3AH3
| Crystal structure of LR5-1, 3-isopropylmalate dehydrogenase created by directed evolution | 分子名称: | 1,2-ETHANEDIOL, Homoisocitrate dehydrogenase, SULFATE ION | 著者 | Tomita, T, Suzuki, Y, Kuzuyama, T, Nishiyama, M. | 登録日 | 2010-04-13 | 公開日 | 2011-02-02 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Enhancement of the latent 3-isopropylmalate dehydrogenase activity of promiscuous homoisocitrate dehydrogenase by directed evolution Biochem.J., 431, 2010
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3AOE
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5K2M
| Bifunctional LysX/ArgX from Thermococcus kodakarensis with LysW-gamma-AAA | 分子名称: | 2-AMINOHEXANEDIOIC ACID, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Yoshida, A, Tomita, T, Nishiyama, M. | 登録日 | 2016-05-19 | 公開日 | 2016-09-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | 主引用文献 | Lysine Biosynthesis of Thermococcus kodakarensis with the Capacity to Function as an Ornithine Biosynthetic System. J. Biol. Chem., 291, 2016
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6XYO
| Multiple system atrophy Type I alpha-synuclein filament | 分子名称: | Alpha-synuclein | 著者 | Schweighauser, M, Shi, Y, Tarutani, A, Kametani, F, Murzin, A.G, Ghetti, B, Matsubara, T, Tomita, T, Ando, T, Hasegawa, K, Murayama, S, Yoshida, M, Hasegawa, M, Scheres, S.H.W, Goedert, M. | 登録日 | 2020-01-30 | 公開日 | 2020-02-12 | 最終更新日 | 2020-09-30 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structures of alpha-synuclein filaments from multiple system atrophy. Nature, 585, 2020
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6XYP
| Multiple system atrophy Type II-1 alpha-synuclein filament | 分子名称: | Alpha-synuclein | 著者 | Schweighauser, M, Shi, Y, Tarutani, A, Kametani, F, Murzin, A.G, Ghetti, B, Matsubara, T, Tomita, T, Ando, T, Hasegawa, K, Murayama, S, Yoshida, M, Hasegawa, M, Scheres, S.H.W, Goedert, M. | 登録日 | 2020-01-30 | 公開日 | 2020-02-12 | 最終更新日 | 2020-09-30 | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | 主引用文献 | Structures of alpha-synuclein filaments from multiple system atrophy. Nature, 585, 2020
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6XYQ
| Multiple system atrophy Type II-2 alpha-synuclein filament | 分子名称: | Alpha-synuclein | 著者 | Schweighauser, M, Shi, Y, Tarutani, A, Kametani, F, Murzin, A.G, Ghetti, B, Matsubara, T, Tomita, T, Ando, T, Hasegawa, K, Murayama, S, Yoshida, M, Hasegawa, M, Scheres, S.H.W, Goedert, M. | 登録日 | 2020-01-30 | 公開日 | 2020-02-12 | 最終更新日 | 2020-09-30 | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | 主引用文献 | Structures of alpha-synuclein filaments from multiple system atrophy. Nature, 585, 2020
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5EIO
| Crystal structure of LysY from Thermus thermophilus complexed with NADP+ and LysW-gamma-aminoadipic semialdehyde | 分子名称: | ACETIC ACID, N-acetyl-gamma-glutamyl-phosphate/N-acetyl-gamma-aminoadipyl-phosphate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Shimizu, T, Tomita, T, Nishiyama, M. | 登録日 | 2015-10-30 | 公開日 | 2016-03-23 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal Structure of the LysYLysW Complex from Thermus thermophilus. J.Biol.Chem., 291, 2016
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4YB4
| Crystal structure of homoisocitrate dehydrogenase from Thermus thermophilus in complex with homoisocitrate, magnesium ion (II) and NADH | 分子名称: | (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylic acid, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, GLYCEROL, ... | 著者 | Takahashi, K, Tomita, T, Kuzuyama, T, Nishiyama, M. | 登録日 | 2015-02-18 | 公開日 | 2016-03-09 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure of homoisocitrate dehydrogenase from Thermus thermophilus in complex with homoisocitrate, magnesium(II) and NADH To Be Published
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4Y1P
