1WZE
 
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1WZI
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1Y7T
 | | Crystal structure of NAD(H)-depenent malate dehydrogenase complexed with NADPH | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Malate dehydrogenase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Tomita, T, Fushinobu, S, Kuzuyama, T, Nishiyama, M. | | 登録日 | 2004-12-10 | | 公開日 | 2005-08-02 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Crystal structure of NAD-dependent malate dehydrogenase complexed with NADP(H)
Biochem.Biophys.Res.Commun., 334, 2005
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6IPW
 | | Crystal structure of CqsB2 from Streptomyces exfoliatus in complex with the product, 1-(2-hydroxypropyl)-2-methyl-carbazole-3,4-dione | | 分子名称: | 2-methyl-1-[(2R)-2-oxidanylpropyl]-9H-carbazole-3,4-dione, CqsB2 | | 著者 | Tomita, T, Kobayashi, M, Nishiyama, M, Kuzuyama, T. | | 登録日 | 2018-11-05 | | 公開日 | 2019-10-16 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | An Unprecedented Cyclization Mechanism in the Biosynthesis of Carbazole Alkaloids in Streptomyces.
Angew.Chem.Int.Ed.Engl., 58, 2019
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6IPV
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5GUE
 | | Crystal structure of CotB2 (GGSPP/Mg2+-Bound Form) from Streptomyces melanosporofaciens | | 分子名称: | Cyclooctat-9-en-7-ol synthase, MAGNESIUM ION, phosphonooxy-[(10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl]sulfanyl-phosphinic acid | | 著者 | Tomita, T, Kim, S.-Y, Ozaki, T, Yoshida, A, Kuzuyama, T, Nishiyama, M. | | 登録日 | 2016-08-28 | | 公開日 | 2017-06-07 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural Insights into the CotB2-Catalyzed Cyclization of Geranylgeranyl Diphosphate to the Diterpene Cyclooctat-9-en-7-ol
ACS Chem. Biol., 12, 2017
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5GUL
 | | Crystal structure of Tris/PPix2/Mg2+ bound form of cyclolavandulyl diphosphate synthase (CLDS) from Streptomyces sp. CL190 | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cyclolavandulyl diphosphate synthase, MAGNESIUM ION, ... | | 著者 | Tomita, T, Kobayashi, M, Nishiyama, M, Kuzuyama, T. | | 登録日 | 2016-08-29 | | 公開日 | 2017-08-30 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | | 主引用文献 | Structure and Mechanism of the Monoterpene Cyclolavandulyl Diphosphate Synthase that Catalyzes Consecutive Condensation and Cyclization.
Angew. Chem. Int. Ed. Engl., 56, 2017
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5GUC
 | | Crystal structure of CotB2 (apo form) from Streptomyces melanosporofaciens | | 分子名称: | Cyclooctat-9-en-7-ol synthase, FORMIC ACID | | 著者 | Tomita, T, Kim, S.-Y, Ozaki, T, Yoshida, A, Kuzuyama, T, Nishiyama, M. | | 登録日 | 2016-08-28 | | 公開日 | 2017-06-07 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural Insights into the CotB2-Catalyzed Cyclization of Geranylgeranyl Diphosphate to the Diterpene Cyclooctat-9-en-7-ol
ACS Chem. Biol., 12, 2017
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5GUK
 | | Crystal structure of apo form of cyclolavandulyl diphosphate synthase (CLDS) from Streptomyces sp. CL190 | | 分子名称: | CHLORIDE ION, Cyclolavandulyl diphosphate synthase | | 著者 | Tomita, T, Kobayashi, M, Nishiyama, M, Kuzuyama, T. | | 登録日 | 2016-08-29 | | 公開日 | 2017-08-30 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure and Mechanism of the Monoterpene Cyclolavandulyl Diphosphate Synthase that Catalyzes Consecutive Condensation and Cyclization.
