aminotransferase from M. tuberculosis in the internal aldimine form
分子名称: L-LYSINE-EPSILON AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE
著者Tripathi, S.M, Ramachandran, R.
登録日2006-03-24
公開日2006-08-14
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Direct Evidence for a Glutamate Switch Necessary for Substrate Recognition: Crystal Structures of Lysine Epsilon-Aminotransferase (Rv3290C) from Mycobacterium Tuberculosis H37Rv.
J.Mol.Biol., 362, 2006
2CJH
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BU of 2cjh by Molmil
Lysine aminotransferase from M. tuberculosis in the internal aldimine form with bound substrate 2-ketoglutarate
分子名称: 2-OXOGLUTARIC ACID, L-LYSINE-EPSILON AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE
著者Tripathi, S.M, Ramachandran, R.
登録日2006-04-03
公開日2006-08-14
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Direct Evidence for a Glutamate Switch Necessary for Substrate Recognition: Crystal Structures of Lysine Epsilon-Aminotransferase (Rv3290C) from Mycobacterium Tuberculosis H37Rv.
J.Mol.Biol., 362, 2006
2JJF
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BU of 2jjf by Molmil
N328A mutant of M. tuberculosis Rv3290c
分子名称: L-LYSINE EPSILON AMINOTRANSFERASE
著者tripathi, S.M, Ramachandran, R.
登録日2008-04-04
公開日2009-06-30
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Mutational Analysis of Mycobacterium Tuberculosis Lysine Epsilon-Aminotransferase and Inhibitor Co-Crystal Structures, Reveals Distinct Binding Modes.
Biochem.Biophys.Res.Commun., 463, 2015
2JJH
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BU of 2jjh by Molmil
E243 mutant of M. tuberculosis Rv3290C
分子名称: 2-OXOGLUTARIC ACID, L-LYSINE EPSILON AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE
著者Tripathi, S.M, Ramachandran, R.
登録日2008-04-04
公開日2009-06-30
最終更新日2020-01-15
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Mutational Analysis of Mycobacterium Tuberculosis Lysine Epsilon-Aminotransferase and Inhibitor Co-Crystal Structures, Reveals Distinct Binding Modes.
Biochem.Biophys.Res.Commun., 463, 2015
2CJG
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BU of 2cjg by Molmil
Lysine aminotransferase from M. tuberculosis in bound PMP form
分子名称: 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, L-LYSINE-EPSILON AMINOTRANSFERASE
著者Tripathi, S.M, Ramachandran, R.
登録日2006-04-01
公開日2006-08-14
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Direct Evidence for a Glutamate Switch Necessary for Substrate Recognition: Crystal Structures of Lysine Epsilon-Aminotransferase (Rv3290C) from Mycobacterium Tuberculosis H37Rv.
J.Mol.Biol., 362, 2006
2CJD
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BU of 2cjd by Molmil
Lysine aminotransferase from M. tuberculosis in external aldimine form
分子名称: L-LYSINE-EPSILON AMINOTRANSFERASE, LYSINE, PYRIDOXAL-5'-PHOSPHATE
著者Tripathi, S.M, Ramachandran, R.
登録日2006-03-31
公開日2006-08-14
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Direct Evidence for a Glutamate Switch Necessary for Substrate Recognition: Crystal Structures of Lysine Epsilon-Aminotransferase (Rv3290C) from Mycobacterium Tuberculosis H37Rv.
J.Mol.Biol., 362, 2006
2JJG
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BU of 2jjg by Molmil
Crystal structure of the M. tuberculosis Lysine-epsilon aminotransferase (Rv3290c) complexed to an inhibitor
分子名称: (2S)-1-methyl-2-[(2S,4R)-2-methyl-4-phenylpentyl]piperidine, L-LYSINE EPSILON AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE
著者Tripathi, S.M, Ramachandran, R.
登録日2008-04-04
公開日2009-06-30
最終更新日2017-01-25
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Mutational Analysis of Mycobacterium Tuberculosis Lysine Epsilon-Aminotransferase and Inhibitor Co-Crystal Structures, Reveals Distinct Binding Modes.
Biochem.Biophys.Res.Commun., 463, 2015

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