7OY6
Crystal structure of human DYRK1A in complex with ARN25068
Summary for 7OY6
Entry DOI | 10.2210/pdb7oy6/pdb |
Descriptor | Dual specificity tyrosine-phosphorylation-regulated kinase 1A, ~{N}4-(3-cyclopropyl-1~{H}-pyrazol-5-yl)-~{N}2-(phenylmethyl)thieno[3,2-d]pyrimidine-2,4-diamine (3 entities in total) |
Functional Keywords | inhibitor, complex, gsk-3b, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 42225.71 |
Authors | Tripathi, S.K.,Balboni, B.,Demuro, S.,DiMartino, R.,Ortega, J.,Girotto, S.,Cavalli, A. (deposition date: 2021-06-23, release date: 2022-03-02, Last modification date: 2024-01-31) |
Primary citation | Demuro, S.,Sauvey, C.,Tripathi, S.K.,Di Martino, R.M.C.,Shi, D.,Ortega, J.A.,Russo, D.,Balboni, B.,Giabbai, B.,Storici, P.,Girotto, S.,Abagyan, R.,Cavalli, A. ARN25068, a versatile starting point towards triple GSK-3 beta /FYN/DYRK1A inhibitors to tackle tau-related neurological disorders. Eur.J.Med.Chem., 229:114054-114054, 2022 Cited by PubMed: 34959172DOI: 10.1016/j.ejmech.2021.114054 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.38 Å) |
Structure validation
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