| Crystal structure of 3-isopropylmalate dehydrogenase (Saci_0600) from Sulfolobus acidocaldarius complex with 3-isopropylmalate and Mg2+ | 分子名称: | 3-ISOPROPYLMALIC ACID, 3-isopropylmalate dehydrogenase, MAGNESIUM ION, ... | 著者 | Takahashi, K, Tomita, T, Kuzuyama, T, Nishiyama, M. | 登録日 | 2015-02-08 | 公開日 | 2016-03-09 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Characterization of two beta-decarboxylating dehydrogenases from Sulfolobus acidocaldarius Extremophiles, 20, 2016
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8HAR
| SAH-bound C-Methyltransferase Fur6 from Streptomyces sp. KO-3988 | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Fur6, S-ADENOSYL-L-HOMOCYSTEINE | 著者 | Noguchi, T, Nagata, R, Tomita, T, Kuzuyama, T. | 登録日 | 2022-10-26 | 公開日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | Reductive biosynthesis of meroterpenoids via transient diazotization To Be Published
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8GYH
| Crystal structure of Fic25 (apo form) from Streptomyces ficellus | 分子名称: | DegT/DnrJ/EryC1/StrS family aminotransferase, GLYCEROL, IMIDAZOLE | 著者 | Kurosawa, S, Yoshida, A, Tomita, T, Nishiyama, M. | 登録日 | 2022-09-22 | 公開日 | 2023-02-22 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Mechanisms of Sugar Aminotransferase-like Enzymes to Synthesize Stereoisomers of Non-proteinogenic Amino Acids in Natural Product Biosynthesis. Acs Chem.Biol., 18, 2023
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8GYJ
| Crystal structure of Fic25 complexed with PLP-(5S,6S)-N2-acetyl-DADH adduct from Streptomyces ficellus | 分子名称: | (2~{S},5~{S},6~{S})-2-acetamido-6-[[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylamino]-5,7-bis(oxidanyl)heptanoic acid, DegT/DnrJ/EryC1/StrS family aminotransferase, GLYCEROL, ... | 著者 | Kurosawa, S, Yoshida, A, Tomita, T, Nishiyama, M. | 登録日 | 2022-09-22 | 公開日 | 2023-02-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Mechanisms of Sugar Aminotransferase-like Enzymes to Synthesize Stereoisomers of Non-proteinogenic Amino Acids in Natural Product Biosynthesis. Acs Chem.Biol., 18, 2023
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8GYI
| Crystal structure of Fic25 (holo form) from Streptomyces ficellus | 分子名称: | DegT/DnrJ/EryC1/StrS family aminotransferase, GLYCEROL, IMIDAZOLE, ... | 著者 | Kurosawa, S, Yoshida, A, Tomita, T, Nishiyama, M. | 登録日 | 2022-09-22 | 公開日 | 2023-02-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Mechanisms of Sugar Aminotransferase-like Enzymes to Synthesize Stereoisomers of Non-proteinogenic Amino Acids in Natural Product Biosynthesis. Acs Chem.Biol., 18, 2023
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5HN4
| Crystal structure of beta-decarboxylating dehydrogenase (TK0280) from Thermococcus kodakarensis complexed with Mn and homoisocitrate | 分子名称: | (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylic acid, Homoisocitrate dehydrogenase, IMIDAZOLE, ... | 著者 | Shimizu, T, Tomita, T, Nishiyama, M. | 登録日 | 2016-01-18 | 公開日 | 2016-12-07 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | 主引用文献 | Structure and function of an ancestral-type beta-decarboxylating dehydrogenase from Thermococcus kodakarensis Biochem. J., 474, 2017
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5HN5
| Crystal structure of beta-decarboxylating dehydrogenase (TK0280) from Thermococcus kodakarensis complexed with Mn and isocitrate | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Homoisocitrate dehydrogenase, ISOCITRIC ACID, ... | 著者 | Shimizu, T, Tomita, T, Nishiyama, M. | 登録日 | 2016-01-18 | 公開日 | 2016-12-07 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Structure and function of an ancestral-type beta-decarboxylating dehydrogenase from Thermococcus kodakarensis Biochem. J., 474, 2017
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5HN6
| Crystal structure of beta-decarboxylating dehydrogenase (TK0280) from Thermococcus kodakarensis complexed with Mn and 3-isopropylmalate | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 3-ISOPROPYLMALIC ACID, Homoisocitrate dehydrogenase, ... | 著者 | Shimizu, T, Tomita, T, Nishiyama, M. | 登録日 | 2016-01-18 | 公開日 | 2016-12-07 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure and function of an ancestral-type beta-decarboxylating dehydrogenase from Thermococcus kodakarensis Biochem. J., 474, 2017