Angew. Chem. Int. Ed. Engl., 56, 2017
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3CBF
 | | Crystal structure of LysN, alpha-aminoadipate aminotransferase, from Thermus thermophilus HB27 | | 分子名称: | (2S)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]hexanedioic acid, Alpha-aminodipate aminotransferase | | 著者 | Tomita, T, Miyazaki, T, Miyagawa, T, Fushinobu, S, Kuzuyama, T, Nishiyama, M. | | 登録日 | 2008-02-21 | | 公開日 | 2009-01-13 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | | 主引用文献 | Mechanism for multiple-substrates recognition of alpha-aminoadipate aminotransferase from Thermus thermophilus
Proteins, 2008
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5GUD
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2EGY
 | | Crystal structure of LysN, alpha-aminoadipate aminotransferase (substrate free form), from Thermus thermophilus HB27 | | 分子名称: | Alpha-aminodipate aminotransferase, PYRIDOXAL-5'-PHOSPHATE | | 著者 | Tomita, T, Miyazaki, T, Miyagawa, T, Fushinobu, S, Kuzuyama, T, Nishiyama, M. | | 登録日 | 2007-03-02 | | 公開日 | 2008-03-04 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | | 主引用文献 | Crystal structure of LysN, alpha-aminoadipate aminotransferase, from Thermus thermophilus HB27
To be Published
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2ZP7
 | | Crystal structure of LysN, alpha-aminoadipate aminotransferase (Leucine complex), from Thermus thermophilus HB27 | | 分子名称: | Alpha-aminodipate aminotransferase, LEUCINE, PYRIDOXAL-5'-PHOSPHATE | | 著者 | Tomita, T, Miyazaki, T, Miyagawa, T, Fushinobu, S, Kuzuyama, T, Nishiyama, M. | | 登録日 | 2008-06-30 | | 公開日 | 2009-01-13 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | Mechanism for multiple-substrates recognition of alpha-aminoadipate aminotransferase from Thermus thermophilus
Proteins, 2008
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2CVQ
 | | Crystal structure of NAD(H)-dependent malate dehydrogenase complexed with NADPH | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Malate dehydrogenase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Tomita, T, Fushinobu, S, Kuzuyama, T, Nishiyama, M. | | 登録日 | 2005-06-13 | | 公開日 | 2005-08-02 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | | 主引用文献 | Crystal structure of NAD-dependent malate dehydrogenase complexed with NADP(H)
Biochem.Biophys.Res.Commun., 334, 2005
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2Z1Y
 | | Crystal structure of LysN, alpha-aminoadipate aminotransferase (complexed with N-(5'-phosphopyridoxyl)-L-leucine), from Thermus thermophilus HB27 | | 分子名称: | Alpha-aminodipate aminotransferase, LEUCINE, PYRIDOXAL-5'-PHOSPHATE | | 著者 | Tomita, T, Miyazaki, T, Miyagawa, T, Fushinobu, S, Kuzuyama, T, Nishiyama, M. | | 登録日 | 2007-05-16 | | 公開日 | 2008-06-03 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Mechanism of broad substrate specificity of alpha-aminoadipate aminotransferase from Thermus thermophilus
To be Published
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5X3D
 | | Crystal structure of HEP-CMP-bound form of cytidylyltransferase (CyTase) domain of Fom1 from Streptomyces wedmorensis | | 分子名称: | Phosphoenolpyruvate phosphomutase, [[(2R,3S,4R,5R)-5-(4-azanyl-2-oxidanylidene-pyrimidin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-(2-hydroxyethyl)phosphinic acid | | 著者 | Tomita, T, Cho, S.H, Kuzuyama, T, Nishiyama, M. | | 登録日 | 2017-02-04 | | 公開日 | 2017-09-13 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | Fosfomycin Biosynthesis via Transient Cytidylylation of 2-Hydroxyethylphosphonate by the Bifunctional Fom1 Enzyme
ACS Chem. Biol., 12, 2017
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3VPB
 | | ArgX from Sulfolobus tokodaii complexed with LysW/Glu/ADP/Mg/Zn/Sulfate | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Alpha-aminoadipate carrier protein lysW, GLUTAMIC ACID, ... | | 著者 | Tomita, T, Ouchi, T, Kuzuyama, T, Nishiyama, M. | | 登録日 | 2012-02-29 | | 公開日 | 2013-02-27 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Lysine and arginine biosyntheses mediated by a common carrier protein in Sulfolobus
Nat.Chem.Biol., 9, 2013
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3AOG
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3AH3
 | | Crystal structure of LR5-1, 3-isopropylmalate dehydrogenase created by directed evolution | | 分子名称: | 1,2-ETHANEDIOL, Homoisocitrate dehydrogenase, SULFATE ION | | 著者 | Tomita, T, Suzuki, Y, Kuzuyama, T, Nishiyama, M. | | 登録日 | 2010-04-13 | | 公開日 | 2011-02-02 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Enhancement of the latent 3-isopropylmalate dehydrogenase activity of promiscuous homoisocitrate dehydrogenase by directed evolution
Biochem.J., 431, 2010
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3VPD
 | | LysX from Thermus thermophilus complexed with AMP-PNP | | 分子名称: | CITRIC ACID, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ribosomal protein S6 modification protein, ... | | 著者 | Tomita, T, Ouchi, T, Kuzuyama, T, Nishiyama, M. | | 登録日 | 2012-02-29 | | 公開日 | 2013-02-27 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Lysine and arginine biosyntheses mediated by a common carrier protein in Sulfolobus.
Nat.Chem.Biol., 9, 2013
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3VPC
 | | ArgX from Sulfolobus tokodaii complexed with ADP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Putative acetylornithine deacetylase | | 著者 | Tomita, T, Horie, A, Kuzuyama, T, Nishiyama, M. | | 登録日 | 2012-02-29 | | 公開日 | 2013-02-27 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | | 主引用文献 | Lysine and arginine biosyntheses mediated by a common carrier protein in Sulfolobus.
Nat.Chem.Biol., 9, 2013
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3AOE
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5XOY
 | | Crystal structure of LysK from Thermus thermophilus in complex with Lysine | | 分子名称: | LYSINE, SULFATE ION, [LysW]-lysine hydrolase | | 著者 | Tomita, T, Fujita, S, Hasebe, F, Cho, S.-H, Yoshida, A, Kuzuyama, T, Nishiyama, M. | | 登録日 | 2017-05-31 | | 公開日 | 2017-09-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | | 主引用文献 | Crystal structure of LysK, an enzyme catalyzing the last step of lysine biosynthesis in Thermus thermophilus, in complex with lysine: Insight into the mechanism for recognition of the amino-group carrier protein, LysW
Biochem. Biophys. Res. Commun., 491, 2017
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3VVE
 | | Crystal structure of TTC0807 complexed with Lysine | | 分子名称: | Amino acid ABC transporter, binding protein, LYSINE, ... | | 著者 | Tomita, T, Kanemaru, Y, Hasebe, F, Kuzuyama, T, Nishiyama, M. | | 登録日 | 2012-07-21 | | 公開日 | 2013-06-26 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Two ATP-Binding Cassette Transporters Involved in (S)-2-Aminoethyl-Cysteine Uptake in Thermus thermophilus
J.Bacteriol., 195, 2013
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3VV5
 | | Crystal structure of TTC0807 complexed with (S)-2-aminoethyl-L-cysteine (AEC) | | 分子名称: | Amino acid ABC transporter, binding protein, L-THIALYSINE, ... | | 著者 | Tomita, T, Kanemaru, Y, Hasebe, F, Kuzuyama, T, Nishiyama, M. | | 登録日 | 2012-07-16 | | 公開日 | 2013-06-26 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Two ATP-Binding Cassette Transporters Involved in (S)-2-Aminoethyl-Cysteine Uptake in Thermus thermophilus
J.Bacteriol., 195, 2013
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