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5HN3
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5EIN
| Crystal structure of C148A mutant of LysY from Thermus thermophilus in complex with NADP+ and LysW-gamma-aminoadipic acid | 分子名称: | Alpha-aminoadipate carrier protein LysW, FORMIC ACID, N-acetyl-gamma-glutamyl-phosphate/N-acetyl-gamma-aminoadipyl-phosphate reductase, ... | 著者 | Shimizu, T, Tomita, T, Nishiyama, M. | 登録日 | 2015-10-30 | 公開日 | 2016-03-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal Structure of the LysYLysW Complex from Thermus thermophilus. J.Biol.Chem., 291, 2016
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6IR4
| Crystal structure of BioU from Synechocystis sp.PCC6803 (apo form) | 分子名称: | Slr0355 protein | 著者 | Sakaki, K, Oishi, K, Shimizu, T, Tomita, T, Kuzuyama, T, Nishiyama, M. | 登録日 | 2018-11-10 | 公開日 | 2020-01-15 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A suicide enzyme catalyzes multiple reactions for biotin biosynthesis in cyanobacteria. Nat.Chem.Biol., 16, 2020
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6ITD
| Crystal structure of BioU (K124A) from Synechocystis sp.PCC6803 in complex with the analog of reaction intermediate, 3-(1-aminoethyl)-nonanedioic acid | 分子名称: | 3-(1-AMINOETHYL)NONANEDIOIC ACID, Slr0355 protein | 著者 | Sakaki, K, Tomita, T, Kuzuyama, T, Nishiyama, M. | 登録日 | 2018-11-21 | 公開日 | 2020-01-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A suicide enzyme catalyzes multiple reactions for biotin biosynthesis in cyanobacteria. Nat.Chem.Biol., 16, 2020
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6K36
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2DT9
| Crystal structure of the regulatory subunit of aspartate kinase from Thermus flavus | 分子名称: | ACETATE ION, Aspartokinase, THREONINE | 著者 | Yoshida, A, Tomita, T, Fushinobu, S, Kuzuyama, T, Nishiyama, M. | 登録日 | 2006-07-11 | 公開日 | 2007-07-17 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Crystal structures of the regulatory subunit of Thr-sensitive aspartate kinase from Thermus thermophilus Febs J., 276, 2009
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2DTJ
| Crystal structure of regulatory subunit of aspartate kinase from Corynebacterium glutamicum | 分子名称: | Aspartokinase, CITRIC ACID, THREONINE | 著者 | Yoshida, A, Tomita, T, Fushinobu, S, Kuzuyama, T, Nishiyama, M. | 登録日 | 2006-07-12 | 公開日 | 2007-05-01 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Structural Insight into Concerted Inhibition of alpha(2)beta(2)-Type Aspartate Kinase from Corynebacterium glutamicum J.Mol.Biol., 368, 2007
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6KTQ
| Crystal structure of catalytic domain of homocitrate synthase from Sulfolobus acidocaldarius (SaHCS(dRAM)) in complex with alpha-ketoglutarate/Zn2+/CoA | 分子名称: | 2-OXOGLUTARIC ACID, COENZYME A, Homocitrate synthase, ... | 著者 | Suzuki, T, Tomita, T, Kuzuyama, T, Nishiyama, M. | 登録日 | 2019-08-28 | 公開日 | 2020-09-02 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Involvement of subdomain II in the recognition of acetyl-CoA revealed by the crystal structure of homocitrate synthase from Sulfolobus acidocaldarius. Febs J., 288, 2021
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3WWN
| Crystal structure of LysZ from Thermus thermophilus complex with LysW | 分子名称: | OrfF, Putative acetylglutamate kinase-like protein, SULFATE ION, ... | 著者 | Yoshida, A, Tomita, T, Kuzuyama, T, Nishiyama, M. | 登録日 | 2014-06-21 | 公開日 | 2014-11-19 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structural insight into amino group-carrier protein-mediated lysine biosynthesis: crystal structure of the LysZ·LysW complex from Thermus thermophilus. J.Biol.Chem., 290, 2015
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